SMi Source Lesson Oncology Primer: Stem Cells

  • SMi Source lesson Oncology Primer: Stem Cells has the following microlearning topics

    • 1. Cancer Stem Cells: Introduction

    2. Cancer Stem Cells: Learning Objectives

    3. Cancer Stem Cells: Definition of Terms

    4. Models of Tumor Development

    5. Stochastic or Clonal Evolution Model

    6. Cancer Stem Cell Model

    7. Knowledge Check: The Cancer Stem Cell Model

    8. Knowledge Check: Tumorigenicity of Cancer Stem Cells

    9. Knowledge Check: Characteristics of Cancer Stem Cells

    10. The Origin of the Cancer Stem Cells

    11. Epithelial-to-Mesenchymal Transition and Cancer Stem Cells

    12. Knowledge Check: Potential Sources of Cancer Stem Cells

    13. Knowledge Check: Epthelial-to-Mesenchymal Transition

    14. Experimental Validation of Cancer Stem Cells

    15. Knowledge Check: Experimental Validation of the Cancer Stem Cell Model

    16. Knowledge Check: Experimental Validation of the Cancer Stem Cell Model From Animal Studies

    17. Breast Cancer, Breast Micro-Anatomy

    18. Localization and Differentiation of Mammary Stem Cells, Localization of Breast Cancers

    19. Evidence for Breast Cancer Stem Cells

    20. Breast Cancer Stem Cells and Main Breast Cancer Subtypes

    21. Origination of Different Breast Cancer Subtypes

    22. Breast Cancer Stem Cells and Metastasis

    23. Knowledge Check: Characteristics of Normal Adult Breast Stem Cells and Breast Cancer Stem Cells

    24. Knowledge Check: Potential Sources of Cancer Stem Cells

    25. Isolation of Cancer Stem Cells from Other Tumor Types

    26. Cancer Stem Cells and Self-Renewal Pathways

    27. Hedgehog Pathway and Cancer Stem Cells

    28. Notch Pathway and Cancer Stem Cells

    29. Wnt Pathway and Cancer Stem Cells

    30. Signaling and Cancer Stem Cells

    31. Knowledge Check: Signaling Pathways

    32. Knowledge Check: Gamma Secretase in Pathways

    33. Therapeutic Implications of Cancer Stem Cells

    34. Therapeutic Options

    35. Targeting the Notch Pathway: γ Secretase Inhibitors

    36. Targeting the Notch pathway: Monoclonal Antibodies to Notch Receptors or Ligands

    37. Targeting the Hedgehog Pathway

    38. Targeting the Wnt Pathway

    39. Antibody-Based Targeting of Stem Cell-Associated Markers

    40. Induction of Cancer Stem Cell Differentiation

    41. Additional Therapeutic Agents with Potential Anticancer Stem Cell Activity

    42. Knowledge Check: Resistance of Cancer Stem Cells

    43. Knowledge Check: Mechanism of Action

  • Lesson Oncology Primer: Stem Cells teaches these concepts

    • Cancer Stem Cells

    Cancer Stem Cells: Introduction

  • Lesson Oncology Primer: Stem Cells addresses these key points

    • Cancer Stem Cells

    A rare subset of cells found within tumors that:

    • Have stem cell characteristics, including the potential for indefinite self-renewal and differentiation.

    Normal Stem Cells:

    • Differentiate into mature specialized cell types

    Cancer Stem Cells:

    • Give rise to abnormally differentiated tumor cells that make up the bulk of the tumor

  • Lesson Oncology Primer: Stem Cells is built from these main references. Log into SMi Source for a complete list and details.

    • Cancer stem cell definition. UKEssays. http://www.ukessays.com/essays/biology/cancer-stem-cell-definition-biology essay.php. Accessed June 15th, 2015.

    Dalerba P, Cho RW, Clarke MF. Cancer stem cells: models and concepts. Annu Rev Med. 2007;58:267-84.

  • Lesson Oncology Primer: Stem Cells introduces and defines these terms

    • Cancer stem cells: A subset of tumor cells that possess stem-cell characteristics, including the potential for differentiation and indefinite self-renewal.