SMi Source lesson Reproduction: Hypogonadism Pathophysiology has the following microlearning topics
1. Learning Objectives
2. What is Male Hypogonadism?
3. Male Reproductive Physiology
4. Testosterone Biosynthetic Pathway
5. Androgen Production in Leydig Cells
6. Testosterone as a Prohormone
7. Androgen Actions on Target Tissues
8. Mechanism of Androgen Action
9. Plasma Protein Binding and Sex Hormone-Binding Globulin (SHBG)
10. Testosterone Metabolism
11. Hypothalamic-Pituitary-Gonadal Axis
12. Feedback Regulation
13. Overview: Male Hypogonadism
14. Primary Male Hypogonadism
15. Primary Male Hypogonadism: Klinefelter's Syndrome
16. Primary Male Hypogonadism: Testicular Trauma and Anorchia
17. Primary Male Hypogonadism: Infectious Agents
18. Primary Male Hypogonadism: LH Receptor Mutations
19. Secondary Male Hypogonadism
20. Secondary Male Hypogonadism: LH and FSH Dysfunction
21. Tertiary Male Hypogonadism
22. Tertiary Male Hypogonadism: Kallman Syndrome, GnRH Deficiency, GPR54, Opioid Use
23. Overview: Adult and Late-Onset Hypogonadism
24. Epidemiology of Adult and Late-Onset Hypogonadism
25. Pathophyisology of Adult and Late-Onset Hypogonadism: Testosterone
26. Pathophyisology of Adult and Late-Onset Hypogonadism: Hypothalamus, Pituitary, Testes
27. Clinical Presentation: Signs and Symptoms
28. Differential Diagnosis
29. Diagnosis of Suspected Androgen Deficiency: Endocrine Society (ES)
30. Diagnosis of Suspected Androgen Deficiency: Diagnosis and Evaluation of Patients with Suspected Androgen Deficiency
31. Diagnosis and Evaluation of Patients with Suspected Androgen Deficiency: ISA/ISSAM/EAU/EAA/ASA - Replacement Therapy
32. Diagnosis and Evaluation of Patients with Suspected Androgen Deficiency: ISA/ISSAM/EAU/EAA/ASA - Reference Ranges
33. Further Evaluation of Men Deemed Androgen-Deficient: Recommendations from the Endocrine Society (ES)
34. ISA/ISSAM/EAU/EAA/ASA Recommendation Regarding LH and Prolactin and Screening for Androgen Deficiency
35. Comorbidities: Overview
36. Knowledge Checks
