Functions of the Skin

Psychosocial Function of Skin

Anatomy of the Skin

Structures in Skin

Summary: Skin and Skin Disorders

Functions of the Skin

Functions of the Skin

Skin As Barrier

Functions of the Skin

Functions of the Skin

Summary: Skin and Skin Disorders

Skin Anatomy

Anatomy of the Skin

Anatomy of the Skin

Fabry Disease : Overview

Common Clinical Manifestations: Dermatological

Functions of the Skin

Blood Reservoir

Functions of the Skin

Functions of the Skin
Skin As Barrier
Temperature Regulation
Sensation
Metabolis...

Summary: Skin and Skin Disorders

Skin Diseases
Skin Anatomy
Functions of the Skin

Anatomy of the Skin

The Dermis

Skin Diseases

Skin Disease (Dermatosis)
Signs of Skin Disease
Types of Skin Diseases
Dermatitis

Anatomy of the Skin

The Epidermis

Immune System of the Skin

Skin Barrier

Functions of the Skin

Metabolism

Functions of the Skin

Temperature Regulation

Functions of the Skin

Excretion

Structure and Function of the Skin

Overview: Structure and Function of the Skin

Layers of the Skin: Epidermis

Layers of the Skin: Epidermis: Introduction

Skin Diseases

Types of Skin Diseases

Skin Diseases

Disease of the Hair Follicle and Sebaceous Gland

Anatomy and Physiology of the Skin: Summary

Anatomy and Physiology of the Skin: Summary

Anatomy of the Skin

Anatomy of the Skin
The Epidermis
The Dermis
Structures in Skin
Hair, Hair Folli...

Skin Diseases

Skin Infections

Skin Diseases

Signs of Skin Disease

Immune System of the Skin

Immune System of the Skin: Overview

Skin Diseases

Skin Disease (Dermatosis)

Anatomy of the Skin

Sweat (Sudoriferous) Glands

Anatomy and Physiology of the Skin: Introduction

Anatomy and Physiology of the Skin: Learning Objectives

Summary: Skin and Skin Disorders

Skin Diseases

Functions of the Skin

Sensation

Normal Skin Anatomy

The Structure and Function of Normal Skin

Skin Diseases

Scaling Papular Disease

Layers of the Skin: Epidermis

Epidermal Layers

Skin Diseases

Dermatitis

Anatomy of the Skin

Nails

Anatomy of the Skin

Hair, Hair Follicles, and Sebaceous Glands

Layers of the Skin: Dermal-Epidermal Junction, Dermis

Layers of the Skin: Dermal-Epidermal Junction, Dermis: Overview

Anatomy and Physiology of the Skin: Introduction

Anatomy and Physiology of the Skin: Introduction

Layers of the Skin: Epidermis

Epidermal Functions: Desquamation

Layers of the Skin: Epidermis

Other Cells of the Epidermis

Overview of Skin Structure and Function

Overview of Skin Structure and Function

Skin Prick Test

Skin Prick Test

Oxidative Stress

Oxidative Stress: The Major Cause of Skin Aging

Layers of the Skin: Epidermis

Epidermis Layers

Layers of the Skin: Epidermis

Epidermal Functions: Keratinocyte Differentiation

Layers of the Skin: Dermal-Epidermal Junction, Dermis

Other Components of the Dermis: Ground Substance

Layers of the Skin: Dermal-Epidermal Junction, Dermis

Cells of the Dermis

Layers of the Skin: Dermal-Epidermal Junction, Dermis

Other Components of the Dermis

Immune System of the Skin

Acquired Immune Response Memory

Layers of the Skin: Epidermis

Epidermal Functions: Keratinocyte Proliferation and Differentiation

Immune System of the Skin

Innate-Acquired Immune System Interactions

Immune System of the Skin

Acquired Immune Responses

Introduction: Psoriasis

Psoriasis Skin Dysregulation

Anatomy and Pathophysiology

Structure and Function of the Skin

The Immune Response

The Skin Barrier

Anatomy and Pathophysiology

Structure of the Epidermis
Structure and Function of the Skin

Anatomy and Pathophysiology

Structure of the Epidermis
Structure and Function of the Skin

The Immune Response

The Skin Barrier
The Skin Barrier: Th1 and Th2 Responses

Oxidative Stress

Free Radicals: Agents of Aging
Oxidative Stress: The Major Cause of Skin Aging
Sources of ...

Introduction: Psoriasis

Definition of Psoriasis
Psoriasis Skin Dysregulation

HAART-Associated Adverse Clinical Events

Skin Rashes

The Immune Response

The Skin Barrier: Th1 and Th2 Responses

Clinical Features/Presentation

Manifestations: Overview
Areas of Skin Involvement and Extent of Involvement
Types of Psor...

Diagnosis of Fabry Disease

Diagnostic Tests: Urinalysis and Skin Biopsy

Clinical Features/Presentation

Areas of Skin Involvement and Extent of Involvement

Anatomy and Pathophysiology

Structure of the Epidermis

HAART-Associated Adverse Clinical Events

HAART-Associated Adverse Clinical Events
Lactic Acidosis
Liver Toxicity
Glucose Intol...

Sun and Environmental Protection Factors

Environmental Protection Factor (EPF)

Sun and Environmental Protection Factors

Sun Protection Factor (SPF)

Sun and Environmental Protection Factors

Sun Protection Factor (SPF)
Environmental Protection Factor (EPF)

Immunology: Introduction

Immunology: Learning Objectives

Innate and Adaptive (Acquired) Immune Systems

Innate and Adaptive (Acquired) Immune Systems: Overview

Definition of Atopic Dermatitis

Definition of Atopic Dermatitis

Pathophysiology

Pathophysiological Mechanisms

Risk Factors

Genetic Risk Factors in AD

Innate and Adaptive (Acquired) Immune Systems

Characteristics of Innate and Adaptive Immunity

Diagnosis

Diagnostic Criteria for AD

Atopic Dermatitis: Introduction

Atopic Dermatitis: Introduction

Oxidative Stress

Free Radicals: Agents of Aging

Dermal Tissue

Dermal Tissue

Atopy vs. Allergy

Hypersensitivity Overview, Atopy versus Allergy

Epidemiology

Historical Trends in the Prevalence of AD

Diagnosis

EASI

Therapeutic Application

Therapeutic Application

Risk Factors

AD and Environmental Risk Factors

Atopy vs. Allergy

Hypersensitivity Disorders

Physiology of Immune System Dysregulation

Cytokines Trigger

Cells of the Immune System

Overview of Cells of the Immune System

B Cells and Antibodies

Immunoglobulin Isotypes

Atopy vs. Allergy

Hypersensitivity Disorders: Gell-Coombs Classification

The Immune Response: Overview

The Immune Response: Overview

The Inflammatory Response: Overview

Overview, Tissue Insult and Damage

Mechanisms of Select Autoimmune Disorders

Psoriasis

Mechanisms of Select Autoimmune Disorders

Psoriasis: Psoriatic keratinocytes Pathway

Innate and Adaptive (Acquired) Immune Systems

Self vs. Non-Self

Innate and Adaptive (Acquired) Immune Systems

How Innate and Adaptive Responses Work Together

Pro- and Anti-Inflammatory Cytokines/Mediators

Overview, Proinflammatory versus Anti-Inflammatory Cytokines

T Cells and Cell-Mediated Responses

T Cell Activation

T Cells and Cell-Mediated Responses

T Cell Lineage

Pathophysiology

Phosphodiesterases and the Pathogenesis of AD

Diagnosis

The Patient-Oriented Eczema Measure (POEM)

Biologic Targets

Pathology of Psoriasis

Biological Products/Allergenics

Discovery and Development of Biologics

Physiology of Immune System Dysregulation

T Regulatory Cells (Tregs)
Cytokines Trigger

Diagnosis

Biomarkers in AD

Oxidative Stress

Sources of Oxidative Stress

Male Reproductive Physiology

Testosterone

Pro- and Anti-Inflammatory Cytokines/Mediators

Signaling Pathways Regulating Production and Transcription of Inflammatory Mediators

B Cells and Antibodies

Overview of B Cell Responses, Overview of Antibody Production

Complications of RA

Rheumatoid Nodules

Anatomy and Pathophysiology

Clinical Examination: Lentigo Maligna Melanoma (LMM)

Lupus Introduction

Lupus Systemic Lupus Erythematosus (SLE)

Summary: Innate and Adaptive Immune Responses

Summary: Innate and Adaptive Immune Responses

Mechanisms of Select Autoimmune Disorders

Psoriasis: Upregulated Cytokines

Clinical Features of Angioedema Classes

Clinical Features of Angioedema Classes

Immunology: Introduction

Immunology: Introduction

Innate and Adaptive (Acquired) Immune Systems

Characteristics of Innate and Adaptive Immunity

Epidemiology

Global Prevalence of AD

Male Reproductive Physiology

Testes
Testosterone

Psoriasis Therapies

Topical Glucocorticoids: Adverse Effects

Lenalidomide

Lenalidomide: Adverse Reactions

Epidemiology

Epidemiology of Systemic Lupus Erythematosus (SLE): Cutaneous Lupus Erythematosus (CLE)

Psoriasis Therapies

Systemic Therapies: Methotrexate
Systemic Therapies Overview
Methotrexate: Mechanism of Ac...

Psoriasis Therapies

Topical Retinoids: Adverse Effects
Topical Anthralin
Topical Anthralin: Therapeutic Use

Pathological Angiogenesis

Diseases Associated with Uncontrolled Angiogenesis

Carcinomas

Classification Based on Epithelial Cell Type

Cells of the Immune System

The Lymphatic System

The Inflammatory Response: Antigen Processing and Presentation by Macrophages

The Inflammatory Response: Overview

Epidemiology

Prevalence of AD in the United States

The Inflammatory Response: Leukocyte Migration

The Inflammatory Response: Leukocyte Migration: Overview

Anatomy and Pathophysiology

Clinical Examination: Acral Lentiginous Melanoma (ALM)

Introduction

Introduction

Lupus Introduction

Lupus Systemic Lupus Erythematosus (SLE)
Historical Context
Symptoms of Lupus

Natural History

Natural History

Diagnosis of Kidney Disease

Diagnosis: Patient History, Physical Examination and Urinalysis

Mechanisms of Select Autoimmune Disorders

Systemic Lupus Erythematosus: Symptoms and Risk

Conclusions

Melanoma: Conclusions

Impact of Psoriasis

Physical Impact

Diagnostic Methods of Criteria for Psoriasis

Diagnostic Methods

Management

Goals of Treatment

Potential Factors in the Development of Psoriasis

Stress

Impact of Psoriasis

Physical Impact

Impact of Psoriasis

Physical Impact

Diagnostic Methods of Criteria for Psoriasis

Patient History

Psoriasis Therapies

Topical Anthralin: Therapeutic Use

Current Treatment

Radiation Therapy (RT): Complications

Summary: Pathophysiology of Lupus

Summary: Pathophysiology of Lupus

Infliximab

Infliximab Safety

Disease State

Definition and Classification

Introduction to the Innate and Adaptive Immune Systems

Interactive Exercise: Components and Actions of Adaptive and Innate Immunity
The Immune System

Psoriatic Arthritis

Psoriatic Arthritis (PsA)

Testosterone Replacement Therapy: Transdermal Testosterone Patch

Transdermal Testosterone Patch: Dosage and Administration

Pathophysiology

Somatic Nociceptive Pain

Introduction: Psoriasis

Introduction: Psoriasis

Diagnostic Methods of Criteria for Psoriasis

Typical Presentation at Diagnosis

Summary: Psoriasis

Diagnostic Methods

Summary: Psoriasis

Typical Presentation at Diagnosis

Treatment Teams

Treatment Team

Psoriasis Therapies

Systemic Therapies: Methotrexate

Hypersensitivity

Type I Hypersensitivity Reaction: Immediate Hypersensitivity

Diagnostic Methods of Criteria for Psoriasis

Patient History
Diagnostic Criteria

Immunosuppression

Immunosuppression

Summary: Psoriasis and Biologics

Psoriasis

Anatomy and Pathophysiology

Clinical Evaluation: Visual Examination

Potential Factors in the Development of Psoriasis

Potential Factors in Etiology of Psoriasis
Genetic Factors
Infectious Factors
Drug an...

Epidemiology

Epidemiology of Systemic Lupus Erythematosus (SLE): Mortality and Survival
Epidemiology of Syst...

Biologic Targets

Pathology of Psoriasis
T-Cell Cytokines
Biologic Targets

Infliximab

Pivotal Trials: Efficacy of Maintenance
Infliximab Safety

Autoimmune Disease Examples

Interactivity: Autoimmune Diseases

Forms of Lupus

Cutaneous Lupus Erythematosus (CLE)
Forms of Lupus
Systemic Lupus Erythematosus

Overlapping Diseases

SLE and Scleroderma

Summary: Psoriasis

Diagnostic Methods
Typical Presentation at Diagnosis
Severity of Psoriasis
Clinical A...

Psoriasis Therapies

Photochemotherapy
Excimer Laser Therapy (High Energy 308 nm)

Epidemiology

Age of Onset

Diagnostic Methods of Criteria for Psoriasis

Physicians Who Diagnose Psoriasis
Diagnostic Methods
Typical Presentation at Diagnosis

Psoriasis Therapies

Photochemotherapy

Introduction: Psoriasis Therapies and Treatments

Introduction: Psoriasis Therapies and Treatments

Mechanisms of Select Autoimmune Disorders

Systemic Lupus Erythematosus (SLE)

Traditional Immunosuppressive Therapies

Corticosteroids: Gene Expression (Therapeutic Uses of Corticosteroids)

Primary Afferents

Primary Afferents

The Extracellular Matrix

The Extracellular Matrix

Systemic Therapy

Administration Routes

Lupus Introduction

Historical Context

Forms of Lupus

Forms of Lupus

Diagnosis of SLE

Hallmark Autoantibodies: Rheumatoid Factor (RF)

Introduction: Psoriasis

Definition of Psoriasis

Physiology of Immune System Dysregulation

Cytokines

Physiology of Immune System Dysregulation

Cytokines Trigger

Physiology of Immune System Dysregulation

Pathophysiology of Psoriasis

Summary: Psoriasis

Psoriasis Definition

Clinical Features/Presentation

Manifestations: Overview

Impact of Psoriasis

Patient Scenario 1

Summary: Psoriasis

Cutaneous and Extracutaneous Manifestations

Development of Monoclonal Antibodies

Safety of Therapeutic Antibodies

Psoriasis Therapies

OTC Topical Salicylic Acid

Psoriasis Therapies

Excimer Laser Therapy (High Energy 308 nm)

Introduction to the Innate and Adaptive Immune Systems

Innate and Adaptive Immunity

Bone Matrix

Collagen

Anatomy and Pathophysiology

Patient Demographics: Geography and Trends

Male Reproductive Physiology

Androgen Actions on Target Tissues

Mosaicism

Somatic Mosaicism

Testosterone Replacement Therapy: Warnings and Precautions and Adverse Effects

Warnings and Precautions

Pharmacological Treatments

Norepinephrine and Dopamine Reuptake Inhibitor (NDRI)

Traditional Immunosuppressive Therapies

Traditional Immunosuppressive Therapies
Traditional Immunosuppressive Agents
Corticosteroi...

Typical Clinical Course

Patient Scenario: SLE

Treatment Guidelines

Overview of Treatment Guidelines

Epidemiology and Natural History

Natural History

Primary Afferents

Dorsal Horn
Primary Afferents
Nociceptors
Theories for Signal Transduction Mechanism

Atherosclerosis: Complications

Peripheral Arterial Disease (PAD)

Hypersensitivity

Type I Hypersensitivity Reaction: Immediate Hypersensitivity
Hypersensitivity Disorders: Type 1...

Testosterone Replacement Therapy: Transdermal Testosterone Patch

Transdermal Testosterone Patch

Clinical Features of Angioedema Without Urticaria (Bradykinin-Mediated)

HAE with Normal C1-INH

Introduction

Ectodermal Germ Layer

Traditional Immunosuppressive Therapies

Corticosteroids: Adverse Effects

Cytokines

Tumor Necrosis Factor Alpha in Disease

The Innate and Adaptive Immune System

The Innate and Adaptive Immune System

T Cells and Cell-Mediated Immune Responses

T-Cell Activation

Physiology of Immune System Dysregulation

Overview of Immune Dysregulation

Summary: Psoriasis

Pathophysiology of Psoriasis

Diagnostic Methods of Criteria for Psoriasis

Severity of Psoriasis

Summary: Psoriasis

Severity of Psoriasis

Diagnosis of RA

Clinical Measures - Other Tests

Testosterone Replacement Therapy: Testosterone Gel

Testosterone Gel: Dosage and Administration

Autoimmune Disorders

Introduction: Autoimmune Disorders: Affects Almost Any Part of the Body

Autoimmune Disease Examples

Autoimmune Diseases
Interactive Exercise: Immunology Terms
Interactivity: Autoimmune Disea...

Lenalidomide

Lenalidomide: Proposed Mechanism of Action
Lenalidomide: Overview
Lenalidomide: Indication...

Immunosuppression

Immunosuppression
Tuberculosis (TB)
Tuberculosis Testing and Monitoring

Absorption and Bioavailability

Absorption, C_max, and AUC

Epidemiology

Epidemiology of Systemic Lupus Erythematosus (SLE): Geographical and Racial Distribution

Diagnosis of SLE

Standard Measures of Disease Activity Used in Clinical Trials: SLICC/ACR Damage Index for SLE

Complications/Comorbidities of SLE

Osteoporosis

Lupus Pathogenesis

Pathogenic Autoantibodies in SLE

Liver Diseases Overview

Genetic Diseases, Hereditary Hemochromatosis

Clinical Manifestations

Signs and Symptoms: Physical Examination

Clinical Features/Presentation

Extracutaneous Manifestations

Treatment Teams

Treatment Team
Emotional Support

Immunosuppression

Tuberculosis Testing and Monitoring

Summary: Issues in Pediatric Diabetes

Case Study: Evan - Symptoms and Solution

Male Reproductive Physiology

Testosterone as a Prohormone

Overview of Gastric Cancer

Quality of Life (QOL)

Testosterone Replacement Therapy: Testosterone Gel

Testosterone Gel

Niacin (Nicotinic Acid)

Efficacy and Safety: Word of Caution

Signs and Symptoms

Symptoms Related to Abnormalities in Hematopoiesis

Signs and Symptoms

Extramedullary Hematopoiesis

T1DM Overview

Type 1 Diabetes Symptoms

Sarcomas

Classification of Sarcomas

Treatment Guidelines

Overview of Treatment Guidelines
Guidelines for Treatment of Psoriasis Patients Limited Disease

T1DM (Type 1 Diabetes)

Type 1 Diabetes Symptoms

Summary: Psoriasis

Psoriasis Definition
Potential Factors in Etiology of Psoriasis
Pathophysiology of Psorias...

Atherosclerosis: Complications

Overview
Coronary Artery Disease
Transient Ischemic Attack (TIA)
Ischemic Stroke

Atherosclerosis: Complications

Coronary Artery Disease

Forms of Lupus

Neonatal Lupus

Epidemiology

Epidemiology of Systemic Lupus Erythematosus (SLE): Geographical and Racial Distribution
Epidem...

Pathophysiology

Cancer Pain
Visceral Nociceptive Pain
Neuropathic Pain
Somatic Nociceptive Pain

Pathophysiology

Cancer Pain
Visceral Nociceptive Pain
Neuropathic Pain
Somatic Nociceptive Pain

Overlapping Diseases

Mixed Connective Tissue Disease

T Cells and Cell-Mediated Immune Responses

T-Cell Activation

Physiology of Immune System Dysregulation

Cytokines
T Cell Cytokines

Impact of Psoriasis

Psychological Impact: Depression, Anxiety, and Stress

Psoriasis Therapies

Methotrexate: Clinical Efficacy

Adalimumab

Adverse Reactions

Overview of Pathophysiology and Treatment

Type 1 Diabetes Symptoms

Examples of Pharmacological Profiles: Insulins

Insulin: Pharmacological Profile, Factors Affecting Insulin Absorption

Primary Cancer Categories

Main Categories of Cancer

Epidemiology

Incidence
Age of Onset
Gender and Age

Disease State

Common Complications

Overlapping Diseases

SLE and Secondary Sjogren's Syndrome
SLE and Scleroderma
SLE and Overlapping Diseases ...

Traditional Immunosuppressive Therapies

Corticosteroids: Immediate Effect (Anti-Inflammatory)
Corticosteroids: Gene Expression
Cor...

Summary: Psoriasis and Biologics

Psoriasis
Immunosuppression
Choice of Therapy
Biologic Targets
Combination Thera...

Pathophysiology

Cardiovascular

Atherosclerosis: Complications

Coronary Artery Disease

Traditional Immunosuppressive Therapies

Corticosteroids: Gene Expression
Corticosteroids: Gene Expression (The Anti-Inflammatory Effect...

Environmental Mechanisms

Viral

Diagnosis of SLE

Standard Measures of Disease Activity Used in Clinical Trials: SLEDAI-2K
Standard Measures of D...

Complications/Comorbidities of SLE

Osteoporosis
Osteonecrosis (ON)

Clinical Manifestations

Associated Diseases

Pharmacological Agents

Other Agents

Psoriasis Therapies

OTC Topical Coal Tar
OTC Topical Salicylic Acid
OTC Moisturizers and Emollients

Immunosuppression

Tuberculosis (TB)
Tuberculosis Testing and Monitoring

Guidelines for Anticoagulant Venous Thromboembolism Therapy

Venous Thromboembolism Treatment: Complications During Therapy

Definition of Venous Thromboembolism (VTE)

Venous Thromboembolism (VTE) Location and the Relationship between DVT and PE

Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE) Diagnosis and Treatment Guidelines

VTE Diagnosis Overview

Pathophysiology of HAE

Pathophysiology of HAE

Overview of Breast Cancer

Staging and Performance Status

Diagnostic Methods of Criteria for Psoriasis

Differential Diagnosis

Hypersensitivity

Type IV Hypersensitivity Reaction Subgroups
Gell-Coombs Classification
Type I Hypersensiti...

Introduction

Implantation
Gastrulation
Ectodermal Germ Layer
Endodermal Germ Layer
Mesodermal...

Adalimumab

Pivotal Trials: Psoriasis Trial II
Psoriasis Trial II: Efficacy
Adverse Reactions

Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE) Diagnosis and Treatment Guidelines

VTE Diagnosis: Signs and Symptoms of PE

Guidelines for Anticoagulant Therapy

Venous Thromboembolism (VTE)

Effects of Opioids

Effects of Opioids

Clinical Use of Opioids

Clinical Use of Opioids

Genetic Instability

Genetic Instability: Introduction

Long-Term Management and Patient Education in HAE

Self-Administration

Diagnosis of SLE

Hallmark Autoantibodies: Antiphospholipid Antibodies
Hallmark Autoantibodies: Rheumatoid Factor...

Summary: Psoriasis

Prevalence
Incidence
Cutaneous and Extracutaneous Manifestations
Onset, Episodes, Fla...

Potential Factors in the Development of Psoriasis

Infectious Factors

Psoriasis Therapies

Topical Overview

Development of Monoclonal Antibodies

Monoclonal Antibody Production in Hybridomas
Monoclonal Antibody Production in CHO Cells
M...

Epidemiology

Overview of HAE Epidemiology

Clinical Assessment Tools in Psoriasis

Clinical Assessment Tools

Anatomy and Pathophysiology

Clinical Examination: Melanoma Detection and Location

Physiology of Immune System Dysregulation

Dermal Dendritic Cell Activation

Typical Course of Plaque Psoriasis

Onset, Episodes, Flare-Ups, Triggers
Complications and Comorbidities of Psoriasis

Typical Course of Plaque Psoriasis

Complications and Comorbidities of Psoriasis

Diabetes Annotations

Abasaglar insulin glargine

Overview of Pain: The Nociceptor

Nociceptors

Diabetes Annotations

Humalog 200 units/ml KwikPen SmPC

Heart Failure: Treatments

Implantable Defibrillator

Primary Afferents

Aδ and C Nociceptors

Etanercept

Dosage and Administration

Cytopenias in MDS

Thrombocytopenia

T2DM Diagnosis

Signs and Symptoms

Psoriatic Arthritis

Psoriatic Arthritis (PsA) Pathophysiology

Patient Types and Risk Factors for Bleeding

Hemostasis and Bleeding Disorders

Infection

Opportunistic Infections

Overview of Pain: The Nociceptor

Nociceptors
A-δ and C Nociceptors
Transient Receptor Potential Cation Channel (TRPV1)...

Overview of Pain: The Nociceptor

Nociceptors
A-δ and C Nociceptors
Transient Receptor Potential Cation Channel (TRPV1)...

Overview of Pain: The Nociceptor

A-δ and C Nociceptors

Physiology of Immune System Dysregulation

Keratinocyte Remodeling

Psoriasis Therapies

Topical Retinoids: Tazarotene

Psoriasis Therapies

Topical Anthralin

Introduction to Kidney Disease

Chronic Kidney Disease: Signs and Symptoms

Gaucher Disease: Overview

Classification

Clinical Features of Angioedema Classes

Hereditary Angioedema: Clinical Features Overview

Summary: Psoriasis

Cytokines Trigger

Summary: Psoriasis

Cytokines Trigger
Types of Psoriasis

Clinical Features/Presentation

Types of Psoriasis

The Clinical Course of HIV Disease

Initial Infection

Lupus Introduction

Symptoms of Lupus

Overview of Pain: Central Sensitization

Acute Phase

Physiology of Immune System Dysregulation

Keratinocytes and Cytokines
Keratinocyte Remodeling

Psoriatic Arthritis

Pathophysiology of Psoriatic Arthritis (PsA)
Psoriatic Arthritis (PsA) Pathophysiology

Etanercept

Overview: Description of Etanercept
Etanercept Indication
Dosage and Administration

Goals of Treatment

Overview of Treatment Goals

First-line Treatment Options

Other Locoregional Therapies

Types of Psoriasis

Types of Psoriasis

Cytopenias in MDS

Thrombocytopenia

Lupus Pathogenesis

Dysfunctional Response of the Immune System

Lupus Pathogenesis

Autoimmune Mechanisms
Dysfunctional Response of the Immune System

Interpretation of Results

Case: Sharon T.

Atherosclerosis Contribution to Cardiovascular Diseases

Peripheral Arterial Disease (PAD)

Infection

HIV Infection
Progression to AIDS
CD4 Cell Counts
Opportunistic Infections

The Clinical Course of HIV Disease

Opportunistic Infections

Introduction to Immunopathology

Organ Transplant Rejection: How the Immune System Distinguishes between Self and Non-Self

Overview of Pain: The Nociceptor

Transient Receptor Potential Cation Channel (TRPV1)

Introduction to the Innate and Adaptive Immune Systems

The Immune System

Nociceptive versus Neuropathic Pain

Nociceptive versus Neuropathic Pain

Fabry Disease : Overview

Common Clinical Manifestations: Vascular

Hereditary Angioedema: General Approach

Treatment During Prodromal Symptoms

Eye Structure

Structure of the Human Eye

The Clinical Course of HIV Disease

Initial Infection
Acute Infection
Asymptomatic
HIV treatment
Progression to AIDS...

What are the Determinants of PK? ADME

Interactive Exercise: Administration

The Inflammatory Response

Inflammation

Organs Affected by Diabetes

Organs Affected by Diabetes

Introduction to Immunopathology

Hypersensitivity Disorders: Type I Immediate Hypersensitivity

Overview of Pain: Central Sensitization

Central Sensitization
Acute Phase
Late Phase
COX-2 and Central Sensitization

Overview of Pain: Central Sensitization

Central Sensitization
Acute Phase
Late Phase
COX-2 and Central Sensitization

The Inflammatory Response

Inflammation
Inflammation Resolving

Psoriasis Therapies

Topical Retinoids: Tazarotene
Therapeutic Efficacy: Tarazotene Use
Therapeutic Efficacy: C...

Anatomy and Pathophysiology

Clinical Examination: Biopsy

Overview: Angiogenesis

Functions of Angiogenesis

Traditional Immunosuppressive Therapies

Fungal or Bacterial Derivatives

The Clinical Course of HIV Disease

Initial Infection
Acute Infection
Asymptomatic
HIV treatment
Progression to AIDS

Glucose Measurement

CGMS Systems

The Innate Immune Response

Pattern Recognition Receptors (PRRs)

Glucose Measures: Self-Monitoring

Glucose Meters, SMBG, Continuous Glucose Monitoring (CGM)

Inflammatory Response in Action

Interactive Exercise: Inflammation
Interactive Exercise: The Inflammation Process
Interact...

Complications of RA

Major Organs Affected by RA

Migraine

Types of Migraine

VTE Clinical Picture: Natural History, Clinical Syndromes, Complications

Complications Associated with VTE

Venous Thromboembolism (VTE) Clinical Picture

Complications Associated with VTE

Approved Oral Treatments for Multiple Sclerosis

Approved Oral Treatments for Multiple Sclerosis: Aubagio

Types of Therapies for Male Hypogonadism

Testosterone Replacement Therapy

Heart Failure: Treatments

Intervention - Invasive Techniques
Implantable Defibrillator
Cardiac Resynchronization The...

Glucose Measurement

CGMS Systems

Calcium Homeostasis

Control of Calcium Homeostasis

Steroids

Treatments: Steroids

Psoriasis Therapies

Phototherapy Overview
Phototherapy Ultraviolet B (UVB) (290 to 320 nm)

Psoriasis Therapies

Phototherapy Ultraviolet B (UVB) (290 to 320 nm)

Bone Function

Calcium Homeostasis

Atherosclerosis Contribution to Cardiovascular Diseases

Coronary Artery Disease: Myocardial Infarction

Medical Device Regulation

Human Factors Studies

Cytopenias in MDS

Anemia
Anemia: Ineffective Erythropoiesis
Anemia: Hypoproliferative Erythropoiesis
An...

Non-biologic DMARDs: Methotrexate

Safety Issues and Side Effects

Pathophysiology

T Cell Initiation of MS

Calcium Homeostasis

Calcium in the Body
Calcium Homeostasis
Control of Calcium Homeostasis

Forms of Lupus

Cutaneous Lupus Erythematosus (CLE)

Pharmacokinetics: Absorption

Factors that Affect Absorption: Route of Administration

Microvascular Complications

Diabetic Neuropathy: Pathogenesis

Eye Structure

Sclera and Conjunctiva

Typical Clinical Course

Organ Systems Involved

What are the Determinants of PK? ADME

Interactive Exercise: Drug Absorption and Elimination
Elimination: Metabolism & Excretion
...

Autoimmune Disease Processes

Consequences of Autoimmune Diseases: Common Autoimmune Diseases

Introduction to Immunopathology

Hypersensitivity Disorders
Hypersensitivity Disorders: Type I Immediate Hypersensitivity
H...

Autoimmune Disease Processes

Consequences of Autoimmune Diseases: The Natural History of Autoimmune Disorders

Pharmacokinetics: Absorption

ADME
What is Drug Absorption?
Factors that Affect Absorption
Factors that Affect Abso...

Pharmacokinetics: Absorption

Factors that Affect Absorption
Factors that Affect Absorption: Drug Properties
Factors tha...

Approved Parenteral Treatments for Multiple Sclerosis

Approved Parenteral Therapies for RRMS: Extavia

Statins

Efficacy and Safety: Secondary Prevention

Pathophysiology

Immunopathophysiology: T Cell Initiation of MS

Hemostasis

Disorders of Hemostasis: Abnormal Bleeding

Introduction to Immunopathology

Organ Transplant Rejection: Class I MHC and Class II MHC Proteins
Organ Transplant Rejection: H...

Autoimmune Disease Processes

The Etiology of Autoimmune Disease
The Etiology of Autoimmune Disease: Genetic Factors (Risk)

Autoimmune Disease Processes

Consequences of Autoimmune Diseases: Progression and Destruction in Autoimmune Disorders (Mechanisms...

SLE Treatments: MAbs/Biologics

Belimumab Clinical Trials 2 and 3: Efficacy
Belimumab Clinical Trials 2 and 3: Warnings and Pre...

SLE Treatments: MAbs/Biologics

Belimumab Clinical Trials 2 and 3: Warnings and Precautions

Biologics in Current Use - Abatacept

Warnings: Abatacept

Introduction to Immunopathology

Organ Transplant Rejection: Class I MHC and Class II MHC Proteins
Organ Transplant Rejection: H...

Currently Approved Therapies: Gilenya

Gilenya

Organs Affected by Diabetes

Organs Affected by Diabetes
Eyes
Kidneys
Peripheral Nervous System
Heart
Ce...

T1DM (Type 1 Diabetes)

Incidence of T1DM Varies with Race

Standard Agents: Therapeutic Challenges

Unfractionated Heparin: Warnings and Precautions

Hypersensitivity

Hypersensitivity: Hypersensitivity Disorders

Currently Approved Therapies: Novantrone

Aubagio

Pathophysiology

Overview
T Cell Initiation of MS Blood Brain Barrier
B Cells and Autoantibodies in Diseas...

Cells of the Immune System

Immune Cell Development

Standard Agents: Overview

Vitamin K Antagonists (VKAs)

Standard Agents: Therapeutic Challenges

Therapeutic Challenges of Antithrombotic Treatment

Clinical Applications of Monoclonal Antibodies

A Closer Look At mABS Used as Therapies

Steroids

Glucocorticoids: Mode of Action
The Anti-Inflammatory Effects of Corticosteroids
Glucocort...

Steroids

Glucocorticoids: Side Effects

Pathophysiology

Immunopathophysiology: Myelin-Reactive T Cells
Immunopathophysiology: T Cell Initiation of MS -...

Heart Failure: Treatments

Overview
Prevention
Treatment Guidelines
Intervention - Medications
ACE Inhibito...

Clinical Applications of Monoclonal Antibodies

Clinical Applications of Monoclonal Antibodies: Learning Objectives
Detection, Diagnosis, and M...