Immunology: Introduction

Immunology: Learning Objectives

Immunology: Introduction

Immunology: Introduction

Introduction to Therapeutic Immunology

Therapeutic Immunology: Immunodiagnostics and Immunotherapy

Additional concepts in MS Therapy

Immunologic Concepts

Introduction to Therapeutic Immunology

Traditional Immunosuppressive Agents

Introduction to Therapeutic Immunology

Vaccination Successes

Introduction to Therapeutic Immunology

Immunotherapy

Introduction to Therapeutic Immunology

Biologic Therapies

Introduction to Therapeutic Immunology

Categories of Biologic Therapy

Introduction to Therapeutic Immunology

Edward Jenner: Vaccination

Introduction to Therapeutic Immunology

Limitations of Traditional Immunosuppressive Drugs

Introduction to Therapeutic Immunology

Edward Jenner: Vaccination
Vaccination Successes
Therapeutic Immunology: Immunodiagnostics...

B Cells and Humoral-Mediated Immune Responses

Overview: Immunology

Cytokines

Overview: Cytokines

Traditional Immunosuppressive Therapies

Fungal or Bacterial Derivatives

Traditional Immunosuppressive Therapies

Traditional Immunosuppressive Therapies
Traditional Immunosuppressive Agents
Corticosteroi...

Autoimmune Disease Examples

Autoimmune Diseases
Interactive Exercise: Immunology Terms
Interactivity: Autoimmune Disea...

Cells of the Immune System

The Lymphatic System
Lymphoid Organs
Lymph Node
Lymph Node: T Cell Activation
Ly...

The Inflammatory Response

Inflammation
Inflammation Resolving

Hypersensitivity

Antibody-Mediated Hypersensitivity

T Cells and Cell-Mediated Responses

T Cell Activation

T Cells and Cell-Mediated Immune Responses

T-Cell Activation

Inflammatory Response in Action

Acute Inflammation

Introduction to Monoclonal Antibodies

Antibodies as Therapy

Introduction to Monoclonal Antibodies

The Hybridoma Breakthrough

Introduction to Monoclonal Antibodies

Recombinant mAbs

Cells of the Immune System

Spleen

The Inflammatory Response

The Complement System: Outcomes

The Innate and Adaptive Immune System

The Innate and Adaptive Immune System

Inflammatory Response in Action

Chronic Inflammation

Autoimmune Disease Examples

Autoimmune Diseases

Hypersensitivity

Hypersensitivity Diseases

Hypersensitivity

Types of Hypersensitivity Responses

Traditional Immunosuppressive Therapies

Corticosteroids

Traditional Immunosuppressive Therapies

Cytotoxic Agents

T Cells and Cell-Mediated Immune Responses

T-Cell Activation

The Inflammatory Response

Inflammation Resolving

The Immune Response: Overview

The Immune Response: Overview

The Immune Response

The Skin Barrier

The Innate Immune Response

Inflammatory Gene Transcription

The Immune Response

The Adaptive (or Acquired) Immune Response

Cells of the Immune System

The Lymphatic System

Cells of the Immune System

Lymph Node

Overview: The Inflammatory Response

Overview: The Inflammatory Response

The Inflammatory Response

Leukocyte Migration: Rolling and adhesion

The Inflammatory Response

The Complement System: The Complement

Complement System in Action

The Complement Cascade

Complement System in Action

Activation of Complement

The Inflammatory Response

Phagocytosis

Cytokines

Tumor Necrosis Factor Alpha in Disease

Self vs. Non-Self

Self vs. Non-Self

The Inflammatory Response

Leukocyte Migration: Transmigration and Emigration, Chemotaxis

Inflammatory Response in Action

Systemic Inflammation

Concepts in Cancer Immunology

Cancer Immunoediting

The Inflammatory Response

Inflammation

Cells of the Immune System

Immune Cell Development

Cells of the Immune System

Lymphoid Organs

Immunology of Cancer: Introduction

Immunology of Cancer: Introduction

Introduction: Basics of Immunology

Introduction: Basics of Immunology

Emerging Hypotheses on Treatment

Immunological Concepts: Monoclonal Antibodies

The Inflammatory Response

The Complement System: The Complement
The Complement System: The Compete Cascade
The Compl...

Traditional Immunosuppressive Therapies

Traditional Immunosuppressive Therapies

Introduction to Monoclonal Antibodies

Hybridoma Technology: Limitations

Traditional Immunosuppressive Therapies

Traditional Immunosuppressive Agents

Traditional Immunosuppressive Therapies

Corticosteroids: Gene Expression

Soluble Receptors and Other Cytokine Inhibitors

Soluble Receptors and Other Cytokine Inhibitors

Soluble Receptors and Other Cytokine Inhibitors

Abatacept

Clinical Applications of Monoclonal Antibodies

Clinical Applications of Monoclonal Antibodies: Learning Objectives

Clinical Applications of Monoclonal Antibodies

Biological Actions of mAbs

Clinical Applications of Monoclonal Antibodies

mAbs in Clinical Trials

Clinical Applications of Monoclonal Antibodies

New Antibody Formats

Traditional Immunosuppressive Therapies

Traditional Immunosuppressive Therapies
Traditional Immunosuppressive Agents

Traditional Immunosuppressive Therapies

Corticosteroids: Immediate Effect (Anti-Inflammatory)
Corticosteroids: Gene Expression
Cor...

Inflammatory Response in Action

Interactive Exercise: Inflammation
Interactive Exercise: The Inflammation Process
Interact...

The Inflammatory Response

Role of MHC in Antigen Presentation

The Inflammatory Response

The Complement System: Classical Pathway

T Cells and Cell-Mediated Immune Responses

Negative Selection

T Cells and Cell-Mediated Immune Responses

Anergy

Clinical Applications of Monoclonal Antibodies

Cancer Immunotherapy

Summary: Innate and Adaptive Immune Responses

Summary: Innate and Adaptive Immune Responses

Soluble Receptors and Other Cytokine Inhibitors

Cytokine Neutralizers

Cells of the Immune System

Lymph Node: T Cell Activation

The Inflammatory Response

Antigen Presentation: MHC/HLA

The Inflammatory Response

The Complement System: Inactive Proenzyme

T Cells and Cell-Mediated Immune Responses

Apoptosis

B Cells and Antibodies

Immunoglobulin Isotypes

Introduction to the Innate and Adaptive Immune Systems

The Immune System

Autoimmune Disease Examples

Autoimmune Disease Progression

Traditional Immunosuppressive Therapies

Corticosteroids: Adverse Effects

Clinical Applications of Monoclonal Antibodies

Receptor Cross-Linking

The Inflammatory Response

Role of MHC in Antigen Presentation
Antigen Presentation: APC and T Cell

The Inflammatory Response

Antigen Presentation: MHC/HLA (Association between HLA and Diseases)

The Inflammatory Response

Antigen Presentation: APC and T Cell

Cells of the Immune System

Lymph Node: B Cell Activation

B Cells and Humoral-Mediated Immune Responses

Isotypes

Adaptive Immune System Components

Adaptive Immunity

Adaptive Immune System Components

Intracellular Antigens

Adaptive Immune System Components

Extracellular Antigens

Hypersensitivity

Immediate Hypersensitivity (Type I)

The Inflammatory Response

The Complement System: The Compete Cascade

The Immune Response

The Skin Barrier
The Skin Barrier: Th1 and Th2 Responses

The Immune Response

The Skin Barrier: Th1 and Th2 Responses

The Innate Immune Response

Pattern Recognition Receptors (PRRs)

The Immune Response

How Innate and Adaptive Responses Work Together

Hypersensitivity

Hypersensitivity Diseases
Types of Hypersensitivity Responses
Immediate Hypersensitivity (...

Soluble Receptors and Other Cytokine Inhibitors

Abatacept
Mechanism of Action of Abatacept (Orencia)
Abatacept: A Soluble Fusion Protein

Cells of the Immune System

The Lymphatic System

Autoimmune Disease Examples

Interactivity: Autoimmune Diseases

Traditional Immunosuppressive Therapies

Corticosteroids: Gene Expression
Corticosteroids: Gene Expression (The Anti-Inflammatory Effect...

Cells of the Immune System

Lymph Node
Lymph Node: T Cell Activation
Lymph Node: B Cell Activation

Complement System in Action

The Complement Cascade
Activation of Complement
Interactive Exercise: Complement Cascade

Atopy vs. Allergy

Hypersensitivity Disorders

Introduction to the Innate and Adaptive Immune Systems

Interactive Exercise: Components and Actions of Adaptive and Innate Immunity
The Immune System

Concepts in Cancer Immunology

Cancer Immunosurveillance

T Cells and Cell-Mediated Immune Responses

Peripheral Tolerance
Peripheral Tolerance: Apoptosis in Clonal Deletion
Anergy
Suppre...

Clinical Applications of Monoclonal Antibodies

Receptor Cross-Linking
Inducing Complement-Mediated Cytotoxicity
Inducing Antibody-Depende...

T Cells and Cell-Mediated Immune Responses

Expression of T Cell Receptors (TCRs)
Apoptosis
Central Tolerance
Positive Selection

Adaptive Immune System Components

Adaptive Immunity
Intracellular Antigens
Extracellular Antigens
Interactive Exercise:...

Clinical Applications of Monoclonal Antibodies

Clinical Applications of Monoclonal Antibodies: Learning Objectives
Detection, Diagnosis, and M...

Soluble Receptors and Other Cytokine Inhibitors

Cytokine Inhibitors: Three Major Strategies

Introduction to Monoclonal Antibodies

Hybridoma Technology: Making a Monoclonal Antibody

Clinical Applications of Monoclonal Antibodies

Therapeutic mAbs: Examples of Approved Agents

Soluble Receptors and Other Cytokine Inhibitors

Soluble Receptors and Other Cytokine Inhibitors
Overview of Cytokine Therapy: Types of Cytokine...

Atopy vs. Allergy

Hypersensitivity Disorders: Gell-Coombs Classification

Soluble Receptors and Other Cytokine Inhibitors

Agents That Block Cytokine Receptors

Soluble Receptors and Other Cytokine Inhibitors

Soluble Receptor Therapies

Soluble Receptors and Other Cytokine Inhibitors

Enbrel (etanercept) Indications

Introduction to Monoclonal Antibodies

Four General Classes of mAb Therapies

Clinical Applications of Monoclonal Antibodies

A Closer Look At mABS Used as Therapies

Clinical Applications of Monoclonal Antibodies

Blocking the Actions of a Target Molecule

The Inflammatory Response

Antigen Presentation: MHC/HLA (Association between HLA and Diseases)

T Cells and Cell-Mediated Immune Responses

Central Tolerance

Traditional Immunosuppressive Therapies

Corticosteroids: Immediate Effect (Anti-Inflammatory)

Traditional Immunosuppressive Therapies

Corticosteroids: Gene Expression (Therapeutic Uses of Corticosteroids)

Soluble Receptors and Other Cytokine Inhibitors

Overview of Cytokine Therapy: Types of Cytokines

Soluble Receptors and Other Cytokine Inhibitors

Agents That Activate Anti-Inflammatory Pathways

Soluble Receptors and Other Cytokine Inhibitors

Abatacept: A Soluble Fusion Protein

Introduction to Monoclonal Antibodies

Early Antibody Therapy: Polyclonal Antibodies

Clinical Applications of Monoclonal Antibodies

Detection, Diagnosis, and Monitoring of Diseases and Disease-Related Molecules

Clinical Applications of Monoclonal Antibodies

Therapeutic mAbs: In the Treatment of Diseases

T Cells and Cell-Mediated Immune Responses

Peripheral Tolerance

T Cells and Cell-Mediated Immune Responses

T-Cell Specificity and Function

TH2 and TH2 Immune Responses

TH1 and TH2 Helper T Cells

TH2 and TH2 Immune Responses

TH2 Cells Coordinate Humoral Response

Soluble Receptors and Other Cytokine Inhibitors

Mechanism of Action of Abatacept (Orencia)

Clinical Applications of Monoclonal Antibodies

Inducing Complement-Mediated Cytotoxicity

Traditional Immunosuppressive Therapies

Corticosteroids: Gene Expression (The Anti-Inflammatory Effects of Corticosteroids)

Introduction to Monoclonal Antibodies

Naming Monoclonal Antibodies: Pali-vi-zu-mab

Clinical Applications of Monoclonal Antibodies

Inducing Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC)

T Cells and Cell-Mediated Immune Responses

Peripheral Tolerance

B Cells, Antibodies and Antibody-Mediated Immune Responses

BAFF and APRIL Receptor Signaling

B Cells and Humoral-Mediated Immune Responses

Immunoglobulin Effector Mechanisms

T Cells and Cell-Mediated Immune Responses

Positive Selection

T Cells and Cell-Mediated Immune Responses

T-Cell Activation - Costimulation

T Cells and Cell-Mediated Immune Responses

T-Cell Activation

Soluble Receptors and Other Cytokine Inhibitors

Soluble Receptor Therapies
Mechanism of Action of Enbrel (etanercept): Tumor Necrosis Factor In...

Innate and Adaptive (Acquired) Immune Systems

Self vs. Non-Self

T Cells and Cell-Mediated Responses

T Cell Lineage

Introduction to the Innate and Adaptive Immune Systems

Innate and Adaptive Immunity

TH2 and TH2 Immune Responses

CD4+ Helper T Cell Activation

TH2 and TH2 Immune Responses

TH1 Cells Coordinate Cell-Mediated Response

Hypersensitivity

Immune-Complex-Mediated Hypersensitivity (Type III)

Hypersensitivity

T Cell-Mediated Hypersensitivity (Type IV)

T Cells and Cell-Mediated Immune Responses

Peripheral Tolerance: Apoptosis in Clonal Deletion

B Cells and Humoral-Mediated Immune Responses

Overview of Antibody Production: B Cell Expression and Maturation

B Cells and Humoral-Mediated Immune Responses

Overview of Antibody Production: B Cell Clonal Expansion

B Cells and Humoral-Mediated Immune Responses

Immunoglobulins: IgG

B Cells and Humoral-Mediated Immune Responses

B Cells and Cytokine Production

Soluble Receptors and Other Cytokine Inhibitors

Cytokine Neutralizers
Cytokine Inhibitors: Three Major Strategies
Agents That Block Cytoki...

Adaptive Immune System Components

Activation of Humoral Immunity and Activation of Cell-Mediated Immunity

Cells of the Immune System

Overview of Cells of the Immune System

B Cells and Antibodies

Overview of B Cell Responses, Overview of Antibody Production

T Cells and Cell-Mediated Immune Responses

Expression of T Cell Receptors (TCRs)

TH2 and TH2 Immune Responses

TH1 and TH2 Helper T Cells
CD4+ Helper T Cell Activation
TH2 Cells Coordinate Humoral Resp...

Innate and Adaptive (Acquired) Immune Systems

Characteristics of Innate and Adaptive Immunity

The Inflammatory Response: Overview

Overview, Tissue Insult and Damage

Atopy vs. Allergy

Hypersensitivity Overview, Atopy versus Allergy

Introduction to Monoclonal Antibodies

Antibodies as Therapy
Early Antibody Therapy: Polyclonal Antibodies
Hybridoma Technology: ...

Innate and Adaptive (Acquired) Immune Systems

Characteristics of Innate and Adaptive Immunity

The Inflammatory Response: Antigen Processing and Presentation by Macrophages

The Inflammatory Response: Overview

The Inflammatory Response: Leukocyte Migration

The Inflammatory Response: Leukocyte Migration: Overview

Soluble Receptors and Other Cytokine Inhibitors

Mechanism of Action of Enbrel (etanercept): Tumor Necrosis Factor Inhibitor
Enbrel (etanercept)...

Additional concepts in MS Therapy

Immunologic Concepts
Genetic Concepts
Neurodegeneration
Neuroprotection
Remyelin...

T Cells and Cell-Mediated Immune Responses

Peripheral Tolerance
Peripheral Tolerance: Apoptosis in Clonal Deletion

B Cells and Humoral-Mediated Immune Responses

B-Cell Activation and Regulation: B-Cell Receptor (BCR)
B-Cell Maturation: B-Cell Precursors

T Cells and Cell-Mediated Immune Responses

Peripheral Tolerance: B Cell Peripheral Tolerance

T Cells and Cell-Mediated Immune Responses

Separation of the Autoreactive T Cell from the Host Antigen

B Cells, Antibodies and Antibody-Mediated Immune Responses

B Cell Production of Interleukin-10 (IL-10): Resolution of Autoimmune Disease Inflammatory Response

T Cells and Cell-Mediated Immune Responses

Suppression by T Regulatory Cells (Suppressor T Cells)

Innate and Adaptive (Acquired) Immune Systems

Innate and Adaptive (Acquired) Immune Systems: Overview

Soluble Receptors and Other Cytokine Inhibitors

Mechanism of Action of Enbrel (etanercept): Tumor Necrosis Factor Inhibitor

Soluble Receptors and Other Cytokine Inhibitors

The Rationale for Cytokine Therapy: Drugs That Act As Cytokines or Anticytokines

B Cells, Antibodies and Antibody-Mediated Immune Responses

B Cell Production of Interleukin-10 (IL-10): Downregulation the Active Inflammatory Response

T Cells and Cell-Mediated Immune Responses

Release from Bone Marrow and Migration to the Thymus

T Cells and Cell-Mediated Immune Responses

T-Cell Activation - T-Cell Receptor (TCR)

Innate and Adaptive (Acquired) Immune Systems

How Innate and Adaptive Responses Work Together

Pro- and Anti-Inflammatory Cytokines/Mediators

Overview, Proinflammatory versus Anti-Inflammatory Cytokines

B Cells, Antibodies and Antibody-Mediated Immune Responses

BAFF (B-cell Activating Factor) and APRIL (A Proliferation-Inducing Ligand)

B Cells, Antibodies and Antibody-Mediated Immune Responses

B-Cell Activation and Regulation: Antibody Production

B Cells, Antibodies and Antibody-Mediated Immune Responses

BAFF and APRIL: Effects on B Cell Maturation

B Cells and Humoral-Mediated Immune Responses

B-Cell Activation and Regulation: B-Cell Receptor (BCR)

B Cells and Humoral-Mediated Immune Responses

B-Cell Maturation: B-Cell Precursors

Pro- and Anti-Inflammatory Cytokines/Mediators

Signaling Pathways Regulating Production and Transcription of Inflammatory Mediators

B Cells, Antibodies and Antibody-Mediated Immune Responses

Antigen Processing and Presentation and MHC, Role of MHC in Antigen Presentation

Cancer Immunotherapy

Cancer Immunotherapy

Cancer Immunotherapy

Cancer Immunotherapy

Emerging Hypotheses on Treatment

Emerging Hypotheses on Treatment: Myelination-Targeted Antibodies
Cell Therapy
Human Stem ...

Innate Immunity

Innate Tumor Immunity: Macrophages

Cancer Immunotherapy

Adoptive T Cell Transfer

Cancer Immunotherapy

Cancer Vaccines

Suppression of Tumor Immunity

Overview of Immunosuppressive Mechanisms

Layers of the Skin: Epidermis

Epidermal Functions: Keratinocyte Differentiation

Emerging Hypotheses on Treatment

Immunological Concepts: Vaccines

Emerging Hypotheses on Treatment

Immunological Concepts: Summary

Innate Immunity

Innate Versus Adaptive Immunity in Anti-tumor Responses

Suppression of Tumor Immunity

Evasion of T Cell Recognition or Activation

Innate Immunity

Dendritic Cells and Anti-tumor Immunity

Innate Immunity

Innate Tumor Immunity: Natural Killer Cells

Adaptive T Cell Immunity

Induction of Adaptive T Cell Immunity

Adaptive T Cell Immunity

Cytotoxic T Cells (CTLs) and Tumor Cell Killing

Concepts in Cancer Immunology

Cancer Immunosurveillance

Concepts in Cancer Immunology

Cancer Immunoediting

Adaptive T Cell Immunity

Antigen Presentation and T Cell Activation

Adaptive T Cell Immunity

CD4+ T Helper Cells and Tumor Immunity

Emerging Hypotheses on Treatment

Immunological Concepts: Emerging Hypotheses on Treatment

Emerging Hypotheses on Treatment

Immunological Concepts: Oral Immune-Modulating Drugs

Basics of Immunology of Cancer

Cancer Vaccines: Types of Cancer Vaccines

Innate Immunity

Dendritic Cells and Antitumor Immunity

Innate Immunity

Innate Versus Adaptive Immunity in Antitumor Responses

Innate Immunity

Innate Tumor Immunity: Natural Killer Cells

Innate Immunity

Innate Tumor Immunity: Macrophages

Adaptive T Cell Immunity

Induction of Adaptive T Cell Immunity

Adaptive T Cell Immunity

Antigen Presentation and T Cell Activation

Adaptive T Cell Immunity

Cytotoxic T Cells (CTLs) and Tumor Cell Killing

Adaptive T Cell Immunity

CD4+ T Helper Cells and Tumor Immunity

Suppression of Tumor Immunity

Overview of Immunosuppressive Mechanisms

Suppression of Tumor Immunity

Evasion of T Cell Recognition or Activation

Cancer Immunotherapy: Adoptive T Cell Transfer

Adoptive T Cell Transfer

The Innate and Adaptive Immune System

Learning Objectives

Learning Objectives

Learning Objectives

Pathophysiology

Glial Cells, Click-on: Oligodendrocytes

Pathophysiology

Glial Cells, Click-on: Astrocytes

Pathophysiology

Glial Cells, Click-on: Microglia

Pathophysiology

Autoimmune Disease

Pathophysiology

Autoimmune Disease

Key Concepts in Autoimmunity: The Importance of Tolerance

The Birth and Early Education of Lymphocytes: Peripheral Tolerance (Separation of the Autoreactive T...

Hypersensitivity

Type IV Hypersensitivity Reaction Subgroups

Pathophysiology

Neurodegeneration

Pathophysiology

Glial Cells, Click-on: Oligodendrocytes
Glial Cells, Click-on: Astrocytes
Glial Cells, Cli...

Pathophysiology

Microglial Mediators of CNS Inflammation and Damage

Pathophysiology

Glial Cells, Click-on: Microglia
Microglial Mediators of CNS Inflammation and Damage

Current Therapies

Severe Relapses: Corticosteroids

Current Therapies

Severe Relapses: Therapeutic Plasma Exchange (TPE)

Additional concepts in MS Therapy

Genetic Concepts

Additional concepts in MS Therapy

Remyelinating Antibodies

Disease Overview

Patient Descriptions

Disease Overview

Etiology

Disease Overview

Classification of MS

Pathophysiology

Autoimmune Disease

Pathophysiology

Pathogenesis

Additional concepts in MS Therapy

Remyelination

Key Concepts in Autoimmunity: The Importance of Tolerance

The Birth and Early Education of Lymphocytes: Peripheral Tolerance (Anergy)

Autoimmune Disease Processes

Consequences of Autoimmune Diseases: Common Autoimmune Diseases

Autoimmune Diseases: Introduction

Epidemiology and Impact

Hypersensitivity

Autoimmune Diseases Classified as Hypersensitivity Reactions

Disease Overview

Relapses

Disease Overview

Disease Variability

Pathophysiology

Overview

Pathophysiology

Myelin-Reactive T Cells

Current Therapies

Hormonal Therapies

Current Therapies

Chemotherapeutic Agents

Current Therapies

Symptomatic Therapies - Severe Relapses

Key Concepts in Autoimmunity: The Importance of Tolerance

The Birth and Early Education of Lymphocytes: Central Tolerance

Key Concepts in Autoimmunity: The Importance of Tolerance

The Birth and Early Education of Lymphocytes: Central Tolerance (Negative Selection)

Introduction to Immunopathology

Hypersensitivity Disorders: Type II Antibody-Mediated

Introduction to Immunopathology

Hypersensitivity Disorders: Type III Immune Complex-Mediated

Key Concepts in Autoimmunity: The Importance of Tolerance

The Birth and Early Education of Lymphocytes: B Cell Peripheral Tolerance

Key Concepts in Autoimmunity: The Importance of Tolerance

The Birth and Early Education of Lymphocytes: Peripheral Tolerance (Apoptosis in Clonal Deletion)

Mechanisms of Autoimmune Disease: The Breakdown of Tolerance

The Breakdown of Tolerance: Molecular Mimicry

Autoimmune Disease Processes

The Etiology of Autoimmune Disease: Genetic Factors (Family and Population Studies)

Autoimmune Disease Processes

The Etiology of Autoimmune Disease: Lifestyle Factors

Autoimmune Disease Processes

Epitopes and Antigenic Determinants

Additional concepts in MS Therapy

Neurodegeneration

Key Concepts in Autoimmunity: The Importance of Tolerance

Key Terms and Concepts in Tolerance

Autoimmune Diseases: Introduction

The Breakdown of Tolerance: Molecular Mimicry

Hypersensitivity

Type II Reaction Examples

Autoimmune Diseases: Introduction

Mechanisms: Failure of Lymphocyte Suppression by Regulatory T Cells

Autoimmune Diseases: Introduction

Mechanisms: MHC Complex/Receptor Disorders

Autoimmune Diseases: Introduction

Mechanisms: Failure of Apoptosis Via Fas Receptors

Disease Overview

Progression

Disease Overview

Epidemiology

Pathophysiology

Autoimmune Disease: Overview

Pathophysiology

Demyelination

Current Therapies

Symptomatic Therapies - Symptom Reduction

Current Therapies

Intensive Immune Suppression For Non-Responders

Current Therapies

Cell Therapy

Additional concepts in MS Therapy

Neuroprotection

Autoimmune Disorders

Mechanisms: Failure of T Cell Suppression by Regulatory T Cells

Autoimmune Disorders

Mechanisms: MHC Complex/Receptor Disorders

Autoimmune Disorders

Mechanisms: Presence of Superantigens

Key Concepts in Autoimmunity: The Importance of Tolerance

The Birth and Early Education of Lymphocytes: Expression of T Cell Receptors (TCRs)

Key Concepts in Autoimmunity: The Importance of Tolerance

The Birth and Early Education of Lymphocytes: B Cell Central Tolerance

Introduction to Immunopathology

Immunopathologies: Clinical Consequences

Introduction to Immunopathology

Organ Transplant Rejection: How the Immune System Distinguishes between Self and Non-Self

Introduction to Immunopathology

Hypersensitivity Disorders

Introduction to Immunopathology

Autoimmune Diseases: The Spectrum of Attack

Introduction to Immunopathology

Organ Transplant Rejection: How the Immune System Distinguishes between Self and Non-Self

Introduction to Immunopathology

Immunodeficiency Syndromes

Key Concepts in Autoimmunity: The Importance of Tolerance

The Birth and Early Education of Lymphocytes: Tolerance (Some Thoughts...)

Mechanisms of Autoimmune Disease: The Breakdown of Tolerance

The Breakdown of Tolerance: MHC Complex/Receptor Disorders

Autoimmune Disease Processes

The Etiology of Autoimmune Disease: Genetic Factors (Risk)

Autoimmune Disease Processes

The Etiology of Autoimmune Disease: Genetic Factors (Introduction)

Autoimmune Disease Processes

Consequences of Autoimmune Diseases: Progression and Destruction in Autoimmune Disorders (Mechanisms...

Autoimmune Disease Processes

Consequences of Autoimmune Diseases: Progression and Destruction in Autoimmune Disorders (Epitope Sp...

HAE Diagnosis

Overview of HAE Diagnosis

Hypersensitivity

Limitations

Autoimmune Diseases: Introduction

The Breakdown of Tolerance

Autoimmune Diseases: Introduction

General Mechanism Underlying Autoimmune Disease

Introduction: Autoimmune Disorders and Hypersensitivity

Introduction: Autoimmune Disorders and Hypersensitivity - Immunopathologies

Introduction: Autoimmune Disorders and Hypersensitivity

Introduction: Autoimmune Disorders and Hypersensitivity - Causes and Statistics

Hypersensitivity

Introduction: Hypersensitivity

Hypersensitivity

Gell-Coombs Classification

Hypersensitivity

Hypersensitivity Disorders: Type III Immune Complex-Mediated

Autoimmune Diseases: Introduction

Mechanisms: Loss of T Cell Anergy

Autoimmune Diseases: Introduction

Mechanisms: Release of Sequestered Antigens

Autoimmune Diseases: Introduction

Mechanisms: Presence of Superantigens

Mechanisms of Select Autoimmune Disorders

Systemic Lupus Erythematosus: Failure of Vital Organs

Mechanisms of Select Autoimmune Disorders

Rheumatoid Arthritis: TH17

Mechanisms of Select Autoimmune Disorders

Psoriasis: Upregulated Cytokines

Mechanisms of Select Autoimmune Disorders

Psoriasis Arthritis: Pain and Swelling in Joints

Mechanisms of Select Autoimmune Disorders

Ankylosing Spondylitis: Enthesis and Kyphosis

Mechanisms of Select Autoimmune Disorders

Ankylosing Spondylitis: Heredity

Mechanisms of Select Autoimmune Disorders

Multiple Sclerosis: Demyelination

Disease Overview

Definition of Multiple Sclerosis

Disease Overview

Clinical Presentation

Pathophysiology

T Cell Initiation of MS Blood Brain Barrier

Pathophysiology

T Cell Initiation of MS

Pathophysiology

Plaques - Pathology

Additional concepts in MS Therapy

Cell Transplantation

Autoimmune Disorders

Mechanisms: Release of Sequestered Antigens

Autoimmune Disorders

Mechanisms: Failure of Apoptosis Via Fas Receptors

Introduction

Introduction: Autoimmune Diseases

Hypersensitivity

Hypersensitivity: Hypersensitivity Disorders

Mechanisms of Select Autoimmune Disorders

Systemic Lupus Erythematosus

Biologic DMARDs

Introduction to Biologic Disease-Modifying Antirheumatic Drugs (DMARDs)

Key Concepts in Autoimmunity: The Importance of Tolerance

The Birth and Early Education of Lymphocytes

Key Concepts in Autoimmunity: The Importance of Tolerance

The Birth and Early Education of Lymphocytes: Deletion of Cells that Lack T Cell Receptors

Key Concepts in Autoimmunity: The Importance of Tolerance

The Birth and Early Education of Lymphocytes: Central Tolerance (Positive Selection)

Introduction to Immunopathology

Immunopathologies: Categories

Introduction to Immunopathology

Hypersensitivity Disorders: Type I Immediate Hypersensitivity

Introduction to Immunopathology

Hypersensitivity Disorders: Type IV T-Cell-Mediated (Delayed)

Introduction to Immunopathology

Autoimmune Diseases: General Mechanism Underlying Autoimmune Disease

Introduction to Immunopathology

Autoimmune Diseases

Introduction to Immunopathology

Organ Transplant Rejection: HLA Typing for Transplant

Introduction to Immunopathology

Organ Transplant Rejection: Introduction

Introduction to Immunopathology

Organ Transplant Rejection: Host-Versus-Graft Disease (HVGD) and Graft-Versus-Host Disease (GVHD)

Key Concepts in Autoimmunity: The Importance of Tolerance

The Birth and Early Education of Lymphocytes: Peripheral Tolerance

Key Concepts in Autoimmunity: The Importance of Tolerance

The Birth and Early Education of Lymphocytes: Peripheral Tolerance (Peripheral mechanisms)

Key Concepts in Autoimmunity: The Importance of Tolerance

The Birth and Early Education of Lymphocytes: Peripheral Tolerance (Suppression by T Regulatory Cell...

Mechanisms of Autoimmune Disease: The Breakdown of Tolerance

Mechanisms of Autoimmune Disease: The Breakdown of Tolerance

Mechanisms of Autoimmune Disease: The Breakdown of Tolerance

The Breakdown of Tolerance: Loss of T Cell Anergy

Mechanisms of Autoimmune Disease: The Breakdown of Tolerance

The Breakdown of Tolerance: Failure of T Cell Suppression by Regulatory T Cells

Mechanisms of Autoimmune Disease: The Breakdown of Tolerance

The Breakdown of Tolerance: Release of Sequestered Antigens

Mechanisms of Autoimmune Disease: The Breakdown of Tolerance

The Breakdown of Tolerance: Presence of Superantigens

Mechanisms of Autoimmune Disease: The Breakdown of Tolerance

The Breakdown of Tolerance: Failure of Apoptosis via Fas Receptors

Autoimmune Disease Processes

The Etiology of Autoimmune Disease

Autoimmune Disease Processes

The Etiology of Autoimmune Disease: Genetic Factors (Chromosomal Evidence: The Importance of HLA)

Autoimmune Disease Processes

The Etiology of Autoimmune Disease: Hormonal Factors

Autoimmune Disease Processes

The Etiology of Autoimmune Disease: Environmental Factors

Autoimmune Disease Processes

The Etiology of Autoimmune Disease: Environmental Factors (Non-Infectious Agents)

Autoimmune Disease Processes

Consequences of Autoimmune Diseases: Progression and Destruction in Autoimmune Disorders (Mechanisms...

Autoimmune Disease Processes

Consequences of Autoimmune Diseases: The Natural History of Autoimmune Disorders

Key Concepts in Autoimmunity: The Importance of Tolerance

The Birth and Early Education of Lymphocytes: Peripheral Tolerance
The Birth and Early Educatio...

Hypersensitivity

Type I Hypersensitivity Reaction: Immediate Hypersensitivity

Hypersensitivity

Hypersensitivity Disorders: Type 1 Immediate Hypersensitivity

Hypersensitivity

Type II Hypersensitivity Reaction (Antibody Mediated)

Mechanisms of Select Autoimmune Disorders

Systemic Lupus Erythematosus: Symptoms and Risk

Mechanisms of Select Autoimmune Disorders

Systemic Lupus Erythematosus: Multisymptom Disease

Mechanisms of Select Autoimmune Disorders

Psoriasis Arthritis: Psoriatic Spondylitis

Disease Overview

Prognosis

Pathophysiology

B Cells and Autoantibodies in Disease Progression

Current Therapies

Goals of Disease Modifying Therapy (DMT)

Current Therapies

Rationale for Early Treatment

Autoimmune Disorders

Mechanisms: The Breakdown of Tolerance Molecular Mimicry

Autoimmune Disorders

Mechanisms: Loss of T Cell Anergy

Autoimmune Disorders

Introduction: Autoimmune Disorders: Affects Almost Any Part of the Body

Autoimmune Disorders

Introduction: Autoimmune Disorders: Statistics

Mechanisms of Select Autoimmune Disorders

Rheumatoid Arthritis: Early Stages of RA

Mechanisms of Select Autoimmune Disorders

Multiple Sclerosis

Mechanisms of Select Autoimmune Disorders

Multiple Sclerosis: Axon Damage

Autoimmune Disease Processes

The Breakdown of Tolerance: The Hidden Role of Cryptic Epitopes

Autoimmune Disease Processes

Consequences of Autoimmune Diseases: TNF-α In Autoimmune Disease: Potential Harm OR Benefit?

Key Concepts in Autoimmunity: The Importance of Tolerance

The Birth and Early Education of Lymphocytes: Expression of T Cell Receptors (TCRs)
The Birth a...

Hypersensitivity

Type II Hypersensitivity Reaction (Antibody Mediated)
Type II Reaction Examples

Hypersensitivity

Hypersensitivity Disorders: Type IV T-Cell-Mediated (Delayed)

Mechanisms of Select Autoimmune Disorders

Rheumatoid Arthritis: Patients

Mechanisms of Select Autoimmune Disorders

Psoriasis: Psoriatic keratinocytes Pathway

Introduction: Multiple Sclerosis

Introduction: Hypersensitivity Reactions

Mechanisms of Select Autoimmune Disorders

Psoriasis

Mechanisms of Select Autoimmune Disorders

Psoriasis Arthritis

Mechanisms of Select Autoimmune Disorders

Ankylosing Spondylitis

Mechanisms of Select Autoimmune Disorders

Systemic Lupus Erythematosus (SLE)

Key Concepts in Autoimmunity: The Importance of Tolerance

The Birth and Early Education of Lymphocytes: Release from Bone Marrow and Migration to the Thymus

Key Concepts in Autoimmunity: The Importance of Tolerance

The Birth and Early Education of Lymphocytes: Central Tolerance
The Birth and Early Education o...

Introduction to Immunopathology

Immunopathologies: Clinical Consequences
Immunopathologies: Categories

Introduction to Immunopathology

Autoimmune Diseases: Epidemiology and Impact

Autoimmune Disease Processes

The Etiology of Autoimmune Disease: Environmental Factors (Infectious Agents)

Autoimmune Disease Processes

Epitopes and Antigenic Determinants
The Breakdown of Tolerance: The Hidden Role of Cryptic Epit...

Hypersensitivity

Type IV Hypersensitivity Reaction Subgroups
Gell-Coombs Classification
Type I Hypersensiti...

Pathophysiology

Pathophysiological Mechanisms

Autoimmune Diseases: Introduction

Autoimmune Diseases: Introduction

Diagnosis of SLE

1997 ACR Diagnostic Criteria

Autoimmune Diseases: Introduction

Autoimmune Diseases: Introduction
Epidemiology and Impact

Hypersensitivity

Type I Hypersensitivity Reaction: Immediate Hypersensitivity
Hypersensitivity Disorders: Type 1...

Mechanisms of Select Autoimmune Disorders

Rheumatoid Arthritis: Cell Migration, Neoangiogenesis, and Early Stages

Mechanisms of Select Autoimmune Disorders

Multiple Sclerosis: Molecular Mimicry

Mechanisms of Select Autoimmune Disorders

Multiple Sclerosis: T Cells, B Cells, Axon Damage

Pathophysiology

Plaques - Pathology
Plaques - Histology

Pathophysiology

Plaques - Histology

Mechanisms of Select Autoimmune Disorders

Rheumatoid Arthritis

Key Concepts in Autoimmunity: The Importance of Tolerance

The Birth and Early Education of Lymphocytes: Expression of T Cell Receptors (TCRs)
The Birth a...

Introduction to Immunopathology

Organ Transplant Rejection: Class I MHC and Class II MHC Proteins

Key Concepts in Autoimmunity: The Importance of Tolerance

The Birth and Early Education of Lymphocytes: B Cell Central Tolerance
The Birth and Early Educ...

Introduction to Immunopathology

Hypersensitivity Disorders
Hypersensitivity Disorders: Type I Immediate Hypersensitivity
H...

Autoimmune Disease Processes

The Etiology of Autoimmune Disease: Genetic Factors (Risk)
The Etiology of Autoimmune Disease: ...

Autoimmune Disease Processes

Consequences of Autoimmune Diseases: Progression and Destruction in Autoimmune Disorders (Mechanisms...

Autoimmune Disease Processes

Consequences of Autoimmune Diseases: Progression and Destruction in Autoimmune Disorders (Mechanisms...

Autoimmune Disease Processes

Consequences of Autoimmune Diseases: Progression and Destruction in Autoimmune Disorders (Mechanisms...

Immunogenicity

Immunogenicity: Introduction

Soft Tissue Sarcomas (STSs)

Anatomy and Pathophysiology: Mechanisms of Disease Development and Progression

Pathophysiology

Overview
T Cell Initiation of MS Blood Brain Barrier
B Cells and Autoantibodies in Diseas...

Introduction to Immunopathology

Autoimmune Diseases: Epidemiology and Impact
Autoimmune Diseases: General Mechanism Underlying ...

Autoimmune Disease Processes

The Etiology of Autoimmune Disease: Environmental Factors (Infectious Agents)
The Etiology of A...

Autoimmune Disease Processes

Consequences of Autoimmune Diseases: Progression and Destruction in Autoimmune Disorders (Mechanisms...

Advancing Technologies

Biomarkers: Neurodegenerative Biomarkers

Proteins

Protein Modifications: Pegylation

Autoimmune Diseases: Introduction

The Breakdown of Tolerance
The Breakdown of Tolerance: Molecular Mimicry
Mechanisms: Loss ...

Disease Overview

Definition of Multiple Sclerosis
Prognosis
Clinical Presentation
Patient Descriptions...

Mechanisms of Autoimmune Disease: The Breakdown of Tolerance

Mechanisms of Autoimmune Disease: The Breakdown of Tolerance
The Breakdown of Tolerance: Molecu...

Autoimmune Disease Processes

The Etiology of Autoimmune Disease
The Etiology of Autoimmune Disease: Genetic Factors (Risk)

Autoimmune Diseases: Introduction

General Mechanism Underlying Autoimmune Disease
The Breakdown of Tolerance
The Breakdown o...

Current Therapies

Goals of Disease Modifying Therapy (DMT)
Symptomatic Therapies - Symptom Reduction
Hormona...

Autoimmune Disorders

Mechanisms: The Breakdown of Tolerance Molecular Mimicry
Mechanisms: Loss of T Cell Anergy

Introduction to Immunopathology

Organ Transplant Rejection: Class I MHC and Class II MHC Proteins
Organ Transplant Rejection: H...

Mechanisms of Autoimmune Disease: The Breakdown of Tolerance

Mechanisms of Autoimmune Disease: The Breakdown of Tolerance
The Breakdown of Tolerance: Molecu...

Autoimmune Disease Processes

The Etiology of Autoimmune Disease
The Etiology of Autoimmune Disease: Genetic Factors (Risk)

HCV Infection

Natural History of HCV Infection

Natural History of Type 1 Diabetes

Natural History of Type 1 Diabetes

Summary: Diabetes: Type 1 Pathophysiology

Pathophysiology of Type 1 Diabetes

Medical Device Regulation

Regulatory Classifications: Investigational Device Exemption (IDE)

Biosimilars

Example of a Biosimilar Not Approved by the EMA

Basaglar T1DM: Summary

Pathophysiology of Type 1 Diabetes

Liver Diseases Overview

Primary Sclerosing Cholangitis (PSC)

Biological Products

Biologics and Protein Therapeutics

Regulation of Biosimilars

Quality and Ingredient Requirements

Country-Specific Definitions and Regulatory Guidelines

European Medicines Agency (EMA)

Introduction to Immunopathology

Organ Transplant Rejection: Class I MHC and Class II MHC Proteins
Organ Transplant Rejection: H...

Regulation of Biosimilars

Manufacturing Requirements

Biopharmaceuticals/Biologics

Biologics: Specific Subclass of Drug

HCV Infection

Risk Factors Associated With Transmission of HCV
Impact of the Epidemic
HCV Infection

Gaucher Disease: Overview

Clinical Manifestations

Immunogenicity

Immunogenicity: Introduction
Factors Influencing Immunogenicity
Factors Influencing Immuno...

Management of C1-INH-HAE

Overview of Management of C1-INH-HAE

Advancing Technologies

Biomarkers: Disease Process-Specific Biomarkers
Biomarkers: Inflammation Biomarkers
Biomar...

Proteins

Types of Cytokines
Protein Modifications
Manufacturing Biologic Proteins
Agonist

Hereditary Angioedema: Historical Perspective

Hereditary Angioedema: Historical Perspective

Classification Review and Diagnostic Considerations

Classification Review and Diagnostic Considerations

Typical Course of Plaque Psoriasis

Onset, Episodes, Flare-Ups, Triggers
Complications and Comorbidities of Psoriasis

Typical Course of Plaque Psoriasis

Complications and Comorbidities of Psoriasis

Hereditary Angioedema: Definitions

Hereditary Angioedema: Definitions

Currently Approved Therapies: Tysabri

Tysabri

Pathophysiology

Immunopathophysiology: T Cell Initiation of MS

Country-Specific Definitions and Regulatory Guidelines

Japanese Ministry of Health, Labour and Welfare (MHLW)

Pathophysiology

Immunopathophysiology: Myelin-Reactive T Cells
Immunopathophysiology: T Cell Initiation of MS -...

Inhaled Corticosteroids (ICS)

Important Features of Corticosteroid Therapy in the Treatment of Asthma
Corticosteroids: Cellul...

Inhaled Corticosteroids (ICS)

Important Features of Corticosteroid Therapy in the Treatment of Asthma

Inhaled Corticosteroids (ICS)

How Does Asthma Affect Respiration?

Inhaled Corticosteroids (ICS)

Asthma: Inflammation and Bronchospasm

Inhaled Corticosteroids (ICS)

Important Features of Corticosteroid Therapy in the Treatment of Asthma

Inhaled Corticosteroids (ICS)

Important Features of Corticosteroid Therapy in the Treatment of Asthma

Inhaled Corticosteroids (ICS)

Important Features of Corticosteroid Therapy in the Treatment of Asthma

Inhaled Corticosteroids (ICS)

Important Features of Corticosteroid Therapy in the Treatment of Asthma

Inhaled Corticosteroids (ICS)

Corticosteroids: Cellular Mechanisms of Action

Inhaled Corticosteroids (ICS)

Corticosteroids: Mechanisms of Action

Leukotriene Modifiers

Leukotriene Modifiers
Leukotriene Chemical Structure
Leukotriene Production
Leukotrie...

Long-Acting Beta 2 Adrenergic Agonists

Normal Anatomy and Physiology
Pathophysiology of Asthma
Beta 2 Adrenergic Receptor Mechani...

Inhaled Corticosteroids (ICS)

Corticosteroids

Inhaled Corticosteroids (ICS)

Normal Respiration

Inhaled Corticosteroids (ICS)

How Does Asthma Affect Respiration?
Asthma: Inflammation and Bronchospasm

Inhaled Corticosteroids (ICS)

Corticosteroid Mechanism of Action

Leukotriene Modifiers

Leukotriene Modifiers

Leukotriene Modifiers

Leukotriene Chemical Structure

Leukotriene Modifiers

Leukotriene Production

Leukotriene Modifiers

Leukotriene Receptors

Leukotriene Modifiers

Leukotriene Receptors

Leukotriene Modifiers

Inflammatory Events Initiated by Leukotriene Receptors

Leukotriene Modifiers

Leukotriene Modifiers

Leukotriene Modifiers

Leukotriene Receptors

Long-Acting Beta 2 Adrenergic Agonists

Normal Anatomy and Physiology

Long-Acting Beta 2 Adrenergic Agonists

Normal Anatomy and Physiology

Long-Acting Beta 2 Adrenergic Agonists

Normal Anatomy and Physiology

Long-Acting Beta 2 Adrenergic Agonists

Pathophysiology of Asthma

Long-Acting Beta 2 Adrenergic Agonists

Pathophysiology of Asthma

Long-Acting Beta 2 Adrenergic Agonists

Pathophysiology of Asthma

Long-Acting Beta 2 Adrenergic Agonists

Pathophysiology of Asthma

Long-Acting Beta 2 Adrenergic Agonists

Beta 2 Adrenergic Receptor Mechanism of Action

Long-Acting Beta 2 Adrenergic Agonists

Beta 2 Adrenergic Receptor Mechanism of Action

Long-Acting Beta 2 Adrenergic Agonists

Beta 2 Adrenergic Receptor Mechanism of Action

Long-Acting Beta 2 Adrenergic Agonists

Beta 2 Adrenergic Receptor Mechanism of Action

Long-Acting Beta 2 Adrenergic Agonists

Beta 2 Adrenergic Receptor Mechanism of Action

Long-Acting Beta 2 Adrenergic Agonists

Beta 2 Adrenergic Receptor Mechanism of Action

Steroids

SLE Treatments: Glucocorticoids

Steroids

Treatments: Steroids

Introduction: Psoriasis Treatment

Introduction: Psoriasis Treatment

Steroids

Glucocorticoids: Mode of Action
The Anti-Inflammatory Effects of Corticosteroids
Glucocort...

Steroids

Glucocorticoids: Mode of Action

Steroids

The Anti-Inflammatory Effects of Corticosteroids

Steroids

Glucocorticoids: Side Effects

Forms of Lupus

Drug-induced Lupus

Forms of Lupus

Cutaneous Lupus Erythematosus (CLE)

Lupus Introduction

Lupus Systemic Lupus Erythematosus (SLE)

Lupus Introduction

Historical Context

Lupus Introduction

Lupus Systemic Lupus Erythematosus (SLE)
Historical Context
Symptoms of Lupus

Lupus Introduction

Symptoms of Lupus

Forms of Lupus

Forms of Lupus

Forms of Lupus

Cutaneous Lupus Erythematosus (CLE)
Forms of Lupus
Systemic Lupus Erythematosus

Forms of Lupus

Systemic Lupus Erythematosus

Lupus Pathogenesis

Autoimmune Mechanisms

Forms of Lupus

Neonatal Lupus

Lupus Pathogenesis

Dysfunctional Response of the Immune System

Lupus Pathogenesis

Dysfunctional Response of the Immune System: Role of BAFF and Cytokines

Lupus Pathogenesis

Dysfunctional Response of the Immune System

Lupus Pathogenesis

Nephritis

Summary: Pathophysiology of Lupus

Summary: Pathophysiology of Lupus

Lupus Pathogenesis

Nephritis
Vasculitis

Lupus Pathogenesis

Vasculitis

Diagnosis of SLE

Hallmark Autoantibodies: Antiphospholipid Antibodies
Hallmark Autoantibodies: Rheumatoid Factor...

Diagnosis of SLE

Hematological Abnormalities
Hallmark Antibodies

Typical Clinical Course

Course of Disease

Epidemiology

Epidemiology of Systemic Lupus Erythematosus (SLE): Mortality and Survival
Epidemiology of Syst...

Epidemiology

Epidemiology of Systemic Lupus Erythematosus (SLE): Mortality and Survival

Epidemiology

Epidemiology of Systemic Lupus Erythematosus (SLE): Gender and Age of Onset

Epidemiology

Epidemiology of Systemic Lupus Erythematosus (SLE): Gender and Age of Onset

Epidemiology

Epidemiology of Systemic Lupus Erythematosus (SLE): Gender

Epidemiology

Epidemiology of Systemic Lupus Erythematosus (SLE): Geographical and Racial Distribution

Epidemiology

Epidemiology of Systemic Lupus Erythematosus (SLE): Geographical and Racial Distribution
Epidem...

Epidemiology

Epidemiology of Systemic Lupus Erythematosus (SLE): Prevalence and Incidence

Introduction: Clinical Presentation of Lupus

Introduction: Clinical Presentation of Lupus

Epidemiology

Epidemiology of Systemic Lupus Erythematosus (SLE): Cutaneous Lupus Erythematosus (CLE)

Typical Clinical Course

Clinical Features/Presentation

Epidemiology

Epidemiology of Systemic Lupus Erythematosus (SLE): Lupus Nephritis (LN)

Typical Clinical Course

Patient Scenario: SLE

Diagnosis of SLE

Hematological Abnormalities

Diagnosis of SLE

Hallmark Antibodies

Diagnosis of SLE

Hallmark Autoantibodies: Antiphospholipid Antibodies

Typical Clinical Course

Symptoms of SLE

Typical Clinical Course

Organ Systems Involved

Diagnosis of SLE

Hallmark Autoantibodies: Rheumatoid Factor (RF)

Diagnosis of SLE

1997 ACR Diagnostic Criteria: Limitations- Clinical Practice

Diagnosis of SLE

Characteristics of Patients with Mild SLE

Diagnosis of SLE

Standard Measures of Disease Activity Used in Clinical Trials: SLAM

Diagnosis of SLE

Standard Measures of Disease Activity Used in Clinical Trials: ECLAM

Diagnosis of SLE

Standard Measures of Disease Activity Used in Clinical Trials

Diagnosis of SLE

Standard Measures of Disease Activity Used in Clinical Trials: SLAM
Standard Measures of Diseas...

Diagnosis of SLE

Standard Measures of Disease Activity Used in Clinical Trials: SLEDAI

Diagnosis of SLE

Standard Measures of Disease Activity Used in Clinical Trials: SELENA-SLEDAI

Diagnosis of SLE

Standard Measures of Disease Activity Used in Clinical Trials: SLEDAI-2K
Standard Measures of D...

Diagnosis of SLE

Standard Measures of Disease Activity Used in Clinical Trials: SLEDAI-2K

Diagnosis of SLE

Differential Diagnosis
Lifelong Monitoring of SLE Patients

Diagnosis of SLE

Standard Measures of Disease Activity Used in Clinical Trials: SLICC/ACR Damage Index for SLE

Diagnosis of SLE

Standard Measures of Disease Activity Used in Clinical Trials: SLE Responder Index (SRI-4)

Diagnosis of SLE

Differential Diagnosis

Diagnosis of SLE

Lifelong Monitoring of SLE Patients

Complications/Comorbidities of SLE

Lupus Nephritis: 1974 WHO Classification of Lupus Nephritis (LN)

Complications/Comorbidities of SLE

Lupus Nephritis and End-Stage Renal Failure

Complications/Comorbidities of SLE

Lupus Nephritis: 1974 WHO Classification of Lupus Nephritis (LN)
Lupus Nephritis and End-Stage ...

Complications/Comorbidities of SLE

Complications/Comorbidities of SLE

Complications/Comorbidities of SLE

Lupus Nephritis: End-Stage Renal Failure

Complications/Comorbidities of SLE

Cardiovascular Disease (CVD)

Overlapping Diseases

SLE and Secondary Sjogren's Syndrome
SLE and Scleroderma
SLE and Overlapping Diseases ...

Complications/Comorbidities of SLE

Lupus Nephritis: 2003 ISN-RPS Classification of Lupus Nephritis (LN)

Complications/Comorbidities of SLE

Osteoporosis
Osteonecrosis (ON)

Complications/Comorbidities of SLE

Osteoporosis

Complications/Comorbidities of SLE

Shrinking Lung Syndrome

Complications/Comorbidities of SLE

Quality of Life in SLE

Overlapping Diseases

SLE and Secondary Sjogren's Syndrome

Overlapping Diseases

SLE and Scleroderma

Complications/Comorbidities of SLE

Neuropsychiatric and Neurocognitive Dysfunction

Complications/Comorbidities of SLE

Quality of Life in SLE

Complications/Comorbidities of SLE

Quality of Life in SLE

SLE Treatments: Immunosuppressants

Mycophenolate mofetil: Side Effects

SLE Treatments: Immunosuppressants

Mycophenolate mofetil: Efficacy in Lupus Nephritis

SLE Treatments: Immunosuppressants

Immunosuppressants: Azathioprine (AZA)
Azathioprine (AZA): Side Effects

SLE Treatments: Immunosuppressants

Immunosuppressants: Azathioprine (AZA)

SLE Treatments: Immunosuppressants

Azathioprine (AZA): Side Effects

SLE Treatments: Immunosuppressants

Mycophenolate mofetil: Side Effects
Mycophenolate mofetil: Efficacy in Lupus Nephritis
Imm...

SLE Treatments: Immunosuppressants

Immunosuppressants: Mycophenolate mofetil

SLE Treatments: Immunosuppressants

Cyclophosphamide (CTX) Limited by Significant Toxicity

SLE Treatments: Immunosuppressants

Cyclophosphamide (CTX) Limited by Significant Toxicity
Immunosuppressants: Cyclophosphamide (CT...

SLE Treatments: Immunosuppressants

Immunosuppressants: Cyclophosphamide (CTX)

SLE Treatments: Antimalarials

Antimalarials: Efficacy

SLE Treatments: Antimalarials

Antimalarials: Side Effects

SLE Treatments: Antimalarials

Antimalarials: Indicated for Use in SLE

SLE Treatments: Antimalarials

Antimalarials: Mode of Action

Steroids

Glucocorticoids: Efficacy

SLE Treatments: NSAIDs

NSAIDs in SLE

SLE Treatments: NSAIDs

Main Types of NSAIDs

SLE Treatments: NSAIDs

Mode of Action

SLE Treatments: NSAIDs

Indicated for Use in SLE

Therapies: Approved and Off-Label

Therapies: Approved
Therapies: Off-Label

Therapeutic Approach: Guidelines

Management of Lupus Nephritis (LN)

Therapies: Approved and Off-Label

Therapies: Approved

Therapies: Approved and Off-Label

Therapies: Off-Label

Therapeutic Approach: Guidelines

Management of Antiphospholipid Syndrome (APS) in SLE

Therapeutic Approach: Guidelines

Management of Lupus Nephritis (LN)
Management of Antiphospholipid Syndrome (APS) in SLE
Th...

Therapeutic Approach: Guidelines

Therapeutic Approach: Guidelines

Therapeutic Approach: Guidelines

Management of SLE: Treatment

SLE Treatments: NSAIDs

Main Types of NSAIDs
Mode of Action
Indicated for Use in SLE

Therapeutic Approach: Guidelines

Management of SLE: Adjunct Therapy

Therapeutic Approach: Guidelines

Management of Neuropsychiatric Systemic Lupus Erythematosus (NPSLE)

Therapeutic Approach: Guidelines

Management of Pregnancy in SLE

Introduction: Lupus Treatments

Treatment of SLE

Goals of Therapy

Goals of SLE Therapy

Lupus Risk Factors

Genetics

Lupus Pathogenesis

Autoimmune Mechanisms
Dysfunctional Response of the Immune System

Lupus Risk Factors

Genetics
Combination of Genetics and Environment

Lupus Risk Factors

Combination of Genetics and Environment

Lupus Risk Factors

Environment

Lupus Risk Factors

Triggers

Lupus Pathogenesis

Dysfunctional Response of the Immune System: Role of BAFF and Cytokines

Lupus Pathogenesis

Dysfunctional Response of the Immune System: B Cells and T Cells
Autoantibodies in SLE

Lupus Pathogenesis

Dysfunctional Response of the Immune System: B Cells and T Cells

Lupus Pathogenesis

Autoantibodies in SLE

Lupus Pathogenesis

Pathogenic Autoantibodies in SLE

Diagnosis of SLE

Hallmark Autoantibodies

Diagnosis of SLE

Hallmark Autoantibodies: Antibodies Directed Against Ribonucleoproteins

Diagnosis of SLE

Hallmark Autoantibodies: Complement

Diagnosis of SLE

1997 ACR Diagnostic Criteria: Limitations- Clinical Practice
Characteristics of Patients with M...

Diagnosis of SLE

1997 ACR Diagnostic Criteria: Limitations- Clinical Studies

Diagnosis of SLE

Standard Measures of Disease Activity Used in Clinical Trials: BILAG, SLAM, ECLAM

Complications/Comorbidities of SLE

Osteonecrosis (ON)

Overlapping Diseases

SLE and Overlapping Diseases (Overlap Syndrome)

Overlapping Diseases

SLE and Rheumatoid Arthritis (RA)

Overlapping Diseases

SLE and Myositis

Overlapping Diseases

SLE and Antiphospholipid Syndrome (APS)

Overlapping Diseases

Mixed Connective Tissue Disease

SLE Treatments: Immunosuppressants

Immunosuppressants: Methotrexate (MTX)
Methotrexate (MTX): Mode of Action
Methotrexate (MT...

SLE Treatments: Immunosuppressants

Immunosuppressants: Methotrexate (MTX)

SLE Treatments: Immunosuppressants

Methotrexate (MTX): Mode of Action

SLE Treatments: Immunosuppressants

Methotrexate (MTX): Side Effects

SLE Treatments: Immunosuppressants

Immunosuppressants: Cyclosporine A (CsA)
Cyclosporine A (CsA): Mode of Action
Cyclosporine...

SLE Treatments: Immunosuppressants

Immunosuppressants: Cyclosporine A (CsA)

SLE Treatments: Immunosuppressants

Cyclosporine A (CsA): Mode of Action

SLE Treatments: Immunosuppressants

Cyclosporine A (CsA): Efficacy in Proliferative LN

SLE Treatments: Immunosuppressants

Cyclosporine A (CsA): Side Effects

SLE Treatments: Immunosuppressants

Immunosuppressants: IVIg
IVIg: Case Reports
IVIg: Side Effects

SLE Treatments: Immunosuppressants

Immunosuppressants: IVIg

SLE Treatments: Immunosuppressants

IVIg: Case Reports

SLE Treatments: Immunosuppressants

IVIg: Side Effects

SLE Treatments: Immunosuppressants

Immunosuppressants: Leflunomide

SLE Treatments: Immunosuppressants

Immunosuppressants: Tacrolimus

SLE Treatments: Immunosuppressants

Immunosuppressants: Sirolimus

SLE Treatments: MAbs/Biologics

Monoclonal Antibodies (MAbs) Biologics: Introduction

SLE Treatments: MAbs/Biologics

Belimumab
Belimumab: Indication
Belimumab: Mechanism of Action
Belimumab: Dosage and ...

SLE Treatments: MAbs/Biologics

Belimumab

SLE Treatments: MAbs/Biologics

Belimumab: Indication

SLE Treatments: MAbs/Biologics

Belimumab: Mechanism of Action

SLE Treatments: MAbs/Biologics

Belimumab: Dosage and Administration

SLE Treatments: MAbs/Biologics

Belimumab: Clinical Trials
Belimumab: Clinical Trial 1(Phase II)
Belimumab Clinical Trials...

SLE Treatments: MAbs/Biologics

Belimumab: Clinical Trials

SLE Treatments: MAbs/Biologics

Belimumab: Clinical Trial 1(Phase II)

SLE Treatments: MAbs/Biologics

Belimumab Clinical Trials 2 and 3: Trial Design
Belimumab Clinical Trials 2 and 3: Study Endpo...

SLE Treatments: MAbs/Biologics

Belimumab Clinical Trials 2 and 3: Trial Design

SLE Treatments: MAbs/Biologics

Belimumab Clinical Trials 2 and 3: Trial Design

SLE Treatments: MAbs/Biologics

Belimumab Clinical Trials 2 and 3: Study Endpoints

SLE Treatments: MAbs/Biologics

Belimumab Clinical Trials 2 and 3: Efficacy

SLE Treatments: MAbs/Biologics

Belimumab Clinical Trials 2 and 3: Efficacy
Belimumab Clinical Trials 2 and 3: Warnings and Pre...

SLE Treatments: MAbs/Biologics

Belimumab Clinical Trials 2 and 3: Efficacy

SLE Treatments: MAbs/Biologics

Belimumab Clinical Trials 2 and 3: Warnings and Precautions

SLE Treatments: MAbs/Biologics

MAbs/Biologics: Rituximab
Rituximab: Mode of Action
Rituximab: Efficacy
Rituximab: Si...

SLE Treatments: MAbs/Biologics

MAbs/Biologics: Rituximab

SLE Treatments: MAbs/Biologics

Rituximab: Mode of Action

SLE Treatments: MAbs/Biologics

Rituximab: Efficacy

SLE Treatments: MAbs/Biologics

Rituximab: Side Effects

SLE Treatments: MAbs/Biologics

MAbs/Biologics: Abatacept
Abatacept: Efficacy
Abatacept: Side Effects

SLE Treatments: MAbs/Biologics

MAbs/Biologics: Abatacept

SLE Treatments: MAbs/Biologics

Abatacept: Efficacy

SLE Treatments: MAbs/Biologics

Abatacept: Side Effects

SLE Treatments: MAbs/Biologics

MAbs/Biologics: Infliximab
Infliximab: Mode of Action
Infliximab: Efficacy and Safety

SLE Treatments: MAbs/Biologics

MAbs/Biologics: Infliximab

SLE Treatments: MAbs/Biologics

Infliximab: Mode of Action

SLE Treatments: MAbs/Biologics

Infliximab: Efficacy and Safety

SLE Treatments: MAbs/Biologics

MAbs/Biologics: Eculizumab
MAbs/Biologics: Ustekinumab

SLE Treatments: MAbs/Biologics

MAbs/Biologics: Eculizumab

SLE Treatments: MAbs/Biologics

MAbs/Biologics: Ustekinumab

SLE Treatments: Other

Danazol

SLE Treatments: Other

Plasmapheresis

SLE Treatments: Other

Plasmapheresis

SLE Treatments: Other

Plasmapheresis

SLE Treatments: Other

Other: Dialysis
Other: Renal Transplantation
Combination Therapies

SLE Treatments: Other

Other: Dialysis

SLE Treatments: Other

Other: Renal Transplantation

SLE Treatments: Other

Combination Therapies

Emerging Therapies for SLE

Emerging Therapies for SLE

Summary: Psoriasis

Cytokines Trigger

Impact of Psoriasis

Psychosocial Impact: Impaired Relationships
Effect on Social, Personal and Work Life

Mechanisms of Action

Corticosteroid Mechanism of Action
Beta 2 Adrenergic Agonist
Leukotriene Modifiers

Mechanisms of Action

Corticosteroid Mechanism of Action

Mechanisms of Action

Beta 2 Adrenergic Agonist

Mechanisms of Action

Leukotriene Modifiers

Variables

Demographic and Comorbid Variables

IgE and Omalizumab

IgE and Omalizumab

FEV1: Forced Expiratory Volume

FEV1: Forced Expiratory Volume

PEF: Peak Expiratory Flow

PEF: Peak Expiratory Flow

Introduction: Psoriasis

Definition of Psoriasis
Psoriasis Skin Dysregulation

Introduction: Psoriasis

Definition of Psoriasis

Introduction: Psoriasis

Psoriasis Skin Dysregulation

Potential Factors in the Development of Psoriasis

Potential Factors in Etiology of Psoriasis
Genetic Factors
Infectious Factors
Drug an...

Potential Factors in the Development of Psoriasis

Potential Factors in Etiology of Psoriasis

Potential Factors in the Development of Psoriasis

Genetic Factors

Potential Factors in the Development of Psoriasis

Infectious Factors

Potential Factors in the Development of Psoriasis

Drug and Environmental Factors

Potential Factors in the Development of Psoriasis

Geographical Location

Potential Factors in the Development of Psoriasis

Stress

Potential Factors in the Development of Psoriasis

Sites of Trauma: Koebner Phenomenon

Physiology of Immune System Dysregulation

Overview of Immune Dysregulation

Physiology of Immune System Dysregulation

Dermal Dendritic Cell Activation

Physiology of Immune System Dysregulation

T Cell Activation

Physiology of Immune System Dysregulation

Cytokines
T Cell Cytokines

Physiology of Immune System Dysregulation

Cytokines

Physiology of Immune System Dysregulation

T Cell Cytokines

Physiology of Immune System Dysregulation

T Regulatory Cells (Tregs)
Cytokines Trigger

Physiology of Immune System Dysregulation

Keratinocytes and Cytokines
Keratinocyte Remodeling

Physiology of Immune System Dysregulation

T Regulatory Cells (Tregs)

Physiology of Immune System Dysregulation

Cytokines Trigger

Physiology of Immune System Dysregulation

Cytokines Trigger

Physiology of Immune System Dysregulation

Cytokines Trigger

Physiology of Immune System Dysregulation

Keratinocytes and Cytokines

Physiology of Immune System Dysregulation

Keratinocyte Remodeling

Physiology of Immune System Dysregulation

Pathophysiology of Psoriasis

Types of Psoriasis

Types of Psoriasis

Psoriatic Arthritis

Psoriatic Arthritis (PsA)

Psoriatic Arthritis

Pathophysiology of Psoriatic Arthritis (PsA)
Psoriatic Arthritis (PsA) Pathophysiology

Psoriatic Arthritis

Pathophysiology of Psoriatic Arthritis (PsA)

Psoriatic Arthritis

Psoriatic Arthritis (PsA) Pathophysiology

Psoriatic Arthritis

Psoriatic Arthritis (PsA) Pathophysiology

Summary: Psoriasis

Psoriasis Definition
Potential Factors in Etiology of Psoriasis
Pathophysiology of Psorias...

Summary: Psoriasis

Psoriasis Definition

Summary: Psoriasis

Potential Factors in Etiology of Psoriasis

Summary: Psoriasis

Pathophysiology of Psoriasis

Summary: Psoriasis

Cytokines Trigger
Types of Psoriasis

Summary: Psoriasis

Types of Psoriasis

Introduction: Psoriasis

Introduction: Psoriasis

Epidemiology

Prevalence: Definition

Clinical Features/Presentation

Manifestations: Overview

Epidemiology

Prevalence

Epidemiology

Incidence
Age of Onset
Gender and Age

Epidemiology

Incidence

Epidemiology

Age of Onset

Epidemiology

Gender and Age

Epidemiology

Mortality and Survival

Clinical Features/Presentation

Signs and Symptoms

Clinical Features/Presentation

Manifestations: Overview
Areas of Skin Involvement and Extent of Involvement
Types of Psor...

Clinical Features/Presentation

Areas of Skin Involvement and Extent of Involvement

Clinical Features/Presentation

Types of Psoriasis

Clinical Features/Presentation

Extracutaneous Manifestations

Typical Course of Plaque Psoriasis

Onset, Episodes, Flare-Ups, Triggers

Impact of Psoriasis

Overview: Impact of Psoriasis

Impact of Psoriasis

Psychological Impact: Depression, Anxiety, and Stress

Impact of Psoriasis

Psychosocial Impact: Impaired Relationships

Impact of Psoriasis

Effect on Social, Personal and Work Life

Impact of Psoriasis

Physical Impact

Impact of Psoriasis

Physical Impact

Impact of Psoriasis

Physical Impact

Psoriasis Therapies

OTC Topical Coal Tar

Impact of Psoriasis

Economic Impact
Occupational Impact

Impact of Psoriasis

Economic Impact

Impact of Psoriasis

Occupational Impact

Impact of Psoriasis

Patient Scenario 1

Impact of Psoriasis

Patient Scenario 2

Impact of Psoriasis

Patient Scenario 3

Diagnostic Methods of Criteria for Psoriasis

Physicians Who Diagnose Psoriasis
Diagnostic Methods
Typical Presentation at Diagnosis

Diagnostic Methods of Criteria for Psoriasis

Physicians Who Diagnose Psoriasis

Diagnostic Methods of Criteria for Psoriasis

Diagnostic Methods

Diagnostic Methods of Criteria for Psoriasis

Typical Presentation at Diagnosis

Diagnostic Methods of Criteria for Psoriasis

Patient History
Diagnostic Criteria

Diagnostic Methods of Criteria for Psoriasis

Patient History

Diagnostic Methods of Criteria for Psoriasis

Diagnostic Criteria

Diagnostic Methods of Criteria for Psoriasis

Differential Diagnosis

Diagnostic Methods of Criteria for Psoriasis

Severity of Psoriasis

Diagnostic Methods of Criteria for Psoriasis

No Widely Accepted Definition

Clinical Assessment Tools in Psoriasis

Clinical Assessment Tools

Summary: Psoriasis

Prevalence
Incidence
Cutaneous and Extracutaneous Manifestations
Onset, Episodes, Fla...

Summary: Psoriasis

Prevalence

Summary: Psoriasis

Incidence

Summary: Psoriasis

Cutaneous and Extracutaneous Manifestations

Summary: Psoriasis

Onset, Episodes, Flare-Ups, Triggers

Summary: Psoriasis

Complications and Comorbidities of Psoriasis

Summary: Psoriasis

Impact of Psoriasis

Summary: Psoriasis

Diagnostic Methods
Typical Presentation at Diagnosis
Severity of Psoriasis
Clinical A...

Summary: Psoriasis

Diagnostic Methods

Summary: Psoriasis

Typical Presentation at Diagnosis

Summary: Psoriasis

Severity of Psoriasis

Summary: Psoriasis

Clinical Assessment Tools

Goals of Treatment

Primary Treatment Goals
Patient Compliance and Adherence
Reasonable Expectations for Patie...

Goals of Treatment

Primary Treatment Goals

Goals of Treatment

Patient Compliance and Adherence

Goals of Treatment

Reasonable Expectations for Patients

Treatment Teams

Treatment Team
Emotional Support

Treatment Teams

Treatment Team

Treatment Teams

Emotional Support

Choice of Therapy

Benefit/Risk
Psoriasis Severity Affects Treatment Choice

Choice of Therapy

Benefit/Risk

Choice of Therapy

Psoriasis Severity Affects Treatment Choice

Treatment Guidelines

Overview of Treatment Guidelines
Guidelines for Treatment of Psoriasis Patients Limited Disease

Treatment Guidelines

Overview of Treatment Guidelines

Treatment Guidelines

Guidelines for Treatment of Psoriasis Patients Limited Disease

Treatment Guidelines

Management of Subtypes of Psoriasis Patients with Limited Disease
FDA Pregnancy Drug Risk Categ...

Treatment Guidelines

Management of Subtypes of Psoriasis Patients with Limited Disease

Treatment Guidelines

Management of Subtypes of Psoriasis Patients with Limited Disease

Treatment Guidelines

Management of Subtypes of Psoriasis Patients with Limited Disease

Treatment Guidelines

FDA Pregnancy Drug Risk Categories

Treatment Guidelines

Management of Subtypes of Psoriasis Patients with Limited Disease

Treatment Guidelines

Management of Subtypes of Psoriasis Candidates for UV-Based, Oral PUVA or Systemic Therapy
Mana...

Treatment Guidelines

Management of Subtypes of Psoriasis Candidates for UV-Based, Oral PUVA or Systemic Therapy

Treatment Guidelines

Management of Subtypes of Psoriasis Erythrodermic Psoriasis

Treatment Guidelines

Management of Subtypes of Psoriasis Adults with Palmoplantar Psoriasis

Treatment Guidelines

Management of Subtypes of Psoriasis Extensive Chronic Plaque Psoriasis

Psoriasis Therapies

Psoriasis Therapies

Psoriasis Therapies

Topical Overview

Psoriasis Therapies

Topical Glucocorticoids
Topical Glucocorticoids: Mechanism of Action

Psoriasis Therapies

Topical Glucocorticoids

Psoriasis Therapies

Topical Glucocorticoids: Mechanism of Action

Psoriasis Therapies

Topical Glucocorticoids: Therapeutic Regimens

Psoriasis Therapies

Therapeutic Efficacy: Plaque Psoriasis

Psoriasis Therapies

Therapeutic Efficacy: Scalp Psoriasis

Psoriasis Therapies

Topical Glucocorticoids: Adverse Effects

Psoriasis Therapies

Topical Vitamin D Analogs
Topical Vitamin D Analogs: Mechanism of Action
Topical Vitamin D...

Psoriasis Therapies

Topical Vitamin D Analogs

Psoriasis Therapies

Topical Vitamin D Analogs: Mechanism of Action

Psoriasis Therapies

Topical Vitamin D Analogs: Therapeutic Efficacy

Psoriasis Therapies

Topical Vitamin D Analogs: Adverse Effects

Psoriasis Therapies

Systemic Therapies: Methotrexate

Psoriasis Therapies

Topical Retinoids: Tazarotene
Therapeutic Efficacy: Tarazotene Use
Therapeutic Efficacy: C...

Psoriasis Therapies

Topical Retinoids: Tazarotene

Psoriasis Therapies

Therapeutic Efficacy: Tarazotene Use

Psoriasis Therapies

Therapeutic Efficacy: Combination Therapy

Psoriasis Therapies

Topical Retinoids: Adverse Effects
Topical Anthralin
Topical Anthralin: Therapeutic Use

Psoriasis Therapies

Topical Retinoids: Adverse Effects

Psoriasis Therapies

Topical Anthralin

Psoriasis Therapies

Topical Anthralin: Therapeutic Use

Psoriasis Therapies

OTC Topical Coal Tar
OTC Topical Salicylic Acid
OTC Moisturizers and Emollients

Psoriasis Therapies

OTC Topical Salicylic Acid

Psoriasis Therapies

OTC Moisturizers and Emollients

Psoriasis Therapies

Phototherapy Overview
Phototherapy Ultraviolet B (UVB) (290 to 320 nm)

Psoriasis Therapies

Phototherapy Overview

Psoriasis Therapies

Phototherapy Ultraviolet B (UVB) (290 to 320 nm)

Psoriasis Therapies

Photochemotherapy
Excimer Laser Therapy (High Energy 308 nm)

Psoriasis Therapies

Photochemotherapy

Psoriasis Therapies

Excimer Laser Therapy (High Energy 308 nm)

Psoriasis Therapies

Systemic Therapies: Methotrexate
Systemic Therapies Overview
Methotrexate: Mechanism of Ac...

Psoriasis Therapies

Systemic Therapies Overview

Psoriasis Therapies

Methotrexate: Mechanism of Action

Psoriasis Therapies

Methotrexate: Adverse Effects

Psoriasis Therapies

Methotrexate: Clinical Efficacy

Psoriasis Therapies

Systemic Therapies: Cyclosporine A (CsA)
Cyclosporine A (CsA): Mechanism of Action
Cyclosp...

Psoriasis Therapies

Systemic Therapies: Cyclosporine A (CsA)

Psoriasis Therapies

Cyclosporine A (CsA): Mechanism of Action

Psoriasis Therapies

Cyclosporine A (CsA): Clinical Efficacy

Psoriasis Therapies

Cyclosporine A (CsA): Adverse Effects

Psoriasis Therapies

Systemic Therapies: Retinoids
Retinoids: Mechanism of Action
Retinoids: Clinical Efficacy

Psoriasis Therapies

Systemic Therapies: Retinoids

Psoriasis Therapies

Retinoids: Mechanism of Action

Psoriasis Therapies

Retinoids: Clinical Efficacy

Psoriasis Therapies

Retinoids: Adverse Effects

Psoriasis Therapies

Systemic Therapies: Off-Label Agents
Off-Label Agents: Clinical Efficacy and Safety
Biolog...

Psoriasis Therapies

Systemic Therapies: Off-Label Agents

Psoriasis Therapies

Off-Label Agents: Clinical Efficacy and Safety

Psoriasis Therapies

Biologics: TNF-Targeted Agents

Psoriatic Arthritis Therapies

Psoriatic Arthritis Therapies: Overview
Treatment Recommendations

Psoriatic Arthritis Therapies

Psoriatic Arthritis Therapies: Overview

Psoriatic Arthritis Therapies

Treatment Recommendations

Psoriatic Arthritis Therapies

Symptomatic Treatment
Symptomatic Treatment: Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Psoriatic Arthritis Therapies

Symptomatic Treatment

Psoriatic Arthritis Therapies

Symptomatic Treatment: Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Psoriatic Arthritis Therapies

Disease-Modifying Anti-Rheumatic Drugs (DMARDs)
Disease-Modifying Anti-Rheumatic Drugs (DMARDs)...

Psoriatic Arthritis Therapies

Disease-Modifying Anti-Rheumatic Drugs (DMARDs)

Psoriatic Arthritis Therapies

Disease-Modifying Anti-Rheumatic Drugs (DMARDs): Biologics

Psoriatic Arthritis Therapies

Other Options

Summary: Psoriasis Treatments

Goals of Psoriasis Treatment
Choice of Therapy
Treatment Guidelines
Psoriasis Therapi...

Summary: Psoriasis Treatments

Goals of Psoriasis Treatment

Summary: Psoriasis Treatments

Choice of Therapy

Summary: Psoriasis Treatments

Treatment Guidelines

Summary: Psoriasis Treatments

Psoriasis Therapies

Summary: Psoriasis Treatments

Psoriatic Arthritis Therapies

Introduction: Psoriasis Therapies and Treatments

Introduction: Psoriasis Therapies and Treatments

Introduction: Biologics for Psoriasis

Biologics, What Are They?
Conventional Versus Biologic Therapies
Biologics: Administration

Introduction: Biologics for Psoriasis

Biologics, What Are They?

Introduction: Biologics for Psoriasis

Conventional Versus Biologic Therapies

Introduction: Biologics for Psoriasis

Biologics: Administration

Immunosuppression

Immunosuppression
Tuberculosis (TB)
Tuberculosis Testing and Monitoring

Immunosuppression

Immunosuppression

Immunosuppression

Tuberculosis (TB)
Tuberculosis Testing and Monitoring

Immunosuppression

Tuberculosis (TB)

Immunosuppression

Tuberculosis Testing and Monitoring

Guidelines for Use of Biologics

Choice of Therapy
Choice of Therapy: Treatment Choice and Guidelines

Guidelines for Use of Biologics

Choice of Therapy

Guidelines for Use of Biologics

Choice of Therapy: Treatment Choice and Guidelines

Biologic Targets

Pathology of Psoriasis
T-Cell Cytokines
Biologic Targets

Biologic Targets

Pathology of Psoriasis

Biologic Targets

T-Cell Cytokines

Biologic Targets

Biologic Targets

Biologic Targets

Structural Differences in TNF-Blocking Biologics
Functional Differences in TNF-Blocking Agents

Biologic Targets

Structural Differences in TNF-Blocking Biologics

Biologic Targets

Functional Differences in TNF-Blocking Agents

Biologic Targets

IL-12/23 Antibody

Adalimumab

Overview: Description
Indication
Dosage and Administration

Adalimumab

Overview: Description

Adalimumab

Indication

Adalimumab

Dosage and Administration

Adalimumab

Pivotal Trials
Pivotal Trials: Psoriasis Trial I
Psoriasis Trial I: Endpoints
Psorias...

Adalimumab

Pivotal Trials

Adalimumab

Pivotal Trials: Psoriasis Trial I
Psoriasis Trial I: Endpoints
Psoriasis Trial I: Efficacy

Adalimumab

Pivotal Trials: Psoriasis Trial I

Adalimumab

Psoriasis Trial I: Endpoints

Adalimumab

Psoriasis Trial I: Efficacy

Adalimumab

Pivotal Trials: Psoriasis Trial II
Psoriasis Trial II: Efficacy
Adverse Reactions

Adalimumab

Pivotal Trials: Psoriasis Trial II

Adalimumab

Psoriasis Trial II: Efficacy

Adalimumab

Adverse Reactions

Adalimumab

Adalimumab Warnings

Infliximab

Overview: Description of Infliximab
Infliximab Indication
Dosage and Administration

Infliximab

Overview: Description of Infliximab

Infliximab

Infliximab Indication

Infliximab

Dosage and Administration

Infliximab

Pivotal Trials: Overview
Psoriasis Trial I: Study Design
Psoriasis Trial II: Study Design

Infliximab

Pivotal Trials: Overview

Infliximab

Psoriasis Trial I: Study Design

Infliximab

Psoriasis Trial II: Study Design

Infliximab

Psoriasis Trial III: Study Design

Infliximab

Pivotal Trials: Endpoints

Infliximab

Pivotal Trials: Efficacy of Induction

Infliximab

Pivotal Trials: Efficacy of Maintenance
Infliximab Safety

Infliximab

Pivotal Trials: Efficacy of Maintenance

Infliximab

Infliximab Safety

Infliximab

Safety: Boxed Warning

Etanercept

Overview: Description of Etanercept
Etanercept Indication
Dosage and Administration

Etanercept

Overview: Description of Etanercept

Etanercept

Etanercept Indication

Etanercept

Dosage and Administration

Etanercept

Pivotal Trials: Overview
Psoriasis Trial I: Study Design
Psoriasis Trial II: Study Design

Etanercept

Pivotal Trials: Overview

Etanercept

Psoriasis Trial I: Study Design

Etanercept

Psoriasis Trial II: Study Design

Etanercept

Psoriasis Trials I and II: Endpoints

Etanercept

Pivotal Trials: Efficacy

Etanercept

Safety

Etanercept

Safety: Boxed Warning

Ustekinumab

Overview: Ustekinumab
Indication
Dosage and Administration

Ustekinumab

Overview: Ustekinumab

Ustekinumab

Indication

Ustekinumab

Dosage and Administration

Ustekinumab

Pivotal Trials: Overview
Pivotal Trials: Trial Design
Pivotal Trials: Endpoints
Pivot...

Ustekinumab

Pivotal Trials: Overview

Ustekinumab

Pivotal Trials: Trial Design

Ustekinumab

Pivotal Trials: Endpoints

Ustekinumab

Pivotal Trials: Efficacy
Efficacy: Effect of Patient Weight
Efficacy: Trial I through Week...

Ustekinumab

Pivotal Trials: Efficacy

Ustekinumab

Efficacy: Effect of Patient Weight

Ustekinumab

Efficacy: Trial I through Week 52

Ustekinumab

Ustekinumab Safety

Summary: Psoriasis and Biologics

Psoriasis
Immunosuppression
Choice of Therapy
Biologic Targets
Combination Thera...

Summary: Psoriasis and Biologics

Psoriasis

Summary: Psoriasis and Biologics

Immunosuppression

Summary: Psoriasis and Biologics

Choice of Therapy

Summary: Psoriasis and Biologics

Biologic Targets

Summary: Psoriasis and Biologics

Combination Therapy

Goals of Treatment

Patient Education and Goals

Monoclonal Antibodies in Action

Effector Mechanisms - Overview
Neutralization of Circulating Factor
Antibody-Dependent Cel...

TNF-Targeted Biologics in Current Use - Etanercept

Mechanism of Action: Etanercept

Pathophysiology

Summary of RA Pathology
Summary of RA Pathology: T Cells
Summary of RA Pathology: B Cells

Pathophysiology

Summary of RA Pathology

Pathophysiology

Summary of RA Pathology: T Cells

Pathophysiology

Summary of RA Pathology: B Cells
Summary of RA Pathology: Antigen Presentation
Summary of ...

Pathophysiology

Summary of RA Pathology: B Cells

Pathophysiology

Summary of RA Pathology: Antigen Presentation

Pathophysiology

Summary of RA Pathology: Direct and Indirect Production of Proinflammatory Cytokines

Pathophysiology

Summary of RA Pathology: Production of autoantibodies

NSAIDs

Mechanism of Action (MOA): NSAIDs and COX Enzymes

Glucocorticoids

Mechanism of Action (MOA): Glucocorticoids

Nonbiologic DMARDs: Methotrexate

Mechanism of Action (MOA): Dihydrofolate Reductase (DHFR)

Nonbiologic DMARDs: Leflunomide

Mechanism of Action (MOA): Leflunomide

Monoclonal Antibodies

Biologic Therapies

Monoclonal Antibodies

Monoclonal Antibody Structure

Monoclonal Antibodies

Monoclonal Antibody Production
Monoclonal Antibody Production: Knowledge Check

Monoclonal Antibodies

Monoclonal Antibody Production

Monoclonal Antibodies in Action

Effector Mechanisms - Overview

Monoclonal Antibodies in Action

Neutralization of Circulating Factor

Monoclonal Antibodies in Action

Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC)

Monoclonal Antibodies in Action

Complement Dependent Cytotoxicity (CDC)

Monoclonal Antibodies in Action

Receptor Binding: Cross-linking

Monoclonal Antibodies in Action

Receptor Binding: Blockade/activation

Monoclonal Antibodies in Action

Conjugate Delivery: Toxin/Radionuclide

Monoclonal Antibodies in Action

Conjugate Delivery: Antibody-Directed Enzyme Prodrug Therapy (ADEPT)

TNF-Targeted Biologics in Current Use - Infliximab

Mechanism of Action (MOA): Infliximab

Other Biologics in Current Use - Anakinra

Mechanism of Action (MOA): Anakinra & IL-1Ra

Biologics in Current Use - Abatacept

Mechanism of Action (MOA): Abatacept & CTLA4

Other Biologics in Current Use - Rituximab

Mechanism of Action (MOA): Rituximab

Pannus at the Cellular Level

Synovial Pannus

Joints Affected by RA

Joints Affected by RA

Joints Affected by RA

Joints Affected by RA
Synovitis and the Synovial Pannus
Synovial Joints
Exercise: Nor...

Joints Affected by RA

Synovitis and the Synovial Pannus

Pannus at the Cellular Level

Lymphocytes: T Cells and B Cells

B Cells in RA

B Cells in RA

T Cells in RA

T Cells in RA
Helper T Cells: CD4+
Type I and Type 2 Helper T Cells
Antigen-Presentin...

Joints Affected by RA

Synovial Joints

Pannus at the Cellular Level

Synovial Pannus
Lymphocytes: T Cells and B Cells
A Joint Affected by RA
The Synovium

Pannus at the Cellular Level

A Joint Affected by RA

Pannus at the Cellular Level

The Synovium

Pannus at the Cellular Level

Neutrophils

Pannus at the Cellular Level

Macrophages

Pannus at the Cellular Level

Osteoclasts

T Cells in RA

T Cells in RA

T Cells in RA

Helper T Cells: CD4+

T Cells in RA

Type I and Type 2 Helper T Cells

T Cells in RA

Antigen-Presenting Cell and Antigen Fragment on MHC

B Cells in RA

B Cells in RA
Antigen Presentation
Normal B Cells
Antigen Presentation by an APC

B Cells in RA

Antigen Presentation

B Cells in RA

Normal B Cells

B Cells in RA

Antigen Presentation by an APC

B Cells in RA

The B Cell as an APC

B Cells in RA

Autoantibody Production
Autoantibody Production: How Antibodies Work
Autoantibody Producti...

B Cells in RA

Autoantibody Production

B Cells in RA

Autoantibody Production: How Antibodies Work

B Cells in RA

Autoantibody Production: Macrophages

B Cells in RA

Autoantibody Production: Rheumatoid Factor

B Cells in RA

B Cell Receptors

B Cells in RA

Pro-Inflammatory Cytokine Production

Learning Objectives

Learning Objectives

Pathophysiology

The Inflammatory Process in RA

Introduction: Rheumatoid Arthritis

Introduction: Rheumatoid Arthritis

Pathophysiology

The Inflammatory Process in RA

The Inflammatory Process in RA

Proinflammatory Pathways

The Inflammatory Process in RA

Response Regulation

Pathophysiology

Role of T Cells: Migration and Activation

Pathophysiology

Role of T Cells: Expression

Pathophysiology

Role of B Cells

Pathophysiology

Antigen Presentation

Pathophysiology

Cytokine and Autoantibody Production

Pathophysiology

B-Cell Regulation: BAFF/TNF-Super-family

Diagnosis of RA

2010 Rheumatoid Arthritis Classification - Goal and Eligibility

Pathophysiology

Role of B Cells

Pathophysiology

Rheumatoid Factor (RF)

Pathophysiology

Role of RF-Producing B Cells

Pathophysiology

Anti-citrullinated protein antibodies (ACPA)

Pathophysiology

Autoantibodies

Pathophysiology

Roles of Other Immune System Cells

Learning Objectives

Learning Objectives

Diagnosis of RA

Clinical Measures - Synovial Fluid Analysis

Introduction

What Is Rheumatoid Arthritis? Chronic Inflammation

Introduction

What Is Rheumatoid Arthritis? Organ Involvement

Epidemiology

Prevalence

Epidemiology

Incidence

Epidemiology

Mortality and Survival

Disease Definition and Clinical Course

Clinical Features and Presentation

Disease Definition and Clinical Course

Course of Disease

Disease Definition and Clinical Course

Effect of Disease Modifying Therapy

Disease Definition and Clinical Course

Work Disability

Diagnosis of RA

Overview - Diagnosis of RA

Diagnosis of RA

2010 Rheumatoid Arthritis Classification

Diagnosis of RA

2010 Rheumatoid Arthritis Classification - Criteria

Diagnosis of RA

2010 Rheumatoid Arthritis Classification - Other Clinical Presentations

Diagnosis of RA

2010 Rheumatoid Arthritis Classification - Definitions

Diagnosis of RA

2010 Rheumatoid Arthritis Classification - Comparison to 1987 Classification

Diagnosis of RA

Clinical Measures - Overview

Diagnosis of RA

Clinical Measures - Complete Blood Cell (CBC) Count

Diagnosis of RA

Clinical Measures - Imaging Studies

Diagnosis of RA

Clinical Measures - Other Tests

Diagnosis of RA

Clinical Measures - Identification of Biomarkers

Diagnosis of RA

Clinical Measures - Biomarkers and Rheumatoid Factor

Diagnosis of RA

Clinical Measures - Measures used in Clinical Trials

Diagnosis of RA

Measures Used in Clinical Trials - Assessment of Joint Damage by X-Ray

Diagnosis of RA

Measures Used in Clinical Trials - ACR

Diagnosis of RA

Measures Used in Clinical Trials - DAS

Diagnosis of RA

Measures Used in Clinical Trials - EULAR

Diagnosis of RA

Differential Diagnosis

Complications of RA

Rheumatoid Nodules

Complications of RA

Complications of RA

Complications of RA

Major Organs Affected by RA

Risk Factors

Genetics and Environmental Factors

Risk Factors

Additional Postulated Risk Factors: Infectious Agents and Vaccination Complications

Risk Factors

Additional Postulated Risk Factors: Hormones and Education Level

Learning Objectives

Learning Objectives

Introduction

Introduction: Rheumatoid Arthritis Treatment

Therapeutic Approach

Therapeutic Approach: ACR Guidelines

Therapeutic Approach

Therapeutic Approach: Differences from Earlier ACR Recommendations

Analgesics

Analgesics

NSAIDs

Introduction: NSAIDs

Glucocorticoids

Glucocorticoids: Use in RA

Glucocorticoids

Use in RA: ACR Guidelines

Non-biologic DMARDs

Introduction: DMARDs

Non-biologic DMARDs

Antimalarials (hydroxychloroquine)

Non-biologic DMARDs

Sulfasalazine

Non-biologic DMARDs: Methotrexate

Introduction: Methotrexate (MTX)

Non-biologic DMARDs: Methotrexate

Methotrexate: Efficacy

Non-biologic DMARDs: Methotrexate

Pivotal Clinical Studies

Non-biologic DMARDs: Methotrexate

Pivotal Clinical Studies: Methotrexate

Non-biologic DMARDs: Methotrexate

Clinical Studies: Multidrug Combinations

Non-biologic DMARDs: Methotrexate

MTX in Combination: Two Year Randomized, Double-Blind, Placebo-Controlled Trial

Non-biologic DMARDs: Methotrexate

Methotrexate Use: RA Indication

Non-biologic DMARDs: Methotrexate

Methotrexate: Use Contraindications

Non-biologic DMARDs: Methotrexate

Methotrexate Dosage: Oral

Non-biologic DMARDs: Methotrexate

Methotrexate Dosage: Safety and Side Effects

Non-biologic DMARDs: Methotrexate

Safety Issues and Side Effects

Non-biologic DMARDs: Leflunomide

Introduction: Leflunomide

Non-biologic DMARDs: Leflunomide

Use: Indications, Contraindications, Safety Issues and Side Effects

Summary

Summary: Methotrexate (MTX)

Summary: RA Treatment Guidelines

Summary: RA Treatment Guidelines

Learning Objectives

Learning Objectives

Background on Biologic Therapies

Biologics in the Treatment of Rheumatoid Arthritis (RA)

Background on Biologic Therapies

Monoclonal Antibodies

Biologics in use for RA

Effector Mechanisms: TNFα

Biologics in use for RA

Effector Mechanisms: Inhibition of TNFα

Learning Objectives

Learning Objectives

Biologic DMARDs

Biologic DMARDs: Background

TNF-Targeted Biologics in Current Use - Etanercept

Use: Indication for Rheumatoid Arthritis, Dosage and Administration

Biologic DMARDs

Background: Adverse Events

TNF-Targeted Biologics in Current Use - Etanercept

Warnings: Etanercept

TNF-Targeted Biologics in Current Use - Infliximab

Use: Indication, Dosage and Administration for RA

TNF-Targeted Biologics in Current Use - Infliximab

Warnings: Infliximab

TNF-Targeted Biologics in Current Use - Adalimumab

Mechanism of Action: Adalimumab

TNF-Targeted Biologics in Current Use - Adalimumab

Use in RA: Indications, Dosage and Administration

TNF-Targeted Biologics in Current Use - Adalimumab

Dosage, Administration, and Warnings

TNF-Targeted Biologics in Current Use - Golimumab

Mechanism of Action: Golimumab

TNF-Targeted Biologics in Current Use - Golimumab

Use and Indication for RA: Golimumab

TNF-Targeted Biologics in Current Use - Golimumab

Warnings: Golimumab

TNF-Targeted Biologics in Current Use - Certolizumab Pegol

Mechanism of Action: Certolizumab Pegol

TNF-Targeted Biologics in Current Use - Certolizumab Pegol

Use, Indication for RA, Dosage and Administration: Certolizumab Pegol

TNF-Targeted Biologics in Current Use - Certolizumab Pegol

Warnings: Certolizumab Pegol

Other Biologics in Current Use - Anakinra

Use in RA, Indications, Dosage and Administration: Anakinra

Other Biologics in Current Use - Anakinra

Warnings: Anakinra

Biologics in Current Use - Abatacept

Use, Indication for RA, Dosage and Administration: Abatacept

Biologics in Current Use - Abatacept

Warnings: Abatacept

Other Biologics in Current Use - Rituximab

Use, Indication for RA, Dosage and Administration: Rituximab

Other Biologics in Current Use - Rituximab

Recommended Dose for Rheumatoid Arthritis and Concomitant Medications: Rituximab

Other Biologics in Current Use - Rituximab

Warnings: Rituximab

Other Biologics in Current Use - Tocilizumab

Mechanism of Action: Tocilizumab

Other Biologics in Current Use - Tocilizumab

Use, Indication, Dosage and Administration: Tocilizumab

Other Biologics in Current Use - Tocilizumab

Dosage Modifications: Tocilizumab

Other Biologics in Current Use - Tocilizumab

Warnings: Tocilizumab

Background of Clinical Trials

Initial studies with Monoclonal Antibodies

Background of Clinical Trials

Clinical Trials of Biologic RA Treatments

Clinical Trials of Biologic Agents

Introduction: Clinical Trials of Biologic Agents

Etanercept: Clinical Studies

Etanercept: Clinical Studies

Infliximab: Clinical Studies

Infliximab: Clinical Studies

Adalimumab: Clinical Studies

Adalimumab: Clinical Studies

Golimumab: Clinical Studies

Golimumab: Clinical Studies

Certolizumab Pegol: Clinical Studies

Certolizumab Pegol: Clinical Studies

Anakinra: Clinical Studies

Anakinra: Clinical Studies

Abatacept: Clinical Studies

Abatacept: Clinical Studies

Rituximab: Clinical Studies

Rituximab: Clinical Studies

Tocilizumab: Clinical Studies

Tocilizumab: Clinical Studies

Review of Clinical Trials and Meta-analyses of Biologic Agents

Comparisons of Clinical Trial Results

Review of Clinical Trials and Meta-analyses of Biologic Agents

Introduction: Review of Clinical Trials

Review of Clinical Trials and Meta-analyses of Biologic Agents

Biologic Treatments and Remission in Early RA

Review of Clinical Trials and Meta-analyses of Biologic Agents

Efficacy of Biologic Agent Monotherapy in MTX-Naive Patients

Review of Clinical Trials and Meta-analyses of Biologic Agents

Efficacy of Biologic Treatment and MTX Combination Therapy in MTX-Naive Patients

Review of Clinical Trials and Meta-analyses of Biologic Agents

Efficacy of Biologic Treatment and MTX Combination Therapy in MTX-Experienced Patients

Review of Clinical Trials and Meta-analyses of Biologic Agents

Efficacy of Combined Biologic Treatment and DMARD Therapy in DMARD-Experienced Patients

Review of Clinical Trials and Meta-analyses of Biologic Agents

Sequential Use of TNFα inhibitors

Review of Clinical Trials and Meta-analyses of Biologic Agents

Sequential Use of TNFα inhibitors: Comparing Studies

Anatomy and Physiology of the Skin: Introduction

Anatomy and Physiology of the Skin: Introduction

Anatomy and Physiology of the Skin: Introduction

Anatomy and Physiology of the Skin: Learning Objectives

Overview of Skin Structure and Function

Overview of Skin Structure and Function

Layers of the Skin: Epidermis

Layers of the Skin: Epidermis: Introduction

Layers of the Skin: Epidermis

Epidermis Layers

Layers of the Skin: Epidermis

Epidermal Layers

Layers of the Skin: Epidermis

Epidermal Functions: Keratinocyte Proliferation and Differentiation

Layers of the Skin: Epidermis

Epidermal Functions: Desquamation

Layers of the Skin: Epidermis

Other Cells of the Epidermis

Layers of the Skin: Dermal-Epidermal Junction, Dermis

Layers of the Skin: Dermal-Epidermal Junction, Dermis: Overview

Layers of the Skin: Dermal-Epidermal Junction, Dermis

Cells of the Dermis

Layers of the Skin: Dermal-Epidermal Junction, Dermis

Other Components of the Dermis

Layers of the Skin: Dermal-Epidermal Junction, Dermis

Other Components of the Dermis: Ground Substance

Immune System of the Skin

Immune System of the Skin: Overview

Immune System of the Skin

Skin Barrier

Immune System of the Skin

Innate-Acquired Immune System Interactions

Immune System of the Skin

Acquired Immune Responses

Immune System of the Skin

Acquired Immune Response Memory

Anatomy and Physiology of the Skin: Summary

Anatomy and Physiology of the Skin: Summary

Atopic Dermatitis: Introduction

Atopic Dermatitis: Introduction

Normal Skin Anatomy

The Structure and Function of Normal Skin

Definition of Atopic Dermatitis

Definition of Atopic Dermatitis

Epidemiology

Global Prevalence of AD

Epidemiology

Prevalence of AD in the United States

Epidemiology

Historical Trends in the Prevalence of AD

Natural History

Natural History

Risk Factors

AD and Environmental Risk Factors

Risk Factors

Genetic Risk Factors in AD

Pathophysiology

Phosphodiesterases and the Pathogenesis of AD

Diagnosis

Diagnostic Criteria for AD

Diagnosis

EASI

Diagnosis

The Patient-Oriented Eczema Measure (POEM)

Diagnosis

Biomarkers in AD