SMi Source Lesson Multiple Sclerosis: Pharmacokinetics

  • SMi Source lesson Multiple Sclerosis: Pharmacokinetics has the following microlearning topics

    • 1. MS Pathophysiology

    2. AUC, Cmax, Tmax, Plasma Half-Life, Clearance

    3. Liver Disease

    4. Complete Blood Count (CBC)

    5. Classification of Drugs

    6. Relapsing-Remitting MS (RRMS), Secondary-Progressive MS (SPMS)

  • Lesson Multiple Sclerosis: Pharmacokinetics teaches these concepts

    • Pharmacokinetics, Multiple Sclerosis, MS Pathophysiology

  • Lesson Multiple Sclerosis: Pharmacokinetics addresses these key points

    • Immune-mediated tissue injury

    Three-compartment model:

    • The immune system
    • The target organ
    • The barrier that separates them

    In the case of MS, the immune system is separated from the CNS target by the blood brain barrier.

    • MS trigger - the activation of peripheral T cells. 
    • T cells gain potential to cross through the blood brain barrier
    • Activated immune cells undergo adhesion to the vascular endothelial barrier
    • Chemotactic attraction
    • Active invasion into the CNS
    • Reactivation 

    The differentiation of the invading cells determines if they contribute to injury or, possibly, counter the injury process.