Microlearning Topics
Autoimmune Disease Processes
Consequences of Autoimmune Diseases: The Natural History of Autoimmune Disorders
Autoimmune Disease Processes
Consequences of Autoimmune Diseases: Common Autoimmune Diseases
Pathophysiology
Autoimmune Disease
Pathophysiology
Autoimmune Disease
Autoimmune Disease Processes
Consequences of Autoimmune Diseases: TNF-α In Autoimmune Disease: Potential Harm OR Benefit?
Autoimmune Disease Processes
The Etiology of Autoimmune Disease: Hormonal Factors
Autoimmune Disease Processes
The Etiology of Autoimmune Disease: Lifestyle Factors
Autoimmune Disease Processes
Consequences of Autoimmune Diseases: Progression and Destruction in Autoimmune Disorders (Mechanisms...
Autoimmune Disease Processes
The Etiology of Autoimmune Disease: Environmental Factors (Infectious Agents)
Introduction to Immunopathology
Autoimmune Diseases
Autoimmune Disease Processes
Consequences of Autoimmune Diseases: Progression and Destruction in Autoimmune Disorders (Mechanisms...
Autoimmune Disease Processes
Consequences of Autoimmune Diseases: Progression and Destruction in Autoimmune Disorders (Mechanisms...
Autoimmune Disease Processes
The Etiology of Autoimmune Disease
The Etiology of Autoimmune Disease: Genetic Factors (Risk)
Autoimmune Disease Processes
The Etiology of Autoimmune Disease: Genetic Factors (Risk)
The Etiology of Autoimmune Disease: ...
Introduction: Autoimmune Disorders and Hypersensitivity
Introduction: Autoimmune Disorders and Hypersensitivity - Causes and Statistics
Introduction to Immunopathology
Autoimmune Diseases: Epidemiology and Impact
Autoimmune Diseases: General Mechanism Underlying ...
Autoimmune Disorders
Introduction: Autoimmune Disorders: Statistics
Autoimmune Disease Processes
The Etiology of Autoimmune Disease: Environmental Factors (Infectious Agents)
The Etiology of A...
Autoimmune Disease Processes
The Etiology of Autoimmune Disease
Autoimmune Disease Processes
The Etiology of Autoimmune Disease: Genetic Factors (Family and Population Studies)
Autoimmune Disease Processes
The Etiology of Autoimmune Disease
The Etiology of Autoimmune Disease: Genetic Factors (Risk)
Autoimmune Disease Processes
The Etiology of Autoimmune Disease: Genetic Factors (Chromosomal Evidence: The Importance of HLA)
Autoimmune Disease Processes
The Etiology of Autoimmune Disease: Environmental Factors (Non-Infectious Agents)
Introduction to Immunopathology
Autoimmune Diseases: Epidemiology and Impact
Autoimmune Diseases: Introduction
Autoimmune Diseases: Introduction
Epidemiology and Impact
Hypersensitivity
Autoimmune Diseases Classified as Hypersensitivity Reactions
Autoimmune Diseases: Introduction
Epidemiology and Impact
Autoimmune Disorders
Introduction: Autoimmune Disorders: Affects Almost Any Part of the Body
Autoimmune Disease Processes
The Etiology of Autoimmune Disease: Genetic Factors (Introduction)
Autoimmune Disease Processes
Consequences of Autoimmune Diseases: Progression and Destruction in Autoimmune Disorders (Mechanisms...
Autoimmune Disease Processes
Consequences of Autoimmune Diseases: Progression and Destruction in Autoimmune Disorders (Mechanisms...
Autoimmune Disease Processes
The Etiology of Autoimmune Disease: Genetic Factors (Risk)
Introduction to Immunopathology
Autoimmune Diseases: General Mechanism Underlying Autoimmune Disease
Autoimmune Disease Processes
The Etiology of Autoimmune Disease: Environmental Factors
Autoimmune Disease Processes
Consequences of Autoimmune Diseases: Progression and Destruction in Autoimmune Disorders (Mechanisms...
Autoimmune Disease Processes
The Breakdown of Tolerance: The Hidden Role of Cryptic Epitopes
Introduction
Introduction: Autoimmune Diseases
Mechanisms of Autoimmune Disease: The Breakdown of Tolerance
The Breakdown of Tolerance: Release of Sequestered Antigens
Mechanisms of Autoimmune Disease: The Breakdown of Tolerance
The Breakdown of Tolerance: Loss of T Cell Anergy
Pathophysiology
Autoimmune Disease
Autoimmune Disease Examples
Autoimmune Diseases
Autoimmune Diseases: Introduction
Mechanisms: MHC Complex/Receptor Disorders
Autoimmune Diseases: Introduction
The Breakdown of Tolerance: Molecular Mimicry
Autoimmune Diseases: Introduction
Autoimmune Diseases: Introduction
Autoimmune Diseases: Introduction
The Breakdown of Tolerance
The Breakdown of Tolerance: Molecular Mimicry
Mechanisms: Loss ...
Introduction to Immunopathology
Autoimmune Diseases: The Spectrum of Attack
Mechanisms of Autoimmune Disease: The Breakdown of Tolerance
The Breakdown of Tolerance: Failure of T Cell Suppression by Regulatory T Cells
Mechanisms of Autoimmune Disease: The Breakdown of Tolerance
The Breakdown of Tolerance: Failure of Apoptosis via Fas Receptors
Autoimmune Disease Processes
Epitopes and Antigenic Determinants
The Breakdown of Tolerance: The Hidden Role of Cryptic Epit...
Autoimmune Disease Examples
Autoimmune Disease Progression
Introduction: Autoimmune Disorders and Hypersensitivity
Introduction: Autoimmune Disorders and Hypersensitivity - Immunopathologies
Autoimmune Disease Examples
Interactivity: Autoimmune Diseases
Autoimmune Diseases: Introduction
General Mechanism Underlying Autoimmune Disease
The Breakdown of Tolerance
The Breakdown o...
Mechanisms of Autoimmune Disease: The Breakdown of Tolerance
Mechanisms of Autoimmune Disease: The Breakdown of Tolerance
The Breakdown of Tolerance: Molecu...
Autoimmune Diseases: Introduction
General Mechanism Underlying Autoimmune Disease
Mechanisms of Autoimmune Disease: The Breakdown of Tolerance
Mechanisms of Autoimmune Disease: The Breakdown of Tolerance
The Breakdown of Tolerance: Molecu...
Mechanisms of Autoimmune Disease: The Breakdown of Tolerance
The Breakdown of Tolerance: MHC Complex/Receptor Disorders
Mechanisms of Autoimmune Disease: The Breakdown of Tolerance
The Breakdown of Tolerance: Molecular Mimicry
Mechanisms of Select Autoimmune Disorders
Multiple Sclerosis
Mechanisms of Select Autoimmune Disorders
Rheumatoid Arthritis: Patients
Autoimmune Diseases: Introduction
The Breakdown of Tolerance
Autoimmune Diseases: Introduction
Mechanisms: Presence of Superantigens
Mechanisms of Select Autoimmune Disorders
Rheumatoid Arthritis: TH17
Mechanisms of Select Autoimmune Disorders
Psoriasis: Upregulated Cytokines
Mechanisms of Select Autoimmune Disorders
Ankylosing Spondylitis: Heredity
Mechanisms of Select Autoimmune Disorders
Multiple Sclerosis: Demyelination
Mechanisms of Select Autoimmune Disorders
Psoriasis: Psoriatic keratinocytes Pathway
Mechanisms of Select Autoimmune Disorders
Rheumatoid Arthritis
Autoimmune Disease Processes
Consequences of Autoimmune Diseases: Progression and Destruction in Autoimmune Disorders (Epitope Sp...
Pathology of T1DM
Autoimmune Disorders
Lupus Pathogenesis
Autoimmune Mechanisms
Autoimmune Disease Examples
Autoimmune Diseases
Interactive Exercise: Immunology Terms
Interactivity: Autoimmune Disea...
Autoimmune Disorders
Mechanisms: The Breakdown of Tolerance Molecular Mimicry
Mechanisms: Loss of T Cell Anergy
Etiology and Pathophysiology
Autoimmunity
Autoimmune Disorders
Mechanisms: Release of Sequestered Antigens
Autoimmune Disorders
Mechanisms: MHC Complex/Receptor Disorders
Key Concepts in Autoimmunity: The Importance of Tolerance
The Birth and Early Education of Lymphocytes: Tolerance (Some Thoughts...)
Key Concepts in Autoimmunity: The Importance of Tolerance
The Birth and Early Education of Lymphocytes: Expression of T Cell Receptors (TCRs)
The Birth a...
Autoimmune Diseases: Introduction
Mechanisms: Loss of T Cell Anergy
Autoimmune Diseases: Introduction
Mechanisms: Release of Sequestered Antigens
Autoimmune Diseases: Introduction
Mechanisms: Failure of Lymphocyte Suppression by Regulatory T Cells
Autoimmune Diseases: Introduction
Mechanisms: Failure of Apoptosis Via Fas Receptors
Mechanisms of Select Autoimmune Disorders
Systemic Lupus Erythematosus: Symptoms and Risk
Mechanisms of Select Autoimmune Disorders
Multiple Sclerosis: Molecular Mimicry
Mechanisms of Select Autoimmune Disorders
Systemic Lupus Erythematosus: Failure of Vital Organs
Mechanisms of Select Autoimmune Disorders
Psoriasis Arthritis: Pain and Swelling in Joints
Mechanisms of Select Autoimmune Disorders
Ankylosing Spondylitis: Enthesis and Kyphosis
Key Concepts in Autoimmunity: The Importance of Tolerance
The Birth and Early Education of Lymphocytes: Peripheral Tolerance (Apoptosis in Clonal Deletion)
Mechanisms of Select Autoimmune Disorders
Systemic Lupus Erythematosus: Multisymptom Disease
Mechanisms of Select Autoimmune Disorders
Psoriasis Arthritis: Psoriatic Spondylitis
Mechanisms of Select Autoimmune Disorders
Systemic Lupus Erythematosus (SLE)
Key Concepts in Autoimmunity: The Importance of Tolerance
The Birth and Early Education of Lymphocytes: Expression of T Cell Receptors (TCRs)
The Birth a...
Mechanisms of Select Autoimmune Disorders
Rheumatoid Arthritis: Cell Migration, Neoangiogenesis, and Early Stages
Mechanisms of Select Autoimmune Disorders
Multiple Sclerosis: T Cells, B Cells, Axon Damage
Pathology of T1DM
Autoimmune Disorders
Mechanisms of Autoimmune Disease: The Breakdown of Tolerance
Mechanisms of Autoimmune Disease: The Breakdown of Tolerance
Hypersensitivity
Limitations
Autoimmune Disorders
Mechanisms: Failure of Apoptosis Via Fas Receptors
Autoimmune Disorders
Mechanisms: Loss of T Cell Anergy
Autoimmune Disorders
Mechanisms: The Breakdown of Tolerance Molecular Mimicry
Autoimmune Disease Processes
Epitopes and Antigenic Determinants
Introduction to Immunopathology
Organ Transplant Rejection: Class I MHC and Class II MHC Proteins
Organ Transplant Rejection: H...
Autoimmune Disorders
Mechanisms: Failure of T Cell Suppression by Regulatory T Cells
Key Concepts in Autoimmunity: The Importance of Tolerance
The Birth and Early Education of Lymphocytes: Peripheral Tolerance
The Birth and Early Educatio...
Key Concepts in Autoimmunity: The Importance of Tolerance
Key Terms and Concepts in Tolerance
Key Concepts in Autoimmunity: The Importance of Tolerance
The Birth and Early Education of Lymphocytes
Key Concepts in Autoimmunity: The Importance of Tolerance
The Birth and Early Education of Lymphocytes: Central Tolerance
Key Concepts in Autoimmunity: The Importance of Tolerance
The Birth and Early Education of Lymphocytes: Peripheral Tolerance
Mechanisms of Autoimmune Disease: The Breakdown of Tolerance
The Breakdown of Tolerance: Presence of Superantigens
Hypersensitivity
Type II Reaction Examples
Hypersensitivity
Introduction: Hypersensitivity
Hypersensitivity
Gell-Coombs Classification
Introduction: Multiple Sclerosis
Introduction: Hypersensitivity Reactions
Hypersensitivity
Hypersensitivity: Hypersensitivity Disorders
Pathophysiology
Immunopathophysiology: Autoimmune Disease
Hypersensitivity
Type IV Hypersensitivity Reaction Subgroups
Lupus Pathogenesis
Autoimmune Mechanisms
Dysfunctional Response of the Immune System
Hypersensitivity
Type II Hypersensitivity Reaction (Antibody Mediated)
Type II Reaction Examples
Hypersensitivity
Type I Hypersensitivity Reaction: Immediate Hypersensitivity
Hypersensitivity
Hypersensitivity Disorders: Type 1 Immediate Hypersensitivity
Hypersensitivity
Type II Hypersensitivity Reaction (Antibody Mediated)
Hypersensitivity
Type I Hypersensitivity Reaction: Immediate Hypersensitivity
Hypersensitivity Disorders: Type 1...
Hypersensitivity
Type IV Hypersensitivity Reaction Subgroups
Gell-Coombs Classification
Type I Hypersensiti...
Key Concepts in Autoimmunity: The Importance of Tolerance
The Birth and Early Education of Lymphocytes: Expression of T Cell Receptors (TCRs)
Key Concepts in Autoimmunity: The Importance of Tolerance
The Birth and Early Education of Lymphocytes: Release from Bone Marrow and Migration to the Thymus
Key Concepts in Autoimmunity: The Importance of Tolerance
The Birth and Early Education of Lymphocytes: Deletion of Cells that Lack T Cell Receptors
Key Concepts in Autoimmunity: The Importance of Tolerance
The Birth and Early Education of Lymphocytes: Central Tolerance (Positive Selection)
Key Concepts in Autoimmunity: The Importance of Tolerance
The Birth and Early Education of Lymphocytes: Central Tolerance (Negative Selection)
Key Concepts in Autoimmunity: The Importance of Tolerance
The Birth and Early Education of Lymphocytes: B Cell Central Tolerance
Key Concepts in Autoimmunity: The Importance of Tolerance
The Birth and Early Education of Lymphocytes: Peripheral Tolerance (Peripheral mechanisms)
Key Concepts in Autoimmunity: The Importance of Tolerance
The Birth and Early Education of Lymphocytes: B Cell Peripheral Tolerance
Key Concepts in Autoimmunity: The Importance of Tolerance
The Birth and Early Education of Lymphocytes: Peripheral Tolerance (Suppression by T Regulatory Cell...
Key Concepts in Autoimmunity: The Importance of Tolerance
The Birth and Early Education of Lymphocytes: Peripheral Tolerance (Anergy)
Pathophysiology
Autoimmune Disease: Overview
Key Concepts in Autoimmunity: The Importance of Tolerance
The Birth and Early Education of Lymphocytes: Central Tolerance
The Birth and Early Education o...
Pathophysiology
Overview
T Cell Initiation of MS Blood Brain Barrier
B Cells and Autoantibodies in Diseas...
Key Concepts in Autoimmunity: The Importance of Tolerance
The Birth and Early Education of Lymphocytes: B Cell Central Tolerance
The Birth and Early Educ...
Hypersensitivity
Hypersensitivity Disorders: Type III Immune Complex-Mediated
Hypersensitivity
Hypersensitivity Disorders: Type IV T-Cell-Mediated (Delayed)
Mechanisms of Select Autoimmune Disorders
Psoriasis
Mechanisms of Select Autoimmune Disorders
Psoriasis Arthritis
Mechanisms of Select Autoimmune Disorders
Ankylosing Spondylitis
Mechanisms of Select Autoimmune Disorders
Systemic Lupus Erythematosus
Key Concepts in Autoimmunity: The Importance of Tolerance
The Birth and Early Education of Lymphocytes: Peripheral Tolerance (Separation of the Autoreactive T...
Autoimmune Disorders
Mechanisms: Presence of Superantigens
B Cells, Antibodies and Antibody-Mediated Immune Responses
B Cell Production of Interleukin-10 (IL-10): Resolution of Autoimmune Disease Inflammatory Response
Pathophysiology
Immunopathophysiology: Myelin-Reactive T Cells
Immunopathophysiology: T Cell Initiation of MS -...
Mechanisms of Select Autoimmune Disorders
Rheumatoid Arthritis: Early Stages of RA
Mechanisms of Select Autoimmune Disorders
Multiple Sclerosis: Axon Damage
Therapeutic Monoclonal Antibodies
Targeting Immune Cells
Targeting T Cell Migration
Targeting T Cells and Inflammation
TIDM and Autoimmune Disorders
Heterogeneity of Type 1 Diabetes Mellitus
TIDM and Autoimmune Disorders
Immunotherapy of Type 1 Diabetes
Hypersensitivity
Hypersensitivity Diseases
Hypersensitivity
Types of Hypersensitivity Responses
Hypersensitivity
Antibody-Mediated Hypersensitivity
Hypersensitivity
Hypersensitivity Diseases
Types of Hypersensitivity Responses
Immediate Hypersensitivity (...
Hypersensitivity
Immediate Hypersensitivity (Type I)
Therapeutic Monoclonal Antibodies
Targeting T Cells and Inflammation
Hypersensitivity
Immune-Complex-Mediated Hypersensitivity (Type III)
Hypersensitivity
T Cell-Mediated Hypersensitivity (Type IV)
Therapeutic Monoclonal Antibodies
Neutralization of a Circulating Factor
Complement Dependent Cytotoxicity
Antibody-Dependen...
Liver Diseases Overview
Liver Disease Overview: Key Concepts
Soluble Receptors and Other Cytokine Inhibitors
Agents That Activate Anti-Inflammatory Pathways
Symptoms and Clinical Course of HAE
HAE Due to Decreased C1-INH: Exacerbating Factors
Pathology of T1DM
Type 1 Diabetes: Risk Factors
Introduction to Immunopathology
Immunopathologies: Categories
Introduction to Immunopathology
Hypersensitivity Disorders
Soluble Receptors and Other Cytokine Inhibitors
Soluble Receptors and Other Cytokine Inhibitors
Summary: Psoriasis
Pathophysiology of Psoriasis
Introduction to Immunopathology
Hypersensitivity Disorders
Hypersensitivity Disorders: Type I Immediate Hypersensitivity
H...
Psoriasis Therapies
Biologics: TNF-Targeted Agents
Introduction to Immunopathology
Immunopathologies: Clinical Consequences
Immunopathologies: Categories
Introduction to Therapeutic Immunology
Edward Jenner: Vaccination
Vaccination Successes
Therapeutic Immunology: Immunodiagnostics...
Soluble Receptors and Other Cytokine Inhibitors
Cytokine Neutralizers
Cytokine Inhibitors: Three Major Strategies
Agents That Block Cytoki...
Pathophysiology
Immunopathophysiology: Epstein-Barr Virus (EBV)
Typical Course of Plaque Psoriasis
Complications and Comorbidities of Psoriasis
Introduction to Therapeutic Immunology
Therapeutic Immunology: Immunodiagnostics and Immunotherapy
Introduction to Therapeutic Immunology
Biologic Therapies
Soluble Receptors and Other Cytokine Inhibitors
Overview of Cytokine Therapy: Types of Cytokines
Clinical Manifestations
Signs and Symptoms: Physical Examination
Typical Course of Plaque Psoriasis
Onset, Episodes, Flare-Ups, Triggers
Complications and Comorbidities of Psoriasis
The Inflammatory Response
Antigen Presentation: MHC/HLA (Association between HLA and Diseases)
Pathology of T1DM
Type 1 Diabetes: Risk Factors
Soluble Receptors and Other Cytokine Inhibitors
Soluble Receptors and Other Cytokine Inhibitors
Overview of Cytokine Therapy: Types of Cytokine...
Therapeutic Monoclonal Antibodies
Targeting Immune Cells
Other Programs
Chemokines
Pathology of Type 2 Diabetes Mellitus
Natural History of Type 2 Diabetes
Summary: Psoriasis
Psoriasis Definition
Potential Factors in Etiology of Psoriasis
Pathophysiology of Psorias...
Introduction
Disease Overview: Definition
Current Therapies
Intensive Immune Suppression: Cell Therapy
Current Therapies
Cell Therapy
Additional concepts in MS Therapy
Neuroprotection
Pathology of T1DM
Type 1 Diabetes Disease Pathway: Islet Autoantibodies
Pathophysiology of HAE
Acquired C1-Inhibitor Deficiency Angioedema
Pathology of T1DM
Natural History of Type 1 Diabetes
Psoriasis Therapies
Systemic Therapies: Off-Label Agents
Off-Label Agents: Clinical Efficacy and Safety
Biolog...
Clinical Manifestations
Complications of Chronic Cholestasis
Animal Models of MS
Animal Models of MS
Natural History of Type 1 Diabetes
Natural History of Type 1 Diabetes
Emerging Hypotheses on Treatment
Neurodegeneration: Myelination-Targeted Antibodies
Disease Overview
Definition of Multiple Sclerosis
Pathophysiology
T Cell Initiation of MS
B Cells, Antibodies and Antibody-Mediated Immune Responses
B Cell Production of Interleukin-10 (IL-10): Downregulation the Active Inflammatory Response
Animal Models of MS
TMEV Infection Model
Lupus Introduction
Historical Context
Therapies: Approved and Off-Label
Therapies: Approved
Introduction: Lupus Treatments
Treatment of SLE
Cytokine Examples
Interleukin-4
Lupus Risk Factors
Combination of Genetics and Environment
Lupus Pathogenesis
Autoantibodies in SLE
Diagnosis of SLE
Hallmark Autoantibodies
SLE Treatments: MAbs/Biologics
MAbs/Biologics: Infliximab
SLE Treatments: Other
Plasmapheresis
Primary Biliary Cirrhosis: Introduction
Primary Biliary Cirrhosis: Introduction
Innate and Adaptive (Acquired) Immune Systems
Self vs. Non-Self
Antibodies: Biotech's Most Versatile Players
Antibodies: Highly Specific Therapeutic Agents
Joints Affected by RA
Joints Affected by RA
Summary: Psoriasis
Complications and Comorbidities of Psoriasis
Antibodies and the Immune System
Therapeutic Monoclonal Antibodies
Therapeutic Monoclonal Antibodies
Other Diseases
Pathophysiology
B-Cell Regulation: BAFF/TNF-Super-family
Diagnosis of RA
Overview - Diagnosis of RA
Pathophysiology of Male Hypogonadism
Secondary Male Hypogonadism
Background on Biologic Therapies
Monoclonal Antibodies
Biologic Medical Products
Biologics in the Marketplace
Disease Overview
Definition of Multiple Sclerosis
Prognosis
Clinical Presentation
Patient Descriptions...
Liver Diseases Overview
Introduction to Primary Biliary Cirrhosis (PBC)
The Inflammatory Response
Antigen Presentation: MHC/HLA (Association between HLA and Diseases)
Disease Overview: Multiple Sclerosis
Multiple Sclerosis: Definition
B Cells, Antibodies and Antibody-Mediated Immune Responses
BAFF (B-cell Activating Factor) and APRIL (A Proliferation-Inducing Ligand)
B Cells, Antibodies and Antibody-Mediated Immune Responses
B-Cell Activation and Regulation: Antibody Production
Therapies: Approved and Off-Label
Therapies: Approved
Therapies: Off-Label
Self vs. Non-Self
Self vs. Non-Self
What Disease States Cause Dry Mouth?
Metabolic or Immune Disorders
Physiology of Immune System Dysregulation
Overview of Immune Dysregulation
Active Immunization
Lessons Learned from AN1792
Pathophysiology of Atrial Fibrillation
Atrial Fibrosis
Basaglar T1DM: Introduction
Pathophysiology of Type 1 Diabetes Mellitus
Antibody Production
Antibody Production
Diagnosis of SLE
Hematological Abnormalities
Lupus Risk Factors
Genetics
Combination of Genetics and Environment
SLE Treatments: Immunosuppressants
Immunosuppressants: Cyclosporine A (CsA)
SLE Treatments: Other
Plasmapheresis
Antibodies: Biotech's Most Versatile Players
Antibodies: Highly Specific Therapeutic Agents
Antibodies: Research and Diagnostic Applications
Psoriatic Arthritis
Psoriatic Arthritis (PsA)
Psoriasis Therapies
Systemic Therapies: Cyclosporine A (CsA)
Pathophysiology of Male Hypogonadism
Primary Male Hypogonadism
Pathophysiology of Atrial Fibrillation (AF)
Atrial Fibrosis
What Disease States Cause Dry Mouth?
Salivary Gland Disorders
Metabolic or Immune Disorders
Cancer, Radiation and Chemotherapy
Pharmacological Agents
Ursodeoxycholic Acid (UDCA): Mechanisms of Action
Pathological Angiogenesis
Diseases Associated with Uncontrolled Angiogenesis
Introduction
Disease Overview: Mortality
MS Timeline
Etiology
Environmental Factors
Infectiou...
Other Biologics in Current Use - Rituximab
Mechanism of Action (MOA): Rituximab
Disease Overview: Multiple Sclerosis
Clinical Presentation
Multiple Sclerosis: Definition
Forms of Lupus
Systemic Lupus Erythematosus
Diagnosis of SLE
Hematological Abnormalities
Hallmark Antibodies
Introduction: Clinical Presentation of Lupus
Introduction: Clinical Presentation of Lupus
Typical Clinical Course
Clinical Features/Presentation
Diagnosis of SLE
Differential Diagnosis
SLE Treatments: MAbs/Biologics
MAbs/Biologics: Infliximab
Infliximab: Mode of Action
Infliximab: Efficacy and Safety
Primary Biliary Cirrhosis: Key Concepts
Primary Biliary Cirrhosis: Key Concepts
Atopy vs. Allergy
Hypersensitivity Overview, Atopy versus Allergy
Impact of Psoriasis
Psychological Impact: Depression, Anxiety, and Stress
Details of Selected Neurotransmitters
Acetylcholinesterase (AChE)
Emerging Hypotheses on Treatment
Emerging Hypotheses on Treatment: Myelination-Targeted Antibodies
Cell Therapy
Human Stem ...
Current Therapies
Overview: Current Therapies for MS
Treatment of Acute Relapses: Severe Relapses: Therapeutic P...
Additional concepts in MS Therapy
Immunologic Concepts
Genetic Concepts
Neurodegeneration
Neuroprotection
Remyelin...
Pathogenesis and Clinical Symptomology MS: Introduction
Summary of Pathophysiology of MS
Lupus Introduction
Lupus Systemic Lupus Erythematosus (SLE)
Historical Context
Symptoms of Lupus
Forms of Lupus
Cutaneous Lupus Erythematosus (CLE)
Forms of Lupus
Systemic Lupus Erythematosus
Diagnosis of SLE
Differential Diagnosis
Lifelong Monitoring of SLE Patients
Goals of Therapy
Goals of SLE Therapy
Lupus Pathogenesis
Dysfunctional Response of the Immune System: B Cells and T Cells
Autoantibodies in SLE
Clinical Manifestations
Associated Diseases
Antibodies and the Immune System
Therapeutic Monoclonal Antibodies
Antibody Structure
Antigen Binding
Antibody Product...
Joints Affected by RA
Joints Affected by RA
Synovitis and the Synovial Pannus
Synovial Joints
Exercise: Nor...
Overview of Classification of Angioedema (AE)
Allergic Angioedema (Association with Urticaria)
Differential Diagnoses Considerations
Differential Diagnoses Considerations
Adaptive T Cell Immunity
Antigen Presentation and T Cell Activation
Adaptive T Cell Immunity
Antigen Presentation and T Cell Activation
Introduction to Immunopathology
Hypersensitivity Disorders: Type IV T-Cell-Mediated (Delayed)
Summary: Pathophysiology of Lupus
Summary: Pathophysiology of Lupus
Cytokine Examples
Interleukins and Interferons
Type I Interferons: Interferon-α and Interferon-β
I...
SLE Treatments: Immunosuppressants
Immunosuppressants: Cyclosporine A (CsA)
Cyclosporine A (CsA): Mode of Action
Cyclosporine...
Psoriasis Therapies
Systemic Therapies: Cyclosporine A (CsA)
Cyclosporine A (CsA): Mechanism of Action
Cyclosp...
Current Therapies
Goals of Disease Modifying Therapy (DMT)
Symptomatic Therapies - Symptom Reduction
Hormona...
Diagnosis of SLE
Hallmark Autoantibodies: Antiphospholipid Antibodies
Hallmark Autoantibodies: Rheumatoid Factor...
Summary: Psoriasis
Prevalence
Incidence
Cutaneous and Extracutaneous Manifestations
Onset, Episodes, Fla...
Epidemiology
Overview of HAE Epidemiology
Traditional Immunosuppressive Therapies
Cytotoxic Agents
Introduction to Immunopathology
Hypersensitivity Disorders: Type II Antibody-Mediated
Natural History of Type 1 Diabetes
Differences in Type 1 Diabetes Mellitus
Details of Selected Neurotransmitters
Acetylcholine (ACh)
Acetylcholinesterase (AChE)
Dopamine (DA) and Dopamine Signaling
...
Traditional Immunosuppressive Therapies
Traditional Immunosuppressive Therapies
Traditional Immunosuppressive Agents
Corticosteroi...
Introduction to Therapeutic Immunology
Traditional Immunosuppressive Agents
Traditional Immunosuppressive Therapies
Fungal or Bacterial Derivatives
Introduction to Therapeutic Immunology
Categories of Biologic Therapy
Introduction: The Nervous System
Welcome to the Nervous System
Clinical Applications of Monoclonal Antibodies
A Closer Look At mABS Used as Therapies
Clinical Applications of Monoclonal Antibodies
Clinical Applications of Monoclonal Antibodies: Learning Objectives
Detection, Diagnosis, and M...
Current Therapies
Intensive Immune Suppression: Chemotherapeutic Agents
Introduction
Etiology: Infectious Factors
Emerging Hypotheses on Treatment
Genetic Concepts: Interleukin Receptors
Interpretation of Results
Case: Sharon T.
Emerging Hypotheses on Treatment
Immunological Concepts: Vaccines
Etiology of Multiple Sclerosis
Infectious Factors
Disease Overview
Etiology
Lupus Pathogenesis
Dysfunctional Response of the Immune System: Role of BAFF and Cytokines
Lupus Pathogenesis
Dysfunctional Response of the Immune System: Role of BAFF and Cytokines
Diagnostic Testing: Cerebrospinal Fluid (CSF)
Cerebrospinal Fluid (CSF)
CSF Findings in MS
Diagnostic Testing: Cerebrospinal Fluid (CSF)
CSF Findings in MS
Disease Definition and Clinical Course
Course of Disease
Pathophysiology of Male Hypogonadism
Overview: Male Hypogonadism
Intensive Immune Suppression
Intensive Immune Suppression for Non-Responders
Pathophysiology
Immunopathophysiology: T Cell Initiation of MS
Approved Parenteral Treatments for Multiple Sclerosis
Approved Parenteral Therapies for RRMS: Avonex
Introduction to Immunopathology
Organ Transplant Rejection: Class I MHC and Class II MHC Proteins
Introduction to Immunopathology
Organ Transplant Rejection: Class I MHC and Class II MHC Proteins
Organ Transplant Rejection: H...
Introduction to Immunopathology
Immunopathologies: Clinical Consequences
Introduction to Immunopathology
Organ Transplant Rejection: How the Immune System Distinguishes between Self and Non-Self
Introduction to Immunopathology
Hypersensitivity Disorders: Type I Immediate Hypersensitivity
Introduction to Immunopathology
Hypersensitivity Disorders: Type III Immune Complex-Mediated
Introduction to Immunopathology
Organ Transplant Rejection: How the Immune System Distinguishes between Self and Non-Self
Introduction to Immunopathology
Organ Transplant Rejection: HLA Typing for Transplant
Introduction to Immunopathology
Organ Transplant Rejection: Introduction
Introduction to Immunopathology
Organ Transplant Rejection: Host-Versus-Graft Disease (HVGD) and Graft-Versus-Host Disease (GVHD)
Introduction to Immunopathology
Immunodeficiency Syndromes
Introduction to Therapeutic Immunology
Edward Jenner: Vaccination
Introduction to Therapeutic Immunology
Vaccination Successes
Introduction to Therapeutic Immunology
Immunotherapy
Introduction to Therapeutic Immunology
Limitations of Traditional Immunosuppressive Drugs
Traditional Immunosuppressive Therapies
Traditional Immunosuppressive Therapies
Traditional Immunosuppressive Agents
Traditional Immunosuppressive Therapies
Traditional Immunosuppressive Therapies
Traditional Immunosuppressive Therapies
Traditional Immunosuppressive Agents
Traditional Immunosuppressive Therapies
Corticosteroids: Immediate Effect (Anti-Inflammatory)
Corticosteroids: Gene Expression
Cor...
Traditional Immunosuppressive Therapies
Corticosteroids: Immediate Effect (Anti-Inflammatory)
Traditional Immunosuppressive Therapies
Corticosteroids
Traditional Immunosuppressive Therapies
Corticosteroids: Gene Expression
Corticosteroids: Gene Expression (The Anti-Inflammatory Effect...
Traditional Immunosuppressive Therapies
Corticosteroids: Gene Expression
Traditional Immunosuppressive Therapies
Corticosteroids: Gene Expression (The Anti-Inflammatory Effects of Corticosteroids)
Traditional Immunosuppressive Therapies
Corticosteroids: Gene Expression (Therapeutic Uses of Corticosteroids)
Traditional Immunosuppressive Therapies
Corticosteroids: Adverse Effects
Soluble Receptors and Other Cytokine Inhibitors
The Rationale for Cytokine Therapy: Drugs That Act As Cytokines or Anticytokines
Soluble Receptors and Other Cytokine Inhibitors
Cytokine Neutralizers
Soluble Receptors and Other Cytokine Inhibitors
Cytokine Inhibitors: Three Major Strategies
Soluble Receptors and Other Cytokine Inhibitors
Agents That Block Cytokine Receptors
Soluble Receptors and Other Cytokine Inhibitors
Soluble Receptor Therapies
Soluble Receptors and Other Cytokine Inhibitors
Soluble Receptor Therapies
Mechanism of Action of Enbrel (etanercept): Tumor Necrosis Factor In...
Soluble Receptors and Other Cytokine Inhibitors
Mechanism of Action of Enbrel (etanercept): Tumor Necrosis Factor Inhibitor
Enbrel (etanercept)...
Soluble Receptors and Other Cytokine Inhibitors
Mechanism of Action of Enbrel (etanercept): Tumor Necrosis Factor Inhibitor
Soluble Receptors and Other Cytokine Inhibitors
Enbrel (etanercept) Indications
Soluble Receptors and Other Cytokine Inhibitors
Abatacept
Soluble Receptors and Other Cytokine Inhibitors
Abatacept
Mechanism of Action of Abatacept (Orencia)
Abatacept: A Soluble Fusion Protein
Soluble Receptors and Other Cytokine Inhibitors
Mechanism of Action of Abatacept (Orencia)
Soluble Receptors and Other Cytokine Inhibitors
Abatacept: A Soluble Fusion Protein
Introduction to Monoclonal Antibodies
Antibodies as Therapy
Early Antibody Therapy: Polyclonal Antibodies
Hybridoma Technology: ...
Introduction to Monoclonal Antibodies
Antibodies as Therapy
Introduction to Monoclonal Antibodies
Early Antibody Therapy: Polyclonal Antibodies
Introduction to Monoclonal Antibodies
Hybridoma Technology: Limitations
Introduction to Monoclonal Antibodies
The Hybridoma Breakthrough
Introduction to Monoclonal Antibodies
Hybridoma Technology: Making a Monoclonal Antibody
Introduction to Monoclonal Antibodies
Recombinant mAbs
Introduction to Monoclonal Antibodies
Four General Classes of mAb Therapies
Introduction to Monoclonal Antibodies
Naming Monoclonal Antibodies: Pali-vi-zu-mab
Clinical Applications of Monoclonal Antibodies
Clinical Applications of Monoclonal Antibodies: Learning Objectives
Clinical Applications of Monoclonal Antibodies
Detection, Diagnosis, and Monitoring of Diseases and Disease-Related Molecules
Clinical Applications of Monoclonal Antibodies
Therapeutic mAbs: In the Treatment of Diseases
Clinical Applications of Monoclonal Antibodies
Therapeutic mAbs: Examples of Approved Agents
Clinical Applications of Monoclonal Antibodies
Cancer Immunotherapy
Clinical Applications of Monoclonal Antibodies
Receptor Cross-Linking
Inducing Complement-Mediated Cytotoxicity
Inducing Antibody-Depende...
Clinical Applications of Monoclonal Antibodies
Receptor Cross-Linking
Clinical Applications of Monoclonal Antibodies
Inducing Complement-Mediated Cytotoxicity
Clinical Applications of Monoclonal Antibodies
Inducing Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC)
Clinical Applications of Monoclonal Antibodies
Biological Actions of mAbs
Clinical Applications of Monoclonal Antibodies
Blocking the Actions of a Target Molecule
Clinical Applications of Monoclonal Antibodies
mAbs in Clinical Trials
Clinical Applications of Monoclonal Antibodies
New Antibody Formats
Emerging Hypotheses on Treatment
Immunological Concepts: Oral Immune-Modulating Drugs
T Cells and Cell-Mediated Immune Responses
T-Cell Specificity and Function
T Cells and Cell-Mediated Responses
T Cell Lineage
Cells of the Immune System
Overview of Cells of the Immune System
Immune System of the Skin
Immune System of the Skin: Overview
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