SMi Source lesson Alzheimer's Disease: Biomarkers has the following microlearning topics
1. Learning Objectives
2. Search for Biomarkers in Alzheimer's Disease
3. Characteristics of an Ideal Biomarker
4. Biomarkers and Development of Clinical Therapeutics
5. Biomarkers and Development of Clinical Therapeutics: ADNI
6. Candidate Biomarkers in AD Based on Neuropathology
7. Candidate Biomarkers in AD Based on Genetic Profile
8. Alzheimer's Disease vs. MCI vs. Normal Aging
9. AD Progression, Biomarkers and Pharmacological Therapy
10. ADNI Biomarker Initiative Hypothetical Model
11. Temporal Ordering of Biomarkers and AD Progression
12. Models of AD Initiation and Progression
13. Cerebrospinal Fluid (CSF) Biomarkers
14. CSF Biomarkers: Aβ42
15. CSF Biomarkers: T-tau and P-tau
16. CSF Biomarkers Signature
17. Plasma Biomarkers
18. MRI and Ventricular Expansion
19. PET, Biomarkers and Cognition
20. CSF Biomarkers
21. CSF Biomarkers Study
22. MRI
23. Presymptomatic Diagnosis of AD Pathology
24. Knowledge Checks: CSF Biomarkers
25. CSF Biomarkers
26. PET
27. FDG-PET by Prespecified Regions of Interest (ROIs)
28. FDG-PET by Voxel-Based Approaches
29. SD-SSP PET Approaches
30. Amyloid Imaging with [11C]PIB PET: PIB-PET
31. Amyloid Imaging with [11C]PIB PET: PIB Positivity
32. Amyloid Imaging with AV-45
33. Knowledge Check: Biomarker Predictors
34. Value of Biochemical Markers in Drug Development
35. Biomarkers May Bridge the Gap between Animal Studies and Large Clinical Trials
36. Biomarkers to Monitor and Track Biochemical Drug Effects
37. Biomarkers and Biochemical Drug Effects
38. Knowledge Check: Biomarker Uses
39. Biomarkers as Surrogate Markers
40. Surrogate Marker Use at This Point
