SMi Source Lesson Cardiovascular: Clot formation and Vascular Injury
The lesson teaches the following:
SMi Source lesson Cardiovascular: Clot formation and Vascular Injury has the following microlearning topics
1. Blood Clot Formation
Lesson Cardiovascular: Clot formation and Vascular Injury teaches these concepts
Vascular Injury, Effects, Blood Clot Formation
Lesson Cardiovascular: Clot formation and Vascular Injury addresses these key points
Vascular surgery creates vascular injury at the anastomosis.
Upon vascular injury:
The endothelial cell lining of the vessel lumen is disrupted and the underlying smooth muscle and collagen fibers are exposed to the circulation.
Von Willebrand Factor binds to exposed collagen fibers through its A3 domain.
Collagen-bound von Willebrand Factor then binds to platelets through the GP Ibα receptor.
This interaction acts to tether platelets to thrombogenic surfaces even during rapid blood flow.
Shear forces from blood flow propel the tethered platelet forward where it comes in contact with exposed collagen.
The platelet then binds collagen through integrin receptors, and platelet activation occurs.
Activated platelets release a variety of factors that attract and activate additional platelets at the site of injury to amplify platelet aggregation.
Additional clotting mechanisms result in the production of fibrin which forms dense interlocking strands which help to secure the clot.
Over time, the factors released by activated platelets also attract vascular smooth muscle cells from the media and adventitia to migrate to the intima of the vessel wall.
As these smooth muscle cells migrate and proliferate they cause thickening of the vessel wall and narrowing of the lumen.
This narrowing restricts blood flow and may eventually lead to thrombosis and complete occlusion of the blood vessel.