SMi Source Lesson Hereditary Angioedema

  • SMi Source lesson Hereditary Angioedema has the following microlearning topics

  • 1. Hereditary Angioedema: Introduction

    2. Hereditary Angioedema: Learning Objectives

    3. Hereditary Angioedema: Definitions

    4. Knowledge Check: Hereditary Angioedema

    5. Knowledge Check: Forms of Angioedema

    6. Hereditary Angioedema: Historical Perspective

    7. Knowledge Check: Biochemical Defect

    8. Knowledge Check: Major Factor in HAE

    9. Overview of Clinical Features of Angioedema Without Urticaria (Bradykinin-Mediated)

    10. HAE Due to Decreased C1-INH

    11. Severity of Attacks

    12. HAE with Normal C1-INH

    13. Angioedema with Acquired C1-INH Deficiency

    14. Knowledge Check: HAE and Upper Airway Obstruction

    15. Knowledge Check: HAE Episode Duration

    16. Knowledge Check: HAE Attacks

    17. Knowledge Check: Laryngeal Attacks in HAE Patients

    18. Knowledge Check: HAE with a Normal C1-Inhibitor

    19. Knowledge Check: Factors that Exacerbate HAE

    20. Allergic Angioedema (Association with Urticaria)

    21. Knowledge Check: Factors Associated with Angioedema

    22. Table of Angioedema Classification

    23. Overview of HAE Epidemiology

    24. Knowledge Check: Worldwide HAE

    25. Knowledge Check: Delay in Diagnosis of HAE

    26. Knowledge Check: HAE with Diminished/Defective C1-Inhibitor

    27. Knowledge Check: Medical Cost for HAE Patients

    28. Knowledge Check: Highest Costs for HAE Patients

  • Lesson Hereditary Angioedema teaches these concepts

  • Hereditary Angioedema

    Hereditary Angioedema: Introduction

    HAE

  • Lesson Hereditary Angioedema addresses these key points

  • Angioedema

    • Short-lived (lasting 3-5 days)
    • Swelling
    • Deep dermal layers or subcutaneous tissue
    • Submucosal tissue of various organs

    Allergic Angioedema (AAE)

    • Triggers provoke a classic histamine response
    • Characterized by hives and itching

    Hereditary Angioedema (HAE)

    • Absence of hives and itching
    • Can affect the airway leading to asphyxiation
    • Misdiagnosis/diagnostic delay is common
    • Deficiency/dysfunction of C1 esterase inhibitor
      • Overproduction of bradykinin
    • May be associated with mutation in FXII (Hageman factor)
  • Lesson Hereditary Angioedema is built from these main references. Log into SMi Source for a complete list and details.

  • Bork K. Angioedema. Immunol Allergy Clin N Am. 2014;34:23-31.

    Bork K. Diagnosis and Treatment of Hereditary Angioedema with Normal C1 Inhibitor. Allergy, Asthma & Clinical Immunology. 2010;6:15.

    Parish LC. Hereditary Angioedema: Diagnosis and Management—A Perspective for the Dermatologist. J Am Acad Dermatol. 2011;65:843-850.

    http://dictionary.reference.com/browse/angioedema

  • Lesson Hereditary Angioedema introduces and defines these terms

  • AAE = Allergic Angioedema

    HAE = Hereditary Angioedema