Cytopenias and Gene Mutations in MDS, Changes in Apoptosis
Cytopenias and Gene Mutations in MDS, Deficiencies in Circulating Blood Cells
Cytopenias and Gene Mutations in MDS, Decreases in Apoptosis as MDS Progresses
Cytopenias and Gene Mutations in MDS, Increases in Apoptotic Cytokine Production
Apoptotic cell signal
Deficiencies in Circulating Blood Cells
Early in MDS, there are increases in apoptosis, whereas later as MDS progresses, there may be decreases in apoptosis.
Increases in Apoptotic Cytokine Production
As MDS progresses, there is increased proliferation of hematopoietic progenitor cells as well as decreased apoptosis of those precursor cells, resulting in an increased number of dysfunctional cells.
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Apoptosis: Programmed cell death.
Proliferation: Cell growth, division and propagation.
Hematopoietic: Having to do with the development and production of blood cells.
Cytopenias: Deficiency of peripheral blood cells.
Anemia: Decreased number of circulating red blood cells.
Neutropenia: Decreased number of circulating neutrophils (white blood cells)
Leukopenia: Decreased number of circulating white blood cells.
Granulocytopenia: Decreased number of circulating granulocytes (neutrophils, eosinophils, basophils)
Thrombocytopenia: Decreased number of circulating platelets.
TNFα = Tumor Necrosis Factor
INFγ = Interferon gamma