SMi Source Lesson Infectious Disease: HPV

  • SMi Source lesson Infectious Disease: HPV has the following microlearning topics

  • 1. Detect mRNA - Detect the Disease

    2. Cervical Cancer Progression Model

  • Lesson Infectious Disease: HPV teaches these concepts

  • HPV Testing, Detect mRNA - Detect the Disease, Virology, Oncology, Gynecology

  • Lesson Infectious Disease: HPV addresses these key points

  • Diagnosing women infected with HPV:

    • Most infections are transient and resolve on their own.
    • Persistent HPV infection by one of the 14 high-risk HPV genotypes can lead to cervical disease, including cancer.
    • Testing for mRNA instead of DNA can give clinicians more accurate diagnostic data.

    HPV infected cells typically undergo a series of dysplastic changes over many years.

    Cervical intraepithelial dysplasia (CIN) grades:

    • CIN1 - mild dysplasia
    • CIN2 - moderate dysplasia
    • CIN3 - severe dysplasia
    • Carcinoma

    Cytological classification:

    • Atypical squamous cells of undetermined significance (ASCUS) and low-grade squamous intraepithelial lesions (LSIL)
      • HPV infection
      • CIN1
    • High-grade squamous intraepithelial lesions (HSIL)
      • CIN2
      • CIN3

    The ability to differentiate between a short-term HPV infection and a transforming HPV infection leading to cervical disease is important in patient management strategies as well as for the alleviation of patient anxiety.

  • Lesson Infectious Disease: HPV is built from these main references. Log into SMi Source for a complete list and details.

  • Knipe DM, Howley PM, eds. Fields Virology, Vol. 2, 4th ed., Philadelphia, PA: Lippincott Williams and Wilkins, 2001. P2243

  • Lesson Infectious Disease: HPV introduces and defines these terms

  • HPV = Human Papillomavirus
    CIN = Cervical intraepithelial Dysplasia
    LSIL = Low-grade Squamous Intraepithelial Lesion
    HSIL = High-grade Squamous Intraepithelial Lesion