Genetic Epidemiology

Genetic Epidemiology

Genetic Markers

Genetic Markers: Single Nucleotide Polymorphisms (SNPs)

Genetic Markers

Genetic Markers

Genetic Variation

Genetic Variation

Genetic Variation

Genetic Mutations

Genetic Epidemiology

Analytic Study Designs

Mendelian Genetics

Modes of Inheritance and Pedigrees

Mendelian Genetics

Pedigrees

Genetic Markers

Genetic Advances and Technologies: DNA Sequencing and Dideoxynucleotide

Genetic Markers

Genetic Advances and Technologies: Human Genome Project

Mendelian Genetics

Mendelian Genetics and History of Cholesterol and Atherosclerosis

Basics of DNA

Building Proteins and Universal Genetic Code

Genetic Markers

Genetic Advances and Technologies: Advances Since the Human Genome Project

Genetic Markers

Genetic Advances and Technologies: Polymerase Chain Reaction and Primer

Genetic Markers

Genetic Advances and Technologies: Next Generation Sequencing (NGS)

Genetic Epidemiology

Analyzing Study Data: Confounding

Mendelian Genetics

History of Cholesterol and Atherosclerosis: 1950s to 1970s

Mendelian Genetics

History of Cholesterol and Atherosclerosis

Mendelian Genetics

Mendel's Law of Segregation

Mendelian Genetics

Mendel's Law of Independent Assortment

Linkage Analysis

Linkage

Genetic Epidemiology

Selected Analytic Study Designs

Genetic Epidemiology

Analyzing Study Data

Mendelian Genetics

Sex-Linked (X-Linked) Inheritance

Cell Division

Mitosis

Cell Division

Meiosis

Emerging Hypotheses on Treatment

Genetic Concepts: MS Genomics

Lupus Risk Factors

Genetics

Linkage Analysis

Complex Traits

Triplet Repeat Disorders

Triplet Repeat Expansions

Basics of DNA

The Units of Heredity

Introduction

Etiology: Genetic Factors

Introduction

Etiology: Genetic Factors

Introduction

Etiology: Genetic Factors

Lupus Risk Factors

Genetics
Combination of Genetics and Environment

Mosaicism

Mosaicism

Mosaicism

Somatic Mosaicism

Pathology

Genetic Alterations: Gene Mutations

Disease State

Genetic Risk Factors

Complex Inheritance

Complex Inheritance, Variations on Dominance, Polygenic Traits, Pleiotropy, Penetrance and Expressiv...

Genetic Instability

Genetic Instability: Introduction

Autoimmune Disease Processes

The Etiology of Autoimmune Disease: Genetic Factors (Risk)
The Etiology of Autoimmune Disease: ...

Liver Diseases Overview

Genetic Diseases, Hereditary Hemochromatosis

Linkage Analysis

Calculating Linkage

Linkage Analysis

Logarithm of the Odds (LOD) Score

Triplet Repeat Disorders

Fragile X Syndrome

Genomic Imprinting

Uniparental Disomy

Basics of DNA

Functions of Non-Coding DNA

Basics of DNA

Non-Coding DNA

Basics of DNA

Human Chromosomes and Karyotypes

Triplet Repeat Disorders

Huntington's Disease

Basics of DNA

Structure of DNA

Genomic Imprinting

Triplet Repeat Expansion

Mitochondrial Mutations

Mitochondrial Mutations

Mosaicism

X-Inactivation, Dosage Compensation, and Alport Syndrome (AS)

Basics of DNA

Human Genomic Landscape

Epidemiology

Risk Factors - Genetic Predisposition

Etiology

Genetics

Overview of Obesity

Genetics

BED Pathophysiology

Dopamine Dysregulation: Genetic Factors

Pathology

Genetic Alterations

Etiology

Genetic Factors

Triplet Repeat Disorders

Huntington's Disease: Huntingtin Gene (HTT)

Genomic Imprinting

Genomic Imprinting: Prader-Willi Syndrome (PWS) and Angelman Syndrome (AS)

Clopidogrel

Genetic Variation

Summary: DNA Discovery and Structure

DNA: The Genetic Material

Lupus Risk Factors

Combination of Genetics and Environment

Etiology of Multiple Sclerosis

Genetic Factors: Complex Interactions

Genetics of Sanfilippo Syndrome

Molecular Etiology

Risk Factors

Genetic Risk Factors in AD

Etiology and Pathophysiology

Genetic Predisposition

Potential Factors in the Development of Psoriasis

Genetic Factors

Genetics

APOE and Cholesterol Metabolism

Anatomy and Pathophysiology

Genetic Models of HNSCC Progression

Risk Factors

Genetics and Environmental Factors

The Etiology of Prostate Cancer

Role of Genetic Factors

Etiology of Multiple Sclerosis

Genetic Factors: MS Concordance
Genetic Factors: Major Histocompatibility Complex II (MHCII)

Genetics of Hunter Syndrome

Molecular Etiology

Hemostasis

Disorders of Hemostasis: Abnormal Bleeding

Autoimmune Disease Processes

The Etiology of Autoimmune Disease: Genetic Factors (Risk)

Autoimmune Disease Processes

The Etiology of Autoimmune Disease: Genetic Factors (Introduction)

Autoimmune Disease Processes

The Etiology of Autoimmune Disease
The Etiology of Autoimmune Disease: Genetic Factors (Risk)

Soft Tissue Sarcomas (STSs)

Anatomy and Pathophysiology: Genetic Considerations - Germline Mutations

Non-modifiable Risk Factors

Genetics: Familial DAD

Non-modifiable Risk Factors

Genetics: Sporadic DAD - Isoform ApoE4

Etiology of Multiple Sclerosis

Genetic Factors: MS Concordance
Genetic Factors: Major Histocompatibility Complex II (MHCII)

Lysosomal Storage Disorders: Overview and Definition

Genetics

Diagnosis of Fabry Disease

Diagnostic Tests: Enzyme Assay and Molecular Genetic

Coronary Atherosclerosis: Overview

Genetic Predisposition

Conclusions

Conclusions: Head and Neck Cancer Epidemiology and Genetics

Introduction

Etiology: Genetic Factors

Autoimmune Disease Processes

The Etiology of Autoimmune Disease: Genetic Factors (Chromosomal Evidence: The Importance of HLA)

Introduction

Candidate Biomarkers in AD Based on Genetic Profile

Anatomy and Pathophysiology

Genetic Models of HNSCC Progression
Metastasis and Early Tumor Progression

Anatomy and Pathophysiology

Melanoma Risk Factors: Numerous Nevi and Genetics

Autoimmune Disease Processes

The Etiology of Autoimmune Disease: Genetic Factors (Family and Population Studies)

Additional concepts in MS Therapy

Genetic Concepts

Soft Tissue Sarcomas (STSs)

Anatomy and Pathophysiology: Genetic Considerations - Frequent Chromosomal Translocations in Sarcoma...

Classification Review and Diagnostic Considerations

Diagnostic Considerations: Genetic Testing

Criteria for the Diagnosis of Dementia Due to Alzheimer's Disease

Familial Genetic Mutations

Anatomy and Pathophysiology

Mechanisms of Disease Development and Progression: Genetic Mutations and Impact

Non-modifiable Risk Factors

Genetics: Sporadic DAD - Newly Discovered Genes and Down Syndrome

Introduction

Disease Overview: Mortality
MS Timeline
Etiology
Environmental Factors
Infectiou...

Emerging Hypotheses on Treatment

Genetic Concepts: Interleukin Receptors

Emerging Hypotheses on Treatment

Genetic Concepts: Chances for Success

Potential Factors in the Development of Psoriasis

Potential Factors in Etiology of Psoriasis
Genetic Factors
Infectious Factors
Drug an...

Autoimmune Disease Processes

The Etiology of Autoimmune Disease
The Etiology of Autoimmune Disease: Genetic Factors (Risk)

Emerging Hypotheses on Treatment

Emerging Hypotheses on Treatment: Myelination-Targeted Antibodies
Cell Therapy
Human Stem ...

Emerging Hypotheses on Treatment

Genetic Concepts: Other Genes Potentially Involved in MS

Anatomy and Pathophysiology

Genetic Models of HNSCC Progression

DNA Discovery

Bacteriophage Experiment: DNA is the Genetic Material

Etiology of Multiple Sclerosis

Genetic Factors: MS Concordance

Genetic Instability

Chromosomal Instability

What is Biotechnology?

Genetic Engineering: The Foundation of Biotech

Genetics

High Serum Cholesterol Levels and AD

Genetics of Hunter Syndrome

Inheritance Pattern

Genetics of Gaucher Disease

Molecular Etiology

Genetics of Gaucher Disease

Inheritance Pattern

Genetics of Sanfilippo Syndrome

Inheritance Pattern

Genetics of Metachromatic Leukodystrophy

Molecular Etiology

Genetics of Metachromatic Leukodystrophy

Inheritance Pattern

Genetics of Fabry Disease

Molecular Etiology

Genetics of Fabry Disease

Inheritance Pattern

Etiology of Multiple Sclerosis

Genetic Factors: Major Histocompatibility Complex II (MHCII)

What is Biotechnology?

The History of Biotechnology
What is Biotechnology?
A Global Industry
The Evolution o...

Overview of Obesity

Overweight/Obese Defined
Body Mass Index
Waist Circumference and Obesity
Cause of Obe...

Additional concepts in MS Therapy

Immunologic Concepts
Genetic Concepts
Neurodegeneration
Neuroprotection
Remyelin...

Introduction

Introduction

Introduction

Introduction

Liver Diseases Overview

Liver Disease Overview: Key Concepts

Introduction

Introduction

Overview: Translation (Protein Synthesis)

Translation: Protein Synthesis (Overview)

Disease Overview

Etiology

Disease State

Classification: NSCLC Classification Based on Genomics

Introduction

Etiology

Epidemiology

Etiology

Summary: Psoriasis

Potential Factors in Etiology of Psoriasis

Potential Factors in the Development of Psoriasis

Potential Factors in Etiology of Psoriasis

Diagnosis of Gaucher Disease

Clinical Signs and Symptoms

BED Disease State

Disease Onset and Clinical Course

Pathology of T1DM

Type 1 Diabetes: Risk Factors

Introduction

Protein Structure and Function

Differential Diagnosis

Differential Diagnosis: Other Diseases that Share Some MS Features

Diagnosis and Treatment

Diagnostic Components/Diagnostic Confirmation

Overview of Breast Cancer

Risk Factors for Breast Cancer

Summary: Psoriasis

Psoriasis Definition
Potential Factors in Etiology of Psoriasis
Pathophysiology of Psorias...

Disease State

Etiology of Hyperlipidemia

How Do We Identify DNA Toxicants?

In Vivo Tests

The Hallmarks of Cancer

Enabling Characteristics

Molecular and Cellular Basis

Abnormal Plasma-like Myeloma Cells

Risk Factors

Risk Factors: Overview

Invasion and Metastasis: Introduction

Overview of Cancer: Hallmark Capabilities of Cancer

Physiology of Immune System Dysregulation

Pathophysiology of Psoriasis

Triggers and Risk Factors for Migraine

Risk Factors

Viruses and Mutation

Mutations

Diagnosis of MLD

Diagnostic Components and Findings

Atherosclerosis: Risk Factors

Risk Factors

Atherosclerosis: Risk Factors

Risk Factors

HCV Life Cycle

Viruses Require Cells as Hosts

Natural History of Type 1 Diabetes

Natural History of Type 1 Diabetes

How Do We Identify DNA Toxicants?

In Vitro Tests
In Vivo Tests

Causes of Atrial Fibrillation

Atrial Fibrillation Without Associated Heart Disease - Lone AF

Etiology

Pathogenesis of Schizophrenia

Pathophysiology

Overview: Pathogenesis

Resistance Testing

Genotypic Antiretroviral Resistance Testing

Overview of Obesity

Contributing Factors to Overweight/Obesity

Coronary Atherosclerosis: Overview

Risk Factors and Atherosclerosis

Pathophysiology

Overview

Recombination

Two Copies of RNA

HBV Life Cycle

Viruses Require Cells as Hosts

Etiology of Multiple Sclerosis

Cause of Multiple Sclerosis

Summary: Fetal Alcohol Spectrum Disorders (FASD) Prevention

Risk Factors

Potential Factors in the Development of Psoriasis

Geographical Location

Anatomy and Pathophysiology

Mechanisms of Disease Development and Progression: Immune System Evasion

Classification Review and Diagnostic Considerations

Diagnostic Considerations

Pathology of T1DM

Type 1 Diabetes: Risk Factors

Targeted Therapies

Therapies that Target Oncogenic Fusion Proteins

Viruses and Mutation

Viruses Require Cells As Hosts
Mutations
Mutations Caused by Reverse Transcriptase

Autoimmune Disease Processes

The Etiology of Autoimmune Disease: Environmental Factors

Summary: Psoriasis

Psoriasis Definition

Lysosomal Storage Disorders

Epidemiology

Etiology

Heritability

HBV Life Cycle

Viruses Require Cells as Hosts
Knowledge Check: HBV and Chronic Infection

HBV Life Cycle

Viruses Require Cells as Hosts

Pathogenesis of Primary Osteoporosis

Osteoporosis in Men

Risk Factors

AD and Environmental Risk Factors

HBV Life Cycle

Viruses Require Cells as Hosts

Tumor Suppressor Genes

Tumor Suppressor Genes: Introduction

Atherothrombosis

Overview: Atherosclerotic Process

Summary

HIV Life Cycle

Clinical Course of Alzheimer's Disease

AD Progression, Biomarkers and Pharmacological Therapy

Etiology of Multiple Sclerosis

Cause of Multiple Sclerosis
Environmental Factors

Fetal Alcohol Spectrum

Damage Due to Alcohol Exposure

Mechanisms of Molecular Pathogenesis: Summary

Mechanisms of Molecular Pathogenesis: Summary

Biomarkers

Examples of Current Biomarkers

Introduction to PK

Pharmacokinetics: Patient Characteristics

Lysosomal Storage Disorders: Overview and Definition

Lysosomal Storage Disorders: Overview and Definition

TIDM and Autoimmune Disorders

Immunotherapy of Type 1 Diabetes

Drug Discovery

Biomarkers

Introduction: Psoriasis

Introduction: Psoriasis

Anatomy and Pathophysiology

Melanoma Risk Factors: UV Exposure and Compromised Immune System

Introduction

Introduction: Soft Tissue and Bone Sarcomas

Soft Tissue Sarcomas (STSs)

Anatomy and Pathophysiology: Mechanisms of Disease Development and Progression

Risk Factors for AD

Risk Factors for AD

Causes of Atrial Fibrillation

Causes of Atrial Fibrillation: Overview

Causes of Atrial Fibrillation (AF), Associated Conditions

Causes of Atrial Fibrillation (AF): Overview

Epidemiology and Natural History

Epidemiology

Pathology of T1DM

Natural History of Type 1 Diabetes

Biological Products/Cell Therapy

Discovery and Development of Biologics: Cell Therapy

Heart Failure: Causes

Index Event
Nature of Index Event
Compensatory Mechanisms
Left Ventricular Remodeling

Summary: Pathophysiology of Lupus

Summary: Pathophysiology of Lupus

Etiology

Influencing Factors

Epidemiology and Incidence

Predisposing Causes of Myelodysplastic Syndromes Primary MDS (de novo MDS)

Summary: Epidemiological Research

Summary: Epidemiological Research

Hunter Syndrome: Introduction

Hunter Syndrome: Introduction

Fabry Disease: Introduction

Fabry Disease: Introduction

Atherosclerosis: Overview and Statistics

Overview

Heart Failure: Causes

Compensatory Mechanisms

Introduction

Define a Biologic (Clarification of Terminology, FDA Changes)

HCV Vaccines

Challenges in Vaccine Development

Introduction

Myeloma Etiology

Classification and Staging

Prognosis

Introduction to Immunopathology

Autoimmune Diseases: General Mechanism Underlying Autoimmune Disease

Autoimmune Disease Processes

The Etiology of Autoimmune Disease

Chromosome Abnormalities in MDS

Chromosome Abnormalities: Aneuploidy

Chromosome Abnormalities in MDS

Clonality and Karyotypic Evolution

Chromosome Abnormalities in MDS

Molecular Models for Chromosome Abnormalities

DNA Discovery

Bacteriophage Experiment

Overview: The Cell Cycle and Mitosis

The Cell Cycle and Mitosis: Overview

Animal Models of MS

TMEV Infection Model

Biomarkers

Examples of Current Biomarkers
Candidate Biomarkers

Model Development and Implementation

Model-Centric Data Integration, Development, and Collection

Autoimmune Diseases: Introduction

General Mechanism Underlying Autoimmune Disease

What is Biotechnology?

The Evolution of Biotechnology

Biopharmaceuticals

Making Biopharmaceuticals Better

Mechanisms of Select Autoimmune Disorders

Rheumatoid Arthritis: TH17

Introduction: Psoriasis

Definition of Psoriasis

Overview of Obesity

Cause of Obesity

Soft Tissue Sarcomas (STSs)

Anatomy and Pathophysiology: Familial Predisposition

Conclusions and Future Directions

Sarcomas: Conclusions and Future Directions

Clopidogrel

Drug Interactions and Hyporesponse

Hunter Syndrome: Introduction & Overview

Etiology: Mucopolysaccharidoses (MPS)

Stochastic or Clonal Evolution Model

Stochastic or Clonal Evolution Model

Epidemiology

Juvenile-Onset Parkinson's Disease

Atherosclerosis Contribution to Cardiovascular Diseases

Coronary Artery Disease: Heart Failure

Schizophrenia Disease

Schizophrenia

Risk Stratification Systems

Mutations Linked to PMF and Other Myeloproliferative Neoplasms

Disease Overview

Definition of Multiple Sclerosis
Prognosis
Clinical Presentation
Patient Descriptions...

Risk Factors for Atherosclerosis

Risk Factors and Atherosclerosis

Dyslipidemia Disease State

Etiology

Autoimmune Diseases: Introduction

General Mechanism Underlying Autoimmune Disease
The Breakdown of Tolerance
The Breakdown o...

Introduction

Protein Structure and Function

HCV Life Cycle

Viruses Require Cells as Hosts
HCV Infection
HCV Translation
HCV Replication
Tes...

What is HCV?

HCV Genotypes

Pathophysiology

Immunopathophysiology: Epstein-Barr Virus (EBV)

Gene Silencing: DNA Methylation

Genes Affected by Methylation in MDS: Tumor Suppressor Genes

Cytogenetic Subgroups in MDS

Cytogenetic Subgroups in MDS

IL-1Ra

IL-1Ra Inhibits IL-1β

Epidemiology

Demographics

Mechanisms of Select Autoimmune Disorders

Systemic Lupus Erythematosus: Multisymptom Disease

Physiology of Immune System Dysregulation

Overview of Immune Dysregulation

Summary: Psoriasis

Pathophysiology of Psoriasis

Soft Tissue Sarcomas (STSs)

Anatomy and Pathophysiology: Li-Fraumeni syndrome

Pathophysiology of Atrial Fibrillation

Atrial Fibrosis

Mechanisms of Select Autoimmune Disorders

Rheumatoid Arthritis: Early Stages of RA

Causes of Atrial Fibrillation (AF), Associated Conditions

Familial Atrial Fibrillation
Obesity and Atrial Fibrillation

Biological Products

Manufacturing Process

Sanfilippo Syndrome: Introduction

Sanfilippo Syndrome: Introduction and Overview

Metachromatic Leukodystrophy: Introduction

Metachromatic Leukodystrophy: Introduction and Overview

Immunotherapies

Tumor Cell Therapies

Introduction

Multiple Myeloma (MM)
Interactive Exercise: Cancer Vocabulary
Spectrum of Diseases
Pr...

Prenatal and Postnatal Diagnosis

Diagnosis of HAE In Pregnancy

Neurobiology of Addiction and Withdrawal

Addiction, Tolerance, and Withdrawal

Pathophysiology

Immunopathophysiology: Myelin-Reactive T Cells
Immunopathophysiology: T Cell Initiation of MS -...

Introduction

Define a Biologic (Clarification of Terminology, FDA Changes)
Protein Structure and Function

Molecular and Cellular Basis

Abnormal Plasma-like Myeloma Cells
Normal B Cell Development
Myeloma Cell Development

Overview of Heart Failure

Classification of Heart Failure: Conventional Classification

Diagnostic Workup

Laboratory Tests for AE (Without Urticaria)

Atherosclerosis: Overview and Statistics

Overview

HIV Retrovirus

HIV Core

Viruses and Mutation

Viruses Require Cells As Hosts

Type 2 Diabetes Mellitus (T2DM)

Natural History of T2DM: Summary

Type 2 Diabetes Mellitus (T2DM)

Natural History of T2DM: Summary

What are the Determinants of PK? ADME

ADME

What is HBV?

HBV Genome

Mutations in Genes Responsible for Cell Proliferation

Changes in Apoptosis and Proliferation

Gene Silencing: DNA Methylation

Genes Affected by Methylation in MDS: Tumor Suppressor Genes

Hypomethylating Agents

Gene Silencing Following DNA Methylation

Risk Factors

Alcoholism

Risk Factors

Alcohol Dependence (Alcoholism)

Introduction to Diabetes and Diabetes Terminology

Introduction to Diabetes and Diabetes Terminology

Summary: Diabetes: Type 1 Pathophysiology

Pathophysiology of Type 1 Diabetes

Microvascular Complications

Diabetic Nephropathy: Risk Factors, Treatment

Introduction: Psoriasis

Definition of Psoriasis
Psoriasis Skin Dysregulation

Psoriatic Arthritis

Psoriatic Arthritis (PsA) Pathophysiology

Overview of Obesity

Risk Factors Associated with Being Obese or Overweight

Peak Bone Mass

Factors Affecting Peak Bone Mass

Anatomy and Pathophysiology

Risk Factors: Diet, Oral Hygiene and Inherited Conditions

Introduction

Introduction

Pathophysiology of Male Hypogonadism

Tertiary Male Hypogonadism: Kallman Syndrome, GnRH Deficiency, GPR54, Opioid Use

Pathophysiology of Atrial Fibrillation (AF)

Atrial Fibrosis

Gaucher Disease: Introduction

Gaucher Disease: Introduction

Hereditary Angioedema: Summary

Hereditary Angioedema: Summary

Prevalence and Incidence of CVD

Prevalence and Incidence of Cardiovascular Disease (CVD): Overview

Basaglar T1DM: Summary

Pathophysiology of Type 1 Diabetes

Pathophysiology

Overview
T Cell Initiation of MS Blood Brain Barrier
B Cells and Autoantibodies in Diseas...

Type 2 Diabetes Mellitus (T2DM)

Natural History of T2DM: Summary

Autoimmune Disease Processes

The Etiology of Autoimmune Disease: Environmental Factors (Infectious Agents)
The Etiology of A...

Cellular Organelles

Cellular Organelles

Overview of Osteoporosis

Bone Biology and Bone Loss

Disease State

Risk Factors

Diagnostic Workup

Causative and Facilitative Factors

T2DM Diagnosis

Signs and Symptoms

Etiology of Hypertension

Risk Factors

Introduction

The Critical Path for Medical Product Development
The Immune System Modulators
Interactive...

Recombination

HIV Subtypes
Two Copies of RNA
Recombination

Resistance Testing

Anti-Retroviral Resistance Testing
Genotypic Antiretroviral Resistance Testing
Phenotypic ...

Heart Failure: Causes

Compensatory Mechanisms

Oral Dosing

Bioavailability (F)

Chromosome Abnormalities in MDS

Chromosome Abnormalities: Translocations and Inversions
Interactive Activity: Chromosomes Abnor...

Hypomethylating Agents

Gene Silencing Following DNA Methylation

Autoimmune Diseases: Introduction

Autoimmune Diseases: Introduction

Introduction to PK

Drug Concentration at Target Site
Different Types of Drug Molecules
Pharmacokinetics vs. P...

Overview of Colorectal Cancer

Non-Modifiable Risk Factors

Autoimmune Diseases: Introduction

Autoimmune Diseases: Introduction
Epidemiology and Impact

Liver Diseases Overview

Hepatitis Due to Drugs, Toxins, and Alcohol: Alcoholic Liver Disease

Liver Diseases Overview

Primary Sclerosing Cholangitis (PSC)

Primary Biliary Cirrhosis: Key Concepts

Primary Biliary Cirrhosis: Key Concepts

Non-Small Cell Lung Cancer: Introduction

Non-Small Cell Lung Cancer: Introduction

Pathophysiology

Nephropathy

Diagnosis and Prognosis

Confirmation with Complete Right Heart Catheterization

Diagnosis and Treatment

Diagnostic Components

Diagnosis of Hunter Syndrome

Diagnostic Tests

Epidemiology

Incidence, Prevalence, and Demographics

Diagnosis of Gaucher Disease

Diagnostic Tests and Surveillance

Atopic Dermatitis: Introduction

Atopic Dermatitis: Introduction

Epidemiology

Risk Factors

Prostate Cancer: Introduction

Prostate Cancer: Introduction

Anxiety Disorders Disease: Introduction

Prevalence of Anxiety Disorders

Migraine

The Evolution of Migraine

Chromosome Abnormalities in MDS

Chromosomes
Chromosomes: Number and Structure
Interactive Activity: Chromosomes - Number a...

Epidemiology and Incidence

Increasing Incidence with Increasing Age of Myelodysplastic Syndromes
Gender and Myelodysplasti...

Atherosclerosis: Overview and Statistics

Overview
Statistics

Summary

HIV Entry
HIV Life Cycle
Splicing
Virus Maturation
Subtypes
Recombination

Introduction to Immunopathology

Autoimmune Diseases: Epidemiology and Impact
Autoimmune Diseases: General Mechanism Underlying ...

Mutations in Genes Responsible for Cell Proliferation

Changes in Apoptosis and Proliferation
Oncogenes
Oncogenes: Small G Proteins (Ras)
On...

Gene Silencing: DNA Methylation

Epigenetic Changes: DNA Methylation
CpG Islands and Histones Deacetylases
Genes Affected b...

Hypomethylating Agents

Mechanism of DNA Methylation
Gene Silencing Following DNA Methylation
Hypomethylating Agen...

Summary: Cell Structure and Mobility

Cell Structure and Mobility: Summary

Summary: Fetal Alcohol Syndrome

Summary: Fetal Alcohol Syndrome

Fetal Alcohol Spectrum

Fetal Alcohol Syndrome (FAS) Alcohol Effects
Fetal Alcohol Spectrum Disorders (FASD)
Fetal...

Summary: Fetal Alcohol Spectrum Disorders (FASD) Prevention

Preventing Fetal Alcohol Spectrum Disorders (FASD)
Routine Alcohol Screening
Risk Factors

Type 2 Diabetes Mellitus

Common Risk Factors for Type 2 Diabetes

Biopharmaceuticals

Biopharmaceuticals
Patents and Generics
Biopharmaceuticals: Specificity of Action
Mak...

Psoriatic Arthritis

Pathophysiology of Psoriatic Arthritis (PsA)
Psoriatic Arthritis (PsA) Pathophysiology

Non-Bioequivalent Insulins

Humulin R U-500: Real World Usage and Outcomes

Biological and Physicochemical Determinants of PK

Drug Elimination: Metabolism and Excretion

Patient Types and Risk Factors for Bleeding

Bleeding Disorders

GLP-1 Receptor Agonists for T2DM

GLP-1 Receptor Agonists: Increasing Duration of Action

Definition and Classification

Spectrum of Disorders

Overview: Cancer VTE

Venous Thromboembolism (VTE) Overview

Country-Specific Definitions and Regulatory Guidelines

India Ministry of Science and Technology (MST)

Overview of Classification of Angioedema (AE)

Allergic Angioedema (Association with Urticaria)

Symptoms and Clinical Course of HAE

Overview: HAE Due to Decreased C1-INH

Classification Review and Diagnostic Considerations

Angioedema Overview

Epidemiology

Risk Factors

Risk Factors for CHD and MI

Risk Factors

Concepts in Cancer Immunology

Cancer Immunosurveillance

Additional Recommendations and Position Statements

National Lipid Association (NLA) Recommendations for Patient-Centered Management of Dyslipidemia

Special Populations

NLA: South Asians

Mechanisms of Select Autoimmune Disorders

Systemic Lupus Erythematosus

What is HCV?

HCV Genome: Regions Encoding Structural and Non-Structural Genes
Hepatitis Viruses
Phyloge...

HIV Retrovirus

Reverse Transcriptase
HIV Core
HIV Messenger RNA
HIV Integrase

HCV Vaccines

The Immune Response
Are Vaccines Feasible with Hepatitis Viruses?
Routes to an Effective H...

What are the Determinants of PK? ADME

Interactive Exercise: Drug Absorption and Elimination
Elimination: Metabolism & Excretion
...

Oral Dosing

Absorption
Lag Time
Bioavailability (F)
Interactive Exercise: Changing Dose
Bioe...

Osteoporosis and Obesity

Background

Epidemiology and Risk Factors for PAH

Risk Factors

Statins

Side Effects

PCSK9 Inhibitors

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)

Atherothrombosis

Overview: Atherothrombosis
Interactivity: Unstable Plaque
Interactivity: Thrombus Formatio...

Classification and Staging

Classification of Myeloma
Diagnostic Criteria
Interactive Exercise: Myeloma Classification...

Chromosome Abnormalities in MDS

Chromosomes
Chromosomes: Number and Structure
Interactive Activity: Chromosomes - Number a...

Risk Factors

Who's at Risk for Having Children with FASD?
Risk Factors Based on Study Population
In...

Risk Factors

Alcohol Dependence (Alcoholism)
Interactive Exercise: Who's at Risk?
Risk Factors Base...

Drug Discovery

Drug Discovery
Target vs. Platform-driven Discovery
Target Validation
Targeting Strat...

PK in Action

PK Prediction

Non-Bioequivalent Insulins

Humulin R U-500: Evaluating Dose Regimens, Clinical Pharmacology, Costs, and Adherence

Cancer Immunotherapy

Adoptive T Cell Transfer

What is HBV?

Hepatitis Viruses
HBV (Molecular Biology of HBV)
The Structure of HBV
HBV Genome

Clinical Features of Angioedema Without Urticaria (Bradykinin-Mediated)

HAE Due to Decreased C1-INH

Epidemiology

Overview of HAE Epidemiology

Relationship between Obesity, Diabetes and Cardiovascular Disease

Obesity: Pathophysiology of Fat Cells

Biological Products/Biologics vs. Biosimilars

How Similar Is Similar

Biological Products/Gene Therapy

Discovery and Development of Biologics: Gene Therapy

Introduction to Immunopathology

Organ Transplant Rejection: Class I MHC and Class II MHC Proteins
Organ Transplant Rejection: H...

VTE Clinical Picture: Risk Factors and Comorbid States

Comorbid States

Biological Products/Biologics vs. Biosimilars

Demonstrating Biosimilarity

Lysosomal Storage Disorders: Introduction

Lysosomal Storage Disorders: Introduction

Pathophysiology

Pathogenesis

Heart Failure: Causes

Nature of Index Event

Marketplace

Multiple Sclerosis

Summary: Myelodysplastic Syndromes

Apoptosis Followed by Proliferation

Liver Diseases Overview

Hepatitis Due to Drugs, Toxins, and Alcohol

Biological Products/Recombinant Proteins

Discovery and Development of Biologics: Recombinant Biologics

Viral Genotype and Resistance

Genotype and Phenotype

Introduction

Multiple Myeloma (MM)

Summary: Myelodysplastic Syndromes

Defining Myelodysplastic Syndromes
Apoptosis Followed by Proliferation
Summary: Myelodyspl...

Mutations

Why Mutations Occur

Lysosomal Storage Disorders

Classification: Oligosaccharidoses, Cystinosis, and Niemann-Pick Type C Disease

Autoimmune Disorders

Mechanisms: The Breakdown of Tolerance Molecular Mimicry

Autoimmune Diseases: Introduction

The Breakdown of Tolerance: Molecular Mimicry

Relationship between Obesity, Diabetes and Cardiovascular Disease

Obesity, Diabetes and Cardiovascular Disease
Obesity: Pathophysiology of Fat Cells
Obesity...

VTE Clinical Picture: Risk Factors and Comorbid States

Risk Factors and Comorbid States

Forms of Lupus

Neonatal Lupus

Pharmacokinetics: Absorption

Low Bioavailability

Clinical Manifestations

Signs and Symptoms

Metachromatic Leukodystrophy: Introduction and Overview

Etiology

Epidemiology

Longitudinal Studies: Age-Associated Diseases

Autoimmune Disorders

Mechanisms: The Breakdown of Tolerance Molecular Mimicry
Mechanisms: Loss of T Cell Anergy

Mechanisms of Autoimmune Disease: The Breakdown of Tolerance

The Breakdown of Tolerance: Molecular Mimicry

Autoimmune Diseases: Introduction

The Breakdown of Tolerance
The Breakdown of Tolerance: Molecular Mimicry
Mechanisms: Loss ...

Pathophysiology

T Cell Initiation of MS

Heart Failure: Risk Factors

Risk Factors

Heart Failure: Risk Factors

Risk Factors

HCV Life Cycle

HCV Replication

Pathophysiology

Anatomical Pathophysiology: Histological Patterns

Histological/Biological Changes

Proteinaceous Deposits

Autoimmune Disease Processes

Consequences of Autoimmune Diseases: Common Autoimmune Diseases

Pathophysiology

Immunopathophysiology: T Cell Initiation of MS

Viral Genotype and Resistance

Genotype and Phenotype
Gene Expression in HIV
Mutation and Resistance
Resistance to D...

Marketplace

Stroke
Diabetes Mellitus
Growth Defects
Anemia
Neutropenia
Hepatitis
R...

Autoimmune Disease Processes

Consequences of Autoimmune Diseases: TNF-α In Autoimmune Disease: Potential Harm OR Benefit?

Introduction to Therapeutic Immunology

Categories of Biologic Therapy

Criteria for the Diagnosis of Dementia Due to Alzheimer's Disease

NINCDS-ADRDA Update

Mechanisms of Autoimmune Disease: The Breakdown of Tolerance

Mechanisms of Autoimmune Disease: The Breakdown of Tolerance
The Breakdown of Tolerance: Molecu...

Mechanisms of Autoimmune Disease: The Breakdown of Tolerance

Mechanisms of Autoimmune Disease: The Breakdown of Tolerance
The Breakdown of Tolerance: Molecu...

Autoimmune Disease Processes

Consequences of Autoimmune Diseases: Progression and Destruction in Autoimmune Disorders (Mechanisms...

Advancing Technologies

Biomarkers: Inflammation Biomarkers

Marketplace

Stroke
Diabetes Mellitus
Growth Defects
Anemia
Neutropenia
Hepatitis
R...

Introduction to Therapeutic Immunology

Edward Jenner: Vaccination
Vaccination Successes
Therapeutic Immunology: Immunodiagnostics...

Mutations

Why Mutations Occur
Loss of Drug Effectiveness
Mutations Selection by Drugs
Cross Res...

Disease Definition and Clinical Course

Course of Disease

Typical Course of Plaque Psoriasis

Onset, Episodes, Flare-Ups, Triggers
Complications and Comorbidities of Psoriasis

Typical Course of Plaque Psoriasis

Complications and Comorbidities of Psoriasis

Introduction to Monoclonal Antibodies

Four General Classes of mAb Therapies

Standard Agents: Therapeutic Challenges

Therapeutic Challenges of Antithrombotic Treatment

Introduction to Monoclonal Antibodies

Antibodies as Therapy
Early Antibody Therapy: Polyclonal Antibodies
Hybridoma Technology: ...

Clinical Applications of Monoclonal Antibodies

A Closer Look At mABS Used as Therapies

Steroids

Glucocorticoids: Mode of Action
The Anti-Inflammatory Effects of Corticosteroids
Glucocort...

Steroids

Glucocorticoids: Side Effects

Advancing Technologies

Biomarkers: Disease Process-Specific Biomarkers
Biomarkers: Inflammation Biomarkers
Biomar...

Clinical Applications of Monoclonal Antibodies

Clinical Applications of Monoclonal Antibodies: Learning Objectives
Detection, Diagnosis, and M...