SMi Source lesson Oncology: Diagnostics for Targeted Care has the following microlearning topics
1. Breast Cancer: Role of HER Therapies
Dysregulation: Many Causes
Targeted Therapies
Targeted Therapies: Signaling Pathways
2. The Right Treatment to the Right Patient at the Right Time
Identifying Protein Expression
IHC and FISH
Lesson Oncology: Diagnostics for Targeted Care teaches these concepts
Diagnostics for Targeted Cancer Care, Targets for Cancer Therapies, Breast Cancer: Role of HER Therapies
Diagnostics for Targeted Cancer Care, Targets for Cancer Therapies, Dysregulation: Many Causes
Diagnostics for Targeted Cancer Care, Targets for Cancer Therapies, Targeted Therapies
Diagnostics for Targeted Cancer Care, Targets for Cancer Therapies, Targeted Therapies: Signaling Pathways
Lesson Oncology: Diagnostics for Targeted Care addresses these key points
HER (or ErbB receptors)
- HER receptors pair with one another or “dimerize” either in homo or hetero dimers
- Dimers are critical for activating signal transduction
- HER2 has no ligand binding site, but is the preferred binding partner with other HER receptors
Signal Transduction
- Can alter gene expression
- Affect processes that are implicated in tumor development
Dysregulation: Many Causes
- Gene mutation
- Receptor overexpression
- Ligand overexpression
- Defective internalization
Targeted therapies
- Trastuzumab
- Lapatinib
- Down-regulated aberrant signaling by blocking ligand activation
- Prevents signal transduction
HER Signaling Pathways
- Over 30 ligands
- 4 receptors that can form up to 10 different combinations
- Can activate numerous signal transduction pathways