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    Lysosomal Storage Disorders

    Lysosomal Storage Disorders: Gaucher Disease

    Lysosomal Storage Disorders: Hunter Syndrome

    Lysosomal Storage Disorders: Sanfilippo Syndrome

    Lysosomal Storage Disorders: Metachromatic Leukodystrophy

    Lysosomal Storage Disorders: Fabry Disease

    Immunology: Primer

    Multiple Sclerosis: Diagnosis and Prognosis

    Biotech: Basics

    Drug R&D: Clinical Trial Design

    Hereditary Angioedema: Treatment

    HIV: Overview of Disease and Impact

    Biotech: Monoclonal Antibodies

    Oncology: Sarcoma

    Biology: Cell Structure and Mobility

    Rheumatoid Arthritis: Clinical Presentation and Assessment

    Genetics: Introduction to Genetic Epidemiology

    Alzheimer's Disease: Pathology

    Oncology: Prostate Cancer

    Major Depressive Disorder: Treatment

    Diabetes: Introduction to Clinical Trial Design

    Multiple Sclerosis: Pathogenesis and Clinical Symptomology

    Lupus: Clinical Presentation

    Anticoagulation: Treatments II

    Rheumatoid Arthritis: Treatments with Biologics

    Hepatology: Anatomy and Physiology of Liver and Overview of Liver Diseases

    Cardiovascular: Hypertension

    Hereditary Angioedema

    Lupus: Pathophysiology

    HCV: Chronic Infection

    Atherosclerosis: Lipid Lowering Agents

    Psoriasis: Treatments

    Hereditary Angioedema: Pathophysiology

    Hereditary Angioedema: Diagnosis

    Pharmacokinetics: PK in Action

    Multiple Sclerosis

    Obesity

    Cardiovascular: Venous Thromboembolism

    Atherosclerosis: Cholesterol Metabolism, Lipoproteins, and Residual Risk

    Hepatology: Anatomy and Physiology of Liver and Overview of Liver Diseases

    Anticoagulation: Antiplatelet Drug Therapy

    Cardiovascular: Cancer VTE

    Immunology: Therapeutic Immunology

    Neurology: Migraines

    Cardiovascular: Platelet Biology

    Psoriasis: Clinical Picture

    Alzheimer's Disease: Diagnostic Criteria

    Myelodysplastic Syndrome: Therapeutic Decisions

    Lupus: Treatments

    Anticoagulation: Treatments I

  • Microlearning Topics

  • Lysosomal Storage Disorders: Introduction

    Lysosomal Storage Disorders: Introduction

    Lysosomal Anatomy and Physiology

    Lysosomes

    Lysosomal Storage Disorders

    Epidemiology

    Lysosomal Storage Disorders: Overview and Definition

    Lysosomal Storage Disorders: Overview and Definition

    Lysosomal Storage Disorders: Summary

    Lysosomal Storage Disorders: Summary

    Lysosomal Storage Disorders: Overview and Definition

    Genetics

    Lysosomal Anatomy and Physiology

    Glycoprotein, N-Glycan, O-Glycan

    Lysosomal Anatomy and Physiology

    Cellular Trafficking

    Lysosomal Anatomy and Physiology

    Cellular Components and Function

    Lysosomal Storage Disorders

    Disease Burden

    Lysosomal Storage Disorders

    Classification

    Lysosomal Storage Disorders

    Clinical Presentation and Manifestations

    Lysosomal Storage Disorders

    Classification: Oligosaccharidoses, Cystinosis, and Niemann-Pick Type C Disease

    Diagnosis and Treatment

    Enzyme Replacement Therapy (ERT)

    Diagnosis and Treatment

    Substrate Reduction Therapy (SRT)

    Diagnosis and Treatment

    Disease-Modifying Therapy

    Classification

    Classification: Mucolipidoses and Sphingolipidoses

    Diagnosis and Treatment

    Diagnostic Components/Diagnostic Confirmation

    Diagnosis and Treatment

    Hematopoietic Stem Cell Transplantation

    Diagnosis and Treatment

    Diagnostic Components

    Therapeutic Goals

    Supportive Therapy

    Epidemiology and Natural History

    Clinical Presentation and Course of Disease

    Hunter Syndrome: Introduction

    Learning Objectives

    Hunter Syndrome: Summary

    Summary and Key Points

    Hunter Syndrome: Summary

    Learning Objectives

    Gaucher Disease: Introduction

    Learning Objectives

    Summary

    Summary & Key Points

    Summary

    Learning Objectives

    Sanfilippo Syndrome: Introduction

    Sanfilippo Syndrome: Introduction

    Summary

    Summary & Key Points

    Summary

    Learning Objectives

    Metachromatic Leukodystrophy: Introduction

    Learning Objectives

    Summary

    Summary and Key Points

    Summary

    Learning Objectives

    Fabry Disease : Introduction

    Learning Objectives

    Fabry Disease : Overview

    Common Clinical Manifestations

    Summary

    Summary and Key Points

    Summary

    Learning Objectives

    Hunter Syndrome: Introduction & Overview

    Overview of Clinical Features

    Gaucher Disease: Overview

    Gaucher Disease: Overview

    Sanfilippo Syndrome: Introduction and Overview

    Etiology

    Fabry Disease : Overview

    Etiology

    Metachromatic Leukodystrophy: Introduction and Overview

    Etiology

    Sanfilippo Syndrome: Introduction and Overview

    Sanfilippo Syndrome: Introduction & Overview

    Metachromatic Leukodystrophy: Introduction and Overview

    Classification

    Metachromatic Leukodystrophy: Introduction

    Metachromatic Leukodystrophy: Introduction and Overview

    Gaucher Disease: Introduction

    Gaucher Disease: Introduction

    Genetics of Hunter Syndrome

    Inheritance Pattern

    Diagnosis of Gaucher Disease

    Diagnosis of Gaucher Disease

    Epidemiology and Natural History

    Incidence and Prevalence

    Metachromatic Leukodystrophy: Introduction and Overview

    Metachromatic Leukodystrophy: Introduction and Overview

    Diagnosis of MLD

    Magnetic Resonance Imaging for MLD

    Fabry Disease : Overview

    Common Clinical Manifestations: Vascular

    Fabry Disease : Overview

    Common Clinical Manifestations: Psychiatric

    Gaucher Disease: Overview

    Etiology

    Therapeutic Goals

    Primary Therapy

    Genetics of Metachromatic Leukodystrophy

    Molecular Etiology

    Epidemiology and Natural History

    Incidence and Prevalence

    Diagnosis of Hunter Syndrome

    Diagnosis of Hunter Syndrome

    Genetics of Gaucher Disease

    Inheritance Pattern

    Epidemiology and Natural History

    Epidemiology

    Diagnosis of MLD

    Magnetic Resonance Imaging (MRI)

    Fabry Disease : Overview

    Common Clinical Manifestations: Dermatological

    Fabry Disease : Overview

    Common Clinical Manifestations: Otological

    Diagnosis of Fabry Disease

    Diagnosis of Fabry Disease by Gender

    Diagnosis of Fabry Disease

    Diagnostic Tests: Urinalysis and Skin Biopsy

    The Inflammatory Response

    Phagocytosis

    Genetics of Gaucher Disease

    Molecular Etiology

    Hunter Syndrome: Introduction & Overview

    Etiology: Mucopolysaccharidoses (MPS)

    Diagnosis of Gaucher Disease

    Clinical Signs and Symptoms

    Therapeutic Goals

    Management & Goals of Treatment

    Genetics of Sanfilippo Syndrome

    Inheritance Pattern

    Epidemiology and Natural History

    Incidence and Prevalence: Types A-D

    Epidemiology and Natural History

    Natural History

    Genetics of Metachromatic Leukodystrophy

    Inheritance Pattern

    Fabry Disease : Overview

    Common Clinical Manifestations

    Fabry Disease : Overview

    Common Clinical Manifestations: Physical

    Fabry Disease : Overview

    Common Clinical Manifestations: Renal

    Fabry Disease : Overview

    Common Clinical Manifestations: Ophthalmological

    Fabry Disease : Overview

    Common Clinical Manifestations: Pulmonary Involvement

    Genetics of Fabry Disease

    Inheritance Pattern

    Epidemiology and Natural History

    Incidence

    Hunter Syndrome: Introduction & Overview

    Etiology: Glycosaminoglycan (GAG)

    Epidemiology and Natural History

    Prevalence of Organ System Involvement in the HOS

    Epidemiology and Natural History

    Clinical Manifestations: Neurological/CNS Involvement

    Sanfilippo Syndrome: Introduction

    Sanfilippo Syndrome: Introduction and Overview

    Genetics of Sanfilippo Syndrome

    Molecular Etiology

    Diagnosis of Sanfilippo Disease

    Diagnostic Components and Findings

    Management

    Treatment Goals and Options

    Diagnosis of MLD

    Diagnostic Components and Findings

    Fabry Disease : Overview

    Common Clinical Manifestations: Gastrointestinal

    Genetics of Fabry Disease

    Molecular Etiology

    Differential Diagnosis

    Differential Diagnosis: Other Diseases that Share Some MS Features

    Drug Discovery

    Biomarkers

    Types of Studies

    Case-Control Study

    Goals of Treatment

    Hereditary Angioedema

    Hunter Syndrome: Introduction

    Hunter Syndrome: Introduction

    Hunter Syndrome: Introduction & Overview

    Overview of Clinical Features: Early Progressive and Slowly Progressive

    Hunter Syndrome: Introduction & Overview

    Hunter Outcome Survey

    Genetics of Hunter Syndrome

    Molecular Etiology

    Fabry Disease: Introduction

    Fabry Disease: Introduction

    Impact

    A Timeline

    Development of Monoclonal Antibodies

    Clinical Trial Goals

    Types of Studies

    Observational Studies: Cohort

    Soft Tissue Sarcomas (STSs)

    STSs: Mechanisms of Disease Development and Progression

    Epidemiology and Natural History

    Clinical Manifestations: Physical

    Diagnosis of Hunter Syndrome

    Diagnostic Tests

    Gaucher Disease: Overview

    Classification

    Epidemiology

    Incidence, Prevalence, and Demographics

    Diagnosis of Gaucher Disease

    Diagnostic Tests and Surveillance

    Sanfilippo Syndrome: Introduction and Overview

    Clinical Features

    Epidemiology and Natural History

    Natural History

    Fabry Disease : Overview

    Common Clinical Manifestations: Neurological

    Epidemiology and Natural History

    Natural History

    Management

    Goals of Treatment

    Cellular Organelles

    Cellular Organelles

    Summary: Cell Structure and Mobility

    Cell Structure and Mobility: Summary

    Diagnosis of RA

    Clinical Measures - Complete Blood Cell (CBC) Count

    Genetic Epidemiology

    Selected Analytic Study Designs

    Neuropathology

    Granulovacuolar Degeneration and Neuropil Threads

    Treatment Options and Guidelines

    Treatment Options for Metastatic Disease:Recommendations

    Metachromatic Leukodystrophy: Introduction and Overview

    Common Clinical Manifestations

    Management

    Treatment Goals and Options

    Diagnosis of Fabry Disease

    Diagnostic Tests: Enzyme Assay and Molecular Genetic

    Pharmacological Treatments

    Mixed Serotonergic Medications (Mixed 5-HT)

    Management

    Goals of Treatment

    Gaucher Disease: Overview

    Clinical Manifestations

    Types of Studies

    Design Types
    Observational Studies: Cohort
    Case-Control Study
    Experimental Studies: D...

    Impact

    A Global Problem
    A Timeline
    HIV-1

    Diabetes Clinical Trial Design: Cohort Designs

    Cohort Study

    Diabetes Clinical Trial Design: Case Control Designs

    Case Control Study

    Signs and Symptoms

    Damage to Specific CNS Regions

    Overlapping Diseases

    SLE and Secondary Sjogren's Syndrome

    Use of Novel Oral Anticoagulants

    Acute Coronary Syndrome (ACS)

    Other Biologics in Current Use - Anakinra

    Use in RA, Indications, Dosage and Administration: Anakinra

    Clinical Manifestations

    Complications of Chronic Cholestasis

    Causes of Secondary Hypertension

    Causes of Secondary Hypertension

    Epidemiology

    Overview of HAE Epidemiology

    Forms of Lupus

    Cutaneous Lupus Erythematosus (CLE)
    Forms of Lupus
    Systemic Lupus Erythematosus

    HCV Infection

    Risk Factors Associated With Transmission of HCV
    Impact of the Epidemic
    HCV Infection

    Statins

    Side Effects

    Diagnosis Confirmation

    Confirmation of a Positive EIA
    Western Blot
    Confirmed Positive
    Indeterminate Results

    Psoriasis Therapies

    Topical Vitamin D Analogs
    Topical Vitamin D Analogs: Mechanism of Action
    Topical Vitamin D...

    Overview of Classification of Angioedema (AE)

    Allergic Angioedema (Association with Urticaria)

    Symptoms and Clinical Course of HAE

    Overview: HAE Due to Decreased C1-INH

    Prenatal and Postnatal Diagnosis

    Diagnosis of HAE In Pregnancy

    Psoriasis Therapies

    Systemic Therapies: Methotrexate
    Systemic Therapies Overview
    Methotrexate: Mechanism of Ac...

    PK Parameters

    Systemic Clearance

    Drug Discovery

    Drug Discovery
    Target vs. Platform-driven Discovery
    Target Validation
    Targeting Strat...

    Management of Hypertension in Special Populations

    Management of Hypertension in Special Populations

    Introduction

    Disease Overview: Mortality
    MS Timeline
    Etiology
    Environmental Factors
    Infectiou...

    Prostate Cancer Risk Factors

    Primary Risk Factors

    Overlapping Diseases

    SLE and Secondary Sjogren's Syndrome
    SLE and Scleroderma
    SLE and Overlapping Diseases ...

    Overview of Obesity

    Overweight/Obese Defined
    Body Mass Index
    Waist Circumference and Obesity
    Cause of Obe...

    VTE Clinical Picture: Risk Factors and Comorbid States

    Risk Factors and Comorbid States

    Development of Monoclonal Antibodies

    Monoclonal Antibody Production in Hybridomas
    Monoclonal Antibody Production in CHO Cells
    M...

    Pathophysiology

    Immunopathophysiology: Myelin-Reactive T Cells
    Immunopathophysiology: T Cell Initiation of MS -...

    VTE Clinical Picture: Risk Factors and Comorbid States

    Risk Factors and Comorbid States

    Dyslipidemia Disease State

    Etiology

    Therapeutic Monoclonal Antibodies

    Emerging Trends: Antibody-Drug Conjugates (ADCs)

    Diabetes Annotations

    Abasaglar insulin glargine

    Biological and Physicochemical Determinants of PK

    Drug Elimination: Metabolism and Excretion

    Liver Diseases Overview

    Genetic Diseases, Hereditary Hemochromatosis

    Emerging Therapies

    Phosphodiesterase III Inhibitors: Cilostazol (PLETAL)

    PCSK9 Inhibitors

    Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)

    Diagnostic Testing: Cerebrospinal Fluid (CSF)

    Cerebrospinal Fluid (CSF)
    CSF Findings in MS

    Diagnostic Testing: Cerebrospinal Fluid (CSF)

    CSF Findings in MS

    Management of C1-INH-HAE

    Long-Term Prophylaxis

    Complications of RA

    Major Organs Affected by RA

    Diagnosis

    Diagnostic Testing: CSF Findings in MS

    Incidence and Risk of VTE in Cancer Patients

    Risk Factors for Cancer-associated VTE

    Traditional Immunosuppressive Therapies

    Cytotoxic Agents

    Triggers and Risk Factors for Migraine

    Risk Factors

    VTE Clinical Picture: Natural History, Clinical Syndromes, Complications

    Natural History of VTE

    Hemostasis

    Disorders of Hemostasis: Abnormal Bleeding

    Clinical Assessment Tools in Psoriasis

    Clinical Assessment Tools

    Clinical Presentation and Clinical Diagnosis of Alzheimer's Disease

    Symptoms of Alzheimer's Disease

    Typical Clinical Course

    Organ Systems Involved

    Criteria for the Diagnosis of Dementia Due to Alzheimer's Disease

    Differential Diagnosis

    Anemia

    Red Blood Cell Transfusion

    Steroids

    Glucocorticoids: Mode of Action
    The Anti-Inflammatory Effects of Corticosteroids
    Glucocort...

    Steroids

    Glucocorticoids: Side Effects

    Advancing Technologies

    Biomarkers: Disease Process-Specific Biomarkers
    Biomarkers: Inflammation Biomarkers
    Biomar...

    Traditional Immunosuppressive Therapies

    Traditional Immunosuppressive Therapies
    Traditional Immunosuppressive Agents
    Corticosteroi...

    Therapeutic Monoclonal Antibodies

    Neutralization of a Circulating Factor
    Complement Dependent Cytotoxicity
    Antibody-Dependen...

    Guidelines for Anticoagulant Venous Thromboembolism Therapy

    Venous Thromboembolism Treatment: Complications During Therapy

    Hypomethylating Agents

    Hypomethylating Agents

    Diagnosis

    Overview: The Challenge of Diagnosis
    Physical Examination: Motor
    Physical Examination: Oth...

    Anemia

    Red Blood Cell Transfusion

    Anemia

    Neutropenia
    Symptoms of Anemia that Warrant Treatment
    Myelodysplastic Syndrome (MDS), Anem...

    Hypomethylating Agents

    Mechanism of DNA Methylation
    Gene Silencing Following DNA Methylation
    Hypomethylating Agen...

    Hypomethylating Agents

    Hypomethylating Agents

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