SMi Source Lesson Multiple Sclerosis: Pathogenesis and Clinical Symptomology

  • SMi Source lesson Multiple Sclerosis: Pathogenesis and Clinical Symptomology has the following microlearning topics

  • 1. Pathology of MS

    2. Pathology-Anatomic

    3. Plaques - Histology

    4. Axon Damage and Neurodegeneration

    5. Summary of Pathophysiology of MS

    6. Animal Models of MS

    7. TMEV Infection Model

    8. Cuprizone Mouse Model

    9. Impact on the Patient

    10. Damage to Specific CNS Regions

    11. Self-Check: Symptoms Resulting from MS

    12. Self-Check: Symptoms Similar to MS

    13. Patient Reports

    14. Patient Reports

    15. Relapses

    16. Symptom Worsening

    17. Classification of MS

    18. Self-Check: Classification of MS

    19. Case Study: Classifications of MS

    20. Case Study: Clinically Isolated Syndrome

    21. Case Study: Relapse with Condition Worsening

    22. Case Study: Relapses and Remissions

    23. Case Study: Percentage Relapses

    24. Classification: Summary

    25. Pathophysiology of MS

  • Lesson Multiple Sclerosis: Pathogenesis and Clinical Symptomology teaches these concepts

  • Multiple Sclerosis (MS): Pathogenesis and Clinical Symptomology

    Pathogenesis and Clinical Symptomology MS: Introduction

    Pathology of MS

  • Lesson Multiple Sclerosis: Pathogenesis and Clinical Symptomology addresses these key points

  • Multiple sclerosis (MS)

    • Disease of perivascular inflammation and demyelination
    • Complex pathophysiology in which axonal damage may not be entirely a result of acute inflammatory demyelination.

    Acute axonal injury:

    • Occurs in active inflammatory lesions
    • Occurs in inactive lesions that have been demyelinated by repeated attacks.


    • Axonal loss
    • Oligodendrocyte death
    • Activation of microglia and astrocytes
    • Gray matter demyelination and damage
  • Lesson Multiple Sclerosis: Pathogenesis and Clinical Symptomology is built from these main references. Log into SMi Source for a complete list and details.

  • Charcot JM. Histologie de la sclerose en plaques. Graz Hosp Paris. 1868.

    De Stefano N, Narayanan S, Francis SJ, et al. Diffuse Axonal and Tissue Injury in Patients with Multiple Sclerosis with Low Cerebral Lesion Load and No Disability. Arch Neurol. 2002.

    Filippi M, Bozzali M, Rovaris M, et al. Evidence for Widespread Axonal Damage at the Earliest Clinical Stage of Multiple Sclerosis. Brain. 2003.

    Frohman EM, Filippi M, Stuve O, et al. Characterizing the Mechanisms of Progression in Multiple Sclerosis: Evidence and New Hypothesis for Future Directions. Arch Neurol. 2005.

    Inglese M, Bendetti B, Fillipi M. The Relation between MRI Measures of Inflammation and Neurodegeneration in Multiple Sclerosis. J Neurol Sci. 2005.

    Peterson LK, Fujinami RS, Inflammation, Demyelination, Neurodegeneration and Neuroprotection in the Pathogenesis of Multiple Sclerosis. J Neuroimmunol. 2007.

    Rudick RA, Lee J-C, Nakamura K, Fisher E. Gray Matter Atrophy Correlates with MS Disability Progression Measured with MSFC but not EDSS. J Neurol Sci. 2009.

    Van der Walt A. Butzkeuven H, Kolbe S, et al. Neuroprotection in Multiple Sclerosis: A Therapeutic Challenge for the Next Decade. Pharmacol Ther. 2010.

    Wilkins A, Scolding N. Protecting Axons in Multiple Sclerosis. Mult Scler. 2008.