SMi Source Lesson Oncology: Diagnostics for Targeted Care

  • SMi Source lesson Oncology: Diagnostics for Targeted Care has the following microlearning topics

  • 1. Breast Cancer: Role of HER Therapies
    Dysregulation: Many Causes
    Targeted Therapies
    Targeted Therapies: Signaling Pathways

    2. The Right Treatment to the Right Patient at the Right Time
    Identifying Protein Expression
    IHC and FISH

  • Lesson Oncology: Diagnostics for Targeted Care teaches these concepts

  • Diagnostics for Targeted Cancer Care, Targets for Cancer Therapies, Breast Cancer: Role of HER Therapies

    Diagnostics for Targeted Cancer Care, Targets for Cancer Therapies, Dysregulation: Many Causes

    Diagnostics for Targeted Cancer Care, Targets for Cancer Therapies, Targeted Therapies

    Diagnostics for Targeted Cancer Care, Targets for Cancer Therapies, Targeted Therapies: Signaling Pathways

  • Lesson Oncology: Diagnostics for Targeted Care addresses these key points

  • HER (or ErbB receptors)

    • HER receptors pair with one another or “dimerize” either in homo or hetero dimers
    • Dimers are critical for activating signal transduction
    • HER2 has no ligand binding site, but is the preferred binding partner with other HER receptors

    Signal Transduction

    • Can alter gene expression
    • Affect processes that are implicated in tumor development

    Dysregulation: Many Causes

    • Gene mutation
    • Receptor overexpression
    • Ligand overexpression
    • Defective internalization

    Targeted therapies

    • Trastuzumab
    • Lapatinib
    • Down-regulated aberrant signaling by blocking ligand activation
    • Prevents signal transduction

    HER Signaling Pathways

    • Over 30 ligands
    • 4 receptors that can form up to 10 different combinations
    • Can activate numerous signal transduction pathways