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    Dermatology: Immunology

    Immunology: Therapeutic Immunology

    Multiple Sclerosis: Gaining Knowledge on Immunology

    Immunology: Primer

    Rheumatoid Arthritis: Immunology Overview

    Oncology Primer: Immunology of Cancer

    Basics of Immunology of Cancer

    Multiple Sclerosis

    Dermatology: Anatomy and Physiology of the Skin

    Multiple Sclerosis: Immunology

    Immunology: Immune System Pathology

    Immunology: Autoimmune Disorders and Hypersensitivity

    Hereditary Angioedema: Diagnosis

    Rheumatoid Arthritis: Treatments with Biologics

    Dermatology: Atopic Dermatitis

    Lupus: Clinical Presentation

    Biotech: Protein Formulation Physical Aspects

    Oncology: Sarcoma

    Biotech: Biologics

    HCV: Chronic Infection

    Diabetes: Type 1- Pathophysiology

    Drug R&D: Combination Product Regulatory Requirements

    Biotech: Biosimilars

    Diabetes: Type 1

    Hepatology: Anatomy and Physiology of Liver and Overview of Liver Diseases

    Biologics

    Lysosomal Storage Disorders: Gaucher Disease

    Hereditary Angioedema: Treatment

    Hereditary Angioedema

    Psoriasis: Clinical Picture

    Multiple Sclerosis: Treatments and Strategies

    Asthma: MOA

    Lupus: Treatments

    Psoriasis: Treatments

    Lupus: Pathophysiology

    Psoriasis: Pathophysiology

    Asthma: Mechanisms of Action and Variables

    Asthma: IgE and Omalizumab, FEV1, and PEF

    Psoriasis: Biologics

    Rheumatoid Arthritis: Biologic Therapy

    Rheumatoid Arthritis: Pathophysiology

    Rheumatoid Arthritis: Treatments with Nonbiologic DMARDS

    Rheumatoid Arthritis

    Rheumatoid Arthritis: Clinical Presentation and Assessment

  • Microlearning Topics

  • Immunology: Introduction

    Immunology: Learning Objectives

    Immunology: Introduction

    Immunology: Introduction

    Introduction to Therapeutic Immunology

    Therapeutic Immunology: Immunodiagnostics and Immunotherapy

    Additional concepts in MS Therapy

    Immunologic Concepts

    Introduction to Therapeutic Immunology

    Traditional Immunosuppressive Agents

    Introduction to Therapeutic Immunology

    Vaccination Successes

    Introduction to Therapeutic Immunology

    Immunotherapy

    Introduction to Therapeutic Immunology

    Biologic Therapies

    Introduction to Therapeutic Immunology

    Categories of Biologic Therapy

    Introduction to Therapeutic Immunology

    Edward Jenner: Vaccination

    Introduction to Therapeutic Immunology

    Limitations of Traditional Immunosuppressive Drugs

    Introduction to Therapeutic Immunology

    Edward Jenner: Vaccination
    Vaccination Successes
    Therapeutic Immunology: Immunodiagnostics...

    B Cells and Humoral-Mediated Immune Responses

    Overview: Immunology

    Cytokines

    Overview: Cytokines

    Traditional Immunosuppressive Therapies

    Fungal or Bacterial Derivatives

    Traditional Immunosuppressive Therapies

    Traditional Immunosuppressive Therapies
    Traditional Immunosuppressive Agents
    Corticosteroi...

    Autoimmune Disease Examples

    Autoimmune Diseases
    Interactive Exercise: Immunology Terms
    Interactivity: Autoimmune Disea...

    Cells of the Immune System

    The Lymphatic System
    Lymphoid Organs
    Lymph Node
    Lymph Node: T Cell Activation
    Ly...

    The Inflammatory Response

    Inflammation
    Inflammation Resolving

    Hypersensitivity

    Antibody-Mediated Hypersensitivity

    T Cells and Cell-Mediated Responses

    T Cell Activation

    T Cells and Cell-Mediated Immune Responses

    T-Cell Activation

    Inflammatory Response in Action

    Acute Inflammation

    Introduction to Monoclonal Antibodies

    Antibodies as Therapy

    Introduction to Monoclonal Antibodies

    The Hybridoma Breakthrough

    Introduction to Monoclonal Antibodies

    Recombinant mAbs

    Cells of the Immune System

    Spleen

    The Inflammatory Response

    The Complement System: Outcomes

    The Innate and Adaptive Immune System

    The Innate and Adaptive Immune System

    Inflammatory Response in Action

    Chronic Inflammation

    Autoimmune Disease Examples

    Autoimmune Diseases

    Hypersensitivity

    Hypersensitivity Diseases

    Hypersensitivity

    Types of Hypersensitivity Responses

    Traditional Immunosuppressive Therapies

    Corticosteroids

    Traditional Immunosuppressive Therapies

    Cytotoxic Agents

    T Cells and Cell-Mediated Immune Responses

    T-Cell Activation

    The Inflammatory Response

    Inflammation Resolving

    The Immune Response: Overview

    The Immune Response: Overview

    The Immune Response

    The Skin Barrier

    The Innate Immune Response

    Inflammatory Gene Transcription

    The Immune Response

    The Adaptive (or Acquired) Immune Response

    Cells of the Immune System

    The Lymphatic System

    Cells of the Immune System

    Lymph Node

    Overview: The Inflammatory Response

    Overview: The Inflammatory Response

    The Inflammatory Response

    Leukocyte Migration: Rolling and adhesion

    The Inflammatory Response

    The Complement System: The Complement

    Complement System in Action

    The Complement Cascade

    Complement System in Action

    Activation of Complement

    The Inflammatory Response

    Phagocytosis

    Cytokines

    Tumor Necrosis Factor Alpha in Disease

    Self vs. Non-Self

    Self vs. Non-Self

    The Inflammatory Response

    Leukocyte Migration: Transmigration and Emigration, Chemotaxis

    Inflammatory Response in Action

    Systemic Inflammation

    Concepts in Cancer Immunology

    Cancer Immunoediting

    The Inflammatory Response

    Inflammation

    Cells of the Immune System

    Immune Cell Development

    Cells of the Immune System

    Lymphoid Organs

    Immunology of Cancer: Introduction

    Immunology of Cancer: Introduction

    Introduction: Basics of Immunology

    Introduction: Basics of Immunology

    Emerging Hypotheses on Treatment

    Immunological Concepts: Monoclonal Antibodies

    The Inflammatory Response

    The Complement System: The Complement
    The Complement System: The Compete Cascade
    The Compl...

    Traditional Immunosuppressive Therapies

    Traditional Immunosuppressive Therapies

    Introduction to Monoclonal Antibodies

    Hybridoma Technology: Limitations

    Traditional Immunosuppressive Therapies

    Traditional Immunosuppressive Agents

    Traditional Immunosuppressive Therapies

    Corticosteroids: Gene Expression

    Soluble Receptors and Other Cytokine Inhibitors

    Soluble Receptors and Other Cytokine Inhibitors

    Soluble Receptors and Other Cytokine Inhibitors

    Abatacept

    Clinical Applications of Monoclonal Antibodies

    Clinical Applications of Monoclonal Antibodies: Learning Objectives

    Clinical Applications of Monoclonal Antibodies

    Biological Actions of mAbs

    Clinical Applications of Monoclonal Antibodies

    mAbs in Clinical Trials

    Clinical Applications of Monoclonal Antibodies

    New Antibody Formats

    Traditional Immunosuppressive Therapies

    Traditional Immunosuppressive Therapies
    Traditional Immunosuppressive Agents

    Traditional Immunosuppressive Therapies

    Corticosteroids: Immediate Effect (Anti-Inflammatory)
    Corticosteroids: Gene Expression
    Cor...

    Inflammatory Response in Action

    Interactive Exercise: Inflammation
    Interactive Exercise: The Inflammation Process
    Interact...

    The Inflammatory Response

    Role of MHC in Antigen Presentation

    The Inflammatory Response

    The Complement System: Classical Pathway

    T Cells and Cell-Mediated Immune Responses

    Negative Selection

    T Cells and Cell-Mediated Immune Responses

    Anergy

    Clinical Applications of Monoclonal Antibodies

    Cancer Immunotherapy

    Summary: Innate and Adaptive Immune Responses

    Summary: Innate and Adaptive Immune Responses

    Soluble Receptors and Other Cytokine Inhibitors

    Cytokine Neutralizers

    Cells of the Immune System

    Lymph Node: T Cell Activation

    The Inflammatory Response

    Antigen Presentation: MHC/HLA

    The Inflammatory Response

    The Complement System: Inactive Proenzyme

    T Cells and Cell-Mediated Immune Responses

    Apoptosis

    B Cells and Antibodies

    Immunoglobulin Isotypes

    Introduction to the Innate and Adaptive Immune Systems

    The Immune System

    Autoimmune Disease Examples

    Autoimmune Disease Progression

    Traditional Immunosuppressive Therapies

    Corticosteroids: Adverse Effects

    Clinical Applications of Monoclonal Antibodies

    Receptor Cross-Linking

    The Inflammatory Response

    Role of MHC in Antigen Presentation
    Antigen Presentation: APC and T Cell

    The Inflammatory Response

    Antigen Presentation: MHC/HLA (Association between HLA and Diseases)

    The Inflammatory Response

    Antigen Presentation: APC and T Cell

    Cells of the Immune System

    Lymph Node: B Cell Activation

    B Cells and Humoral-Mediated Immune Responses

    Isotypes

    Adaptive Immune System Components

    Adaptive Immunity

    Adaptive Immune System Components

    Intracellular Antigens

    Adaptive Immune System Components

    Extracellular Antigens

    Hypersensitivity

    Immediate Hypersensitivity (Type I)

    The Inflammatory Response

    The Complement System: The Compete Cascade

    The Immune Response

    The Skin Barrier
    The Skin Barrier: Th1 and Th2 Responses

    The Immune Response

    The Skin Barrier: Th1 and Th2 Responses

    The Innate Immune Response

    Pattern Recognition Receptors (PRRs)

    The Immune Response

    How Innate and Adaptive Responses Work Together

    Hypersensitivity

    Hypersensitivity Diseases
    Types of Hypersensitivity Responses
    Immediate Hypersensitivity (...

    Soluble Receptors and Other Cytokine Inhibitors

    Abatacept
    Mechanism of Action of Abatacept (Orencia)
    Abatacept: A Soluble Fusion Protein

    Cells of the Immune System

    The Lymphatic System

    Autoimmune Disease Examples

    Interactivity: Autoimmune Diseases

    Traditional Immunosuppressive Therapies

    Corticosteroids: Gene Expression
    Corticosteroids: Gene Expression (The Anti-Inflammatory Effect...

    Cells of the Immune System

    Lymph Node
    Lymph Node: T Cell Activation
    Lymph Node: B Cell Activation

    Complement System in Action

    The Complement Cascade
    Activation of Complement
    Interactive Exercise: Complement Cascade

    Atopy vs. Allergy

    Hypersensitivity Disorders

    Introduction to the Innate and Adaptive Immune Systems

    Interactive Exercise: Components and Actions of Adaptive and Innate Immunity
    The Immune System

    Concepts in Cancer Immunology

    Cancer Immunosurveillance

    T Cells and Cell-Mediated Immune Responses

    Peripheral Tolerance
    Peripheral Tolerance: Apoptosis in Clonal Deletion
    Anergy
    Suppre...

    Clinical Applications of Monoclonal Antibodies

    Receptor Cross-Linking
    Inducing Complement-Mediated Cytotoxicity
    Inducing Antibody-Depende...

    T Cells and Cell-Mediated Immune Responses

    Expression of T Cell Receptors (TCRs)
    Apoptosis
    Central Tolerance
    Positive Selection

    Adaptive Immune System Components

    Adaptive Immunity
    Intracellular Antigens
    Extracellular Antigens
    Interactive Exercise:...

    Clinical Applications of Monoclonal Antibodies

    Clinical Applications of Monoclonal Antibodies: Learning Objectives
    Detection, Diagnosis, and M...

    Soluble Receptors and Other Cytokine Inhibitors

    Cytokine Inhibitors: Three Major Strategies

    Introduction to Monoclonal Antibodies

    Hybridoma Technology: Making a Monoclonal Antibody

    Clinical Applications of Monoclonal Antibodies

    Therapeutic mAbs: Examples of Approved Agents

    Soluble Receptors and Other Cytokine Inhibitors

    Soluble Receptors and Other Cytokine Inhibitors
    Overview of Cytokine Therapy: Types of Cytokine...

    Atopy vs. Allergy

    Hypersensitivity Disorders: Gell-Coombs Classification

    Soluble Receptors and Other Cytokine Inhibitors

    Agents That Block Cytokine Receptors

    Soluble Receptors and Other Cytokine Inhibitors

    Soluble Receptor Therapies

    Soluble Receptors and Other Cytokine Inhibitors

    Enbrel (etanercept) Indications

    Introduction to Monoclonal Antibodies

    Four General Classes of mAb Therapies

    Clinical Applications of Monoclonal Antibodies

    A Closer Look At mABS Used as Therapies

    Clinical Applications of Monoclonal Antibodies

    Blocking the Actions of a Target Molecule

    The Inflammatory Response

    Antigen Presentation: MHC/HLA (Association between HLA and Diseases)

    T Cells and Cell-Mediated Immune Responses

    Central Tolerance

    Traditional Immunosuppressive Therapies

    Corticosteroids: Immediate Effect (Anti-Inflammatory)

    Traditional Immunosuppressive Therapies

    Corticosteroids: Gene Expression (Therapeutic Uses of Corticosteroids)

    Soluble Receptors and Other Cytokine Inhibitors

    Overview of Cytokine Therapy: Types of Cytokines

    Soluble Receptors and Other Cytokine Inhibitors

    Agents That Activate Anti-Inflammatory Pathways

    Soluble Receptors and Other Cytokine Inhibitors

    Abatacept: A Soluble Fusion Protein

    Introduction to Monoclonal Antibodies

    Early Antibody Therapy: Polyclonal Antibodies

    Clinical Applications of Monoclonal Antibodies

    Detection, Diagnosis, and Monitoring of Diseases and Disease-Related Molecules

    Clinical Applications of Monoclonal Antibodies

    Therapeutic mAbs: In the Treatment of Diseases

    T Cells and Cell-Mediated Immune Responses

    Peripheral Tolerance

    T Cells and Cell-Mediated Immune Responses

    T-Cell Specificity and Function

    TH2 and TH2 Immune Responses

    TH1 and TH2 Helper T Cells

    TH2 and TH2 Immune Responses

    TH2 Cells Coordinate Humoral Response

    Soluble Receptors and Other Cytokine Inhibitors

    Mechanism of Action of Abatacept (Orencia)

    Clinical Applications of Monoclonal Antibodies

    Inducing Complement-Mediated Cytotoxicity

    Traditional Immunosuppressive Therapies

    Corticosteroids: Gene Expression (The Anti-Inflammatory Effects of Corticosteroids)

    Introduction to Monoclonal Antibodies

    Naming Monoclonal Antibodies: Pali-vi-zu-mab

    Clinical Applications of Monoclonal Antibodies

    Inducing Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC)

    T Cells and Cell-Mediated Immune Responses

    Peripheral Tolerance

    B Cells, Antibodies and Antibody-Mediated Immune Responses

    BAFF and APRIL Receptor Signaling

    B Cells and Humoral-Mediated Immune Responses

    Immunoglobulin Effector Mechanisms

    T Cells and Cell-Mediated Immune Responses

    Positive Selection

    T Cells and Cell-Mediated Immune Responses

    T-Cell Activation - Costimulation

    T Cells and Cell-Mediated Immune Responses

    T-Cell Activation

    Soluble Receptors and Other Cytokine Inhibitors

    Soluble Receptor Therapies
    Mechanism of Action of Enbrel (etanercept): Tumor Necrosis Factor In...

    Innate and Adaptive (Acquired) Immune Systems

    Self vs. Non-Self

    T Cells and Cell-Mediated Responses

    T Cell Lineage

    Introduction to the Innate and Adaptive Immune Systems

    Innate and Adaptive Immunity

    TH2 and TH2 Immune Responses

    CD4+ Helper T Cell Activation

    TH2 and TH2 Immune Responses

    TH1 Cells Coordinate Cell-Mediated Response

    Hypersensitivity

    Immune-Complex-Mediated Hypersensitivity (Type III)

    Hypersensitivity

    T Cell-Mediated Hypersensitivity (Type IV)

    T Cells and Cell-Mediated Immune Responses

    Peripheral Tolerance: Apoptosis in Clonal Deletion

    B Cells and Humoral-Mediated Immune Responses

    Overview of Antibody Production: B Cell Expression and Maturation

    B Cells and Humoral-Mediated Immune Responses

    Overview of Antibody Production: B Cell Clonal Expansion

    B Cells and Humoral-Mediated Immune Responses

    Immunoglobulins: IgG

    B Cells and Humoral-Mediated Immune Responses

    B Cells and Cytokine Production

    Soluble Receptors and Other Cytokine Inhibitors

    Cytokine Neutralizers
    Cytokine Inhibitors: Three Major Strategies
    Agents That Block Cytoki...

    Adaptive Immune System Components

    Activation of Humoral Immunity and Activation of Cell-Mediated Immunity

    Cells of the Immune System

    Overview of Cells of the Immune System

    B Cells and Antibodies

    Overview of B Cell Responses, Overview of Antibody Production

    T Cells and Cell-Mediated Immune Responses

    Expression of T Cell Receptors (TCRs)

    TH2 and TH2 Immune Responses

    TH1 and TH2 Helper T Cells
    CD4+ Helper T Cell Activation
    TH2 Cells Coordinate Humoral Resp...

    Innate and Adaptive (Acquired) Immune Systems

    Characteristics of Innate and Adaptive Immunity

    The Inflammatory Response: Overview

    Overview, Tissue Insult and Damage

    Atopy vs. Allergy

    Hypersensitivity Overview, Atopy versus Allergy

    Introduction to Monoclonal Antibodies

    Antibodies as Therapy
    Early Antibody Therapy: Polyclonal Antibodies
    Hybridoma Technology: ...

    Innate and Adaptive (Acquired) Immune Systems

    Characteristics of Innate and Adaptive Immunity

    The Inflammatory Response: Antigen Processing and Presentation by Macrophages

    The Inflammatory Response: Overview

    The Inflammatory Response: Leukocyte Migration

    The Inflammatory Response: Leukocyte Migration: Overview

    Soluble Receptors and Other Cytokine Inhibitors

    Mechanism of Action of Enbrel (etanercept): Tumor Necrosis Factor Inhibitor
    Enbrel (etanercept)...

    Additional concepts in MS Therapy

    Immunologic Concepts
    Genetic Concepts
    Neurodegeneration
    Neuroprotection
    Remyelin...

    T Cells and Cell-Mediated Immune Responses

    Peripheral Tolerance
    Peripheral Tolerance: Apoptosis in Clonal Deletion

    B Cells and Humoral-Mediated Immune Responses

    B-Cell Activation and Regulation: B-Cell Receptor (BCR)
    B-Cell Maturation: B-Cell Precursors

    T Cells and Cell-Mediated Immune Responses

    Peripheral Tolerance: B Cell Peripheral Tolerance

    T Cells and Cell-Mediated Immune Responses

    Separation of the Autoreactive T Cell from the Host Antigen

    B Cells, Antibodies and Antibody-Mediated Immune Responses

    B Cell Production of Interleukin-10 (IL-10): Resolution of Autoimmune Disease Inflammatory Response

    T Cells and Cell-Mediated Immune Responses

    Suppression by T Regulatory Cells (Suppressor T Cells)

    Innate and Adaptive (Acquired) Immune Systems

    Innate and Adaptive (Acquired) Immune Systems: Overview

    Soluble Receptors and Other Cytokine Inhibitors

    Mechanism of Action of Enbrel (etanercept): Tumor Necrosis Factor Inhibitor

    Soluble Receptors and Other Cytokine Inhibitors

    The Rationale for Cytokine Therapy: Drugs That Act As Cytokines or Anticytokines

    B Cells, Antibodies and Antibody-Mediated Immune Responses

    B Cell Production of Interleukin-10 (IL-10): Downregulation the Active Inflammatory Response

    T Cells and Cell-Mediated Immune Responses

    Release from Bone Marrow and Migration to the Thymus

    T Cells and Cell-Mediated Immune Responses

    T-Cell Activation - T-Cell Receptor (TCR)

    Innate and Adaptive (Acquired) Immune Systems

    How Innate and Adaptive Responses Work Together

    Pro- and Anti-Inflammatory Cytokines/Mediators

    Overview, Proinflammatory versus Anti-Inflammatory Cytokines

    B Cells, Antibodies and Antibody-Mediated Immune Responses

    BAFF (B-cell Activating Factor) and APRIL (A Proliferation-Inducing Ligand)

    B Cells, Antibodies and Antibody-Mediated Immune Responses

    B-Cell Activation and Regulation: Antibody Production

    B Cells, Antibodies and Antibody-Mediated Immune Responses

    BAFF and APRIL: Effects on B Cell Maturation

    B Cells and Humoral-Mediated Immune Responses

    B-Cell Activation and Regulation: B-Cell Receptor (BCR)

    B Cells and Humoral-Mediated Immune Responses

    B-Cell Maturation: B-Cell Precursors

    Pro- and Anti-Inflammatory Cytokines/Mediators

    Signaling Pathways Regulating Production and Transcription of Inflammatory Mediators

    B Cells, Antibodies and Antibody-Mediated Immune Responses

    Antigen Processing and Presentation and MHC, Role of MHC in Antigen Presentation

    Cancer Immunotherapy

    Cancer Immunotherapy

    Cancer Immunotherapy

    Cancer Immunotherapy

    Emerging Hypotheses on Treatment

    Emerging Hypotheses on Treatment: Myelination-Targeted Antibodies
    Cell Therapy
    Human Stem ...

    Innate Immunity

    Innate Tumor Immunity: Macrophages

    Cancer Immunotherapy

    Adoptive T Cell Transfer

    Cancer Immunotherapy

    Cancer Vaccines

    Suppression of Tumor Immunity

    Overview of Immunosuppressive Mechanisms

    Layers of the Skin: Epidermis

    Epidermal Functions: Keratinocyte Differentiation

    Emerging Hypotheses on Treatment

    Immunological Concepts: Vaccines

    Emerging Hypotheses on Treatment

    Immunological Concepts: Summary

    Innate Immunity

    Innate Versus Adaptive Immunity in Anti-tumor Responses

    Suppression of Tumor Immunity

    Evasion of T Cell Recognition or Activation

    Innate Immunity

    Dendritic Cells and Anti-tumor Immunity

    Innate Immunity

    Innate Tumor Immunity: Natural Killer Cells

    Adaptive T Cell Immunity

    Induction of Adaptive T Cell Immunity

    Adaptive T Cell Immunity

    Cytotoxic T Cells (CTLs) and Tumor Cell Killing

    Concepts in Cancer Immunology

    Cancer Immunosurveillance

    Concepts in Cancer Immunology

    Cancer Immunoediting

    Adaptive T Cell Immunity

    Antigen Presentation and T Cell Activation

    Adaptive T Cell Immunity

    CD4+ T Helper Cells and Tumor Immunity

    Emerging Hypotheses on Treatment

    Immunological Concepts: Emerging Hypotheses on Treatment

    Emerging Hypotheses on Treatment

    Immunological Concepts: Oral Immune-Modulating Drugs

    Basics of Immunology of Cancer

    Cancer Vaccines: Types of Cancer Vaccines

    Innate Immunity

    Dendritic Cells and Antitumor Immunity

    Innate Immunity

    Innate Versus Adaptive Immunity in Antitumor Responses

    Innate Immunity

    Innate Tumor Immunity: Natural Killer Cells

    Innate Immunity

    Innate Tumor Immunity: Macrophages

    Adaptive T Cell Immunity

    Induction of Adaptive T Cell Immunity

    Adaptive T Cell Immunity

    Antigen Presentation and T Cell Activation

    Adaptive T Cell Immunity

    Cytotoxic T Cells (CTLs) and Tumor Cell Killing

    Adaptive T Cell Immunity

    CD4+ T Helper Cells and Tumor Immunity

    Suppression of Tumor Immunity

    Overview of Immunosuppressive Mechanisms

    Suppression of Tumor Immunity

    Evasion of T Cell Recognition or Activation

    Cancer Immunotherapy: Adoptive T Cell Transfer

    Adoptive T Cell Transfer

    The Innate and Adaptive Immune System

    Learning Objectives

    Learning Objectives

    Learning Objectives

    Pathophysiology

    Glial Cells, Click-on: Oligodendrocytes

    Pathophysiology

    Glial Cells, Click-on: Astrocytes

    Pathophysiology

    Glial Cells, Click-on: Microglia

    Pathophysiology

    Autoimmune Disease

    Pathophysiology

    Autoimmune Disease

    Key Concepts in Autoimmunity: The Importance of Tolerance

    The Birth and Early Education of Lymphocytes: Peripheral Tolerance (Separation of the Autoreactive T...

    Hypersensitivity

    Type IV Hypersensitivity Reaction Subgroups

    Pathophysiology

    Neurodegeneration

    Pathophysiology

    Glial Cells, Click-on: Oligodendrocytes
    Glial Cells, Click-on: Astrocytes
    Glial Cells, Cli...

    Pathophysiology

    Microglial Mediators of CNS Inflammation and Damage

    Pathophysiology

    Glial Cells, Click-on: Microglia
    Microglial Mediators of CNS Inflammation and Damage

    Current Therapies

    Severe Relapses: Corticosteroids

    Current Therapies

    Severe Relapses: Therapeutic Plasma Exchange (TPE)

    Additional concepts in MS Therapy

    Genetic Concepts

    Additional concepts in MS Therapy

    Remyelinating Antibodies

    Disease Overview

    Patient Descriptions

    Disease Overview

    Etiology

    Disease Overview

    Classification of MS

    Pathophysiology

    Autoimmune Disease

    Pathophysiology

    Pathogenesis

    Additional concepts in MS Therapy

    Remyelination

    Key Concepts in Autoimmunity: The Importance of Tolerance

    The Birth and Early Education of Lymphocytes: Peripheral Tolerance (Anergy)

    Autoimmune Disease Processes

    Consequences of Autoimmune Diseases: Common Autoimmune Diseases

    Autoimmune Diseases: Introduction

    Epidemiology and Impact

    Hypersensitivity

    Autoimmune Diseases Classified as Hypersensitivity Reactions

    Disease Overview

    Relapses

    Disease Overview

    Disease Variability

    Pathophysiology

    Overview

    Pathophysiology

    Myelin-Reactive T Cells

    Current Therapies

    Hormonal Therapies

    Current Therapies

    Chemotherapeutic Agents

    Current Therapies

    Symptomatic Therapies - Severe Relapses

    Key Concepts in Autoimmunity: The Importance of Tolerance

    The Birth and Early Education of Lymphocytes: Central Tolerance

    Key Concepts in Autoimmunity: The Importance of Tolerance

    The Birth and Early Education of Lymphocytes: Central Tolerance (Negative Selection)

    Introduction to Immunopathology

    Hypersensitivity Disorders: Type II Antibody-Mediated

    Introduction to Immunopathology

    Hypersensitivity Disorders: Type III Immune Complex-Mediated

    Key Concepts in Autoimmunity: The Importance of Tolerance

    The Birth and Early Education of Lymphocytes: B Cell Peripheral Tolerance

    Key Concepts in Autoimmunity: The Importance of Tolerance

    The Birth and Early Education of Lymphocytes: Peripheral Tolerance (Apoptosis in Clonal Deletion)

    Mechanisms of Autoimmune Disease: The Breakdown of Tolerance

    The Breakdown of Tolerance: Molecular Mimicry

    Autoimmune Disease Processes

    The Etiology of Autoimmune Disease: Genetic Factors (Family and Population Studies)

    Autoimmune Disease Processes

    The Etiology of Autoimmune Disease: Lifestyle Factors

    Autoimmune Disease Processes

    Epitopes and Antigenic Determinants

    Additional concepts in MS Therapy

    Neurodegeneration

    Key Concepts in Autoimmunity: The Importance of Tolerance

    Key Terms and Concepts in Tolerance

    Autoimmune Diseases: Introduction

    The Breakdown of Tolerance: Molecular Mimicry

    Hypersensitivity

    Type II Reaction Examples

    Autoimmune Diseases: Introduction

    Mechanisms: Failure of Lymphocyte Suppression by Regulatory T Cells

    Autoimmune Diseases: Introduction

    Mechanisms: MHC Complex/Receptor Disorders

    Autoimmune Diseases: Introduction

    Mechanisms: Failure of Apoptosis Via Fas Receptors

    Disease Overview

    Progression

    Disease Overview

    Epidemiology

    Pathophysiology

    Autoimmune Disease: Overview

    Pathophysiology

    Demyelination

    Current Therapies

    Symptomatic Therapies - Symptom Reduction

    Current Therapies

    Intensive Immune Suppression For Non-Responders

    Current Therapies

    Cell Therapy

    Additional concepts in MS Therapy

    Neuroprotection

    Autoimmune Disorders

    Mechanisms: Failure of T Cell Suppression by Regulatory T Cells

    Autoimmune Disorders

    Mechanisms: MHC Complex/Receptor Disorders

    Autoimmune Disorders

    Mechanisms: Presence of Superantigens

    Key Concepts in Autoimmunity: The Importance of Tolerance

    The Birth and Early Education of Lymphocytes: Expression of T Cell Receptors (TCRs)

    Key Concepts in Autoimmunity: The Importance of Tolerance

    The Birth and Early Education of Lymphocytes: B Cell Central Tolerance

    Introduction to Immunopathology

    Immunopathologies: Clinical Consequences

    Introduction to Immunopathology

    Organ Transplant Rejection: How the Immune System Distinguishes between Self and Non-Self

    Introduction to Immunopathology

    Hypersensitivity Disorders

    Introduction to Immunopathology

    Autoimmune Diseases: The Spectrum of Attack

    Introduction to Immunopathology

    Organ Transplant Rejection: How the Immune System Distinguishes between Self and Non-Self

    Introduction to Immunopathology

    Immunodeficiency Syndromes

    Key Concepts in Autoimmunity: The Importance of Tolerance

    The Birth and Early Education of Lymphocytes: Tolerance (Some Thoughts...)

    Mechanisms of Autoimmune Disease: The Breakdown of Tolerance

    The Breakdown of Tolerance: MHC Complex/Receptor Disorders

    Autoimmune Disease Processes

    The Etiology of Autoimmune Disease: Genetic Factors (Risk)

    Autoimmune Disease Processes

    The Etiology of Autoimmune Disease: Genetic Factors (Introduction)

    Autoimmune Disease Processes

    Consequences of Autoimmune Diseases: Progression and Destruction in Autoimmune Disorders (Mechanisms...

    Autoimmune Disease Processes

    Consequences of Autoimmune Diseases: Progression and Destruction in Autoimmune Disorders (Epitope Sp...

    HAE Diagnosis

    Overview of HAE Diagnosis

    Hypersensitivity

    Limitations

    Autoimmune Diseases: Introduction

    The Breakdown of Tolerance

    Autoimmune Diseases: Introduction

    General Mechanism Underlying Autoimmune Disease

    Introduction: Autoimmune Disorders and Hypersensitivity

    Introduction: Autoimmune Disorders and Hypersensitivity - Immunopathologies

    Introduction: Autoimmune Disorders and Hypersensitivity

    Introduction: Autoimmune Disorders and Hypersensitivity - Causes and Statistics

    Hypersensitivity

    Introduction: Hypersensitivity

    Hypersensitivity

    Gell-Coombs Classification

    Hypersensitivity

    Hypersensitivity Disorders: Type III Immune Complex-Mediated

    Autoimmune Diseases: Introduction

    Mechanisms: Loss of T Cell Anergy

    Autoimmune Diseases: Introduction

    Mechanisms: Release of Sequestered Antigens

    Autoimmune Diseases: Introduction

    Mechanisms: Presence of Superantigens

    Mechanisms of Select Autoimmune Disorders

    Systemic Lupus Erythematosus: Failure of Vital Organs

    Mechanisms of Select Autoimmune Disorders

    Rheumatoid Arthritis: TH17

    Mechanisms of Select Autoimmune Disorders

    Psoriasis: Upregulated Cytokines

    Mechanisms of Select Autoimmune Disorders

    Psoriasis Arthritis: Pain and Swelling in Joints

    Mechanisms of Select Autoimmune Disorders

    Ankylosing Spondylitis: Enthesis and Kyphosis

    Mechanisms of Select Autoimmune Disorders

    Ankylosing Spondylitis: Heredity

    Mechanisms of Select Autoimmune Disorders

    Multiple Sclerosis: Demyelination

    Disease Overview

    Definition of Multiple Sclerosis

    Disease Overview

    Clinical Presentation

    Pathophysiology

    T Cell Initiation of MS Blood Brain Barrier

    Pathophysiology

    T Cell Initiation of MS

    Pathophysiology

    Plaques - Pathology

    Additional concepts in MS Therapy

    Cell Transplantation

    Autoimmune Disorders

    Mechanisms: Release of Sequestered Antigens

    Autoimmune Disorders

    Mechanisms: Failure of Apoptosis Via Fas Receptors

    Introduction

    Introduction: Autoimmune Diseases

    Hypersensitivity

    Hypersensitivity: Hypersensitivity Disorders

    Mechanisms of Select Autoimmune Disorders

    Systemic Lupus Erythematosus

    Biologic DMARDs

    Introduction to Biologic Disease-Modifying Antirheumatic Drugs (DMARDs)

    Key Concepts in Autoimmunity: The Importance of Tolerance

    The Birth and Early Education of Lymphocytes

    Key Concepts in Autoimmunity: The Importance of Tolerance

    The Birth and Early Education of Lymphocytes: Deletion of Cells that Lack T Cell Receptors

    Key Concepts in Autoimmunity: The Importance of Tolerance

    The Birth and Early Education of Lymphocytes: Central Tolerance (Positive Selection)

    Introduction to Immunopathology

    Immunopathologies: Categories

    Introduction to Immunopathology

    Hypersensitivity Disorders: Type I Immediate Hypersensitivity

    Introduction to Immunopathology

    Hypersensitivity Disorders: Type IV T-Cell-Mediated (Delayed)

    Introduction to Immunopathology

    Autoimmune Diseases: General Mechanism Underlying Autoimmune Disease

    Introduction to Immunopathology

    Autoimmune Diseases

    Introduction to Immunopathology

    Organ Transplant Rejection: HLA Typing for Transplant

    Introduction to Immunopathology

    Organ Transplant Rejection: Introduction

    Introduction to Immunopathology

    Organ Transplant Rejection: Host-Versus-Graft Disease (HVGD) and Graft-Versus-Host Disease (GVHD)

    Key Concepts in Autoimmunity: The Importance of Tolerance

    The Birth and Early Education of Lymphocytes: Peripheral Tolerance

    Key Concepts in Autoimmunity: The Importance of Tolerance

    The Birth and Early Education of Lymphocytes: Peripheral Tolerance (Peripheral mechanisms)

    Key Concepts in Autoimmunity: The Importance of Tolerance

    The Birth and Early Education of Lymphocytes: Peripheral Tolerance (Suppression by T Regulatory Cell...

    Mechanisms of Autoimmune Disease: The Breakdown of Tolerance

    Mechanisms of Autoimmune Disease: The Breakdown of Tolerance

    Mechanisms of Autoimmune Disease: The Breakdown of Tolerance

    The Breakdown of Tolerance: Loss of T Cell Anergy

    Mechanisms of Autoimmune Disease: The Breakdown of Tolerance

    The Breakdown of Tolerance: Failure of T Cell Suppression by Regulatory T Cells

    Mechanisms of Autoimmune Disease: The Breakdown of Tolerance

    The Breakdown of Tolerance: Release of Sequestered Antigens

    Mechanisms of Autoimmune Disease: The Breakdown of Tolerance

    The Breakdown of Tolerance: Presence of Superantigens

    Mechanisms of Autoimmune Disease: The Breakdown of Tolerance

    The Breakdown of Tolerance: Failure of Apoptosis via Fas Receptors

    Autoimmune Disease Processes

    The Etiology of Autoimmune Disease

    Autoimmune Disease Processes

    The Etiology of Autoimmune Disease: Genetic Factors (Chromosomal Evidence: The Importance of HLA)

    Autoimmune Disease Processes

    The Etiology of Autoimmune Disease: Hormonal Factors

    Autoimmune Disease Processes

    The Etiology of Autoimmune Disease: Environmental Factors

    Autoimmune Disease Processes

    The Etiology of Autoimmune Disease: Environmental Factors (Non-Infectious Agents)

    Autoimmune Disease Processes

    Consequences of Autoimmune Diseases: Progression and Destruction in Autoimmune Disorders (Mechanisms...

    Autoimmune Disease Processes

    Consequences of Autoimmune Diseases: The Natural History of Autoimmune Disorders

    Key Concepts in Autoimmunity: The Importance of Tolerance

    The Birth and Early Education of Lymphocytes: Peripheral Tolerance
    The Birth and Early Educatio...

    Hypersensitivity

    Type I Hypersensitivity Reaction: Immediate Hypersensitivity

    Hypersensitivity

    Hypersensitivity Disorders: Type 1 Immediate Hypersensitivity

    Hypersensitivity

    Type II Hypersensitivity Reaction (Antibody Mediated)

    Mechanisms of Select Autoimmune Disorders

    Systemic Lupus Erythematosus: Symptoms and Risk

    Mechanisms of Select Autoimmune Disorders

    Systemic Lupus Erythematosus: Multisymptom Disease

    Mechanisms of Select Autoimmune Disorders

    Psoriasis Arthritis: Psoriatic Spondylitis

    Disease Overview

    Prognosis

    Pathophysiology

    B Cells and Autoantibodies in Disease Progression

    Current Therapies

    Goals of Disease Modifying Therapy (DMT)

    Current Therapies

    Rationale for Early Treatment

    Autoimmune Disorders

    Mechanisms: The Breakdown of Tolerance Molecular Mimicry

    Autoimmune Disorders

    Mechanisms: Loss of T Cell Anergy

    Autoimmune Disorders

    Introduction: Autoimmune Disorders: Affects Almost Any Part of the Body

    Autoimmune Disorders

    Introduction: Autoimmune Disorders: Statistics

    Mechanisms of Select Autoimmune Disorders

    Rheumatoid Arthritis: Early Stages of RA

    Mechanisms of Select Autoimmune Disorders

    Multiple Sclerosis

    Mechanisms of Select Autoimmune Disorders

    Multiple Sclerosis: Axon Damage

    Autoimmune Disease Processes

    The Breakdown of Tolerance: The Hidden Role of Cryptic Epitopes

    Autoimmune Disease Processes

    Consequences of Autoimmune Diseases: TNF-α In Autoimmune Disease: Potential Harm OR Benefit?

    Key Concepts in Autoimmunity: The Importance of Tolerance

    The Birth and Early Education of Lymphocytes: Expression of T Cell Receptors (TCRs)
    The Birth a...

    Hypersensitivity

    Type II Hypersensitivity Reaction (Antibody Mediated)
    Type II Reaction Examples

    Hypersensitivity

    Hypersensitivity Disorders: Type IV T-Cell-Mediated (Delayed)

    Mechanisms of Select Autoimmune Disorders

    Rheumatoid Arthritis: Patients

    Mechanisms of Select Autoimmune Disorders

    Psoriasis: Psoriatic keratinocytes Pathway

    Introduction: Multiple Sclerosis

    Introduction: Hypersensitivity Reactions

    Mechanisms of Select Autoimmune Disorders

    Psoriasis

    Mechanisms of Select Autoimmune Disorders

    Psoriasis Arthritis

    Mechanisms of Select Autoimmune Disorders

    Ankylosing Spondylitis

    Mechanisms of Select Autoimmune Disorders

    Systemic Lupus Erythematosus (SLE)

    Key Concepts in Autoimmunity: The Importance of Tolerance

    The Birth and Early Education of Lymphocytes: Release from Bone Marrow and Migration to the Thymus

    Key Concepts in Autoimmunity: The Importance of Tolerance

    The Birth and Early Education of Lymphocytes: Central Tolerance
    The Birth and Early Education o...

    Introduction to Immunopathology

    Immunopathologies: Clinical Consequences
    Immunopathologies: Categories

    Introduction to Immunopathology

    Autoimmune Diseases: Epidemiology and Impact

    Autoimmune Disease Processes

    The Etiology of Autoimmune Disease: Environmental Factors (Infectious Agents)

    Autoimmune Disease Processes

    Epitopes and Antigenic Determinants
    The Breakdown of Tolerance: The Hidden Role of Cryptic Epit...

    Hypersensitivity

    Type IV Hypersensitivity Reaction Subgroups
    Gell-Coombs Classification
    Type I Hypersensiti...

    Pathophysiology

    Pathophysiological Mechanisms

    Autoimmune Diseases: Introduction

    Autoimmune Diseases: Introduction

    Diagnosis of SLE

    1997 ACR Diagnostic Criteria

    Autoimmune Diseases: Introduction

    Autoimmune Diseases: Introduction
    Epidemiology and Impact

    Hypersensitivity

    Type I Hypersensitivity Reaction: Immediate Hypersensitivity
    Hypersensitivity Disorders: Type 1...

    Mechanisms of Select Autoimmune Disorders

    Rheumatoid Arthritis: Cell Migration, Neoangiogenesis, and Early Stages

    Mechanisms of Select Autoimmune Disorders

    Multiple Sclerosis: Molecular Mimicry

    Mechanisms of Select Autoimmune Disorders

    Multiple Sclerosis: T Cells, B Cells, Axon Damage

    Pathophysiology

    Plaques - Pathology
    Plaques - Histology

    Pathophysiology

    Plaques - Histology

    Mechanisms of Select Autoimmune Disorders

    Rheumatoid Arthritis

    Key Concepts in Autoimmunity: The Importance of Tolerance

    The Birth and Early Education of Lymphocytes: Expression of T Cell Receptors (TCRs)
    The Birth a...

    Introduction to Immunopathology

    Organ Transplant Rejection: Class I MHC and Class II MHC Proteins

    Key Concepts in Autoimmunity: The Importance of Tolerance

    The Birth and Early Education of Lymphocytes: B Cell Central Tolerance
    The Birth and Early Educ...

    Introduction to Immunopathology

    Hypersensitivity Disorders
    Hypersensitivity Disorders: Type I Immediate Hypersensitivity
    H...

    Autoimmune Disease Processes

    The Etiology of Autoimmune Disease: Genetic Factors (Risk)
    The Etiology of Autoimmune Disease: ...

    Autoimmune Disease Processes

    Consequences of Autoimmune Diseases: Progression and Destruction in Autoimmune Disorders (Mechanisms...

    Autoimmune Disease Processes

    Consequences of Autoimmune Diseases: Progression and Destruction in Autoimmune Disorders (Mechanisms...

    Autoimmune Disease Processes

    Consequences of Autoimmune Diseases: Progression and Destruction in Autoimmune Disorders (Mechanisms...

    Immunogenicity

    Immunogenicity: Introduction

    Soft Tissue Sarcomas (STSs)

    Anatomy and Pathophysiology: Mechanisms of Disease Development and Progression

    Pathophysiology

    Overview
    T Cell Initiation of MS Blood Brain Barrier
    B Cells and Autoantibodies in Diseas...

    Introduction to Immunopathology

    Autoimmune Diseases: Epidemiology and Impact
    Autoimmune Diseases: General Mechanism Underlying ...

    Autoimmune Disease Processes

    The Etiology of Autoimmune Disease: Environmental Factors (Infectious Agents)
    The Etiology of A...

    Autoimmune Disease Processes

    Consequences of Autoimmune Diseases: Progression and Destruction in Autoimmune Disorders (Mechanisms...

    Advancing Technologies

    Biomarkers: Neurodegenerative Biomarkers

    Proteins

    Protein Modifications: Pegylation

    Autoimmune Diseases: Introduction

    The Breakdown of Tolerance
    The Breakdown of Tolerance: Molecular Mimicry
    Mechanisms: Loss ...

    Disease Overview

    Definition of Multiple Sclerosis
    Prognosis
    Clinical Presentation
    Patient Descriptions...

    Mechanisms of Autoimmune Disease: The Breakdown of Tolerance

    Mechanisms of Autoimmune Disease: The Breakdown of Tolerance
    The Breakdown of Tolerance: Molecu...

    Autoimmune Disease Processes

    The Etiology of Autoimmune Disease
    The Etiology of Autoimmune Disease: Genetic Factors (Risk)

    Autoimmune Diseases: Introduction

    General Mechanism Underlying Autoimmune Disease
    The Breakdown of Tolerance
    The Breakdown o...

    Current Therapies

    Goals of Disease Modifying Therapy (DMT)
    Symptomatic Therapies - Symptom Reduction
    Hormona...

    Autoimmune Disorders

    Mechanisms: The Breakdown of Tolerance Molecular Mimicry
    Mechanisms: Loss of T Cell Anergy

    Introduction to Immunopathology

    Organ Transplant Rejection: Class I MHC and Class II MHC Proteins
    Organ Transplant Rejection: H...

    Mechanisms of Autoimmune Disease: The Breakdown of Tolerance

    Mechanisms of Autoimmune Disease: The Breakdown of Tolerance
    The Breakdown of Tolerance: Molecu...

    Autoimmune Disease Processes

    The Etiology of Autoimmune Disease
    The Etiology of Autoimmune Disease: Genetic Factors (Risk)

    HCV Infection

    Natural History of HCV Infection

    Natural History of Type 1 Diabetes

    Natural History of Type 1 Diabetes

    Summary: Diabetes: Type 1 Pathophysiology

    Pathophysiology of Type 1 Diabetes

    Medical Device Regulation

    Regulatory Classifications: Investigational Device Exemption (IDE)

    Biosimilars

    Example of a Biosimilar Not Approved by the EMA

    Basaglar T1DM: Summary

    Pathophysiology of Type 1 Diabetes

    Liver Diseases Overview

    Primary Sclerosing Cholangitis (PSC)

    Biological Products

    Biologics and Protein Therapeutics

    Regulation of Biosimilars

    Quality and Ingredient Requirements

    Country-Specific Definitions and Regulatory Guidelines

    European Medicines Agency (EMA)

    Introduction to Immunopathology

    Organ Transplant Rejection: Class I MHC and Class II MHC Proteins
    Organ Transplant Rejection: H...

    Regulation of Biosimilars

    Manufacturing Requirements

    Biopharmaceuticals/Biologics

    Biologics: Specific Subclass of Drug

    HCV Infection

    Risk Factors Associated With Transmission of HCV
    Impact of the Epidemic
    HCV Infection

    Gaucher Disease: Overview

    Clinical Manifestations

    Immunogenicity

    Immunogenicity: Introduction
    Factors Influencing Immunogenicity
    Factors Influencing Immuno...

    Management of C1-INH-HAE

    Overview of Management of C1-INH-HAE

    Advancing Technologies

    Biomarkers: Disease Process-Specific Biomarkers
    Biomarkers: Inflammation Biomarkers
    Biomar...

    Proteins

    Types of Cytokines
    Protein Modifications
    Manufacturing Biologic Proteins
    Agonist

    Hereditary Angioedema: Historical Perspective

    Hereditary Angioedema: Historical Perspective

    Classification Review and Diagnostic Considerations

    Classification Review and Diagnostic Considerations

    Typical Course of Plaque Psoriasis

    Onset, Episodes, Flare-Ups, Triggers
    Complications and Comorbidities of Psoriasis

    Typical Course of Plaque Psoriasis

    Complications and Comorbidities of Psoriasis

    Hereditary Angioedema: Definitions

    Hereditary Angioedema: Definitions

    Currently Approved Therapies: Tysabri

    Tysabri

    Pathophysiology

    Immunopathophysiology: T Cell Initiation of MS

    Country-Specific Definitions and Regulatory Guidelines

    Japanese Ministry of Health, Labour and Welfare (MHLW)

    Pathophysiology

    Immunopathophysiology: Myelin-Reactive T Cells
    Immunopathophysiology: T Cell Initiation of MS -...

    Inhaled Corticosteroids (ICS)

    Important Features of Corticosteroid Therapy in the Treatment of Asthma
    Corticosteroids: Cellul...

    Inhaled Corticosteroids (ICS)

    Important Features of Corticosteroid Therapy in the Treatment of Asthma

    Inhaled Corticosteroids (ICS)

    How Does Asthma Affect Respiration?

    Inhaled Corticosteroids (ICS)

    Asthma: Inflammation and Bronchospasm

    Inhaled Corticosteroids (ICS)

    Important Features of Corticosteroid Therapy in the Treatment of Asthma

    Inhaled Corticosteroids (ICS)

    Important Features of Corticosteroid Therapy in the Treatment of Asthma

    Inhaled Corticosteroids (ICS)

    Important Features of Corticosteroid Therapy in the Treatment of Asthma

    Inhaled Corticosteroids (ICS)

    Important Features of Corticosteroid Therapy in the Treatment of Asthma

    Inhaled Corticosteroids (ICS)

    Corticosteroids: Cellular Mechanisms of Action

    Inhaled Corticosteroids (ICS)

    Corticosteroids: Mechanisms of Action

    Leukotriene Modifiers

    Leukotriene Modifiers
    Leukotriene Chemical Structure
    Leukotriene Production
    Leukotrie...

    Long-Acting Beta 2 Adrenergic Agonists

    Normal Anatomy and Physiology
    Pathophysiology of Asthma
    Beta 2 Adrenergic Receptor Mechani...

    Inhaled Corticosteroids (ICS)

    Corticosteroids

    Inhaled Corticosteroids (ICS)

    Normal Respiration

    Inhaled Corticosteroids (ICS)

    How Does Asthma Affect Respiration?
    Asthma: Inflammation and Bronchospasm

    Inhaled Corticosteroids (ICS)

    Corticosteroid Mechanism of Action

    Leukotriene Modifiers

    Leukotriene Modifiers

    Leukotriene Modifiers

    Leukotriene Chemical Structure

    Leukotriene Modifiers

    Leukotriene Production

    Leukotriene Modifiers

    Leukotriene Receptors

    Leukotriene Modifiers

    Leukotriene Receptors

    Leukotriene Modifiers

    Inflammatory Events Initiated by Leukotriene Receptors

    Leukotriene Modifiers

    Leukotriene Modifiers

    Leukotriene Modifiers

    Leukotriene Receptors

    Long-Acting Beta 2 Adrenergic Agonists

    Normal Anatomy and Physiology

    Long-Acting Beta 2 Adrenergic Agonists

    Normal Anatomy and Physiology

    Long-Acting Beta 2 Adrenergic Agonists

    Normal Anatomy and Physiology

    Long-Acting Beta 2 Adrenergic Agonists

    Pathophysiology of Asthma

    Long-Acting Beta 2 Adrenergic Agonists

    Pathophysiology of Asthma

    Long-Acting Beta 2 Adrenergic Agonists

    Pathophysiology of Asthma

    Long-Acting Beta 2 Adrenergic Agonists

    Pathophysiology of Asthma

    Long-Acting Beta 2 Adrenergic Agonists

    Beta 2 Adrenergic Receptor Mechanism of Action

    Long-Acting Beta 2 Adrenergic Agonists

    Beta 2 Adrenergic Receptor Mechanism of Action

    Long-Acting Beta 2 Adrenergic Agonists

    Beta 2 Adrenergic Receptor Mechanism of Action

    Long-Acting Beta 2 Adrenergic Agonists

    Beta 2 Adrenergic Receptor Mechanism of Action

    Long-Acting Beta 2 Adrenergic Agonists

    Beta 2 Adrenergic Receptor Mechanism of Action

    Long-Acting Beta 2 Adrenergic Agonists

    Beta 2 Adrenergic Receptor Mechanism of Action

    Steroids

    SLE Treatments: Glucocorticoids

    Steroids

    Treatments: Steroids

    Introduction: Psoriasis Treatment

    Introduction: Psoriasis Treatment

    Steroids

    Glucocorticoids: Mode of Action
    The Anti-Inflammatory Effects of Corticosteroids
    Glucocort...

    Steroids

    Glucocorticoids: Mode of Action

    Steroids

    The Anti-Inflammatory Effects of Corticosteroids

    Steroids

    Glucocorticoids: Side Effects

    Forms of Lupus

    Drug-induced Lupus

    Forms of Lupus

    Cutaneous Lupus Erythematosus (CLE)

    Lupus Introduction

    Lupus Systemic Lupus Erythematosus (SLE)

    Lupus Introduction

    Historical Context

    Lupus Introduction

    Lupus Systemic Lupus Erythematosus (SLE)
    Historical Context
    Symptoms of Lupus

    Lupus Introduction

    Symptoms of Lupus

    Forms of Lupus

    Forms of Lupus

    Forms of Lupus

    Cutaneous Lupus Erythematosus (CLE)
    Forms of Lupus
    Systemic Lupus Erythematosus

    Forms of Lupus

    Systemic Lupus Erythematosus

    Lupus Pathogenesis

    Autoimmune Mechanisms

    Forms of Lupus

    Neonatal Lupus

    Lupus Pathogenesis

    Dysfunctional Response of the Immune System

    Lupus Pathogenesis

    Dysfunctional Response of the Immune System: Role of BAFF and Cytokines

    Lupus Pathogenesis

    Dysfunctional Response of the Immune System

    Lupus Pathogenesis

    Nephritis

    Summary: Pathophysiology of Lupus

    Summary: Pathophysiology of Lupus

    Lupus Pathogenesis

    Nephritis
    Vasculitis

    Lupus Pathogenesis

    Vasculitis

    Diagnosis of SLE

    Hallmark Autoantibodies: Antiphospholipid Antibodies
    Hallmark Autoantibodies: Rheumatoid Factor...

    Diagnosis of SLE

    Hematological Abnormalities
    Hallmark Antibodies

    Typical Clinical Course

    Course of Disease

    Epidemiology

    Epidemiology of Systemic Lupus Erythematosus (SLE): Mortality and Survival
    Epidemiology of Syst...

    Epidemiology

    Epidemiology of Systemic Lupus Erythematosus (SLE): Mortality and Survival

    Epidemiology

    Epidemiology of Systemic Lupus Erythematosus (SLE): Gender and Age of Onset

    Epidemiology

    Epidemiology of Systemic Lupus Erythematosus (SLE): Gender and Age of Onset

    Epidemiology

    Epidemiology of Systemic Lupus Erythematosus (SLE): Gender

    Epidemiology

    Epidemiology of Systemic Lupus Erythematosus (SLE): Geographical and Racial Distribution

    Epidemiology

    Epidemiology of Systemic Lupus Erythematosus (SLE): Geographical and Racial Distribution
    Epidem...

    Epidemiology

    Epidemiology of Systemic Lupus Erythematosus (SLE): Prevalence and Incidence

    Introduction: Clinical Presentation of Lupus

    Introduction: Clinical Presentation of Lupus

    Epidemiology

    Epidemiology of Systemic Lupus Erythematosus (SLE): Cutaneous Lupus Erythematosus (CLE)

    Typical Clinical Course

    Clinical Features/Presentation

    Epidemiology

    Epidemiology of Systemic Lupus Erythematosus (SLE): Lupus Nephritis (LN)

    Typical Clinical Course

    Patient Scenario: SLE

    Diagnosis of SLE

    Hematological Abnormalities

    Diagnosis of SLE

    Hallmark Antibodies

    Diagnosis of SLE

    Hallmark Autoantibodies: Antiphospholipid Antibodies

    Typical Clinical Course

    Symptoms of SLE

    Typical Clinical Course

    Organ Systems Involved

    Diagnosis of SLE

    Hallmark Autoantibodies: Rheumatoid Factor (RF)

    Diagnosis of SLE

    1997 ACR Diagnostic Criteria: Limitations- Clinical Practice

    Diagnosis of SLE

    Characteristics of Patients with Mild SLE

    Diagnosis of SLE

    Standard Measures of Disease Activity Used in Clinical Trials: SLAM

    Diagnosis of SLE

    Standard Measures of Disease Activity Used in Clinical Trials: ECLAM

    Diagnosis of SLE

    Standard Measures of Disease Activity Used in Clinical Trials

    Diagnosis of SLE

    Standard Measures of Disease Activity Used in Clinical Trials: SLAM
    Standard Measures of Diseas...

    Diagnosis of SLE

    Standard Measures of Disease Activity Used in Clinical Trials: SLEDAI

    Diagnosis of SLE

    Standard Measures of Disease Activity Used in Clinical Trials: SELENA-SLEDAI

    Diagnosis of SLE

    Standard Measures of Disease Activity Used in Clinical Trials: SLEDAI-2K
    Standard Measures of D...

    Diagnosis of SLE

    Standard Measures of Disease Activity Used in Clinical Trials: SLEDAI-2K

    Diagnosis of SLE

    Differential Diagnosis
    Lifelong Monitoring of SLE Patients

    Diagnosis of SLE

    Standard Measures of Disease Activity Used in Clinical Trials: SLICC/ACR Damage Index for SLE

    Diagnosis of SLE

    Standard Measures of Disease Activity Used in Clinical Trials: SLE Responder Index (SRI-4)

    Diagnosis of SLE

    Differential Diagnosis

    Diagnosis of SLE

    Lifelong Monitoring of SLE Patients

    Complications/Comorbidities of SLE

    Lupus Nephritis: 1974 WHO Classification of Lupus Nephritis (LN)

    Complications/Comorbidities of SLE

    Lupus Nephritis and End-Stage Renal Failure

    Complications/Comorbidities of SLE

    Lupus Nephritis: 1974 WHO Classification of Lupus Nephritis (LN)
    Lupus Nephritis and End-Stage ...

    Complications/Comorbidities of SLE

    Complications/Comorbidities of SLE

    Complications/Comorbidities of SLE

    Lupus Nephritis: End-Stage Renal Failure

    Complications/Comorbidities of SLE

    Cardiovascular Disease (CVD)

    Overlapping Diseases

    SLE and Secondary Sjogren's Syndrome
    SLE and Scleroderma
    SLE and Overlapping Diseases ...

    Complications/Comorbidities of SLE

    Lupus Nephritis: 2003 ISN-RPS Classification of Lupus Nephritis (LN)

    Complications/Comorbidities of SLE

    Osteoporosis
    Osteonecrosis (ON)

    Complications/Comorbidities of SLE

    Osteoporosis

    Complications/Comorbidities of SLE

    Shrinking Lung Syndrome

    Complications/Comorbidities of SLE

    Quality of Life in SLE

    Overlapping Diseases

    SLE and Secondary Sjogren's Syndrome

    Overlapping Diseases

    SLE and Scleroderma

    Complications/Comorbidities of SLE

    Neuropsychiatric and Neurocognitive Dysfunction

    Complications/Comorbidities of SLE

    Quality of Life in SLE

    Complications/Comorbidities of SLE

    Quality of Life in SLE

    SLE Treatments: Immunosuppressants

    Mycophenolate mofetil: Side Effects

    SLE Treatments: Immunosuppressants

    Mycophenolate mofetil: Efficacy in Lupus Nephritis

    SLE Treatments: Immunosuppressants

    Immunosuppressants: Azathioprine (AZA)
    Azathioprine (AZA): Side Effects

    SLE Treatments: Immunosuppressants

    Immunosuppressants: Azathioprine (AZA)

    SLE Treatments: Immunosuppressants

    Azathioprine (AZA): Side Effects

    SLE Treatments: Immunosuppressants

    Mycophenolate mofetil: Side Effects
    Mycophenolate mofetil: Efficacy in Lupus Nephritis
    Imm...

    SLE Treatments: Immunosuppressants

    Immunosuppressants: Mycophenolate mofetil

    SLE Treatments: Immunosuppressants

    Cyclophosphamide (CTX) Limited by Significant Toxicity

    SLE Treatments: Immunosuppressants

    Cyclophosphamide (CTX) Limited by Significant Toxicity
    Immunosuppressants: Cyclophosphamide (CT...

    SLE Treatments: Immunosuppressants

    Immunosuppressants: Cyclophosphamide (CTX)

    SLE Treatments: Antimalarials

    Antimalarials: Efficacy

    SLE Treatments: Antimalarials

    Antimalarials: Side Effects

    SLE Treatments: Antimalarials

    Antimalarials: Indicated for Use in SLE

    SLE Treatments: Antimalarials

    Antimalarials: Mode of Action

    Steroids

    Glucocorticoids: Efficacy

    SLE Treatments: NSAIDs

    NSAIDs in SLE

    SLE Treatments: NSAIDs

    Main Types of NSAIDs

    SLE Treatments: NSAIDs

    Mode of Action

    SLE Treatments: NSAIDs

    Indicated for Use in SLE

    Therapies: Approved and Off-Label

    Therapies: Approved
    Therapies: Off-Label

    Therapeutic Approach: Guidelines

    Management of Lupus Nephritis (LN)

    Therapies: Approved and Off-Label

    Therapies: Approved

    Therapies: Approved and Off-Label

    Therapies: Off-Label

    Therapeutic Approach: Guidelines

    Management of Antiphospholipid Syndrome (APS) in SLE

    Therapeutic Approach: Guidelines

    Management of Lupus Nephritis (LN)
    Management of Antiphospholipid Syndrome (APS) in SLE
    Th...

    Therapeutic Approach: Guidelines

    Therapeutic Approach: Guidelines

    Therapeutic Approach: Guidelines

    Management of SLE: Treatment

    SLE Treatments: NSAIDs

    Main Types of NSAIDs
    Mode of Action
    Indicated for Use in SLE

    Therapeutic Approach: Guidelines

    Management of SLE: Adjunct Therapy

    Therapeutic Approach: Guidelines

    Management of Neuropsychiatric Systemic Lupus Erythematosus (NPSLE)

    Therapeutic Approach: Guidelines

    Management of Pregnancy in SLE

    Introduction: Lupus Treatments

    Treatment of SLE

    Goals of Therapy

    Goals of SLE Therapy

    Lupus Risk Factors

    Genetics

    Lupus Pathogenesis

    Autoimmune Mechanisms
    Dysfunctional Response of the Immune System

    Lupus Risk Factors

    Genetics
    Combination of Genetics and Environment

    Lupus Risk Factors

    Combination of Genetics and Environment

    Lupus Risk Factors

    Environment

    Lupus Risk Factors

    Triggers

    Lupus Pathogenesis

    Dysfunctional Response of the Immune System: Role of BAFF and Cytokines

    Lupus Pathogenesis

    Dysfunctional Response of the Immune System: B Cells and T Cells
    Autoantibodies in SLE

    Lupus Pathogenesis

    Dysfunctional Response of the Immune System: B Cells and T Cells

    Lupus Pathogenesis

    Autoantibodies in SLE

    Lupus Pathogenesis

    Pathogenic Autoantibodies in SLE

    Diagnosis of SLE

    Hallmark Autoantibodies

    Diagnosis of SLE

    Hallmark Autoantibodies: Antibodies Directed Against Ribonucleoproteins

    Diagnosis of SLE

    Hallmark Autoantibodies: Complement

    Diagnosis of SLE

    1997 ACR Diagnostic Criteria: Limitations- Clinical Practice
    Characteristics of Patients with M...

    Diagnosis of SLE

    1997 ACR Diagnostic Criteria: Limitations- Clinical Studies

    Diagnosis of SLE

    Standard Measures of Disease Activity Used in Clinical Trials: BILAG, SLAM, ECLAM

    Complications/Comorbidities of SLE

    Osteonecrosis (ON)

    Overlapping Diseases

    SLE and Overlapping Diseases (Overlap Syndrome)

    Overlapping Diseases

    SLE and Rheumatoid Arthritis (RA)

    Overlapping Diseases

    SLE and Myositis

    Overlapping Diseases

    SLE and Antiphospholipid Syndrome (APS)

    Overlapping Diseases

    Mixed Connective Tissue Disease

    SLE Treatments: Immunosuppressants

    Immunosuppressants: Methotrexate (MTX)
    Methotrexate (MTX): Mode of Action
    Methotrexate (MT...

    SLE Treatments: Immunosuppressants

    Immunosuppressants: Methotrexate (MTX)

    SLE Treatments: Immunosuppressants

    Methotrexate (MTX): Mode of Action

    SLE Treatments: Immunosuppressants

    Methotrexate (MTX): Side Effects

    SLE Treatments: Immunosuppressants

    Immunosuppressants: Cyclosporine A (CsA)
    Cyclosporine A (CsA): Mode of Action
    Cyclosporine...

    SLE Treatments: Immunosuppressants

    Immunosuppressants: Cyclosporine A (CsA)

    SLE Treatments: Immunosuppressants

    Cyclosporine A (CsA): Mode of Action

    SLE Treatments: Immunosuppressants

    Cyclosporine A (CsA): Efficacy in Proliferative LN

    SLE Treatments: Immunosuppressants

    Cyclosporine A (CsA): Side Effects

    SLE Treatments: Immunosuppressants

    Immunosuppressants: IVIg
    IVIg: Case Reports
    IVIg: Side Effects

    SLE Treatments: Immunosuppressants

    Immunosuppressants: IVIg

    SLE Treatments: Immunosuppressants

    IVIg: Case Reports

    SLE Treatments: Immunosuppressants

    IVIg: Side Effects

    SLE Treatments: Immunosuppressants

    Immunosuppressants: Leflunomide

    SLE Treatments: Immunosuppressants

    Immunosuppressants: Tacrolimus

    SLE Treatments: Immunosuppressants

    Immunosuppressants: Sirolimus

    SLE Treatments: MAbs/Biologics

    Monoclonal Antibodies (MAbs) Biologics: Introduction

    SLE Treatments: MAbs/Biologics

    Belimumab
    Belimumab: Indication
    Belimumab: Mechanism of Action
    Belimumab: Dosage and ...

    SLE Treatments: MAbs/Biologics

    Belimumab

    SLE Treatments: MAbs/Biologics

    Belimumab: Indication

    SLE Treatments: MAbs/Biologics

    Belimumab: Mechanism of Action

    SLE Treatments: MAbs/Biologics

    Belimumab: Dosage and Administration

    SLE Treatments: MAbs/Biologics

    Belimumab: Clinical Trials
    Belimumab: Clinical Trial 1(Phase II)
    Belimumab Clinical Trials...

    SLE Treatments: MAbs/Biologics

    Belimumab: Clinical Trials

    SLE Treatments: MAbs/Biologics

    Belimumab: Clinical Trial 1(Phase II)

    SLE Treatments: MAbs/Biologics

    Belimumab Clinical Trials 2 and 3: Trial Design
    Belimumab Clinical Trials 2 and 3: Study Endpo...

    SLE Treatments: MAbs/Biologics

    Belimumab Clinical Trials 2 and 3: Trial Design

    SLE Treatments: MAbs/Biologics

    Belimumab Clinical Trials 2 and 3: Trial Design

    SLE Treatments: MAbs/Biologics

    Belimumab Clinical Trials 2 and 3: Study Endpoints

    SLE Treatments: MAbs/Biologics

    Belimumab Clinical Trials 2 and 3: Efficacy

    SLE Treatments: MAbs/Biologics

    Belimumab Clinical Trials 2 and 3: Efficacy
    Belimumab Clinical Trials 2 and 3: Warnings and Pre...

    SLE Treatments: MAbs/Biologics

    Belimumab Clinical Trials 2 and 3: Efficacy

    SLE Treatments: MAbs/Biologics

    Belimumab Clinical Trials 2 and 3: Warnings and Precautions

    SLE Treatments: MAbs/Biologics

    MAbs/Biologics: Rituximab
    Rituximab: Mode of Action
    Rituximab: Efficacy
    Rituximab: Si...

    SLE Treatments: MAbs/Biologics

    MAbs/Biologics: Rituximab

    SLE Treatments: MAbs/Biologics

    Rituximab: Mode of Action

    SLE Treatments: MAbs/Biologics

    Rituximab: Efficacy

    SLE Treatments: MAbs/Biologics

    Rituximab: Side Effects

    SLE Treatments: MAbs/Biologics

    MAbs/Biologics: Abatacept
    Abatacept: Efficacy
    Abatacept: Side Effects

    SLE Treatments: MAbs/Biologics

    MAbs/Biologics: Abatacept

    SLE Treatments: MAbs/Biologics

    Abatacept: Efficacy

    SLE Treatments: MAbs/Biologics

    Abatacept: Side Effects

    SLE Treatments: MAbs/Biologics

    MAbs/Biologics: Infliximab
    Infliximab: Mode of Action
    Infliximab: Efficacy and Safety

    SLE Treatments: MAbs/Biologics

    MAbs/Biologics: Infliximab

    SLE Treatments: MAbs/Biologics

    Infliximab: Mode of Action

    SLE Treatments: MAbs/Biologics

    Infliximab: Efficacy and Safety

    SLE Treatments: MAbs/Biologics

    MAbs/Biologics: Eculizumab
    MAbs/Biologics: Ustekinumab

    SLE Treatments: MAbs/Biologics

    MAbs/Biologics: Eculizumab

    SLE Treatments: MAbs/Biologics

    MAbs/Biologics: Ustekinumab

    SLE Treatments: Other

    Danazol

    SLE Treatments: Other

    Plasmapheresis

    SLE Treatments: Other

    Plasmapheresis

    SLE Treatments: Other

    Plasmapheresis

    SLE Treatments: Other

    Other: Dialysis
    Other: Renal Transplantation
    Combination Therapies

    SLE Treatments: Other

    Other: Dialysis

    SLE Treatments: Other

    Other: Renal Transplantation

    SLE Treatments: Other

    Combination Therapies

    Emerging Therapies for SLE

    Emerging Therapies for SLE

    Summary: Psoriasis

    Cytokines Trigger

    Impact of Psoriasis

    Psychosocial Impact: Impaired Relationships
    Effect on Social, Personal and Work Life

    Mechanisms of Action

    Corticosteroid Mechanism of Action
    Beta 2 Adrenergic Agonist
    Leukotriene Modifiers

    Mechanisms of Action

    Corticosteroid Mechanism of Action

    Mechanisms of Action

    Beta 2 Adrenergic Agonist

    Mechanisms of Action

    Leukotriene Modifiers

    Variables

    Demographic and Comorbid Variables

    IgE and Omalizumab

    IgE and Omalizumab

    FEV1: Forced Expiratory Volume

    FEV1: Forced Expiratory Volume

    PEF: Peak Expiratory Flow

    PEF: Peak Expiratory Flow

    Introduction: Psoriasis

    Definition of Psoriasis
    Psoriasis Skin Dysregulation

    Introduction: Psoriasis

    Definition of Psoriasis

    Introduction: Psoriasis

    Psoriasis Skin Dysregulation

    Potential Factors in the Development of Psoriasis

    Potential Factors in Etiology of Psoriasis
    Genetic Factors
    Infectious Factors
    Drug an...

    Potential Factors in the Development of Psoriasis

    Potential Factors in Etiology of Psoriasis

    Potential Factors in the Development of Psoriasis

    Genetic Factors

    Potential Factors in the Development of Psoriasis

    Infectious Factors

    Potential Factors in the Development of Psoriasis

    Drug and Environmental Factors

    Potential Factors in the Development of Psoriasis

    Geographical Location

    Potential Factors in the Development of Psoriasis

    Stress

    Potential Factors in the Development of Psoriasis

    Sites of Trauma: Koebner Phenomenon

    Physiology of Immune System Dysregulation

    Overview of Immune Dysregulation

    Physiology of Immune System Dysregulation

    Dermal Dendritic Cell Activation

    Physiology of Immune System Dysregulation

    T Cell Activation

    Physiology of Immune System Dysregulation

    Cytokines
    T Cell Cytokines

    Physiology of Immune System Dysregulation

    Cytokines

    Physiology of Immune System Dysregulation

    T Cell Cytokines

    Physiology of Immune System Dysregulation

    T Regulatory Cells (Tregs)
    Cytokines Trigger

    Physiology of Immune System Dysregulation

    Keratinocytes and Cytokines
    Keratinocyte Remodeling

    Physiology of Immune System Dysregulation

    T Regulatory Cells (Tregs)

    Physiology of Immune System Dysregulation

    Cytokines Trigger

    Physiology of Immune System Dysregulation

    Cytokines Trigger

    Physiology of Immune System Dysregulation

    Cytokines Trigger

    Physiology of Immune System Dysregulation

    Keratinocytes and Cytokines

    Physiology of Immune System Dysregulation

    Keratinocyte Remodeling

    Physiology of Immune System Dysregulation

    Pathophysiology of Psoriasis

    Types of Psoriasis

    Types of Psoriasis

    Psoriatic Arthritis

    Psoriatic Arthritis (PsA)

    Psoriatic Arthritis

    Pathophysiology of Psoriatic Arthritis (PsA)
    Psoriatic Arthritis (PsA) Pathophysiology

    Psoriatic Arthritis

    Pathophysiology of Psoriatic Arthritis (PsA)

    Psoriatic Arthritis

    Psoriatic Arthritis (PsA) Pathophysiology

    Psoriatic Arthritis

    Psoriatic Arthritis (PsA) Pathophysiology

    Summary: Psoriasis

    Psoriasis Definition
    Potential Factors in Etiology of Psoriasis
    Pathophysiology of Psorias...

    Summary: Psoriasis

    Psoriasis Definition

    Summary: Psoriasis

    Potential Factors in Etiology of Psoriasis

    Summary: Psoriasis

    Pathophysiology of Psoriasis

    Summary: Psoriasis

    Cytokines Trigger
    Types of Psoriasis

    Summary: Psoriasis

    Types of Psoriasis

    Introduction: Psoriasis

    Introduction: Psoriasis

    Epidemiology

    Prevalence: Definition

    Clinical Features/Presentation

    Manifestations: Overview

    Epidemiology

    Prevalence

    Epidemiology

    Incidence
    Age of Onset
    Gender and Age

    Epidemiology

    Incidence

    Epidemiology

    Age of Onset

    Epidemiology

    Gender and Age

    Epidemiology

    Mortality and Survival

    Clinical Features/Presentation

    Signs and Symptoms

    Clinical Features/Presentation

    Manifestations: Overview
    Areas of Skin Involvement and Extent of Involvement
    Types of Psor...

    Clinical Features/Presentation

    Areas of Skin Involvement and Extent of Involvement

    Clinical Features/Presentation

    Types of Psoriasis

    Clinical Features/Presentation

    Extracutaneous Manifestations

    Typical Course of Plaque Psoriasis

    Onset, Episodes, Flare-Ups, Triggers

    Impact of Psoriasis

    Overview: Impact of Psoriasis

    Impact of Psoriasis

    Psychological Impact: Depression, Anxiety, and Stress

    Impact of Psoriasis

    Psychosocial Impact: Impaired Relationships

    Impact of Psoriasis

    Effect on Social, Personal and Work Life

    Impact of Psoriasis

    Physical Impact

    Impact of Psoriasis

    Physical Impact

    Impact of Psoriasis

    Physical Impact

    Psoriasis Therapies

    OTC Topical Coal Tar

    Impact of Psoriasis

    Economic Impact
    Occupational Impact

    Impact of Psoriasis

    Economic Impact

    Impact of Psoriasis

    Occupational Impact

    Impact of Psoriasis

    Patient Scenario 1

    Impact of Psoriasis

    Patient Scenario 2

    Impact of Psoriasis

    Patient Scenario 3

    Diagnostic Methods of Criteria for Psoriasis

    Physicians Who Diagnose Psoriasis
    Diagnostic Methods
    Typical Presentation at Diagnosis

    Diagnostic Methods of Criteria for Psoriasis

    Physicians Who Diagnose Psoriasis

    Diagnostic Methods of Criteria for Psoriasis

    Diagnostic Methods

    Diagnostic Methods of Criteria for Psoriasis

    Typical Presentation at Diagnosis

    Diagnostic Methods of Criteria for Psoriasis

    Patient History
    Diagnostic Criteria

    Diagnostic Methods of Criteria for Psoriasis

    Patient History

    Diagnostic Methods of Criteria for Psoriasis

    Diagnostic Criteria

    Diagnostic Methods of Criteria for Psoriasis

    Differential Diagnosis

    Diagnostic Methods of Criteria for Psoriasis

    Severity of Psoriasis

    Diagnostic Methods of Criteria for Psoriasis

    No Widely Accepted Definition

    Clinical Assessment Tools in Psoriasis

    Clinical Assessment Tools

    Summary: Psoriasis

    Prevalence
    Incidence
    Cutaneous and Extracutaneous Manifestations
    Onset, Episodes, Fla...

    Summary: Psoriasis

    Prevalence

    Summary: Psoriasis

    Incidence

    Summary: Psoriasis

    Cutaneous and Extracutaneous Manifestations

    Summary: Psoriasis

    Onset, Episodes, Flare-Ups, Triggers

    Summary: Psoriasis

    Complications and Comorbidities of Psoriasis

    Summary: Psoriasis

    Impact of Psoriasis

    Summary: Psoriasis

    Diagnostic Methods
    Typical Presentation at Diagnosis
    Severity of Psoriasis
    Clinical A...

    Summary: Psoriasis

    Diagnostic Methods

    Summary: Psoriasis

    Typical Presentation at Diagnosis

    Summary: Psoriasis

    Severity of Psoriasis

    Summary: Psoriasis

    Clinical Assessment Tools

    Goals of Treatment

    Primary Treatment Goals
    Patient Compliance and Adherence
    Reasonable Expectations for Patie...

    Goals of Treatment

    Primary Treatment Goals

    Goals of Treatment

    Patient Compliance and Adherence

    Goals of Treatment

    Reasonable Expectations for Patients

    Treatment Teams

    Treatment Team
    Emotional Support

    Treatment Teams

    Treatment Team

    Treatment Teams

    Emotional Support

    Choice of Therapy

    Benefit/Risk
    Psoriasis Severity Affects Treatment Choice

    Choice of Therapy

    Benefit/Risk

    Choice of Therapy

    Psoriasis Severity Affects Treatment Choice

    Treatment Guidelines

    Overview of Treatment Guidelines
    Guidelines for Treatment of Psoriasis Patients Limited Disease

    Treatment Guidelines

    Overview of Treatment Guidelines

    Treatment Guidelines

    Guidelines for Treatment of Psoriasis Patients Limited Disease

    Treatment Guidelines

    Management of Subtypes of Psoriasis Patients with Limited Disease
    FDA Pregnancy Drug Risk Categ...

    Treatment Guidelines

    Management of Subtypes of Psoriasis Patients with Limited Disease

    Treatment Guidelines

    Management of Subtypes of Psoriasis Patients with Limited Disease

    Treatment Guidelines

    Management of Subtypes of Psoriasis Patients with Limited Disease

    Treatment Guidelines

    FDA Pregnancy Drug Risk Categories

    Treatment Guidelines

    Management of Subtypes of Psoriasis Patients with Limited Disease

    Treatment Guidelines

    Management of Subtypes of Psoriasis Candidates for UV-Based, Oral PUVA or Systemic Therapy
    Mana...

    Treatment Guidelines

    Management of Subtypes of Psoriasis Candidates for UV-Based, Oral PUVA or Systemic Therapy

    Treatment Guidelines

    Management of Subtypes of Psoriasis Erythrodermic Psoriasis

    Treatment Guidelines

    Management of Subtypes of Psoriasis Adults with Palmoplantar Psoriasis

    Treatment Guidelines

    Management of Subtypes of Psoriasis Extensive Chronic Plaque Psoriasis

    Psoriasis Therapies

    Psoriasis Therapies

    Psoriasis Therapies

    Topical Overview

    Psoriasis Therapies

    Topical Glucocorticoids
    Topical Glucocorticoids: Mechanism of Action

    Psoriasis Therapies

    Topical Glucocorticoids

    Psoriasis Therapies

    Topical Glucocorticoids: Mechanism of Action

    Psoriasis Therapies

    Topical Glucocorticoids: Therapeutic Regimens

    Psoriasis Therapies

    Therapeutic Efficacy: Plaque Psoriasis

    Psoriasis Therapies

    Therapeutic Efficacy: Scalp Psoriasis

    Psoriasis Therapies

    Topical Glucocorticoids: Adverse Effects

    Psoriasis Therapies

    Topical Vitamin D Analogs
    Topical Vitamin D Analogs: Mechanism of Action
    Topical Vitamin D...

    Psoriasis Therapies

    Topical Vitamin D Analogs

    Psoriasis Therapies

    Topical Vitamin D Analogs: Mechanism of Action

    Psoriasis Therapies

    Topical Vitamin D Analogs: Therapeutic Efficacy

    Psoriasis Therapies

    Topical Vitamin D Analogs: Adverse Effects

    Psoriasis Therapies

    Systemic Therapies: Methotrexate

    Psoriasis Therapies

    Topical Retinoids: Tazarotene
    Therapeutic Efficacy: Tarazotene Use
    Therapeutic Efficacy: C...

    Psoriasis Therapies

    Topical Retinoids: Tazarotene

    Psoriasis Therapies

    Therapeutic Efficacy: Tarazotene Use

    Psoriasis Therapies

    Therapeutic Efficacy: Combination Therapy

    Psoriasis Therapies

    Topical Retinoids: Adverse Effects
    Topical Anthralin
    Topical Anthralin: Therapeutic Use

    Psoriasis Therapies

    Topical Retinoids: Adverse Effects

    Psoriasis Therapies

    Topical Anthralin

    Psoriasis Therapies

    Topical Anthralin: Therapeutic Use

    Psoriasis Therapies

    OTC Topical Coal Tar
    OTC Topical Salicylic Acid
    OTC Moisturizers and Emollients

    Psoriasis Therapies

    OTC Topical Salicylic Acid

    Psoriasis Therapies

    OTC Moisturizers and Emollients

    Psoriasis Therapies

    Phototherapy Overview
    Phototherapy Ultraviolet B (UVB) (290 to 320 nm)

    Psoriasis Therapies

    Phototherapy Overview

    Psoriasis Therapies

    Phototherapy Ultraviolet B (UVB) (290 to 320 nm)

    Psoriasis Therapies

    Photochemotherapy
    Excimer Laser Therapy (High Energy 308 nm)

    Psoriasis Therapies

    Photochemotherapy

    Psoriasis Therapies

    Excimer Laser Therapy (High Energy 308 nm)

    Psoriasis Therapies

    Systemic Therapies: Methotrexate
    Systemic Therapies Overview
    Methotrexate: Mechanism of Ac...

    Psoriasis Therapies

    Systemic Therapies Overview

    Psoriasis Therapies

    Methotrexate: Mechanism of Action

    Psoriasis Therapies

    Methotrexate: Adverse Effects

    Psoriasis Therapies

    Methotrexate: Clinical Efficacy

    Psoriasis Therapies

    Systemic Therapies: Cyclosporine A (CsA)
    Cyclosporine A (CsA): Mechanism of Action
    Cyclosp...

    Psoriasis Therapies

    Systemic Therapies: Cyclosporine A (CsA)

    Psoriasis Therapies

    Cyclosporine A (CsA): Mechanism of Action

    Psoriasis Therapies

    Cyclosporine A (CsA): Clinical Efficacy

    Psoriasis Therapies

    Cyclosporine A (CsA): Adverse Effects

    Psoriasis Therapies

    Systemic Therapies: Retinoids
    Retinoids: Mechanism of Action
    Retinoids: Clinical Efficacy

    Psoriasis Therapies

    Systemic Therapies: Retinoids

    Psoriasis Therapies

    Retinoids: Mechanism of Action

    Psoriasis Therapies

    Retinoids: Clinical Efficacy

    Psoriasis Therapies

    Retinoids: Adverse Effects

    Psoriasis Therapies

    Systemic Therapies: Off-Label Agents
    Off-Label Agents: Clinical Efficacy and Safety
    Biolog...

    Psoriasis Therapies

    Systemic Therapies: Off-Label Agents

    Psoriasis Therapies

    Off-Label Agents: Clinical Efficacy and Safety

    Psoriasis Therapies

    Biologics: TNF-Targeted Agents

    Psoriatic Arthritis Therapies

    Psoriatic Arthritis Therapies: Overview
    Treatment Recommendations

    Psoriatic Arthritis Therapies

    Psoriatic Arthritis Therapies: Overview

    Psoriatic Arthritis Therapies

    Treatment Recommendations

    Psoriatic Arthritis Therapies

    Symptomatic Treatment
    Symptomatic Treatment: Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

    Psoriatic Arthritis Therapies

    Symptomatic Treatment

    Psoriatic Arthritis Therapies

    Symptomatic Treatment: Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

    Psoriatic Arthritis Therapies

    Disease-Modifying Anti-Rheumatic Drugs (DMARDs)
    Disease-Modifying Anti-Rheumatic Drugs (DMARDs)...

    Psoriatic Arthritis Therapies

    Disease-Modifying Anti-Rheumatic Drugs (DMARDs)

    Psoriatic Arthritis Therapies

    Disease-Modifying Anti-Rheumatic Drugs (DMARDs): Biologics

    Psoriatic Arthritis Therapies

    Other Options

    Summary: Psoriasis Treatments

    Goals of Psoriasis Treatment
    Choice of Therapy
    Treatment Guidelines
    Psoriasis Therapi...

    Summary: Psoriasis Treatments

    Goals of Psoriasis Treatment

    Summary: Psoriasis Treatments

    Choice of Therapy

    Summary: Psoriasis Treatments

    Treatment Guidelines

    Summary: Psoriasis Treatments

    Psoriasis Therapies

    Summary: Psoriasis Treatments

    Psoriatic Arthritis Therapies

    Introduction: Psoriasis Therapies and Treatments

    Introduction: Psoriasis Therapies and Treatments

    Introduction: Biologics for Psoriasis

    Biologics, What Are They?
    Conventional Versus Biologic Therapies
    Biologics: Administration

    Introduction: Biologics for Psoriasis

    Biologics, What Are They?

    Introduction: Biologics for Psoriasis

    Conventional Versus Biologic Therapies

    Introduction: Biologics for Psoriasis

    Biologics: Administration

    Immunosuppression

    Immunosuppression
    Tuberculosis (TB)
    Tuberculosis Testing and Monitoring

    Immunosuppression

    Immunosuppression

    Immunosuppression

    Tuberculosis (TB)
    Tuberculosis Testing and Monitoring

    Immunosuppression

    Tuberculosis (TB)

    Immunosuppression

    Tuberculosis Testing and Monitoring

    Guidelines for Use of Biologics

    Choice of Therapy
    Choice of Therapy: Treatment Choice and Guidelines

    Guidelines for Use of Biologics

    Choice of Therapy

    Guidelines for Use of Biologics

    Choice of Therapy: Treatment Choice and Guidelines

    Biologic Targets

    Pathology of Psoriasis
    T-Cell Cytokines
    Biologic Targets

    Biologic Targets

    Pathology of Psoriasis

    Biologic Targets

    T-Cell Cytokines

    Biologic Targets

    Biologic Targets

    Biologic Targets

    Structural Differences in TNF-Blocking Biologics
    Functional Differences in TNF-Blocking Agents

    Biologic Targets

    Structural Differences in TNF-Blocking Biologics

    Biologic Targets

    Functional Differences in TNF-Blocking Agents

    Biologic Targets

    IL-12/23 Antibody

    Adalimumab

    Overview: Description
    Indication
    Dosage and Administration

    Adalimumab

    Overview: Description

    Adalimumab

    Indication

    Adalimumab

    Dosage and Administration

    Adalimumab

    Pivotal Trials
    Pivotal Trials: Psoriasis Trial I
    Psoriasis Trial I: Endpoints
    Psorias...

    Adalimumab

    Pivotal Trials

    Adalimumab

    Pivotal Trials: Psoriasis Trial I
    Psoriasis Trial I: Endpoints
    Psoriasis Trial I: Efficacy

    Adalimumab

    Pivotal Trials: Psoriasis Trial I

    Adalimumab

    Psoriasis Trial I: Endpoints

    Adalimumab

    Psoriasis Trial I: Efficacy

    Adalimumab

    Pivotal Trials: Psoriasis Trial II
    Psoriasis Trial II: Efficacy
    Adverse Reactions

    Adalimumab

    Pivotal Trials: Psoriasis Trial II

    Adalimumab

    Psoriasis Trial II: Efficacy

    Adalimumab

    Adverse Reactions

    Adalimumab

    Adalimumab Warnings

    Infliximab

    Overview: Description of Infliximab
    Infliximab Indication
    Dosage and Administration

    Infliximab

    Overview: Description of Infliximab

    Infliximab

    Infliximab Indication

    Infliximab

    Dosage and Administration

    Infliximab

    Pivotal Trials: Overview
    Psoriasis Trial I: Study Design
    Psoriasis Trial II: Study Design

    Infliximab

    Pivotal Trials: Overview

    Infliximab

    Psoriasis Trial I: Study Design

    Infliximab

    Psoriasis Trial II: Study Design

    Infliximab

    Psoriasis Trial III: Study Design

    Infliximab

    Pivotal Trials: Endpoints

    Infliximab

    Pivotal Trials: Efficacy of Induction

    Infliximab

    Pivotal Trials: Efficacy of Maintenance
    Infliximab Safety

    Infliximab

    Pivotal Trials: Efficacy of Maintenance

    Infliximab

    Infliximab Safety

    Infliximab

    Safety: Boxed Warning

    Etanercept

    Overview: Description of Etanercept
    Etanercept Indication
    Dosage and Administration

    Etanercept

    Overview: Description of Etanercept

    Etanercept

    Etanercept Indication

    Etanercept

    Dosage and Administration

    Etanercept

    Pivotal Trials: Overview
    Psoriasis Trial I: Study Design
    Psoriasis Trial II: Study Design

    Etanercept

    Pivotal Trials: Overview

    Etanercept

    Psoriasis Trial I: Study Design

    Etanercept

    Psoriasis Trial II: Study Design

    Etanercept

    Psoriasis Trials I and II: Endpoints

    Etanercept

    Pivotal Trials: Efficacy

    Etanercept

    Safety

    Etanercept

    Safety: Boxed Warning

    Ustekinumab

    Overview: Ustekinumab
    Indication
    Dosage and Administration

    Ustekinumab

    Overview: Ustekinumab

    Ustekinumab

    Indication

    Ustekinumab

    Dosage and Administration

    Ustekinumab

    Pivotal Trials: Overview
    Pivotal Trials: Trial Design
    Pivotal Trials: Endpoints
    Pivot...

    Ustekinumab

    Pivotal Trials: Overview

    Ustekinumab

    Pivotal Trials: Trial Design

    Ustekinumab

    Pivotal Trials: Endpoints

    Ustekinumab

    Pivotal Trials: Efficacy
    Efficacy: Effect of Patient Weight
    Efficacy: Trial I through Week...

    Ustekinumab

    Pivotal Trials: Efficacy

    Ustekinumab

    Efficacy: Effect of Patient Weight

    Ustekinumab

    Efficacy: Trial I through Week 52

    Ustekinumab

    Ustekinumab Safety

    Summary: Psoriasis and Biologics

    Psoriasis
    Immunosuppression
    Choice of Therapy
    Biologic Targets
    Combination Thera...

    Summary: Psoriasis and Biologics

    Psoriasis

    Summary: Psoriasis and Biologics

    Immunosuppression

    Summary: Psoriasis and Biologics

    Choice of Therapy

    Summary: Psoriasis and Biologics

    Biologic Targets

    Summary: Psoriasis and Biologics

    Combination Therapy

    Goals of Treatment

    Patient Education and Goals

    Monoclonal Antibodies in Action

    Effector Mechanisms - Overview
    Neutralization of Circulating Factor
    Antibody-Dependent Cel...

    TNF-Targeted Biologics in Current Use - Etanercept

    Mechanism of Action: Etanercept

    Pathophysiology

    Summary of RA Pathology
    Summary of RA Pathology: T Cells
    Summary of RA Pathology: B Cells

    Pathophysiology

    Summary of RA Pathology

    Pathophysiology

    Summary of RA Pathology: T Cells

    Pathophysiology

    Summary of RA Pathology: B Cells
    Summary of RA Pathology: Antigen Presentation
    Summary of ...

    Pathophysiology

    Summary of RA Pathology: B Cells

    Pathophysiology

    Summary of RA Pathology: Antigen Presentation

    Pathophysiology

    Summary of RA Pathology: Direct and Indirect Production of Proinflammatory Cytokines

    Pathophysiology

    Summary of RA Pathology: Production of autoantibodies

    NSAIDs

    Mechanism of Action (MOA): NSAIDs and COX Enzymes

    Glucocorticoids

    Mechanism of Action (MOA): Glucocorticoids

    Nonbiologic DMARDs: Methotrexate

    Mechanism of Action (MOA): Dihydrofolate Reductase (DHFR)

    Nonbiologic DMARDs: Leflunomide

    Mechanism of Action (MOA): Leflunomide

    Monoclonal Antibodies

    Biologic Therapies

    Monoclonal Antibodies

    Monoclonal Antibody Structure

    Monoclonal Antibodies

    Monoclonal Antibody Production
    Monoclonal Antibody Production: Knowledge Check

    Monoclonal Antibodies

    Monoclonal Antibody Production

    Monoclonal Antibodies in Action

    Effector Mechanisms - Overview

    Monoclonal Antibodies in Action

    Neutralization of Circulating Factor

    Monoclonal Antibodies in Action

    Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC)

    Monoclonal Antibodies in Action

    Complement Dependent Cytotoxicity (CDC)

    Monoclonal Antibodies in Action

    Receptor Binding: Cross-linking

    Monoclonal Antibodies in Action

    Receptor Binding: Blockade/activation

    Monoclonal Antibodies in Action

    Conjugate Delivery: Toxin/Radionuclide

    Monoclonal Antibodies in Action

    Conjugate Delivery: Antibody-Directed Enzyme Prodrug Therapy (ADEPT)

    TNF-Targeted Biologics in Current Use - Infliximab

    Mechanism of Action (MOA): Infliximab

    Other Biologics in Current Use - Anakinra

    Mechanism of Action (MOA): Anakinra & IL-1Ra

    Biologics in Current Use - Abatacept

    Mechanism of Action (MOA): Abatacept & CTLA4

    Other Biologics in Current Use - Rituximab

    Mechanism of Action (MOA): Rituximab

    Pannus at the Cellular Level

    Synovial Pannus

    Joints Affected by RA

    Joints Affected by RA

    Joints Affected by RA

    Joints Affected by RA
    Synovitis and the Synovial Pannus
    Synovial Joints
    Exercise: Nor...

    Joints Affected by RA

    Synovitis and the Synovial Pannus

    Pannus at the Cellular Level

    Lymphocytes: T Cells and B Cells

    B Cells in RA

    B Cells in RA

    T Cells in RA

    T Cells in RA
    Helper T Cells: CD4+
    Type I and Type 2 Helper T Cells
    Antigen-Presentin...

    Joints Affected by RA

    Synovial Joints

    Pannus at the Cellular Level

    Synovial Pannus
    Lymphocytes: T Cells and B Cells
    A Joint Affected by RA
    The Synovium

    Pannus at the Cellular Level

    A Joint Affected by RA

    Pannus at the Cellular Level

    The Synovium

    Pannus at the Cellular Level

    Neutrophils

    Pannus at the Cellular Level

    Macrophages

    Pannus at the Cellular Level

    Osteoclasts

    T Cells in RA

    T Cells in RA

    T Cells in RA

    Helper T Cells: CD4+

    T Cells in RA

    Type I and Type 2 Helper T Cells

    T Cells in RA

    Antigen-Presenting Cell and Antigen Fragment on MHC

    B Cells in RA

    B Cells in RA
    Antigen Presentation
    Normal B Cells
    Antigen Presentation by an APC

    B Cells in RA

    Antigen Presentation

    B Cells in RA

    Normal B Cells

    B Cells in RA

    Antigen Presentation by an APC

    B Cells in RA

    The B Cell as an APC

    B Cells in RA

    Autoantibody Production
    Autoantibody Production: How Antibodies Work
    Autoantibody Producti...

    B Cells in RA

    Autoantibody Production

    B Cells in RA

    Autoantibody Production: How Antibodies Work

    B Cells in RA

    Autoantibody Production: Macrophages

    B Cells in RA

    Autoantibody Production: Rheumatoid Factor

    B Cells in RA

    B Cell Receptors

    B Cells in RA

    Pro-Inflammatory Cytokine Production

    Learning Objectives

    Learning Objectives

    Pathophysiology

    The Inflammatory Process in RA

    Introduction: Rheumatoid Arthritis

    Introduction: Rheumatoid Arthritis

    Pathophysiology

    The Inflammatory Process in RA

    The Inflammatory Process in RA

    Proinflammatory Pathways

    The Inflammatory Process in RA

    Response Regulation

    Pathophysiology

    Role of T Cells: Migration and Activation

    Pathophysiology

    Role of T Cells: Expression

    Pathophysiology

    Role of B Cells

    Pathophysiology

    Antigen Presentation

    Pathophysiology

    Cytokine and Autoantibody Production

    Pathophysiology

    B-Cell Regulation: BAFF/TNF-Super-family

    Diagnosis of RA

    2010 Rheumatoid Arthritis Classification - Goal and Eligibility

    Pathophysiology

    Role of B Cells

    Pathophysiology

    Rheumatoid Factor (RF)

    Pathophysiology

    Role of RF-Producing B Cells

    Pathophysiology

    Anti-citrullinated protein antibodies (ACPA)

    Pathophysiology

    Autoantibodies

    Pathophysiology

    Roles of Other Immune System Cells

    Learning Objectives

    Learning Objectives

    Diagnosis of RA

    Clinical Measures - Synovial Fluid Analysis

    Introduction

    What Is Rheumatoid Arthritis? Chronic Inflammation

    Introduction

    What Is Rheumatoid Arthritis? Organ Involvement

    Epidemiology

    Prevalence

    Epidemiology

    Incidence

    Epidemiology

    Mortality and Survival

    Disease Definition and Clinical Course

    Clinical Features and Presentation

    Disease Definition and Clinical Course

    Course of Disease

    Disease Definition and Clinical Course

    Effect of Disease Modifying Therapy

    Disease Definition and Clinical Course

    Work Disability

    Diagnosis of RA

    Overview - Diagnosis of RA

    Diagnosis of RA

    2010 Rheumatoid Arthritis Classification

    Diagnosis of RA

    2010 Rheumatoid Arthritis Classification - Criteria

    Diagnosis of RA

    2010 Rheumatoid Arthritis Classification - Other Clinical Presentations

    Diagnosis of RA

    2010 Rheumatoid Arthritis Classification - Definitions

    Diagnosis of RA

    2010 Rheumatoid Arthritis Classification - Comparison to 1987 Classification

    Diagnosis of RA

    Clinical Measures - Overview

    Diagnosis of RA

    Clinical Measures - Complete Blood Cell (CBC) Count

    Diagnosis of RA

    Clinical Measures - Imaging Studies

    Diagnosis of RA

    Clinical Measures - Other Tests

    Diagnosis of RA

    Clinical Measures - Identification of Biomarkers

    Diagnosis of RA

    Clinical Measures - Biomarkers and Rheumatoid Factor

    Diagnosis of RA

    Clinical Measures - Measures used in Clinical Trials

    Diagnosis of RA

    Measures Used in Clinical Trials - Assessment of Joint Damage by X-Ray

    Diagnosis of RA

    Measures Used in Clinical Trials - ACR

    Diagnosis of RA

    Measures Used in Clinical Trials - DAS

    Diagnosis of RA

    Measures Used in Clinical Trials - EULAR

    Diagnosis of RA

    Differential Diagnosis

    Complications of RA

    Rheumatoid Nodules

    Complications of RA

    Complications of RA

    Complications of RA

    Major Organs Affected by RA

    Risk Factors

    Genetics and Environmental Factors

    Risk Factors

    Additional Postulated Risk Factors: Infectious Agents and Vaccination Complications

    Risk Factors

    Additional Postulated Risk Factors: Hormones and Education Level

    Learning Objectives

    Learning Objectives

    Introduction

    Introduction: Rheumatoid Arthritis Treatment

    Therapeutic Approach

    Therapeutic Approach: ACR Guidelines

    Therapeutic Approach

    Therapeutic Approach: Differences from Earlier ACR Recommendations

    Analgesics

    Analgesics

    NSAIDs

    Introduction: NSAIDs

    Glucocorticoids

    Glucocorticoids: Use in RA

    Glucocorticoids

    Use in RA: ACR Guidelines

    Non-biologic DMARDs

    Introduction: DMARDs

    Non-biologic DMARDs

    Antimalarials (hydroxychloroquine)

    Non-biologic DMARDs

    Sulfasalazine

    Non-biologic DMARDs: Methotrexate

    Introduction: Methotrexate (MTX)

    Non-biologic DMARDs: Methotrexate

    Methotrexate: Efficacy

    Non-biologic DMARDs: Methotrexate

    Pivotal Clinical Studies

    Non-biologic DMARDs: Methotrexate

    Pivotal Clinical Studies: Methotrexate

    Non-biologic DMARDs: Methotrexate

    Clinical Studies: Multidrug Combinations

    Non-biologic DMARDs: Methotrexate

    MTX in Combination: Two Year Randomized, Double-Blind, Placebo-Controlled Trial

    Non-biologic DMARDs: Methotrexate

    Methotrexate Use: RA Indication

    Non-biologic DMARDs: Methotrexate

    Methotrexate: Use Contraindications

    Non-biologic DMARDs: Methotrexate

    Methotrexate Dosage: Oral

    Non-biologic DMARDs: Methotrexate

    Methotrexate Dosage: Safety and Side Effects

    Non-biologic DMARDs: Methotrexate

    Safety Issues and Side Effects

    Non-biologic DMARDs: Leflunomide

    Introduction: Leflunomide

    Non-biologic DMARDs: Leflunomide

    Use: Indications, Contraindications, Safety Issues and Side Effects

    Summary

    Summary: Methotrexate (MTX)

    Summary: RA Treatment Guidelines

    Summary: RA Treatment Guidelines

    Learning Objectives

    Learning Objectives

    Background on Biologic Therapies

    Biologics in the Treatment of Rheumatoid Arthritis (RA)

    Background on Biologic Therapies

    Monoclonal Antibodies

    Biologics in use for RA

    Effector Mechanisms: TNFα

    Biologics in use for RA

    Effector Mechanisms: Inhibition of TNFα

    Learning Objectives

    Learning Objectives

    Biologic DMARDs

    Biologic DMARDs: Background

    TNF-Targeted Biologics in Current Use - Etanercept

    Use: Indication for Rheumatoid Arthritis, Dosage and Administration

    Biologic DMARDs

    Background: Adverse Events

    TNF-Targeted Biologics in Current Use - Etanercept

    Warnings: Etanercept

    TNF-Targeted Biologics in Current Use - Infliximab

    Use: Indication, Dosage and Administration for RA

    TNF-Targeted Biologics in Current Use - Infliximab

    Warnings: Infliximab

    TNF-Targeted Biologics in Current Use - Adalimumab

    Mechanism of Action: Adalimumab

    TNF-Targeted Biologics in Current Use - Adalimumab

    Use in RA: Indications, Dosage and Administration

    TNF-Targeted Biologics in Current Use - Adalimumab

    Dosage, Administration, and Warnings

    TNF-Targeted Biologics in Current Use - Golimumab

    Mechanism of Action: Golimumab

    TNF-Targeted Biologics in Current Use - Golimumab

    Use and Indication for RA: Golimumab

    TNF-Targeted Biologics in Current Use - Golimumab

    Warnings: Golimumab

    TNF-Targeted Biologics in Current Use - Certolizumab Pegol

    Mechanism of Action: Certolizumab Pegol

    TNF-Targeted Biologics in Current Use - Certolizumab Pegol

    Use, Indication for RA, Dosage and Administration: Certolizumab Pegol

    TNF-Targeted Biologics in Current Use - Certolizumab Pegol

    Warnings: Certolizumab Pegol

    Other Biologics in Current Use - Anakinra

    Use in RA, Indications, Dosage and Administration: Anakinra

    Other Biologics in Current Use - Anakinra

    Warnings: Anakinra

    Biologics in Current Use - Abatacept

    Use, Indication for RA, Dosage and Administration: Abatacept

    Biologics in Current Use - Abatacept

    Warnings: Abatacept

    Other Biologics in Current Use - Rituximab

    Use, Indication for RA, Dosage and Administration: Rituximab

    Other Biologics in Current Use - Rituximab

    Recommended Dose for Rheumatoid Arthritis and Concomitant Medications: Rituximab

    Other Biologics in Current Use - Rituximab

    Warnings: Rituximab

    Other Biologics in Current Use - Tocilizumab

    Mechanism of Action: Tocilizumab

    Other Biologics in Current Use - Tocilizumab

    Use, Indication, Dosage and Administration: Tocilizumab

    Other Biologics in Current Use - Tocilizumab

    Dosage Modifications: Tocilizumab

    Other Biologics in Current Use - Tocilizumab

    Warnings: Tocilizumab

    Background of Clinical Trials

    Initial studies with Monoclonal Antibodies

    Background of Clinical Trials

    Clinical Trials of Biologic RA Treatments

    Clinical Trials of Biologic Agents

    Introduction: Clinical Trials of Biologic Agents

    Etanercept: Clinical Studies

    Etanercept: Clinical Studies

    Infliximab: Clinical Studies

    Infliximab: Clinical Studies

    Adalimumab: Clinical Studies

    Adalimumab: Clinical Studies

    Golimumab: Clinical Studies

    Golimumab: Clinical Studies

    Certolizumab Pegol: Clinical Studies

    Certolizumab Pegol: Clinical Studies

    Anakinra: Clinical Studies

    Anakinra: Clinical Studies

    Abatacept: Clinical Studies

    Abatacept: Clinical Studies

    Rituximab: Clinical Studies

    Rituximab: Clinical Studies

    Tocilizumab: Clinical Studies

    Tocilizumab: Clinical Studies

    Review of Clinical Trials and Meta-analyses of Biologic Agents

    Comparisons of Clinical Trial Results

    Review of Clinical Trials and Meta-analyses of Biologic Agents

    Introduction: Review of Clinical Trials

    Review of Clinical Trials and Meta-analyses of Biologic Agents

    Biologic Treatments and Remission in Early RA

    Review of Clinical Trials and Meta-analyses of Biologic Agents

    Efficacy of Biologic Agent Monotherapy in MTX-Naive Patients

    Review of Clinical Trials and Meta-analyses of Biologic Agents

    Efficacy of Biologic Treatment and MTX Combination Therapy in MTX-Naive Patients

    Review of Clinical Trials and Meta-analyses of Biologic Agents

    Efficacy of Biologic Treatment and MTX Combination Therapy in MTX-Experienced Patients

    Review of Clinical Trials and Meta-analyses of Biologic Agents

    Efficacy of Combined Biologic Treatment and DMARD Therapy in DMARD-Experienced Patients

    Review of Clinical Trials and Meta-analyses of Biologic Agents

    Sequential Use of TNFα inhibitors

    Review of Clinical Trials and Meta-analyses of Biologic Agents

    Sequential Use of TNFα inhibitors: Comparing Studies

    Anatomy and Physiology of the Skin: Introduction

    Anatomy and Physiology of the Skin: Introduction

    Anatomy and Physiology of the Skin: Introduction

    Anatomy and Physiology of the Skin: Learning Objectives

    Overview of Skin Structure and Function

    Overview of Skin Structure and Function

    Layers of the Skin: Epidermis

    Layers of the Skin: Epidermis: Introduction

    Layers of the Skin: Epidermis

    Epidermis Layers

    Layers of the Skin: Epidermis

    Epidermal Layers

    Layers of the Skin: Epidermis

    Epidermal Functions: Keratinocyte Proliferation and Differentiation

    Layers of the Skin: Epidermis

    Epidermal Functions: Desquamation

    Layers of the Skin: Epidermis

    Other Cells of the Epidermis

    Layers of the Skin: Dermal-Epidermal Junction, Dermis

    Layers of the Skin: Dermal-Epidermal Junction, Dermis: Overview

    Layers of the Skin: Dermal-Epidermal Junction, Dermis

    Cells of the Dermis

    Layers of the Skin: Dermal-Epidermal Junction, Dermis

    Other Components of the Dermis

    Layers of the Skin: Dermal-Epidermal Junction, Dermis

    Other Components of the Dermis: Ground Substance

    Immune System of the Skin

    Immune System of the Skin: Overview

    Immune System of the Skin

    Skin Barrier

    Immune System of the Skin

    Innate-Acquired Immune System Interactions

    Immune System of the Skin

    Acquired Immune Responses

    Immune System of the Skin

    Acquired Immune Response Memory

    Anatomy and Physiology of the Skin: Summary

    Anatomy and Physiology of the Skin: Summary

    Atopic Dermatitis: Introduction

    Atopic Dermatitis: Introduction

    Normal Skin Anatomy

    The Structure and Function of Normal Skin

    Definition of Atopic Dermatitis

    Definition of Atopic Dermatitis

    Epidemiology

    Global Prevalence of AD

    Epidemiology

    Prevalence of AD in the United States

    Epidemiology

    Historical Trends in the Prevalence of AD

    Natural History

    Natural History

    Risk Factors

    AD and Environmental Risk Factors

    Risk Factors

    Genetic Risk Factors in AD

    Pathophysiology

    Phosphodiesterases and the Pathogenesis of AD

    Diagnosis

    Diagnostic Criteria for AD

    Diagnosis

    EASI

    Diagnosis

    The Patient-Oriented Eczema Measure (POEM)

    Diagnosis

    Biomarkers in AD

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