SMi Source Lesson Oncology Primer: Invasion and Metastasis

  • SMi Source lesson Oncology Primer: Invasion and Metastasis has the following microlearning topics

    • 1. Overview of Cancer: Hallmark Capabilities of Cancer

    2. Angiogenesis

    3. Changes Associated with Epithelial-Mesenchymal Transition

    4. Integrins

    5. Matrix Metalloproteinases

    6. Intravasation

    7. Survival in Circulation

    8. Arrest at the Destination

    9. Extravasation

    10. Formation of Pre-metastatic Niches

    11. Establishment of Metastases

    12. Cancer Stem Cells

    13. Invasion and Metastasis: Summary

    14. Knowledge Check: Mesenchymal Cell Features

    15. Knowledge Check: Metastatic Process

    16. Knowledge Check: Passive Homing

    17. Knowledge Check: Tissue Microenvironment

  • Lesson Oncology Primer: Invasion and Metastasis teaches these concepts

    • Invasion and Metastasis

    Invasion and Metastasis: Introduction

    Overview of Cancer: Hallmark Capabilities of Cancer

    Cancer

    Oncology

  • Lesson Oncology Primer: Invasion and Metastasis addresses these key points

    • Overview of Cancer: Hallmark Capabilities of Cancer

    • Cancer is the result of several hallmark capabilities acquired by emerging cancer cells as they progress through malignant transformation, combined with underlying genetic instability

    The Spread of Cancer Cells from a Primary Tumor Site to the Secondary Location: Metastatic Cascade

    • Metastasis, the spread of cancer cells from a primary tumor site to the secondary location, poses a major clinical challenge, being unpredictable in occurrence and being the primary cause of mortality in people with cancer

  • Lesson Oncology Primer: Invasion and Metastasis is built from these main references. Log into SMi Source for a complete list and details.

    • D. Hanahan, R.A. Weinberg. Hallmarks of Cancer: The Next Generation. Cell. 144: 646-674, 2011.

    J.E. Talmadge, I.J. Fidler. AACR Centennial Series: The Biology of Cancer Metastasis: Historical Perspective. Cancer Res. 70:5649-5669. 2010.

  • Lesson Oncology Primer: Invasion and Metastasis introduces and defines these terms

    • ECM = Extracellular Matrix