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    Oncology: Epidemiology

    Oncology: Sarcoma

    Oncology: Melanoma

    Oncology: Head and Neck

    Oncology Primer: Invasion and Metastasis

    Basics of Immunology of Cancer

    Oncology Primer: Immunology of Cancer

    Infectious Disease: HPV

    Oncology Primer: Therapy Principles

    Oncology Primer: Stem Cells

    Oncology Primer: Pathological Angiogenesis

    Oncology: Gastric Cancer

    Oncology: Non-Small Cell Lung Cancer

    Oncology Treatment: Axitinib

    Oncology Treatment: Temsirolimus

    Oncology Primer: Classification

    Oncology Primer: Mechanisms of Molecular Pathogenesis

    Oncology: Metastatic Breast Cancer

    Oncology: Multiple Myeloma

    Oncology: Prostate Testosterone and Hormone Treatment of Prostate Cancer

    Oncology Treatment: Temsirolimus

    Oncology Treatment: VEGF Receptor Signaling in Angiogenesis

    Oncology Primer: Overview

    Oncology Treatment: Antineoplastic

    Oncology: Prostate Testosterone and Hormone Treatment of Prostate Cancer

    Oncology Treatment: Avastin

    Oncology Treatment: Sorafenib

    Oncology Treatment: Target Drug Interactions

    Oncology: Prostate Cancer

    Biotech: Monoclonal Antibodies

    Oncology: Colorectal Cancer

    Oncology: Diagnostics for Targeted Care

    Biology: Angiogenesis

    Myelodysplastic Syndrome: Therapeutic Decisions

    Biology: DNA Binding Drugs

    Myelodysplastic Syndrome

    Myelodysplastic Syndrome: Changes in Apoptosis

    Reproduction: Gonadotropin-Releasing Hormone Antagonists

    Myelodysplastic Syndrome: Cytopenias

    Myelodysplastic Syndrome: Molecular and Cytogenetic Features

    Myelodysplastic Syndrome: Therapies

  • Microlearning Topics

  • Immuno-Oncology Workbook

    Oncology Epidemiology: Introduction

    Overview of Oncology Epidemiology

    Introduction

    The Zygote

    Oncology Epidemiology: Summary

    All Cancers: Death Per 100,000 People

    Introduction

    The Blastocyst

    Introduction

    Gastrulation

    Introduction

    Introduction: Sarcomas

    Introduction

    Implantation

    Conclusions

    Melanoma: Conclusions

    Introduction

    Introduction

    Introduction

    Implantation
    Gastrulation
    Ectodermal Germ Layer
    Endodermal Germ Layer
    Mesodermal...

    Introduction

    Embryonic Germ Layer

    Bone Sarcoma

    Current Treatments: Osteosarcoma - Chemotherapy

    Anatomy and Pathophysiology

    Head and Neck Anatomy

    Presentation and Diagnosis

    Incidence

    Presentation and Diagnosis

    Staging

    Current Treatment

    Palliative Therapy

    Current Treatment

    Protocols

    Bone Sarcoma

    Current Treatments: Ewing Sarcoma - Summary

    Bone Sarcoma

    Foundational Clinical Trials: Osteosarcoma - Survival Rates

    Introduction

    Introduction: Head and Neck Cancers

    Anatomy and Pathophysiology

    Clinical Examination: Biopsy

    Foundational Clinical Trials

    Adjuvant Therapy Trials: IFN-α

    Foundational Clinical Trials

    Metastatic Melanoma

    Foundational Clinical Trials

    Metastatic Melanoma

    Anatomy and Pathophysiology

    Risk Factors: Pathogens HPV

    Presentation and Diagnosis

    Clinical Presentation: Signs and Symptoms

    Presentation and Diagnosis

    Clinical Presentation: Physical Examination

    Presentation and Diagnosis

    Clinical Presentation: Staging Investigations

    Current Treatment

    Treatment Overview: Status and Goals

    Current Treatment

    Treatment Overview: Additional Treatment and Surveillance

    Current Treatment

    Curative Surgery

    Investigational Treatment Strategies

    VEGF

    Introduction

    Introduction: Soft Tissue and Bone Sarcomas

    Bone Sarcoma

    Anatomy and Pathophysiology: Osteosarcoma

    Bone Sarcoma

    Anatomy and Pathophysiology: Cellular Classification - Ewing Sarcoma

    Bone Sarcoma

    Anatomy and Pathophysiology: Hereditary

    Bone Sarcoma

    Anatomy and Pathophysiology: Osteosarcoma

    Bone Sarcoma

    Clinical Presentation and Diagnoses: Clinical Presentation and Evaluation

    Bone Sarcoma

    Clinical Presentation and Diagnoses: Physical Examination, Imaging and Biopsy

    Bone Sarcoma

    Clinical Presentation and Diagnoses: AJCC Staging

    Bone Sarcoma

    Current Treatments: Chondrosarcoma

    Introduction

    Introduction: Treatment for Head and Neck Cancers

    Angiogenesis

    Angiogenesis

    Intravasation

    Intravasation

    Introduction

    Endodermal Germ Layer

    Introduction

    Mesodermal Germ Layer

    Anatomy and Pathophysiology

    Superficial spreading melanoma

    Anatomy and Pathophysiology

    Prognostic Factors and Survival: Factors and Statistics

    Current Treatment

    Metastatic Melanoma

    Investigational Treatment Strategies

    Combination Strategies

    Investigational Treatment Strategies

    Investigational Clinical Trials

    Anatomy and Pathophysiology

    Cellular Classification: Nasopharyngeal Carcinoma

    Anatomy and Pathophysiology

    Cellular Classification: Salivary Gland Cancers

    Current Treatment

    Treatment Overview: Therapies and Treatment

    Current Treatment

    Radiation Therapy (RT): Complications

    Conclusions

    Conclusions: Head and Neck Treatment

    Soft Tissue Sarcomas (STSs)

    Anatomy and Pathophysiology: GIST

    Bone Sarcoma

    Clinical Presentation and Diagnoses: Bone Biopsy

    Extravasation

    Extravasation

    Introduction

    Ectodermal Germ Layer

    Anatomy and Pathophysiology

    Clinical Examination: Cutaneous Melanoma

    Current Treatment

    Response Rates of the Standard of Care Chemotherapies

    Anatomy and Pathophysiology

    Cellular Classification: Malignant Salivary Gland Neoplasms

    Presentation and Diagnosis

    Epidemiology

    Conclusions

    Conclusions: Head and Neck Cancer Epidemiology and Genetics

    Anatomy and Pathophysiology

    Patient Demographics

    Anatomy and Pathophysiology

    Staging

    Anatomy and Pathophysiology

    Metastasis and Early Tumor Progression

    Anatomy and Pathophysiology

    Mechanisms of Disease Development and Progression: Chemotherapy Resistance

    Current Treatment

    Salivary Gland Cancer

    Investigational Treatment Strategies

    Vaccines for HNSCC

    Bone Sarcoma

    Current Treatments: Osteosarcoma - Summary

    Anatomy and Pathophysiology

    Epidermal Growth Factor Receptor (EGFR)

    Anatomy and Pathophysiology

    Epidermal Growth Factor Receptor (EGFR)

    Foundational Clinical Trials

    Overview: Clinical Trials in Different Patient Populations

    Foundational Clinical Trials

    Adjuvant Therapy Trials: ECOG

    Anatomy and Pathophysiology

    Head and Neck Anatomy

    Anatomy and Pathophysiology

    Mechanisms of Disease Development and Progression: Immune System Evasion

    Current Treatment

    Impact of Disease and Treatment

    Current Treatment

    Radiation Therapy (RT): Treatment of HNSCC

    Current Treatment

    Chemotherapy (CTx): Toxicities of Treatment, HNSCC Chemotherapy Agents

    Current Treatment

    NCCN Treatment Guidelines

    Foundational Clinical Trials

    Concurrent Chemoradiation Regimens: Incidence of Acute Adverse Events

    Foundational Clinical Trials

    Induction Chemotherapy: VA Cooperative and RTOG 91-11 Studies

    Soft Tissue Sarcomas (STSs)

    Clinical Presentation and Diagnoses: STS with Painless Mass

    Soft Tissue Sarcomas (STSs)

    Clinical Presentation and Diagnoses: Regional Lymph Nodes

    Soft Tissue Sarcomas (STSs)

    Clinical Presentation and Diagnoses: Imaging

    Soft Tissue Sarcomas (STSs)

    Current Treatments: Soft Tissue Sarcomas Radiotherapy

    Soft Tissue Sarcomas (STSs)

    Current Treatments: Soft Tissue Sarcomas (STSs)

    Soft Tissue Sarcomas (STSs)

    Investigational Treatment Strategies: m-TOR

    Soft Tissue Sarcomas (STSs)

    Investigational Treatment Strategies: Tyrosine Kinase Inhibitors

    Soft Tissue Sarcomas (STSs)

    Investigational Treatment Strategies: Targeted Molecular Therapies

    Soft Tissue Sarcomas (STSs)

    Foundational Clinical Trials: Summary of Foundational Studies

    Bone Sarcoma

    Clinical Presentation and Diagnoses: Bone Sarcomas

    Bone Sarcoma

    Current Treatments: Ewing Sarcoma - Reccomendation

    Bone Sarcoma

    Foundational Clinical Trials: Incorporating Ifosfamide

    Bone Sarcoma

    Foundational Clinical Trials: Ewing Sarcoma

    Colonization

    Establishment of Metastases

    Anatomy and Pathophysiology

    Genetic Models of HNSCC Progression

    Anatomy and Pathophysiology

    Epidermal Growth Factor Receptor (EGFR)

    Current Treatment

    Metastatic Melanoma: Biochemotherapy (BCT)

    Current Treatment

    Summary: Metastatic Melanoma Therapies

    Foundational Clinical Trials

    Metastatic Melanoma: Combination Regimens

    Foundational Clinical Trials

    Metastatic Melanoma: Biologics

    Foundational Clinical Trials

    Metastatic Melanoma: IL-2

    Anatomy and Pathophysiology

    Risk Factors: Tobacco

    Current Treatment

    Treatment Overview: Head and Neck Cancers

    Current Treatment

    Chemotherapy (CTx): Advantages and Recommendations

    Current Treatment

    HPV-Positive HNSCC

    Investigational Treatment Strategies

    Tyrosine Kinase Inhibitors

    Investigational Treatment Strategies

    TGF Pathway

    Foundational Clinical Trials

    Radiotherapy Studies

    Foundational Clinical Trials

    Postoperative Radiotherapy and Chemoradiotherapy

    Foundational Clinical Trials

    New Targeted Therapies: Targeted Therapies as Single Therapies

    Foundational Clinical Trials

    Salivary Gland Cancer

    Soft Tissue Sarcomas (STSs)

    Current Treatments: Systemic Individual and Combination Chemotherapeutic Agents

    Soft Tissue Sarcomas (STSs)

    Current Treatments: Gastrointestinal Stromal Tumors (GIST)

    Soft Tissue Sarcomas (STSs)

    Current Treatments: Desmoid Sarcoma

    Soft Tissue Sarcomas (STSs)

    Investigational Treatment Strategies: Antiangiogenic Therapies

    Soft Tissue Sarcomas (STSs)

    Foundational Clinical Trials: Adjuvant Chemotherapy - GIST

    Soft Tissue Sarcomas (STSs)

    Foundational Clinical Trials: Resistance to Imatinib

    Soft Tissue Sarcomas (STSs)

    Foundational Clinical Trials: Neoadjuvant Chemotherapy

    Bone Sarcoma

    Anatomy and Pathophysiology: Cellular Classification - Osteosarcoma

    Bone Sarcoma

    Current Treatments: Osteosarcoma - Amputation and Survival

    Bone Sarcoma

    Foundational Clinical Trials: Chondrosarcoma

    Circulation

    Survival in Circulation

    Circulation

    Arrest at the Destination

    Incidence of Cancer in the U.S.

    Overall Incidence

    Incidence of Cancer in the U.S.

    Recent Trends

    Mortality of Cancer in the U.S.

    Recent Trends

    Anatomy and Pathophysiology

    Patient Demographics: Geography and Trends

    Anatomy and Pathophysiology

    Clinical Examination: Ocular Melanoma

    Anatomy and Pathophysiology

    Clinical Examination: Melanoma Detection and Location

    Anatomy and Pathophysiology

    Clinical Examination: Lentigo Maligna Melanoma (LMM)

    Anatomy and Pathophysiology

    Clinical Examination: Acral Lentiginous Melanoma (ALM)

    Anatomy and Pathophysiology

    Clinical Examination: Lymph Node Involvement

    Current Treatment

    NCCN Guidelines - Stage III and IV

    Current Treatment

    Treatment of Early-Stage Primary Melanoma

    Current Treatment

    Post-Surgical Adjuvant Therapy

    Current Treatment

    Metastatic Melanoma: Combination and Biologic Therapies

    Foundational Clinical Trials

    Metastatic Melanoma:Darthmouth Regimen

    Foundational Clinical Trials

    Metastatic Melanoma: CVD Regimen

    Foundational Clinical Trials

    Combination Chemotherapy Trials in Metastatic Melanoma: Stage IV Melanoma

    Investigational Treatment Strategies

    Investigational Clinical Trials: Immunotherapy

    Anatomy and Pathophysiology

    Cellular Classification: Squamous Cell Carcinoma

    Anatomy and Pathophysiology

    Risk Factors: Alcohol and Pathogens

    Current Treatment

    Chemotherapy (CTx): Concurrent Chemoradiotherapy (CRT), Induction Chemotherapy (IC)

    Current Treatment

    Chemotherapy (CTx): Recurrent, Unresectable, and Metastatic Cancer Chemotherapy

    Investigational Treatment Strategies

    Overview: Investigational Strategies in the Treatment of Head and Neck Cancers

    Investigational Treatment Strategies

    Evolution of Head and Neck Cancer Treatment

    Soft Tissue Sarcomas (STSs)

    Anatomy and Pathophysiology: Sites of Origin

    Soft Tissue Sarcomas (STSs)

    Clinical Presentation and Diagnoses: Biopsy and Biomarkers

    Soft Tissue Sarcomas (STSs)

    Clinical Presentation and Diagnoses: Staging

    Soft Tissue Sarcomas (STSs)

    Current Treatments: Soft Tissue Sarcomas (STSs)

    Soft Tissue Sarcomas (STSs)

    Current Treatments: Adjuvant and Neoadjuvant Chemotherapy

    Soft Tissue Sarcomas (STSs)

    Current Treatments: Chemotherapy - Additional Cycles

    Soft Tissue Sarcomas (STSs)

    Current Treatments: Visceral Disease

    Soft Tissue Sarcomas (STSs)

    Investigational Treatment Strategies

    Soft Tissue Sarcomas (STSs)

    Investigational Treatment Strategies: Novel Chemotherapies

    Soft Tissue Sarcomas (STSs)

    Foundational Clinical Trials: Limb-Sparing Surgery

    Soft Tissue Sarcomas (STSs)

    Foundational Clinical Trials: Surgery and Radiotherapy

    Soft Tissue Sarcomas (STSs)

    Foundational Clinical Trials: Adjuvant Radiotherapy

    Soft Tissue Sarcomas (STSs)

    Foundational Clinical Trials: Adjuvant Chemotherapy (SMAC)

    Soft Tissue Sarcomas (STSs)

    Foundational Clinical Trials: Adjuvant Chemotherapy - Survival

    Bone Sarcoma

    Novel Approaches to Bone Sarcoma

    Bone Sarcoma

    Investigational Treatment Strategies: Bone Sarcoma

    Conclusions and Future Directions

    Sarcomas: Conclusions and Future Directions

    Anatomy and Pathophysiology

    Genetic Models of HNSCC Progression
    Metastasis and Early Tumor Progression

    Anatomy and Pathophysiology

    Epidermal Growth Factor Receptor (EGFR)

    Anatomy and Pathophysiology

    Clinical Evaluation: Visual Examination

    Soft Tissue Sarcomas (STSs)

    Anatomy and Pathophysiology: Li-Fraumeni syndrome

    Conclusions and Future Directions

    Sarcomas: Therapy Key Points

    Prevalence of Cancer in the U.S.

    Overall Prevalence

    Anatomy and Pathophysiology

    Genetic Models of HNSCC Progression

    Anatomy and Pathophysiology

    Melanoma Risk Factors: Numerous Nevi and Genetics

    Soft Tissue Sarcomas (STSs)

    Clinical Presentation and Diagnoses: Biomarkers

    Cancer Immunotherapy

    Cancer Immunotherapy

    Mortality of Cancer in the U.S.

    Overall Mortality

    Current Treatment

    NCCN Guidelines - I IIa, IIb, and IIc

    Cancer Immunotherapy

    Cancer Immunotherapy

    Foundational Clinical Trials

    Combination Chemotherapy Trials in Metastatic Melanoma

    Foundational Clinical Trials

    Induction Chemotherapy: TAX 232 and TAX 324 Studies

    Soft Tissue Sarcomas (STSs)

    Anatomy and Pathophysiology: Genetic Considerations - Frequent Chromosomal Translocations in Sarcoma...

    Foundational Clinical Trials

    Metastatic Melanoma: Biochemotherapy (BCT)

    Soft Tissue Sarcomas (STSs)

    Anatomy and Pathophysiology: Genetic Considerations - Germline Mutations

    Soft Tissue Sarcomas (STSs)

    Clinical Presentation and Diagnoses: Epidemiology and Statistics

    Soft Tissue Sarcomas (STSs)

    Investigational Treatment Strategies: Soft Tissue Sarcoma Investigational Trials

    Bone Sarcoma

    Investigational Treatment Strategies: Selected Investigational Trials

    Bone Sarcoma

    Foundational Clinical Trials: Osteosarcoma - Aggressive Preoperative Chemotherapy

    Colonization

    Cancer Stem Cells

    Anatomy and Pathophysiology

    Melanoma Risk Factors: UV Exposure and Compromised Immune System

    Current Treatment

    Advanced Stage IV Melanoma: Second-Line Therapy

    Foundational Clinical Trials

    Primary Melanoma IFN-α Adjuvant Therapy

    Foundational Clinical Trials

    Metastatic Melanoma: PC Combination Regimen

    Foundational Clinical Trials

    Metastatic Melanoma: Biochemotherapy and Sequential vs. Concurrent BCT

    Investigational Treatment Strategies

    Therapeutic Interventions Against Molecular Mechanisms of Melanoma Progression

    Investigational Treatment Strategies

    Targeting the Molecular Pathways Controlling Tumor Cell Proliferation

    Investigational Treatment Strategies

    Pro-Apoptotic Agents & Chemosensitization to Overcome Drug Resistance: Chemosensitization

    Anatomy and Pathophysiology

    Mechanisms of Disease Development and Progression: Pathogenesis of HNSCC

    Investigational Treatment Strategies

    Epidermal Growth Factor Receptor (EGFR)

    Soft Tissue Sarcomas (STSs)

    Anatomy and Pathophysiology: Mechanisms of Disease Development and Progression

    Soft Tissue Sarcomas (STSs)

    Soft Tissue Sarcomas (STSs): Current Treatments

    Concepts in Cancer Immunology

    Cancer Immunoediting

    Innate Immunity

    Dendritic Cells and Antitumor Immunity

    Innate Immunity

    Innate Tumor Immunity: Macrophages

    Changes in Adhesion Molecules

    Integrins

    Matrix Proteolysis

    Matrix Metalloproteinases

    Colonization

    Formation of Pre-metastatic Niches

    Foundational Clinical Trials

    Metastatic Melanoma: Single-Agent Chemotherapy

    Foundational Clinical Trials

    Metastatic Melanoma: BCT Pooled Analyses

    Investigational Treatment Strategies

    Summary of Current and Investigational Agents: Classic Chemotherapeutics and Immunotherapies

    Investigational Treatment Strategies

    Summary of Current and Investigational Agents: Targeted Agents, Vaccines, and Adoptive Cell Transfer

    Investigational Treatment Strategies

    Investigational Clinical Trials: Targeting Angiogenesis

    Investigational Treatment Strategies

    Investigational Clinical Trials: Toll-Like Receptor Agonists

    Investigational Treatment Strategies

    Investigational Clinical Trials: Adoptive Cell Therapy

    Investigational Treatment Strategies

    Investigational Clinical Trials: Therapeutic Cancer Vaccines

    Investigational Treatment Strategies

    Investigational Clinical Trials: Vaccines and New Targeted Therapies

    Anatomy and Pathophysiology

    Risk Factors: Pathogens, UV Light Occupational and Radiation Exposures

    Current Treatment

    Radiation Therapy (RT): Radiation Fractionation, IMRT, Brachytherapy

    Foundational Clinical Trials

    Concurrent Chemoradiation Regimens: Standard of Care

    Foundational Clinical Trials

    Recurrent Unresectable/Metastatic HNSCC

    Soft Tissue Sarcomas (STSs)

    Anatomy and Pathophysiology: Soft Tissue Sarcomas

    Soft Tissue Sarcomas (STSs)

    Gastrointestinal Stromal Tumor (GIST)

    Soft Tissue Sarcomas (STSs)

    STSs: Mechanisms of Disease Development and Progression

    Soft Tissue Sarcomas (STSs)

    Anatomy and Pathophysiology: Familial Predisposition

    Soft Tissue Sarcomas (STSs)

    Investigational Treatment Strategies: Novel Routes of Drug Delivery and Combination Therapies

    Soft Tissue Sarcomas (STSs)

    Foundational Clinical Trials: Interpretation of Clinical Data

    Introduction: Basics of Immunology

    Introduction: Basics of Immunology

    Incidence of Cancer in the U.S.

    Most Common Cancers in Men and Women

    Anatomy and Pathophysiology

    Mechanisms of Disease Development and Progression: Immune Evasion and Immunosuppression, Angiogenesi...

    Anatomy and Pathophysiology

    Prognostic Factors and Survival: Ulceration and Tumor Depth, Lymph Node Involvement

    Investigational Treatment Strategies

    Targeting the Molecular Pathways Controlling Tumor Cell Proliferation: c-Kit

    Investigational Treatment Strategies

    Targeting the Molecular Pathways Controlling Tumor Cell Proliferation: Importance of Combination Str...

    Foundational Clinical Trials

    New Targeted Therapies: Molecular Therapies in HNSCC

    Anatomy and Pathophysiology

    Risk Factors: Diet, Oral Hygiene and Inherited Conditions

    Concepts in Cancer Immunology

    Cancer Immunosurveillance

    Invasion and Metastasis: Summary

    Invasion and Metastasis: Summary

    Cancer Survival Rates in the U.S.

    Overall Cancer Survival Rates

    Anatomy and Pathophysiology

    Mechanisms of Disease Development and Progression: Genetic Mutations and Impact

    Immunology of Cancer: Introduction

    Immunology of Cancer: Introduction

    Concepts in Cancer Immunology

    Cancer Immunosurveillance

    Childhood and Adolescent Cancers in the U.S.

    Incidence of Childhood Cancers

    Cancer Immunotherapy

    Adoptive T Cell Transfer

    Cancer Immunotherapy

    Cancer Vaccines

    Suppression of Tumor Immunity

    Overview of Immunosuppressive Mechanisms

    Innate Immunity

    Innate Tumor Immunity: Macrophages

    Suppression of Tumor Immunity

    Evasion of T Cell Recognition or Activation

    Investigational Treatment Strategies

    Pro-Apoptotic Agents & Chemosensitization to Overcome Drug Resistance: Pro-apoptotic Agents Under In...

    Innate Immunity

    Innate Tumor Immunity: Natural Killer Cells

    Adaptive T Cell Immunity

    Induction of Adaptive T Cell Immunity

    Adaptive T Cell Immunity

    Cytotoxic T Cells (CTLs) and Tumor Cell Killing

    Suppression of Tumor Immunity

    Evasion of T Cell Recognition or Activation

    Changes in Adhesion Molecules

    Changes Associated with Epithelial-Mesenchymal Transition

    Investigational Treatment Strategies

    c-Kit and HER-2, Carcinoembryonic Antigen (CEA) and Targeted Therapy Clinical Trials for HNSCC

    Innate Immunity

    Innate Versus Adaptive Immunity in Antitumor Responses

    Invasion and Metastasis: Introduction

    Overview of Cancer: Hallmark Capabilities of Cancer

    Innate Immunity

    Innate Versus Adaptive Immunity in Anti-tumor Responses

    Innate Immunity

    Dendritic Cells and Anti-tumor Immunity

    Adaptive T Cell Immunity

    Antigen Presentation and T Cell Activation

    Adaptive T Cell Immunity

    CD4+ T Helper Cells and Tumor Immunity

    Innate Immunity

    Innate Tumor Immunity: Natural Killer Cells

    Adaptive T Cell Immunity

    Induction of Adaptive T Cell Immunity

    Adaptive T Cell Immunity

    Cytotoxic T Cells (CTLs) and Tumor Cell Killing

    Cancer Immunotherapy: Adoptive T Cell Transfer

    Adoptive T Cell Transfer

    Basics of Immunology of Cancer

    Cancer Vaccines: Types of Cancer Vaccines

    Adaptive T Cell Immunity

    Antigen Presentation and T Cell Activation

    Adaptive T Cell Immunity

    CD4+ T Helper Cells and Tumor Immunity

    Suppression of Tumor Immunity

    Overview of Immunosuppressive Mechanisms

    HPV Testing

    Detect mRNA - Detect the Disease

    Cervical Cancer Progression Model

    Cervical Cancer Progression Model

    Learning Objectives

    Learning Objectives

    Cancer Therapy Principles: Introduction

    Cancer Therapy Principles: Overview

    Cancer Stem Cells: Definition of Terms

    Cancer Stem Cells: Definition of Terms

    Cancer Stem Cells: Learning Objectives

    Cancer Stem Cells: Learning Objectives

    Pathological Angiogenesis: Introduction

    Pathological Angiogenesis: Overview

    Learning Objectives

    Introduction

    Introduction

    Introduction

    Staging

    Performance Status (PS)

    Axitinib Targets

    Axitinib Targets

    Temsirolimus Signal Transduction

    Growth Factor Receptor Activation

    Chemotherapy

    Antitumor Antibiotics

    Targeted Therapies

    Therapies that Target Growth Factor Receptors

    Proangiogenic Factors, Processes, and Signaling Pathways

    Regulation of Angiogenesis

    Lung and Breast Carcinomas

    Classification of Lung and Breast Carcinomas

    Mechanisms of Molecular Pathogenesis: Introduction

    Mechanisms of Molecular Pathogenesis: Overview

    Targeted Therapies

    Types of Targeted Therapies

    Targeted Therapies

    Therapies that Target Oncogenic Fusion Proteins

    Immunotherapies

    CD Protein-Targeted Agents

    Hormone Therapy

    Anti-Androgens

    Overview of Breast Cancer

    Symptomatology and Diagnosis of Metastatic Breast Cancer

    Molecular and Cellular Basis

    Chromosomal Translocations

    Molecular and Cellular Basis

    Aneuploidy

    Molecular and Cellular Basis

    Drug Resistant Myeloma Cell Phenotype

    Clinical Progression

    Recurrent Infections

    The Mechanism of Action of GnRH Analogs

    Strategies to Block Testosterone Release: Castration

    Diagnosis of Stomach Cancer

    Tumor Nodes Metastasis (TNM) Staging

    Overview of Breast Cancer

    Staging and Performance Status

    Mechanisms of Molecular Pathogenesis: Summary

    Mechanisms of Molecular Pathogenesis: Summary

    Leukemias, Lymphomas, and Myelomas

    Classification of Lymphomas: Hodgkin Lymphomas

    Cancer Stem Cells: Definition of Terms

    Models of Tumor Development

    Cancer Stem Cells and Breast Cancer

    Breast Cancer Stem Cells and Metastasis

    Cancer Stem Cell Signaling

    Hedgehog Pathway and Cancer Stem Cells

    Cancer Stem Cells and Tumor Therapy

    Targeting the Notch Pathway: γ Secretase Inhibitors

    Cancer Stem Cells and Tumor Therapy

    Targeting the Notch pathway: Monoclonal Antibodies to Notch Receptors or Ligands

    Cancer Stem Cells and Tumor Therapy

    Additional Therapeutic Agents with Potential Anticancer Stem Cell Activity

    Locoregional Therapy

    Locoregional Therapy: Purpose

    Principles of Anti-Angiogenic Therapy

    mTOR Inhibitors

    Chemotherapy

    Platinum Agents

    Targeted Therapies

    Therapies that Target Pro-Angiogenic Factors

    Immunotherapies

    Immunomodulatory Drugs (IMiDs)

    Immunotherapies

    Vaccines

    Hormone Therapy

    Aromatase Inhibitors

    Cancer Therapy Principles: Summary

    Cancer Therapy Principles: Summary

    Introduction

    Multiple Myeloma (MM)

    Molecular and Cellular Basis

    Myeloma Cell Development

    Molecular and Cellular Basis

    Mutations

    Molecular and Cellular Basis

    Myeloma Cell Morphology

    Molecular and Cellular Basis

    Myeloma Immunophenotype

    Molecular and Cellular Basis

    Consequences of the Molecular and Cellular Changes

    Clinical Progression

    Myeloma Disease Progression

    Clinical Progression

    Hypercalcemia

    Clinical Progression

    Hypercalcemia: Symptoms

    Clinical Progression

    Anemia (Low Red Blood Cell Count)

    Clinical Progression

    Multiple Myeloma

    Classification and Staging

    Classification of Myeloma

    Classification and Staging

    Durie-Salmon Subclassifications

    Classification and Staging

    Treatment Options by Stage

    Adenylate Cyclase Pathway

    Inositol Triphosphate and Diacylglycerol: Activation and Catalyzation

    Temsirolimus Targets

    Temsirolimus Targets

    Sorafenib Signal Transduction

    PI3 Kinase, Rac1 and Cell Migration

    Overview of Gastric Cancer

    Regional Variations

    Diagnosis of Stomach Cancer

    Clinical Evaluation of Gastric Cancer

    Oncogenes

    Introduction to Proto-Oncogenes and Oncogenes

    Systemic Therapy

    Systemic Therapy: Purpose

    Systemic Therapy

    Administration Routes

    Leukemias, Lymphomas, and Myelomas

    Classification of Acute Myeloid Leukemia (AML)

    Leukemias, Lymphomas, and Myelomas

    Classification of Chronic Myeloid Leukemia (CML)

    Carcinomas

    Classification of Carcinomas Based on Tissue Localization or Invasion

    Carcinomas

    Classification of Carcinomas Based on Differentiation

    Leukemias, Lymphomas, and Myelomas

    Classification of Lymphomas

    Leukemias, Lymphomas, and Myelomas

    Classification of Myelomas

    The Hallmarks of Cancer

    Autonomous Growth Signaling

    Carcinomas

    Classification of Carcinomas with Mixed Histologies

    Cancer Stem Cells: Introduction

    Cancer Stem Cells: Introduction

    The Hallmarks of Cancer

    Evading Immune Destruction

    Chemotherapy

    Alkylating Agents

    Stochastic or Clonal Evolution Model

    Stochastic or Clonal Evolution Model

    Cancer Stem Cells From Different Tumor Types

    Isolation of Cancer Stem Cells from Other Tumor Types

    Cancer Stem Cell Signaling

    Cancer Stem Cells and Self-Renewal Pathways

    Cancer Stem Cell Signaling

    Wnt Pathway and Cancer Stem Cells

    Cancer Stem Cell Signaling

    Signaling and Cancer Stem Cells

    Cancer Stem Cells and Tumor Therapy

    Targeting the Hedgehog Pathway

    Principles of Anti-Angiogenic Therapy

    VEGF Pathway Inhibition

    The Hallmarks of Cancer

    Reprogramming Energy Metabolism

    Targeted Therapies

    Therapies that Target Other Intracellular Molecules

    Hematopoietic Stem Cell Transplantation

    General Principles of Hematopoietic Stem Cell Transplantation (HSCT)

    Introduction

    Monoclonal Gammopathy of Undetermined Significance (MGUS)

    Introduction

    Prevalence of Monoclonal Gammopathy of Undetermined Significance (MGUS)

    Introduction

    Myeloma Etiology

    Molecular and Cellular Basis

    Abnormal Plasma-like Myeloma Cells

    Molecular and Cellular Basis

    Transforming Mutations

    Molecular and Cellular Basis

    Angiogenesis

    Clinical Progression

    Myeloma Cell Growth

    Clinical Progression

    Bone Pain

    Clinical Progression

    Hypercalcemia
    Hypercalcemia: Symptoms

    Clinical Progression

    Renal Failure

    Clinical Progression

    Hyperviscosity Syndrome

    Classification and Staging

    Prognosis

    Summary

    Damaged Plasma Cells

    Summary

    Myeloma Symptoms

    Understanding Mechanisms

    Conclusion: Antineoplastic Therapies

    Understanding Mechanisms

    Introduction

    The Mechanism of Action of GnRH Analogs

    The Mechanism of Action of GnRH

    The Mechanism of Action of GnRH Analogs

    Strategies to Block Testosterone Release: Inhibition

    Adenylate Cyclase Pathway

    Adenylate Cyclase Pathway: Chemical Signal Pathways

    Adenylate Cyclase Pathway

    Binding GnRH

    Adenylate Cyclase Pathway

    Activated Receptor

    Prostate and Testes Anatomy

    Prostate and Testes Anatomy

    Agonist and Antagonist Cascade

    Agonist and Antagonist Cascade

    Humanized Monoclonal Antibody

    Humanized Monoclonal Antibody, Avastin Targets

    Humanized Monoclonal Antibody

    Production of Monoclonal Antibodies in Mammalian Cell Lines

    Sorafenib Signal Transduction

    Activating Mutations of Raf and Ras

    Sorafenib Signal Transduction

    Ras/Raf/MEK/ERK Signaling

    Sorafenib Signal Transduction

    Ras/PI3 Kinase Signaling

    Sorafenib Signal Transduction

    Cyclin Dependent Kinase Regulation of Cell Cycle Genes

    Sorafenib Signal Transduction

    Akt Signaling and Cell Survival

    Temsirolimus Signal Transduction

    Activation of Ras

    Temsirolimus Signal Transduction

    Akt Signaling and Cell Survival

    Staging

    TNM Lung Classification System

    Structure and Function of the Upper GI Tract

    Microanatomy of the Upper GI Tract

    Overview of Gastric Cancer

    Epidemiology of Gastric Cancer

    Types of Gastric Cancer

    Types of Gastric Cancer by Histology

    Diagnosis of Stomach Cancer

    Symptoms Associated with Gastric Cancer

    Diagnosis of Stomach Cancer

    Biomarkers Used in Gastric Cancer

    First-line Treatment Options

    Systemic Treatment Options for NSCLC: Targeted Therapy

    Additional Treatment Options

    First-line Treatment Recommendations Based on Stage and Genotype

    Additional Treatment Options

    Targeted Therapies in Clinical Trials

    Additional Treatment Options

    Targeted Therapies in Clinical Trials: Additional Targets

    Goals and Types of Therapy

    Goals of Therapy

    Systemic Therapy

    Sequencing of Combination Regimens

    Leukemias, Lymphomas, and Myelomas

    Classification of Acute Lymphocytic Leukemia (ALL)

    The Hallmarks of Cancer

    Primary Hallmark Capabilities of Cancer Cells

    Carcinomas

    Classification of Carcinomas Based on Growth Pattern

    Carcinomas

    Classification of Carcinomas Based on Secretory Properties

    Chemotherapy

    Principles of Chemotherapy

    Cancer Stem Cells and Breast Cancer

    Breast Cancer, Breast Micro-Anatomy

    Cancer Stem Cells and Tumor Therapy

    Therapeutic Options

    Cancer Stem Cells and Tumor Therapy

    Targeting the Wnt Pathway

    Tumor Vascularization

    Angiogenesis in Cancer

    Tumor Vascularization

    Abnormalities

    The Hallmarks of Cancer

    Evasion of Cell Death

    Chemotherapy

    Topoisomerase Inhibitors

    Targeted Therapies

    Therapies that Target Intracellular Kinases

    Immunotherapies

    Introduction to Immunotherapies

    Immunotherapies

    Tumor Cell Therapies

    Hormone Therapy

    Anti-Estrogens

    Hormone Therapy

    Luteinizing Hormone-Releasing Hormone (LHRH) Analogs

    Hematopoietic Stem Cell Transplantation

    Conditioning

    Introduction

    Spectrum of Diseases

    Classification and Staging

    Diagnostic Criteria

    Classification and Staging

    Staging

    Summary

    Defining Multiple Myeloma

    Understanding Mechanisms

    Mechanism of Action

    The Mechanism of Action of GnRH Analogs

    Mechanism of Testosterone Release

    Adenylate Cyclase Pathway

    Adenylate Cyclase Pathway: Receptors

    Sorafenib Signal Transduction

    VEGF Receptor Signaling in Angiogenesis

    Sorafenib Signal Transduction

    VEGF Production in Angiogenesis

    Sorafenib Signal Transduction

    Activation of Ras

    Sorafenib Signal Transduction

    Ras Activation of Raf/MEK/ERK

    Sorafenib Signal Transduction

    Ras/Raf/MEK/ERK Signaling

    Sorafenib Signal Transduction

    Akt Signaling and Proliferation

    Sorafenib Signal Transduction

    Activation of Class III Receptor Tyrosine Kinases

    Sorafenib Signal Transduction

    Jak/Stat Signaling and Gene Transcription

    Temsirolimus Signal Transduction

    Growth Factor Receptor Signaling in Tumorigenesis

    Temsirolimus Signal Transduction

    Akt Signaling Activation of mTOR and Proliferation

    Structure and Function of the Upper GI Tract

    Overview of Digestion

    Structure and Function of the Upper GI Tract

    Major Organs of the Digestive System

    Structure and Function of the Upper GI Tract

    Anatomy of the Upper GI Tract

    Diagnosis of Stomach Cancer

    Tumor Nodes Metastasis (TNM) Stages: Stage 0, Stage I-III, Stage IV

    First-line Treatment Options

    Introduction: First Time Treatment Options

    Leukemias, Lymphomas, and Myelomas

    Classification of Chronic Lymphocytic Leukemia (CLL)

    Cancer Overview: Introduction

    Cancer Overview: Welcome

    Sarcomas

    Cellular Classification

    The Cancer Stem Cell Model

    Cancer Stem Cell Model

    Origin of the Cancer Stem Cells

    Epithelial-to-Mesenchymal Transition and Cancer Stem Cells

    Cancer Stem Cells and Breast Cancer

    Localization and Differentiation of Mammary Stem Cells, Localization of Breast Cancers

    Cancer Stem Cells and Breast Cancer

    Evidence for Breast Cancer Stem Cells

    Cancer Stem Cells and Breast Cancer

    Breast Cancer Stem Cells and Main Breast Cancer Subtypes

    Cancer Stem Cell Signaling

    Notch Pathway and Cancer Stem Cells

    Cancer Stem Cells and Tumor Therapy

    Therapeutic Implications of Cancer Stem Cells

    Cancer Stem Cells and Tumor Therapy

    Antibody-Based Targeting of Stem Cell-Associated Markers

    Cancer Stem Cells and Tumor Therapy

    Induction of Cancer Stem Cell Differentiation

    Locoregional Therapy

    Locoregional Therapy: Surgery

    Locoregional Therapy

    Radiation Therapy

    Tumor Vascularization

    Intussusceptive Angiogenesis

    Tumor Vascularization

    Functions of Angiogenesis

    Sarcomas

    Classification of Sarcomas

    Proangiogenic Factors, Processes, and Signaling Pathways

    Proangiogenic Processes

    Proangiogenic Factors, Processes, and Signaling Pathways

    Intracellular Signaling Pathways

    The Hallmarks of Cancer

    Evasion of Growth Suppressors

    The Hallmarks of Cancer

    Induction of Sustained Angiogenesis

    The Hallmarks of Cancer

    Invasion and Metastasis

    Chemotherapy

    Antimetabolites

    Chemotherapy

    Microtubule Inhibitors

    Immunotherapies

    Immune Checkpoint Inhibitors

    Hormone Therapy

    Rationale and Types

    Anatomy and Pathophysiology

    Structure and Function of the Skin

    Introduction

    Prevalence of Multiple Myeloma

    Molecular and Cellular Basis

    Normal B Cell Development

    Cyclin-Dependent Kinases

    Regulation of the Cell Cycle

    Adenylate Cyclase Pathway

    Inositol Triphosphate and Diacylglycerol: Changes in Cell Function

    Hypothalamus and Pituitary Anatomy

    Hypothalamus and Pituitary Anatomy

    Sorafenib Signal Transduction

    Ras/Raf/MEK/ERK Signaling

    Temsirolimus Signal Transduction

    VEGF Production in Angiogenesis

    Overview of Gastric Cancer

    Gastric Cancer Definitions

    Overview of Gastric Cancer

    Gastric Cancer Epidemiology

    Overview of Gastric Cancer

    Quality of Life (QOL)

    First-line Treatment Options

    Other Locoregional Therapies

    Disease State

    Classification: NSCLC Classification Based on Genomics

    Treatment of Metastatic Breast Cancer

    Palliative Care

    Systemic Therapy

    Combination Regimens

    Carcinomas

    Classification of Carcinomas Based on Morphologic Characteristics

    Origin of the Cancer Stem Cells

    The Origin of the Cancer Stem Cells

    Experimental Validation of the Cancer Stem Cell Model

    Experimental Validation of Cancer Stem Cells

    Cancer Stem Cells and Breast Cancer

    Origination of Different Breast Cancer Subtypes

    Concepts in Cancer Immunology

    Cancer Immunoediting

    Epigenetic Mechanisms

    Epigenetic Mechanisms: Introduction

    Primary Cancer Categories

    Main Categories of Cancer

    Carcinomas

    Carcinoma Classification

    Tumor Vascularization

    Sprouting Angiogenesis

    The Hallmarks of Cancer

    Autonomous Proliferative Signaling

    The Hallmarks of Cancer

    Potential for Limitless Replication

    Chemotherapy

    Toxicities

    Chemotherapy

    Chemotherapy Resistance

    Hematopoietic Stem Cell Transplantation

    Stem Cell Collection

    Hematopoietic Stem Cell Transplantation

    Complications

    Summary

    Defining Multiple Myeloma
    Damaged Plasma Cells
    Myeloma Symptoms

    Epidemiology

    Overview of Lung Cancer Epidemiology and Cancer Rates

    Sorafenib Signal Transduction

    VEGF Receptor Signaling in Angiogenesis
    VEGF Production in Angiogenesis

    Sorafenib Signal Transduction

    Ras/Raf/MEK/ERK Signaling

    Sorafenib Signal Transduction

    Ras/Raf/MEK/ERK Signaling
    Cyclin Dependent Kinase Regulation of Cell Cycle Genes

    Non-Small Cell Lung Cancer: Introduction

    Non-Small Cell Lung Cancer: Introduction

    Disease State

    Classification Based on Histology

    Diagnosis of Stomach Cancer

    Diagnosis of Gastric Cancer

    Epidemiology

    Etiology

    First-line Treatment Options

    Targeted Therapies: ALK Inhibitors

    Additional Treatment Options

    Maintenance Therapy

    Treatment of Metastatic Breast Cancer

    Treatment Recommendations

    Genetic Instability

    Chromosomal Instability

    Environmental Mechanisms

    Environmental Mechanisms: Introduction

    Environmental Mechanisms

    Viral

    Terms and Definitions

    Cancer Terminology

    Leukemias, Lymphomas, and Myelomas

    Classification of Leukemias

    The Hallmarks of Cancer

    Enabling Characteristics

    Sarcomas

    Classification of Soft Tissue Sarcoma

    Cancer Classification: Introduction

    Cancer Classification: Welcome

    Anatomy and Pathophysiology

    Structure of the Epidermis

    Understanding Mechanisms

    Conclusion: Antineoplastic Therapies
    Introduction
    Mechanism of Action

    Disease State

    Classification: Squamous Cell Lung Carcinomas (SCCs)

    Sorafenib Signal Transduction

    Akt Signaling and Proliferation
    Ras/Raf/MEK/ERK Signaling
    Cyclin Dependent Kinase Regulati...

    Types of Gastric Cancer

    Stomach Cancer Etiology and Risk Factors

    Epidemiology

    Risk Factors

    First-line Treatment Options

    Locoregional Treatment

    First-line Treatment Options

    Locoregional Treatment: Radiation Therapy

    First-line Treatment Options

    Systemic Treatment Options for NSCLC

    Additional Treatment Options

    Second- and Third-line Treatment Recommendations

    Treatment Options and Guidelines

    Treatment Options for Metastatic Disease: Sipuleucel-T Immunotherapy

    Antibodies and the Immune System

    Therapeutic Monoclonal Antibodies

    Treatment of Metastatic Breast Cancer

    Treatment of Metastatic Breast Cancer: Introduction

    Tumor Suppressor Genes

    Tumor Suppressor Genes: Introduction

    Environmental Mechanisms

    Obesity

    Carcinomas

    Classification Based on Epithelial Cell Type

    Proangiogenic Factors, Processes, and Signaling Pathways

    Activators of Angiogenesis

    Genetic Instability

    Genetic Instability: Introduction

    Anatomy and Pathophysiology

    Structure of the Epidermis
    Structure and Function of the Skin

    Anatomy and Pathophysiology

    Structure of the Epidermis
    Structure and Function of the Skin

    Additional Treatment Options

    Physician Decision-Making and the Selection of Systemic Therapies for Advanced NSCLC

    Prostate Cancer Detection and Signs

    Symptoms of Prostate Cancer

    Prostate Cancer Staging

    Staging into Prognostic Groups

    Treatment Options and Guidelines

    Treatment Options for Localized Disease: Antiandrogens

    Lung and Breast Carcinomas

    Classification of Breast Carcinomas

    Lung and Breast Carcinomas

    Classification of Lung Carcinomas

    Introduction

    Multiple Myeloma (MM)
    Interactive Exercise: Cancer Vocabulary
    Spectrum of Diseases
    Pr...

    Clinical Progression

    Myeloma Cell Growth
    Myeloma Disease Progression
    Bone Pain
    Hypercalcemia
    Hypercal...

    Classification and Staging

    Classification of Myeloma
    Diagnostic Criteria
    Interactive Exercise: Myeloma Classification...

    Temsirolimus Signal Transduction

    Growth Factor Receptor Activation
    Growth Factor Receptor Signaling in Tumorigenesis
    Activa...

    First-line Treatment Options

    Targeted Therapies: EGFR and VEGF Inhibitors

    The Etiology of Prostate Cancer

    Prostate Cancer Staging

    The Gleason Grading System

    Overview of Colorectal Cancer

    Pathophysiology of CRC

    Tumors of the Central Nervous System

    Classification of CNS Tumors

    Molecular and Cellular Basis

    Abnormal Plasma-like Myeloma Cells
    Normal B Cell Development
    Myeloma Cell Development

    Targets for Cancer Therapies

    Breast Cancer: Role of HER Therapies
    Dysregulation: Many Causes
    Targeted Therapies
    Ta...

    Prostate Cancer Detection and Signs

    Detection of Prostate Cancer: Detection Methods

    Identifying Protein Expression

    The Right Treatment to the Right Patient at the Right Time
    Identifying Protein Expression
    ...

    Prostate Cancer Staging

    American Joint Committee on Cancer (AJCC) TNM System

    Treatment Options and Guidelines

    Treatment Options for Metastatic Disease:Recommendations

    Overview of Colorectal Cancer

    Symptoms of CRC

    Overview of Colorectal Cancer

    Deaths from CRC in the United States

    Overview of Colorectal Cancer

    Risk Factors for CRC

    Overview of Colorectal Cancer

    Non-Modifiable Risk Factors

    Management of Colorectal Cancer

    Management of Colorectal Cancer: Introduction

    Prostate Cancer: Introduction

    Prostate Cancer: Introduction

    Metastatic Breast Cancer: Introduction

    Metastatic Breast Cancer: Introduction

    Overview of Breast Cancer

    Risk Factors for Breast Cancer

    Overview of Breast Cancer

    Classification Based on Gene Expression

    Treatment of Metastatic Breast Cancer

    Overview of Systemic Treatment Options for Metastatic Breast Cancer

    Sorafenib Signal Transduction

    VEGF Receptor Signaling in Angiogenesis
    VEGF Production in Angiogenesis
    Activation of Ras

    Prostate Cancer and Precursor Lesions

    Classification of Prostate Cancers

    The Etiology of Prostate Cancer

    Role of Androgens

    The Etiology of Prostate Cancer

    Role of Genetic Factors

    Anatomy of the Prostate Gland

    Location and Function of the Prostate Gland

    The Epidemiology of Prostate Cancer

    United States Statistics

    The Epidemiology of Prostate Cancer

    Global Statistics of Prostate Cancer

    Treatment Options and Guidelines

    Treatment Options for Localized Disease: Standard Treatment Options

    Treatment Options and Guidelines

    Treatment Options for Metastatic Disease

    Colorectal Cancer: Introduction

    Overview of Colorectal Cancer

    Overview of Colorectal Cancer

    Anatomy of the Large Intestine

    Overview of Colorectal Cancer

    CRC Staging: Primary Tumor Categories

    Antibodies and the Immune System

    Therapeutic Monoclonal Antibodies
    Antibody Structure
    Antigen Binding
    Antibody Product...

    Overview of Breast Cancer

    Overview of Breast Cancer: Introduction

    Overview of Breast Cancer

    Breast Cancer Subtypes and Classification

    Overview of Breast Cancer

    Metastatic Breast Cancer: Common Sites and Progression

    Treatment Options and Guidelines

    Treatment Options for Localized Disease: Hormone Therapy

    Overview of Breast Cancer

    Breast Cancer Subtypes Based on Hormone Receptor Status

    Treatment of Metastatic Breast Cancer

    Targeted Agents Currently Under Development

    Management of Colorectal Cancer

    Overview of Stage IV (Metastatic) CRC

    Prostate Cancer Detection and Signs

    Detection of Prostate Cancer: The Prostate Specific Antigen (PSA) Test

    Treatment Options and Guidelines

    Treatment Options for Localized Disease: Radiation Therapy

    Prostate Cancer Risk Factors

    Primary Risk Factors

    Management of Colorectal Cancer

    Targeted Therapies

    Introduction

    Introduction

    Overview: Angiogenesis

    Functions of Angiogenesis

    Overview: Angiogenesis

    Regulation of Angiogenesis

    Overview: Angiogenesis

    Regulation of Angiogenesis: Inhibitors

    Overview: Angiogenesis

    Angiogenesis Process

    VEGF

    VEGF Family of Cytokines and Receptors

    VEGF

    VEGF Production

    VEGF

    MAP Kinase Pathway

    VEGF

    MAP Kinase Pathway and PI3 Kinase Pathway

    Pathological Angiogenesis

    Diseases Associated with Uncontrolled Angiogenesis

    Pathological Angiogenesis

    Angiogenesis in Cancer

    Pathological Angiogenesis

    Angiogenesis and Cancer: The Angiogenic Switch

    Pathological Angiogenesis

    Anti-angiogenesic Cancer Therapies

    Pathological Angiogenesis

    Anti-angiogenesic Cancer Therapies: VEGF Pathway Inhibition

    Summary: Angiogenesis

    Summary: Angiogenesis

    NCCN Guidelines

    International Prognostic Scoring System (IPSS)

    NCCN Guidelines

    Myelodysplastic Syndrome (MDS), Therapies for Myelodysplastic Syndromes, International Prognostic Sc...

    NCCN Guidelines

    Risk Category and Current Treatment Strategies

    Hypomethylating Agents

    Hypomethylating Agents

    Hypomethylating Agents

    Hypomethylating Agents

    Overview of Cell Activation, Cancer, and the Targets of Anticancer Drugs

    Normal Cell

    Overview of Cell Activation, Cancer, and the Targets of Anticancer Drugs

    Cancer Cell

    Overview of Cell Activation, Cancer, and the Targets of Anticancer Drugs

    Receptor Blockers

    Overview of Cell Activation, Cancer, and the Targets of Anticancer Drugs

    Enzyme Inhibitors

    Overview of Cell Activation, Cancer, and the Targets of Anticancer Drugs

    Transcription Repression

    Overview of Cell Activation, Cancer, and the Targets of Anticancer Drugs

    Antisense Molecules

    Overview of Cell Activation, Cancer, and the Targets of Anticancer Drugs

    DNA-Binding Molecules

    The Formation of the G-quadruplex structure

    Quadruplex Formation

    Overview of Cell Activation, Cancer, and the Targets of Anticancer Drugs

    Transcription

    The Formation of the G-quadruplex structure

    DNA Alkylation

    The Formation of the G-quadruplex structure

    Quadruplex Formation

    Anemia

    Neutropenia
    Symptoms of Anemia that Warrant Treatment
    Myelodysplastic Syndrome (MDS), Anem...

    NCCN Guidelines

    Components of NCCN Guidelines

    Anemia

    Iron Overload

    Anemia

    Iron Overload- Chelation Therapy
    Determining Which Patients Require Iron Chelation Therapy

    Anemia

    Iron Overload

    Anemia

    Neutropenia

    Presentation and Diagnosis

    Presentation: Asymptomatic and Symptomatic
    Presentation: Anemia Classification
    Diagnosis: ...

    Hypomethylating Agents

    Hypomethylating Agents

    Epidemiology and Incidence

    Increasing Incidence with Increasing Age of Myelodysplastic Syndromes

    Epidemiology and Incidence

    Gender and Myelodysplastic Syndromes

    Presentation and Diagnosis

    Presentation: Asymptomatic and Symptomatic
    Presentation: Anemia Classification

    Presentation and Diagnosis

    Presentation: Asymptomatic and Symptomatic

    Summary: Myelodysplastic Syndromes

    Defining Myelodysplastic Syndromes
    Apoptosis Followed by Proliferation
    Summary: Myelodyspl...

    Summary: Myelodysplastic Syndromes

    Defining Myelodysplastic Syndromes

    Classification and Prognosis

    Myelodysplastic Syndromes: French-American-British (FAB) Classification

    Presentation and Diagnosis

    Diagnosis: Blood Laboratory Findings (CBC Differential)

    Introduction to Myelodysplastic Syndromes

    Myelodysplastic Syndromes (MDS)
    Normal Hematopoiesis
    Normal Hematopoiesis: Pluripotent and...

    Introduction to Myelodysplastic Syndromes

    Abnormal Hematopoiesis: Cytopenia

    Introduction to Myelodysplastic Syndromes

    Myelodysplastic Syndromes (MDS)

    Introduction to Myelodysplastic Syndromes

    Normal Hematopoiesis
    Normal Hematopoiesis: Pluripotent and Multipotent Stem Cells
    Normal H...

    Introduction to Myelodysplastic Syndromes

    Normal Hematopoiesis

    Introduction to Myelodysplastic Syndromes

    Normal Hematopoiesis: Pluripotent and Multipotent Stem Cells

    Introduction to Myelodysplastic Syndromes

    Normal Hematopoiesis: Amplification of Committed Progenitor Cells

    Introduction to Myelodysplastic Syndromes

    Normal Hematopoiesis: Factors that Influence Hematopoietic Cell Proliferation, Differentiation and S...

    Introduction to Myelodysplastic Syndromes

    Abnormal Hematopoiesis: Cytopenia
    Abnormal Hematopoiesis: Later MDS and Abnormal Blood Cell Mor...

    Introduction to Myelodysplastic Syndromes

    Abnormal Hematopoiesis: Later MDS and Abnormal Blood Cell Morphology

    Introduction to Myelodysplastic Syndromes

    Abnormal Hematopoiesis: Early MDS

    Introduction to Myelodysplastic Syndromes

    Abnormal Hematopoiesis: Abnormal Cytogenetics

    Presentation and Diagnosis

    Presentation: Anemia Classification

    Presentation and Diagnosis

    Diagnosis: Blood Laboratory Findings (CBC Differential)
    Bone Marrow Aspirate and Biopsy
    Di...

    Presentation and Diagnosis

    Bone Marrow Aspirate and Biopsy
    Diagnosis: Blood Laboratory Findings and Bone Marrow Biopsy

    Presentation and Diagnosis

    Bone Marrow Aspirate and Biopsy

    Presentation and Diagnosis

    Diagnosis: Blood Laboratory Findings and Bone Marrow Biopsy

    Presentation and Diagnosis

    Diseases to Rule Out During MDS Diagnosis

    Epidemiology and Incidence

    Prevalence of Myelodysplastic Syndromes

    Epidemiology and Incidence

    Predisposing Causes of Myelodysplastic Syndromes Primary MDS (de novo MDS)

    Epidemiology and Incidence

    Increasing Incidence with Increasing Age of Myelodysplastic Syndromes
    Gender and Myelodysplasti...

    Epidemiology and Incidence

    Incidence of Myelodysplastic Syndromes

    Epidemiology and Incidence

    Is Incidence of Myelodysplastic Syndromes Increasing?

    Epidemiology and Incidence

    Causes of Myelodysplastic Syndromes Therapy-Related MDS (Secondary MDS)

    Classification and Prognosis

    Classification and Prognosis of Myelodysplastic Syndromes

    Classification and Prognosis

    Myelodysplastic Syndromes: French-American-British (FAB) Classification
    Classification and Prog...

    Summary: Myelodysplastic Syndromes

    Apoptosis Followed by Proliferation

    Classification and Prognosis

    Myelodysplastic Syndromes: World Health Organization (WHO) Classification

    Classification and Prognosis

    Myelodysplastic Syndromes: International Prognostic Scoring System (IPSS)

    Summary: Myelodysplastic Syndromes

    Summary: Myelodysplastic Syndromes Symptoms

    Summary: Myelodysplastic Syndromes

    Myelodysplastic Syndromes Prognosis by IPSS

    Changes in Apoptosis

    Changes in Apoptosis
    Deficiencies in Circulating Blood Cells
    Decreases in Apoptosis as MDS...

    Changes in Apoptosis

    Changes in Apoptosis

    Changes in Apoptosis

    Deficiencies in Circulating Blood Cells

    Changes in Apoptosis

    Decreases in Apoptosis as MDS Progresses

    Changes in Apoptosis

    Increases in Apoptotic Cytokine Production

    Cytopenias in MDS

    Anemia
    Anemia: Ineffective Erythropoiesis
    Anemia: Hypoproliferative Erythropoiesis
    An...

    Cytopenias in MDS

    Anemia
    Anemia: Ineffective Erythropoiesis
    Anemia: Hypoproliferative Erythropoiesis
    An...

    Cytopenias in MDS

    Anemia

    Cytopenias in MDS

    Anemia

    Cytopenias in MDS

    Anemia

    Cytopenias in MDS

    Anemia: Ineffective Erythropoiesis
    Anemia: Hypoproliferative Erythropoiesis
    Anemia: Red Bl...

    Cytopenias in MDS

    Anemia: Ineffective Erythropoiesis

    Cytopenias in MDS

    Anemia

    Cytopenias in MDS

    Anemia: Hypoproliferative Erythropoiesis

    Cytopenias in MDS

    Anemia: Red Blood Cell Loss/Bleeding

    Cytopenias in MDS

    Neutropenia

    Cytopenias in MDS

    Neutropenia

    Cytopenias in MDS

    Neutropenia

    Cytopenias in MDS

    Thrombocytopenia

    Cytopenias in MDS

    Thrombocytopenia

    Cytopenias in MDS

    Thrombocytopenia

    Mutations in Genes Responsible for Cell Proliferation

    Changes in Apoptosis and Proliferation
    Oncogenes
    Oncogenes: Small G Proteins (Ras)
    On...

    Mutations in Genes Responsible for Cell Proliferation

    Changes in Apoptosis and Proliferation

    Mutations in Genes Responsible for Cell Proliferation

    Oncogenes
    Oncogenes: Small G Proteins (Ras)
    Oncogenes: Transcription Factors (c-fos, c-myc...

    Mutations in Genes Responsible for Cell Proliferation

    Oncogenes

    Mutations in Genes Responsible for Cell Proliferation

    Oncogenes: Small G Proteins (Ras)

    Mutations in Genes Responsible for Cell Proliferation

    Oncogenes: Transcription Factors (c-fos, c-myc)

    Gene Silencing: DNA Methylation

    Epigenetic Changes: DNA Methylation
    CpG Islands and Histones Deacetylases
    Genes Affected b...

    Gene Silencing: DNA Methylation

    Epigenetic Changes: DNA Methylation

    Gene Silencing: DNA Methylation

    CpG Islands and Histones Deacetylases

    Gene Silencing: DNA Methylation

    Genes Affected by Methylation in MDS: Tumor Suppressor Genes

    Gene Silencing: DNA Methylation

    Genes Affected by Methylation in MDS: Tumor Suppressor Genes

    Gene Silencing: DNA Methylation

    Genes Affected by Methylation in MDS

    Chromosome Abnormalities in MDS

    Chromosomes
    Chromosomes: Number and Structure
    Interactive Activity: Chromosomes - Number a...

    Chromosome Abnormalities in MDS

    Chromosomes
    Chromosomes: Number and Structure
    Interactive Activity: Chromosomes - Number a...

    Chromosome Abnormalities in MDS

    Chromosomes

    Chromosome Abnormalities in MDS

    Chromosomes: Number and Structure
    Interactive Activity: Chromosomes - Number and Structure

    Chromosome Abnormalities in MDS

    Chromosomes: Number and Structure

    Chromosome Abnormalities in MDS

    Chromosomes: Karyotyping

    Chromosome Abnormalities in MDS

    Chromosomes: Mitosis

    Chromosome Abnormalities in MDS

    Chromosome Abnormalities: Translocations and Inversions
    Interactive Activity: Chromosomes Abnor...

    Chromosome Abnormalities in MDS

    Chromosome Abnormalities: Translocations and Inversions

    Chromosome Abnormalities in MDS

    Chromosome Abnormalities: Aneuploidy

    Chromosome Abnormalities in MDS

    Chromosomes: Fluorescence in situ Hybridization (FISH) Testing

    Cytogenetic Subgroups in MDS

    Cytogenetic Subgroups in MDS

    Chromosome Abnormalities in MDS

    Clonality and Karyotypic Evolution

    Chromosome Abnormalities in MDS

    Molecular Models for Chromosome Abnormalities

    NCCN Guidelines

    Risk Category and Current Treatment Strategies
    Components of NCCN Guidelines
    Therapeutic A...

    NCCN Guidelines

    NCCN Guidelines

    NCCN Guidelines

    International Prognostic Scoring System (IPSS)

    NCCN Guidelines

    Therapeutic Approaches for MDS Treatment

    NCCN Guidelines

    Classification and Prognosis

    NCCN Guidelines

    Classification and Prognosis: French-American-British (FAB)

    NCCN Guidelines

    Classification and Prognosis: French-American-British (FAB)

    NCCN Guidelines

    Classification and Prognosis: French-American-British (FAB)

    NCCN Guidelines

    Classification and Prognosis: French-American-British (FAB)

    NCCN Guidelines

    Myelodysplastic Syndrome (MDS), Therapies for Myelodysplastic Syndromes, Myelodysplastic Syndromes: ...

    NCCN Guidelines

    International Prognostic Scoring System (IPSS)
    Myelodysplastic Syndrome (MDS), Therapies for My...

    NCCN Guidelines

    International Prognostic Scoring System (IPSS)

    Hypomethylating Agents

    Mechanism of DNA Methylation
    Gene Silencing Following DNA Methylation
    Hypomethylating Agen...

    Anemia

    Symptoms of Anemia that Warrant Treatment

    Anemia

    Myelodysplastic Syndrome (MDS), Anemia, Supportive Care for Anemia

    Anemia

    Red Blood Cell Transfusion

    Anemia

    Red Blood Cell Transfusion

    Hypomethylating Agents

    Mechanism of DNA Methylation

    Hypomethylating Agents

    DNA Methylation

    Anemia

    Red Blood Cell Transfusion

    Hypomethylating Agents

    Gene Silencing Following DNA Methylation

    Hypomethylating Agents

    Gene Silencing Following DNA Methylation

    Hypomethylating Agents

    Gene Silencing Following DNA Methylation

    Anemia

    Iron Overload
    Iron Overload- Chelation Therapy
    Determining Which Patients Require Iron Che...

    Anemia

    Iron Overload-Organ Toxicity

    Transplantation

    Bone Marrow Transplantation
    Bone Marrow Transplantation: Autologous Stem Cell Transplantation

    Anemia

    Iron Overload-Organ Toxicity

    Transplantation

    Bone Marrow Transplantation

    Anemia

    Iron Overload-Organ Toxicity

    Transplantation

    Bone Marrow Transplantation: Autologous Stem Cell Transplantation

    Transplantation

    Bone Marrow Transplantation: Allogeneic Bone Marrow Transplantation

    Anemia

    Iron Overload- Chelation Therapy

    Anemia

    Determining Which Patients Require Iron Chelation Therapy

    Anemia

    Anemia and Hematopoietic Growth Factors: Erythroid Stimulating Agents (ESAs)

    Hypomethylating Agents

    Hypomethylating Agents

    Summary

    Treatment Decisions

    Lenalidomide

    Lenalidomide: Proposed Mechanism of Action
    Lenalidomide: Overview
    Lenalidomide: Indication...

    Lenalidomide

    Lenalidomide: Proposed Mechanism of Action

    Lenalidomide

    Lenalidomide: Overview

    Lenalidomide

    Lenalidomide: Indications

    Lenalidomide

    Lenalidomide: Dosage and Administration

    Lenalidomide

    Lenalidomide: Boxed Warnings

    Lenalidomide

    Lenalidomide: Clinical Studies

    Lenalidomide

    Lenalidomide: Adverse Reactions

    Anatomy

    Testosterone and Estrogen

    Anatomy

    Uterine Fibroids

    Anatomy

    Testosterone and Estrogen
    Uterine Fibroids
    Prostate Cancer
    Endometriosis
    Product...

    Anatomy

    Prostate Cancer

    Introduction: Neurocrine GnRH

    Introduction: Neurocrine GnRH

    Anatomy

    Endometriosis

    Anatomy

    Production of Hormones

    Science Normal Hormone Cascade

    GnRH (Gonadotropin Releasing Hormone)

    Agonist and Antagonist Cascade

    GnRH Block Signaling
    Release of LH/FSH
    Antagonist-Based Therapies

    Agonist and Antagonist Cascade

    GnRH Block Signaling

    Agonist and Antagonist Cascade

    Release of LH/FSH

    Agonist and Antagonist Cascade

    Antagonist-Based Therapies

    Summary: Cytopenias in Myelodysplastic Syndromes

    Apoptosis and Cytopenias

    Summary: Cytopenias in Myelodysplastic Syndromes

    Treatment for Anemia: Transfusion

    Summary: Cytopenias in Myelodysplastic Syndromes

    Transfusion and Iron Overload: Pros and Cons

    Summary: Cytopenias in Myelodysplastic Syndromes

    Transfusion and Iron Overload: Iron Chelators

    Summary: Cytopenias in Myelodysplastic Syndromes

    Hematopoietic Growth Factors

    Mutations in Genes Responsible for Cell Proliferation

    Oncogenes: Tyrosine Kinases

    Mutations in Genes Responsible for Cell Proliferation

    Oncogenes: Tyrosine Kinases

    Mutations in Genes Responsible for Cell Proliferation

    Oncogenes: Tyrosine Kinases

    Mutations in Genes Responsible for Cell Proliferation

    Oncogenes: Transcription Factors (c-fos, c-myc)

    Pharmacological Approaches

    Pharmacological Approaches for MDS Treatment

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