SMi Source Lesson Lupus: Pathophysiology

  • SMi Source lesson Lupus: Pathophysiology has the following microlearning topics

  • 1. Lupus Introduction

    2. Forms of Lupus

    3. Drug-induced Lupus

    4. Neonatal Lupus

    5. Lupus Risk Factors

    6. Environment

    7. Triggers

    8. Lupus Pathogenesis

    9. Lupus Pathogenesis

    10. Lupus Pathogenesis

    11. Pathogenic Autoantibodies in SLE

    12. Lupus Pathogenesis

    13. Summary: Pathophysiology of Lupus

    14. Knowledge Check: Pathophysiology of Lupus

    15. Knowledge Check: Neonatal Lupus

    16. Knowledge Check: Lupus

    17. Knowledge Check: Sources of Antigen in Lupus

    18. Knowledge Check: Sources of Tissue Damage in SLE

  • Lesson Lupus: Pathophysiology teaches these concepts

  • Pathophysiology of Lupus, Lupus Introduction, Lupus Systemic Lupus Erythematosus (SLE)

    Pathophysiology of Lupus, Lupus Introduction, Historical Context

    Pathophysiology of Lupus, Lupus Introduction, Symptoms of Lupus

  • Lesson Lupus: Pathophysiology addresses these key points

  • Lupus Systemic Lupus Erythematosus (SLE)

    • Chronic inflammatory auto-immune disorder
    • Can affect almost all organ systems (systemic),especially:
      • Skin 
      • Joints
      • Blood
      • Kidneys
    • Variable presentations, course, and prognosis 
    • Characterized by remissions and flares
    • Mild, serious, life-threatening, or death

    Historical Context

    • “Lupus erythematosus” named for the characteristic skin rash
    • Malar “Butterfly” Rash
    • Systemic
    • Autoimmune
    • A “rheumatic disease”
    • Common feature = presence of symptoms or signs of disease in the joints or periarticular tissues

    ACR Criteria for Classification of SLE:

    • 11 criteria
    • SLE suspected in patients with features affecting ≥ 2 organ systems
    • Patients with ≥ 4 or more criteria at any time
      • SLE diagnosis
      • 95% specificity
      • 85% sensitivity
    • Patients with < 4 criteria may still be diagnosed with SLE
  • Lesson Lupus: Pathophysiology is built from these main references. Log into SMi Source for a complete list and details.

  • American College of Rheumatology Ad Hoc Committee on Systemic Lupus Erythematosus Guidelines. Guidelines for Referral and Management of Systemic Lupus Erythematosus in Adults. Arthritis & Rheumatism. 1999;42(9):1785-1796.

    Firestein: Kelley's Textbook of Rheumatology, 8th ed. 2008 W. B. Saunders Company Ch 75

    Ginzler and Tayar, FACT Sheet, American College of Rheumatology Communications and Marketing Committee. ACR 2012

    Nomenclature, Definition and Classification of Rheumatic Diseases. Can Med Ass J. 1964, 90:1276

    Tsokos G. Systemic Lupus Erythematosus. N Engl J Med 2011;365:2110-21.